- Yale Fertiity Center125A Kings Highway NorthWestport, CT 06880
- Yale Medicine Fertility Center200 West Campus DriveFl 2Orange, CT 06477
Emre Seli, MD
Biography
Emre Seli, MD, specializes in treating complex infertility cases, including women and men who need egg donation or gestational surrogacy. Dr. Seli’s patients experience very high pregnancy rates, with 78 percent achieving live birth through egg donation in 2015. He also addresses the medical, psychological and legal needs of LGBTQ patients attempting parenthood.
Dr. Emre says the most exciting part of his work is combining biomedical research with advances in the field of infertility, including personalized medicine. “The first baby born through IVF (in vitro fertilization) is not even 40 years old,” he notes. “Since then, we have learned how to freeze embryos, eggs and perform diagnostic procedures in the embryo. Every day, a new experimental procedure is being offered to women and men with infertility.”
The Yale Medicine Fertility Center is at the forefront of these discoveries and, Dr. Seli says, “We are constantly collaborating with other leading researchers in the field. As a result, we provide our patients a critical assessment of all options to achieve the best possible outcome."
Dr. Seli is a professor of obstetrics, gynecology and reproductive sciences at Yale School of Medicine. In his laboratory, Dr. Seli researches determinants of egg and embryo health, and mechanisms of ovarian aging. He and his colleagues have made significant contributions within the field of in vitro fertilization (IVF), especially in understanding which embryos might result in a successful pregnancy and birth.
“We continually seek new and better ways of helping our patients,” Dr. Seli says. “One thing is for sure, three years from now, we’ll be doing things differently than we are doing now.”
Titles
- Professor of Obstetrics, Gynecology & Reproductive Sciences
Education & Training
- FellowYale University School of Medicine (2004)
- ResidentYale University School of Medicine (2001)
- MDUniversity of Istanbul (1992)
Languages Spoken
- English
- Français (French)
- Türkçe (Turkish)
Additional Information
- ASRM Prize Paper: American Society for Reproductive Medicine (2019)
- ASRM SART Prize Paper: American Society for Reproductive Medicine (2019)
- Beacon Award: Frontiers in Stem Cells and Reproduction, ICRO, UNESCO (2018)
- President's Achievement Award: Society for Reproductive Investigation (SRI) (2016)
- SRI President's Presenter Award (mentor): Society for Reproductive Investigation (2016), (2017), (2018), (2019)
- Star Award: American Society for Reproductive Medicine (ASRM) (2015), (2016), (2017), (2018), (2019)
- Best Doctors in America: (2015), (2016), (2017), (2018), (2019)
- Excellence in Teaching Award: Association of Professors of Gynecology and Obstetrics (APGO) and Department of Obstetrics and Gynecology, Yale School of Medicine (2013)
- Ira and Ester Rosenwaks New Investigator Award: American Society for Reproductive Medicine (ASRM) (2009)
- ESHRE Basic Science Award: European Society for Human Reproduction and Embryology (ESHRE) (2008)
- AB of Obstetrics & Gynecology, Reproductive Endocrinology & Infertility (2009, recertified: 2020)
- AB of Obstetrics & Gynecology, Obstetrics & Gynecology (2005, recertified: 2020)
- Ata B, Gill P, Cimadomo D, Ubaldi F, Garcia-Velasco J, Seli E. Reply. Recurrent implantation failure in patients undergoing euploid embryo transfers are unlikely to be caused by unmodifiable extra-embryonic factors. Human Reproduction 2024, deae185. PMID: 39173607, DOI: 10.1093/humrep/deae185.
- Gill P, Ata B, Arnanz A, Cimadomo D, Vaiarelli A, Fatemi H, Ubaldi F, Garcia-Velasco J, Seli E. Does Recurrent Implantation Failure Exist? Prevalence and Outcomes of Five Consecutive Euploid Blastocyst Transfers in 123 987 Patients. Obstetrical & Gynecological Survey 2024, 79: 473-474. DOI: 10.1097/ogx.0000000000001310.
- Yildirim R, Seli E. Mitochondria as determinants of reproductive senescence and competence: implications for diagnosis of embryo competence in assisted reproduction. Human Reproduction 2024, deae171. PMID: 39066612, DOI: 10.1093/humrep/deae171.
- Yildirim R, Seli E. Mitochondria as therapeutic targets in assisted reproduction. Human Reproduction 2024, deae170. PMID: 39066614, DOI: 10.1093/humrep/deae170.
- Volovsky M, Scott R, Seli E. Non-invasive preimplantation genetic testing for aneuploidy: is the promise real? Human Reproduction 2024, 39: 1899-1908. PMID: 38970367, DOI: 10.1093/humrep/deae151.
- Dotterweich K, Gill P, Reig A, Whitehead C, Werner M, Seli E. EVALUATING DAY 5 VERSUS DAY 6 BLASTULATION RATES AMONG FRESH VERSUS FROZEN DONOR EGG CYCLES. Fertility And Sterility 2024, 122: e24-e25. DOI: 10.1016/j.fertnstert.2024.05.041.
- Rodríguez-Eguren A, Bueno-Fernandez C, Gómez-Álvarez M, Francés-Herrero E, Pellicer A, Bellver J, Seli E, Cervelló I. Evolution of biotechnological advances and regenerative therapies for endometrial disorders: a systematic review. Human Reproduction Update 2024, 30: 584-613. PMID: 38796750, PMCID: PMC11369227, DOI: 10.1093/humupd/dmae013.
- Ata B, Gill P, Cimadomo D, Ubaldi F, Garcia-Velasco J, Seli E. Reply: Consecutive euploid blastocyst transfers currently represent the best available model for investigating the true prevalence of recurrent implantation failure (RIF), a rare pathology at best. Human Reproduction 2024, 39: 1575-1576. PMID: 38741229, DOI: 10.1093/humrep/deae096.
- Herlihy N, Cakiroglu Y, Whitehead C, Reig A, Tiras B, Scott R, Seli E. Effect of intraovarian platelet-rich plasma injection on IVF outcomes in women with poor ovarian response: the PROVA randomized controlled trial. Human Reproduction 2024, 39: 1495-1503. PMID: 38725194, DOI: 10.1093/humrep/deae093.
- Gill P, Puchalt N, Molinaro T, Werner M, Seli E, Hotaling J, Cheng P. Leukocytospermia does not negatively impact outcomes in in vitro fertilization cycles with intracytoplasmic sperm injection and preimplantation genetic testing for aneuploidy: findings from 5435 cycles. Journal Of Assisted Reproduction And Genetics 2024, 41: 1213-1219. PMID: 38642270, PMCID: PMC11143111, DOI: 10.1007/s10815-024-03085-x.
- Reig A, Seli E. Poor ovarian response classification systems in the clinical setting – time for an update? Current Opinion In Obstetrics & Gynecology 2024, 36: 192-199. PMID: 38597510, DOI: 10.1097/gco.0000000000000950.
- Gill P, Ata B, Arnanz A, Cimadomo D, Vaiarelli A, Fatemi H, Ubaldi F, Garcia-Velasco J, Seli E. Does recurrent implantation failure exist? Prevalence and outcomes of five consecutive euploid blastocyst transfers in 123 987 patients. Human Reproduction 2024, 39: 974-980. PMID: 38452358, DOI: 10.1093/humrep/deae040.
- Cozzolino M, Ergun Y, Ristori E, Garg A, Imamoglu G, Seli E. Disruption of mitochondrial unfolded protein response results in telomere shortening in mouse oocytes and somatic cells. Aging 2024, 16: 2047-2060. PMID: 38349865, PMCID: PMC10911389, DOI: 10.18632/aging.205543.
- Yildirim R, Seli E. The role of mitochondrial dynamics in oocyte and early embryo development. Seminars In Cell And Developmental Biology 2024, 159: 52-61. PMID: 38330625, DOI: 10.1016/j.semcdb.2024.01.007.
- Ergun Y, Imamoglu A, Cozzolino M, Demirkiran C, Basar M, Garg A, Yildirim R, Seli E. Mitochondrial Unfolded Protein Response Gene Clpp Is Required for Oocyte Function and Female Fertility. International Journal Of Molecular Sciences 2024, 25: 1866. PMID: 38339144, PMCID: PMC10855406, DOI: 10.3390/ijms25031866.
- Esbert M, Tao X, Ballesteros A, Yildirim R, Scott R, Seli E. Addition of rapamycin or co-culture with cumulus cells from younger reproductive age women does not improve rescue in vitro oocyte maturation or euploidy rates in older reproductive age women. Molecular Human Reproduction 2024, 30: gaad048. PMID: 38180884, DOI: 10.1093/molehr/gaad048.
- Garg A, Seli E. Leukocyte telomere length and DNA methylome as biomarkers of ovarian reserve and embryo aneuploidy: the intricate relationship between somatic and reproductive aging. Fertility And Sterility 2023, 121: 26-33. PMID: 37979607, DOI: 10.1016/j.fertnstert.2023.11.011.
- Cakiroglu Y, Tohma Y, Yuceturk A, Karaosmanoglu O, Kopuk S, Korun Z, Yazicioglu C, Scott R, Tiras B, Zeyneloglu H, Seli E. SUBENDOMETRIAL AUTOLOGOUS PLATELET RICH PLASMA INJECTION IN PATIENTS WITH UNRESPONSIVE THIN ENDOMETRIUM UNDERGOING FROZEN-THAWED EMBRYO TRANSFER. Fertility And Sterility 2022, 118: e170. DOI: 10.1016/j.fertnstert.2022.08.489.
- Cozzolino M, Herraiz S, Cakiroglu Y, Garcia-Velasco JA, Tiras B, Pacheco A, Rabadan S, Kohls G, Barrio AI, Pellicer A, Seli E. Distress response in granulosa cells of women affected by PCOS with or without insulin resistance. Endocrine 2022, 79: 200-207. PMID: 36149529, DOI: 10.1007/s12020-022-03192-8.
- Cozzolino M, Ergun Y, Seli E. Targeted Deletion of Mitofusin 1 and Mitofusin 2 Causes Female Infertility and Loss of Follicular Reserve. Reproductive Sciences 2022, 30: 560-568. PMID: 35739352, DOI: 10.1007/s43032-022-01014-w.
- Cozzolino M, Seli E. Mitochondrial dysfunction caused by targeted deletion of Mfn1 does not result in telomere shortening in oocytes. Zygote 2022, 30: 735-737. PMID: 35730364, DOI: 10.1017/s0967199422000089.
- Herlihy NS, Klimczak AM, Cheung JKW, Seli E, Scott RT. The chances of obtaining a euploid embryo and subsequent live birth remain consistent with national age-based rates after an in vitro fertilization cycle that produced only aneuploid embryos. Fertility And Sterility 2022, 118: 484-491. PMID: 35691719, DOI: 10.1016/j.fertnstert.2022.05.026.
- Herlihy NS, Seli E. The use of intraovarian injection of autologous platelet rich plasma (PRP) in patients with poor ovarian response and premature ovarian insufficiency. Current Opinion In Obstetrics & Gynecology 2022, 34: 133-137. PMID: 35645011, DOI: 10.1097/gco.0000000000000784.
- Cozzolino M, Herraiz S, Titus S, Roberts L, Romeu M, Peinado I, Scott RT, Pellicer A, Seli E. Transcriptomic landscape of granulosa cells and peripheral blood mononuclear cells in women with PCOS compared to young poor responders and women with normal response. Human Reproduction 2022, 37: 1274-1286. PMID: 35451009, PMCID: PMC9156844, DOI: 10.1093/humrep/deac069.
- Díaz-García C, Herraiz S, Pamplona L, Subirá J, Soriano MJ, Simon C, Seli E, Pellicer A. Follicular activation in women previously diagnosed with poor ovarian response: a randomized, controlled trial. Fertility And Sterility 2022, 117: 747-755. PMID: 35367015, DOI: 10.1016/j.fertnstert.2021.12.034.
- Cakiroglu Y, Yuceturk A, Karaosmanoglu O, Kopuk SY, Korun ZEU, Herlihy N, Scott RT, Tiras B, Seli E. Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP). Aging 2022, 14: 2513-2523. PMID: 35320118, PMCID: PMC9004561, DOI: 10.18632/aging.203972.
- Klimczak AM, Herlihy NS, Scott CS, Hanson BM, Kim JG, Titus S, Seli E, Scott RT. B-cell lymphoma 6 expression is not associated with live birth in a normal responder in vitro fertilization population. Fertility And Sterility 2021, 117: 351-358. PMID: 34809978, DOI: 10.1016/j.fertnstert.2021.09.036.
- Franasiak JM, Alecsandru D, Forman EJ, Gemmell LC, Goldberg JM, Llarena N, Margolis C, Laven J, Schoenmakers S, Seli E. A review of the pathophysiology of recurrent implantation failure. Fertility And Sterility 2021, 116: 1436-1448. PMID: 34674825, DOI: 10.1016/j.fertnstert.2021.09.014.
- Hanson BM, Kim JG, Suarez SI, Ackerman BK, Comito CE, Pangasnan R, Seli E, Hong KH, Scott RT. Embryology outcomes after oocyte vitrification with super-cooled slush nitrogen are similar to outcomes with conventional liquid nitrogen: a randomized controlled trial. Fertility And Sterility 2021, 117: 106-114. PMID: 34654569, DOI: 10.1016/j.fertnstert.2021.08.043.
- Zhu M, Shahbazi M, Martin A, Zhang C, Sozen B, Borsos M, Mandelbaum RS, Paulson RJ, Mole MA, Esbert M, Titus S, Scott RT, Campbell A, Fishel S, Gradinaru V, Zhao H, Wu K, Chen ZJ, Seli E, de los Santos MJ, Goetz M. Human embryo polarization requires PLC signaling to mediate trophectoderm specification. ELife 2021, 10: e65068. PMID: 34569938, PMCID: PMC8514238, DOI: 10.7554/elife.65068.
- Tiegs AW, Titus S, Mehta S, Garcia-Milian R, Seli E, Scott RT. Cumulus cells of euploid versus whole chromosome 21 aneuploid embryos reveal differentially expressed genes. Reproductive BioMedicine Online 2021, 43: 614-626. PMID: 34417138, DOI: 10.1016/j.rbmo.2021.06.015.
- Glatthorn HN, Hanson BM, Kim JG, Herlihy NS, Klimczak AM, Hong KH, Seli E, Scott RT. Individual culture leads to decreased blastocyst formation but does not affect pregnancy outcomes in the setting of a single, vitrified-warmed euploid blastocyst transfer. Journal Of Assisted Reproduction And Genetics 2021, 38: 2157-2164. PMID: 34086147, PMCID: PMC8417170, DOI: 10.1007/s10815-021-02252-8.
- Seli E, Garcia-Velasco JA. Editorial: Assisted reproductive technology (ART) in a changing world. Current Opinion In Obstetrics & Gynecology 2021, 33: 157-158. PMID: 33896914, DOI: 10.1097/gco.0000000000000699.
- Reig A, Herraiz S, Pellicer A, Seli E. Emerging follicular activation strategies to treat women with poor ovarian response and primary ovarian insufficiency. Current Opinion In Obstetrics & Gynecology 2021, 33: 241-248. PMID: 33896920, DOI: 10.1097/gco.0000000000000703.
- Yang M, Tao X, Scott K, Zhan Y, Scott RT, Seli E. Evaluation of genome-wide DNA methylation profile of human embryos with different developmental competences. Human Reproduction 2021, 36: 1682-1690. PMID: 33846747, DOI: 10.1093/humrep/deab074.
- Klimczak AM, Seli E, Scott RT. Noninvasive prenatal testing in women undergoing in vitro fertilization with preimplantation genetic testing. Current Opinion In Obstetrics & Gynecology 2021, 33: 184-187. PMID: 33797422, DOI: 10.1097/gco.0000000000000707.
- Esencan E, Simsek B, Seli E. Analysis of female demographics in the United States: life expectancy, education, employment, family building decisions, and fertility service utilization. Current Opinion In Obstetrics & Gynecology 2021, 33: 170-177. PMID: 33797423, DOI: 10.1097/gco.0000000000000704.
- Hanson BM, Seli E. Preimplantation genetic testing to evaluate for mitochondrial deoxyribonucleic acid disease and aneuploidy: a two-birds-with-one-stone approach. Fertility And Sterility 2021, 115: 1439-1440. PMID: 33795137, DOI: 10.1016/j.fertnstert.2021.03.006.
- Hanson BM, Tao X, Hong KH, Comito CE, Pangasnan R, Seli E, Jalas C, Scott RT. Noninvasive preimplantation genetic testing for aneuploidy exhibits high rates of deoxyribonucleic acid amplification failure and poor correlation with results obtained using trophectoderm biopsy. Fertility And Sterility 2021, 115: 1461-1470. PMID: 33745720, DOI: 10.1016/j.fertnstert.2021.01.028.
- Kim J, Patounakis G, Juneau C, Morin S, Neal S, Bergh P, Seli E, Scott R. The Appraisal of Body Content (ABC) trial: Increased male or female adiposity does not significantly impact in vitro fertilization laboratory or clinical outcomes. Fertility And Sterility 2021, 116: 444-452. PMID: 33581854, DOI: 10.1016/j.fertnstert.2020.12.037.
- Esencan E, Cozzolino M, Imamoglu G, Seli E. Mitochondrial Stress Response Gene Clpp Is Not Required for Granulosa Cell Function. Antioxidants 2020, 10: 1. PMID: 33374937, PMCID: PMC7821922, DOI: 10.3390/antiox10010001.
- Hanson BM, Tao X, Zhan Y, Kim JG, Klimczak AM, Herlihy NS, Scott RT, Seli E. Shorter telomere length of white blood cells is associated with higher rates of aneuploidy among infertile women undergoing in vitro fertilization. Fertility And Sterility 2020, 115: 957-965. PMID: 33272640, DOI: 10.1016/j.fertnstert.2020.09.164.
- Pirtea P, De Ziegler D, Tao X, Sun L, Zhan Y, Ayoubi JM, Seli E, Franasiak JM, Scott RT. Rate of true recurrent implantation failure is low: results of three successive frozen euploid single embryo transfers. Fertility And Sterility 2020, 115: 45-53. PMID: 33077239, DOI: 10.1016/j.fertnstert.2020.07.002.
- Hanson BM, Tao X, Zhan Y, Jenkins TG, Morin SJ, Scott RT, Seli EU. Young women with poor ovarian response exhibit epigenetic age acceleration based on evaluation of white blood cells using a DNA methylation-derived age prediction model. Human Reproduction 2020, 35: 2579-2588. PMID: 33049778, DOI: 10.1093/humrep/deaa206.
- Klimczak AM, Reig A, Neal SA, Seli E, Scott RT. Interpretation of noninvasive prenatal testing results following in vitro fertilization and preimplantation genetic testing for aneuploidy. American Journal Of Obstetrics & Gynecology MFM 2020, 2: 100232. PMID: 33345935, DOI: 10.1016/j.ajogmf.2020.100232.
- Tiegs AW, Tao X, Zhan Y, Whitehead C, Kim J, Hanson B, Osman E, Kim TJ, Patounakis G, Gutmann J, Castelbaum A, Seli E, Jalas C, Scott RT. A multicenter, prospective, blinded, nonselection study evaluating the predictive value of an aneuploid diagnosis using a targeted next-generation sequencing–based preimplantation genetic testing for aneuploidy assay and impact of biopsy. Fertility And Sterility 2020, 115: 627-637. PMID: 32863013, DOI: 10.1016/j.fertnstert.2020.07.052.
- Kim J, Juneau C, Patounakis G, Morin S, Neal S, Seli E, Scott R. The appraisal of body content (ABC) trial: obesity does not significantly impact gamete production in infertile men and women. Journal Of Assisted Reproduction And Genetics 2020, 37: 2733-2742. PMID: 32827101, PMCID: PMC7642175, DOI: 10.1007/s10815-020-01930-3.
- Shahbazi MN, Wang T, Tao X, Weatherbee BAT, Sun L, Zhan Y, Keller L, Smith GD, Pellicer A, Scott RT, Seli E, Zernicka-Goetz M. Developmental potential of aneuploid human embryos cultured beyond implantation. Nature Communications 2020, 11: 3987. PMID: 32778678, PMCID: PMC7418029, DOI: 10.1038/s41467-020-17764-7.
- Yang M, Tao X, Titus S, Zhao T, Scott RT, Seli E. Analysis of accessible chromatin landscape in the inner cell mass and trophectoderm of human blastocysts. Molecular Human Reproduction 2020, 26: 702-711. PMID: 32663300, DOI: 10.1093/molehr/gaaa048.
- Cakiroglu Y, Saltik A, Yuceturk A, Karaosmanoglu O, Kopuk SY, Scott RT, Tiras B, Seli E. Effects of intraovarian injection of autologous platelet rich plasma on ovarian reserve and IVF outcome parameters in women with primary ovarian insufficiency. Aging 2020, 12: 10211-10222. PMID: 32507764, PMCID: PMC7346073, DOI: 10.18632/aging.103403.
- Jalas C, Seli E, Scott RT. Key metrics and processes for validating embryo diagnostics. Fertility And Sterility 2020, 114: 16-23. PMID: 32505382, DOI: 10.1016/j.fertnstert.2020.04.053.
- Cozzolino M, Seli E. Mitochondrial function in women with polycystic ovary syndrome. Current Opinion In Obstetrics & Gynecology 2020, 32: 205-212. PMID: 32068544, DOI: 10.1097/gco.0000000000000619.
- Garcia Velasco JA, Seli E. Editorial: Challenges in ART diagnostics. Current Opinion In Obstetrics & Gynecology 2020, 32: 167-168. PMID: 32168032, DOI: 10.1097/gco.0000000000000622.
- Klimczak A, Seli E. Timing of frozen-thawed embryo transfers—does it really matter? Annals Of Translational Medicine 2020, 8: 731. PMID: 32647656, PMCID: PMC7333132, DOI: 10.21037/atm.2020.03.223.
- Pérez-Sánchez M, Díez-Juan A, Beltrán D, Mifsud A, Mercader A, Vidal C, Labarta E, Pellicer A, Seli E, De Los Santos MJ. Mitochondrial DNA content decreases during in vitro human embryo development: insights into mitochondrial DNA variation in preimplantation embryos donated for research. F&S Science 2020, 1: 36-45. PMID: 35559739, DOI: 10.1016/j.xfss.2020.05.001.
- Scott RT, Sun L, Zhan Y, Marin D, Tao X, Seli E. Mitochondrial DNA content is not predictive of reproductive competence in euploid blastocysts. Reproductive BioMedicine Online 2020, 41: 183-190. PMID: 32600944, DOI: 10.1016/j.rbmo.2020.04.011.
- Tiegs AW, Tao X, Landis J, Zhan Y, Franasiak JM, Seli E, Wells D, Fragouli E, Scott RT. Sperm Mitochondrial DNA Copy Number Is Not a Predictor of Intracytoplasmic Sperm Injection (ICSI) Cycle Outcomes. Reproductive Sciences 2020, 27: 1350-1356. PMID: 31994001, DOI: 10.1007/s43032-020-00163-0.
- Esencan E, Jiang Z, Wang T, Zhang M, Soylemez-Imamoglu G, Seli E. Impaired Mitochondrial Stress Response due to CLPP Deletion Is Associated with Altered Mitochondrial Dynamics and Increased Apoptosis in Cumulus Cells. Reproductive Sciences 2020, 27: 621-630. PMID: 31939198, DOI: 10.1007/s43032-019-00063-y.
- Kasapoğlu I, Seli E. Mitochondrial Dysfunction and Ovarian Aging. Endocrinology 2020, 161: bqaa001. PMID: 31927571, DOI: 10.1210/endocr/bqaa001.
- Lara-Molina EE, Franasiak JM, Marin D, Tao X, Díaz-Gimeno P, Florensa M, Martin M, Seli E, Pellicer A. Cumulus cells have longer telomeres than leukocytes in reproductive-age women. Fertility And Sterility 2019, 113: 217-223. PMID: 31594634, DOI: 10.1016/j.fertnstert.2019.08.089.
- Zhang M, Bener MB, Jiang Z, Wang T, Esencan E, Scott III R, Horvath T, Seli E. Mitofusin 1 is required for female fertility and to maintain ovarian follicular reserve. Cell Death & Disease 2019, 10: 560. PMID: 31332167, PMCID: PMC6646343, DOI: 10.1038/s41419-019-1799-3.
- Sofiyeva N, Siepmann T, Barlinn K, Seli E, Ata B. Gonadotropin-Releasing Hormone Analogs for Gonadal Protection During Gonadotoxic Chemotherapy: A Systematic Review and Meta-Analysis. Reproductive Sciences 2019, 26: 939-953. PMID: 30270741, DOI: 10.1177/1933719118799203.
- Zhang M, Bener MB, Jiang Z, Wang T, Esencan E, Scott R, Horvath T, Seli E. Mitofusin 2 plays a role in oocyte and follicle development, and is required to maintain ovarian follicular reserve during reproductive aging. Aging 2019, 11: 3919-3938. PMID: 31204316, PMCID: PMC6628992, DOI: 10.18632/aging.102024.
- Ata B, Seyhan A, Seli E. Diminished ovarian reserve versus ovarian aging: overlaps and differences. Current Opinion In Obstetrics & Gynecology 2019, 31: 139-147. PMID: 30870184, DOI: 10.1097/gco.0000000000000536.
- Kim J, Seli E. Mitochondria as a Biomarker for IVF Outcome. Reproduction 2019, -1: r235-r242. PMID: 30844752, DOI: 10.1530/rep-18-0580.
- Reig A, Seli E. The association between assisted reproductive technologies and low birth weight. Current Opinion In Obstetrics & Gynecology 2019, 31: 183-187. PMID: 30893135, DOI: 10.1097/gco.0000000000000535.
- Esencan E, Kallen A, Zhang M, Seli E. Translational activation of maternally derived mRNAs in oocytes and early embryos and the role of embryonic poly(A) binding protein (EPAB). Biology Of Reproduction 2019, 100: 1147-1157. PMID: 30806655, PMCID: PMC8127035, DOI: 10.1093/biolre/ioz034.
- Marin D, Seli E. In vitro fertilization and infertility do not cause a significant alteration in placental gene expression at the end of the first trimester. Fertility And Sterility 2019, 111: 463-464. PMID: 30737004, DOI: 10.1016/j.fertnstert.2018.12.006.
- Sanchez T, Zhang M, Needleman D, Seli E. Metabolic imaging via fluorescence lifetime imaging microscopy for egg and embryo assessment. Fertility And Sterility 2019, 111: 212-218. PMID: 30691624, DOI: 10.1016/j.fertnstert.2018.12.014.
- Seli E, Wang T, Horvath TL. Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging. Fertility And Sterility 2019, 111: 197-204. PMID: 30691623, DOI: 10.1016/j.fertnstert.2018.11.048.
- Morin SJ, Tao X, Marin D, Zhan Y, Landis J, Bedard J, Scott RT, Seli E. DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation. Aging 2018, 10: 3761-3773. PMID: 30530921, PMCID: PMC6326671, DOI: 10.18632/aging.101670.
- Sanchez T, Wang T, Pedro MV, Zhang M, Esencan E, Sakkas D, Needleman D, Seli E. Metabolic imaging with the use of fluorescence lifetime imaging microscopy (FLIM) accurately detects mitochondrial dysfunction in mouse oocytes. Fertility And Sterility 2018, 110: 1387-1397. PMID: 30446247, PMCID: PMC6289735, DOI: 10.1016/j.fertnstert.2018.07.022.
- Morin SJ, Patounakis G, Juneau CR, Neal SA, Scott RT, Seli E. Diminished ovarian reserve and poor response to stimulation in patients <38 years old: a quantitative but not qualitative reduction in performance. Human Reproduction 2018, 33: 1489-1498. PMID: 30010882, DOI: 10.1093/humrep/dey238.
- Scott R, Zhang M, Seli E. Metabolism of the oocyte and the preimplantation embryo. Current Opinion In Obstetrics & Gynecology 2018, 30: 163-170. PMID: 29708901, DOI: 10.1097/gco.0000000000000455.
- García-Velasco JA, Seli E. How new technical knowledge impacts clinical approach to infertile patients. Current Opinion In Obstetrics & Gynecology 2018, 30: 137-138. PMID: 29652726, DOI: 10.1097/gco.0000000000000461.
- Wang T, Babayev E, Jiang Z, Li G, Zhang M, Esencan E, Horvath T, Seli E. Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging, for oocyte competence, and development of pre‐implantation embryos. Aging Cell 2018, 17: e12784. PMID: 29851234, PMCID: PMC6052477, DOI: 10.1111/acel.12784.
- Morin SJ, Seli E. Assisted Reproductive Technology and Origins of Disease: The Clinical Realities and Implications. Seminars In Reproductive Medicine 2018, 36: 195-203. PMID: 30866006, DOI: 10.1055/s-0038-1677048.
- Cecchino GN, Seli E, Alves da Motta E, García-Velasco J. The role of mitochondrial activity in female fertility and assisted reproductive technologies: overview and current insights. Reproductive BioMedicine Online 2018, 36: 686-697. PMID: 29598846, DOI: 10.1016/j.rbmo.2018.02.007.
- Ata B, Seli E. A universal freeze all strategy. Current Opinion In Obstetrics & Gynecology 2017, 29: 136-145. PMID: 28333696, DOI: 10.1097/gco.0000000000000362.
- Wang T, Zhang M, Jiang Z, Seli E. Mitochondrial dysfunction and ovarian aging. American Journal Of Reproductive Immunology 2017, 77 PMID: 28194828, DOI: 10.1111/aji.12651.
- Lowther KM, Favero F, Yang CR, Taylor HS, Seli E. Embryonic poly(A)-binding protein is required at the preantral stage of mouse folliculogenesis for oocyte–somatic communication†. Biology Of Reproduction 2017, 96: 341-351. PMID: 28203794, DOI: 10.1095/biolreprod.116.141234.
- Babayev E, Wang T, Szigeti-Buck K, Lowther K, Taylor HS, Horvath T, Seli E. Reproductive aging is associated with changes in oocyte mitochondrial dynamics, function, and mtDNA quantity. Maturitas 2016, 93: 121-130. PMID: 27523387, PMCID: PMC5064871, DOI: 10.1016/j.maturitas.2016.06.015.
- Seli E, Garcia-Velasco J. IVF. Current Opinion In Obstetrics & Gynecology 2016, 28: 149-150. PMID: 27077470, DOI: 10.1097/gco.0000000000000275.
- Greenfeld DA, Seli E. Same-sex reproduction. Current Opinion In Obstetrics & Gynecology 2016, 28: 202-205. PMID: 27077473, DOI: 10.1097/gco.0000000000000266.
- Seli E. Mitochondrial DNA as a biomarker for in-vitro fertilization outcome. Current Opinion In Obstetrics & Gynecology 2016, 28: 158-163. PMID: 27077472, DOI: 10.1097/gco.0000000000000274.
- Babayev E, Lalioti MD, Favero F, Seli E. Cross-Talk Between FSH and Endoplasmic Reticulum Stress: A Mutually Suppressive Relationship. Reproductive Sciences 2016, 23: 352-364. PMID: 26342052, PMCID: PMC5933091, DOI: 10.1177/1933719115602770.
- Seli E. Ovarian Aging. Seminars In Reproductive Medicine 2015, 33: 375-376. PMID: 26565386, DOI: 10.1055/s-0035-1567817.
- Ata B, Seli E. Strategies for Controlled Ovarian Stimulation in the Setting of Ovarian Aging. Seminars In Reproductive Medicine 2015, 33: 436-448. PMID: 26562286, DOI: 10.1055/s-0035-1567818.
- Cil AP, Turkgeldi L, Seli E. Oocyte Cryopreservation as a Preventive Measure for Age-Related Fertility Loss. Seminars In Reproductive Medicine 2015, 33: 429-435. PMID: 26562287, DOI: 10.1055/s-0035-1567819.
- Yang CR, Lowther KM, Lalioti MD, Seli E. Embryonic Poly(A)-Binding Protein (EPAB) Is Required for Granulosa Cell EGF Signaling and Cumulus Expansion in Female Mice. Endocrinology 2015, 157: 405-416. PMID: 26492470, PMCID: PMC4701890, DOI: 10.1210/en.2015-1135.
- Babayev E, Seli E. Oocyte mitochondrial function and reproduction. Current Opinion In Obstetrics & Gynecology 2015, 27: 175-181. PMID: 25719756, PMCID: PMC4590773, DOI: 10.1097/gco.0000000000000164.
- Velasco J, Seli E. IVF. Current Opinion In Obstetrics & Gynecology 2015, 27: 165-166. PMID: 25919232, PMCID: PMC4593514, DOI: 10.1097/gco.0000000000000178.
- Karakaya C, Guzeloglu-Kayisli O, Uyar A, Kallen AN, Babayev E, Bozkurt N, Unsal E, Karabacak O, Seli E. Poor ovarian response in women undergoing in vitro fertilization is associated with altered microRNA expression in cumulus cells. Fertility And Sterility 2015, 103: 1469-1476.e3. PMID: 25910568, PMCID: PMC5648585, DOI: 10.1016/j.fertnstert.2015.02.035.
- Karalok HM, Aydin E, Saglam O, Torun A, Guzeloglu-Kayisli O, Lalioti MD, Kristiansson H, Duke CM, Choe G, Flannery C, Kallen CB, Seli E. mRNA-Binding Protein TIA-1 Reduces Cytokine Expression in Human Endometrial Stromal Cells and Is Down-Regulated in Ectopic Endometrium. The Journal Of Clinical Endocrinology & Metabolism 2014, 99: e2610-e2619. PMID: 25140393, PMCID: PMC4255110, DOI: 10.1210/jc.2013-3488.
- Muñoz M, Uyar A, Correia E, Díez C, Fernandez-Gonzalez A, Caamaño JN, Martínez-Bello D, Trigal B, Humblot P, Ponsart C, Guyader-Joly C, Carrocera S, Martin D, Le Guienne B, Seli E, Gomez E. Prediction of pregnancy viability in bovine in vitro-produced embryos and recipient plasma with Fourier transform infrared spectroscopy. Journal Of Dairy Science 2014, 97: 5497-5507. PMID: 24997663, PMCID: PMC4208725, DOI: 10.3168/jds.2014-8067.
- Uyar A, Seli E. The impact of assisted reproductive technologies on genomic imprinting and imprinting disorders. Current Opinion In Obstetrics & Gynecology 2014, 26: 210-221. PMID: 24752003, PMCID: PMC4123998, DOI: 10.1097/gco.0000000000000071.
- Muñoz M, Uyar A, Correia E, Ponsart C, Guyader-Joly C, Martínez-Bello D, Guienne B, Fernandez-Gonzalez A, Díez C, Caamaño JN, Trigal B, Humblot P, Carrocera S, Martin D, Seli E, Gomez E. Metabolomic Prediction of Pregnancy Viability in Superovulated Cattle Embryos and Recipients with Fourier Transform Infrared Spectroscopy. BioMed Research International 2014, 2014: 608579. PMID: 24834432, PMCID: PMC4009133, DOI: 10.1155/2014/608579.
- Ozturk S, Guzeloglu-Kayisli O, Lowther KM, Lalioti MD, Sakkas D, Seli E. Epab is dispensable for mouse spermatogenesis and male fertility. Molecular Reproduction And Development 2014, 81: 390-390. PMID: 24599567, PMCID: PMC4079073, DOI: 10.1002/mrd.22319.
- Seli E, Babayev E, Collins SC, Nemeth G, Horvath TL. Minireview: Metabolism of Female Reproduction: Regulatory Mechanisms and Clinical Implications. Endocrinology 2014, 28: 790-804. PMID: 24678733, PMCID: PMC4042071, DOI: 10.1210/me.2013-1413.
- Karakaya C, Guzeloglu-Kayisli O, Hobbs RJ, Gerasimova T, Uyar A, Erdem M, Oktem M, Erdem A, Gumuslu S, Ercan D, Sakkas D, Comizzoli P, Seli E, Lalioti MD. Follicle-stimulating hormone receptor (FSHR) alternative skipping of exon 2 or 3 affects ovarian response to FSH. Molecular Human Reproduction 2014, 20: 630-643. PMID: 24670307, PMCID: PMC4072182, DOI: 10.1093/molehr/gau024.
- Uyar A, Seli E. Metabolomic Assessment of Embryo Viability. Seminars In Reproductive Medicine 2014, 32: 141-152. PMID: 24515909, PMCID: PMC4109799, DOI: 10.1055/s-0033-1363556.
- Guzeloglu-Kayisli O, Lalioti MD, Babayev E, Torrealday S, Karakaya C, Seli E. Human embryonic poly(A)-binding protein (EPAB) alternative splicing is differentially regulated in human oocytes and embryos. Molecular Human Reproduction 2013, 20: 59-65. PMID: 24002949, DOI: 10.1093/molehr/gat061.
- Seli E, Horvath TL. Natural birth-induced UCP2 in brain development. Reviews In Endocrine And Metabolic Disorders 2013, 14: 347-350. PMID: 23979530, DOI: 10.1007/s11154-013-9262-8.
- Torrealday S, Lalioti MD, Guzeloglu-Kayisli O, Seli E. Characterization of the Gonadotropin Releasing Hormone Receptor (GnRHR) Expression and Activity in the Female Mouse Ovary. Endocrinology 2013, 154: 3877-3887. PMID: 23913446, PMCID: PMC3776864, DOI: 10.1210/en.2013-1341.
- Cil AP, Seli E. Current trends and progress in clinical applications of oocyte cryopreservation. Current Opinion In Obstetrics & Gynecology 2013, 25: 247-254. PMID: 23562954, PMCID: PMC3869229, DOI: 10.1097/gco.0b013e32836091f4.
- Zhang H, Taylor WR, Joseph G, Caracciolo V, Gonzales DM, Sidell N, Seli E, Blackshear PJ, Kallen CB. mRNA-Binding Protein ZFP36 Is Expressed in Atherosclerotic Lesions and Reduces Inflammation in Aortic Endothelial Cells. Arteriosclerosis Thrombosis And Vascular Biology 2013, 33: 1212-1220. PMID: 23559629, PMCID: PMC3844532, DOI: 10.1161/atvbaha.113.301496.
- Uyar A, Torrealday S, Seli E. Cumulus and granulosa cell markers of oocyte and embryo quality. Fertility And Sterility 2013, 99: 979-997. PMID: 23498999, PMCID: PMC3866131, DOI: 10.1016/j.fertnstert.2013.01.129.
- Ozturk S, Guzeloglu-Kayisli O, Demir N, Sozen B, Ilbay O, Lalioti MD, Seli E. Epab and Pabpc1 Are Differentially Expressed During Male Germ Cell Development. Reproductive Sciences 2012, 19: 911-922. PMID: 22814100, PMCID: PMC4046314, DOI: 10.1177/1933719112446086.
- Guzeloglu-Kayisli O, Lalioti MD, Aydiner F, Sasson I, Ilbay O, Sakkas D, Lowther KM, Mehlmann LM, Seli E. Embryonic poly(A)-binding protein (EPAB) is required for oocyte maturation and female fertility in mice. Biochemical Journal 2012, 446: 47-58. PMID: 22621333, PMCID: PMC3955213, DOI: 10.1042/bj20120467.
- Friend K, Brook M, Bezirci FB, Sheets MD, Gray NK, Seli E. Embryonic poly(A)-binding protein (ePAB) phosphorylation is required for Xenopus oocyte maturation. Biochemical Journal 2012, 445: 93-100. PMID: 22497250, PMCID: PMC3955212, DOI: 10.1042/bj20120304.
- Uyar A, Seli E. Embryo assessment strategies and their validation for clinical use. Current Opinion In Obstetrics & Gynecology 2012, 24: 141-150. PMID: 22487726, DOI: 10.1097/gco.0b013e328352cd17.
- Gong D, Seli E. The association between fertility clinic performance and cycle volume: implications for public reporting of provider performance data. Fertility And Sterility 2012, 98: 55-62.e1. PMID: 22521157, DOI: 10.1016/j.fertnstert.2012.03.036.
- Brahma PK, Zhang H, Murray BS, Shu F, Sidell N, Seli E, Kallen CB. The mRNA‐Binding Protein Zfp36 Is Upregulated by β‐Adrenergic Stimulation and Represses IL‐6 Production in 3T3‐L1 Adipocytes. Obesity 2012, 20: 40-47. PMID: 21818148, PMCID: PMC4127993, DOI: 10.1038/oby.2011.259.
- Murk W, Seli E. Fertility preservation as a public health issue: an epidemiological perspective. Current Opinion In Obstetrics & Gynecology 2011, 23: 143-150. PMID: 21415745, DOI: 10.1097/gco.0b013e3283455270.
- Bromer JG, Ata B, Seli M, Lockwood CJ, Seli E. Preterm deliveries that result from multiple pregnancies associated with assisted reproductive technologies in the USA: a cost analysis. Current Opinion In Obstetrics & Gynecology 2011, 23: 168-173. PMID: 21372712, DOI: 10.1097/gco.0b013e32834551cd.
- Karipcin FS, Ensari TA, Kayisli UA, Guzel E, Kallen CB, Seli E. The mRNA-Binding Protein HuR is Regulated in the Menstrual Cycle and Repressed in Ectopic Endometrium. Reproductive Sciences 2011, 18: 145-155. PMID: 20889954, PMCID: PMC3343139, DOI: 10.1177/1933719110382307.
- Schober CS, Aydiner F, Booth CJ, Seli E, Reinke V. The kinase VRK1 is required for normal meiotic progression in mammalian oogenesis. Cells And Development 2011, 128: 178-190. PMID: 21277975, DOI: 10.1016/j.mod.2011.01.004.
- Martin JR, Pels SG, Paidas M, Seli E. Assisted reproduction in a patient with Klippel-Trenaunay syndrome: management of thrombophilia and consumptive coagulopathy. Journal Of Assisted Reproduction And Genetics 2010, 28: 217-219. PMID: 21188495, PMCID: PMC3082665, DOI: 10.1007/s10815-010-9526-0.
- Seli E, Bruce C, Botros L, Henson M, Roos P, Judge K, Hardarson T, Ahlström A, Harrison P, Henman M, Go K, Acevedo N, Siques J, Tucker M, Sakkas D. Receiver operating characteristic (ROC) analysis of day 5 morphology grading and metabolomic Viability Score on predicting implantation outcome. Journal Of Assisted Reproduction And Genetics 2010, 28: 137-144. PMID: 21063765, PMCID: PMC3059520, DOI: 10.1007/s10815-010-9501-9.
- Greenfeld DA, Seli E. Gay men choosing parenthood through assisted reproduction: medical and psychosocial considerations. Fertility And Sterility 2010, 95: 225-229. PMID: 20643400, DOI: 10.1016/j.fertnstert.2010.05.053.
- Seli E, Robert C, Sirard MA. OMICS in assisted reproduction: possibilities and pitfalls. Molecular Human Reproduction 2010, 16: 513-530. PMID: 20538894, DOI: 10.1093/molehr/gaq041.
- Ata B, Seli E. Economics of assisted reproductive technologies. Current Opinion In Obstetrics & Gynecology 2010, 22: 183-188. PMID: 20125015, DOI: 10.1097/gco.0b013e3283373c13.
- Luk J, Greenfeld DA, Seli E. Third party reproduction and the aging couple. Maturitas 2010, 66: 389-396. PMID: 20451337, DOI: 10.1016/j.maturitas.2010.03.024.
- Aydiner F, Yetkin CE, Seli E. Perspectives on emerging biomarkers for non-invasive assessment of embryo viability in assisted reproduction. 2010, 10: 206-15. PMID: 20196727, DOI: 10.2174/156652410790963349.
- Gerasimova T, Thanasoula MN, Zattas D, Seli E, Sakkas D, Lalioti MD. Identification and in Vitro Characterization of Follicle Stimulating Hormone (FSH) Receptor Variants Associated with Abnormal Ovarian Response to FSH. The Journal Of Clinical Endocrinology & Metabolism 2010, 95: 529-536. PMID: 20061434, PMCID: PMC2840851, DOI: 10.1210/jc.2009-1304.
- Seli E, Vergouw CG, Morita H, Botros L, Roos P, Lambalk CB, Yamashita N, Kato O, Sakkas D. Noninvasive metabolomic profiling as an adjunct to morphology for noninvasive embryo assessment in women undergoing single embryo transfer. Fertility And Sterility 2009, 94: 535-542. PMID: 19589524, DOI: 10.1016/j.fertnstert.2009.03.078.
- Botros L, Sakkas D, Seli E. Metabolomics and its application for non-invasive embryo assessment in IVF. Molecular Human Reproduction 2008, 14: 679-690. PMID: 19129367, PMCID: PMC2639446, DOI: 10.1093/molehr/gan066.
- Seli E, Botros L, Sakkas D, Burns DH. Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization. Fertility And Sterility 2008, 90: 2183-2189. PMID: 18842260, DOI: 10.1016/j.fertnstert.2008.07.1739.
- Guzeloglu-Kayisli O, Pauli S, Demir H, Lalioti MD, Sakkas D, Seli E. Identification and characterization of human embryonic poly(A) binding protein (EPAB). Molecular Human Reproduction 2008, 14: 581-588. PMID: 18716053, DOI: 10.1093/molehr/gan047.
- Bromer JG, Seli E. Assessment of embryo viability in assisted reproductive technology: shortcomings of current approaches and the emerging role of metabolomics. Current Opinion In Obstetrics & Gynecology 2008, 20: 234-241. PMID: 18460937, DOI: 10.1097/gco.0b013e3282fe723d.
- Seli E, Yaba A, Guzeloglu-Kayisli O, Lalioti MD. Alternative splicing of the mouse embryonic poly(A) binding protein (Epab) mRNA is regulated by an exonic splicing enhancer: a model for post-transcriptional control of gene expression in the oocyte. Molecular Human Reproduction 2008, 14: 393-398. PMID: 18492745, PMCID: PMC2453241, DOI: 10.1093/molehr/gan028.
- Scott R, Seli E, Miller K, Sakkas D, Scott K, Burns DH. Noninvasive metabolomic profiling of human embryo culture media using Raman spectroscopy predicts embryonic reproductive potential: a prospective blinded pilot study. Fertility And Sterility 2008, 90: 77-83. PMID: 18281045, DOI: 10.1016/j.fertnstert.2007.11.058.
- Seli E, Sakkas D, Scott R, Kwok SC, Rosendahl SM, Burns DH. Noninvasive metabolomic profiling of embryo culture media using Raman and near-infrared spectroscopy correlates with reproductive potential of embryos in women undergoing in vitro fertilization. Fertility And Sterility 2007, 88: 1350-1357. PMID: 17923129, DOI: 10.1016/j.fertnstert.2007.07.1390.
- Seli E, Guzeloglu-Kayisli O, Kayisli UA, Kizilay G, Arici A. Estrogen increases apoptosis in the arterial wall in a murine atherosclerosis model. Fertility And Sterility 2007, 88: 1190-1196. PMID: 17498707, DOI: 10.1016/j.fertnstert.2007.01.132.
- Daftary GS, Kayisli U, Seli E, Bukulmez O, Arici A, Taylor HS. Salpingectomy increases peri-implantation endometrial HOXA10 expression in women with hydrosalpinx. Fertility And Sterility 2006, 87: 367-372. PMID: 17173899, DOI: 10.1016/j.fertnstert.2006.06.041.
- Seli E, Guzeloglu-Kayisli O, Cakmak H, Kayisli UA, Selam B, Arici A. Estradiol increases apoptosis in human coronary artery endothelial cells by up-regulating Fas and Fas ligand expression. The Journal Of Clinical Endocrinology & Metabolism 2006, 91: 4995-5001. PMID: 17003091, DOI: 10.1210/jc.2006-1225.
- Kayisli UA, Seli E. Stem cells and fertility: what does the future hold? Current Opinion In Obstetrics & Gynecology 2006, 18: 338-343. PMID: 16735836, DOI: 10.1097/01.gco.0000193008.88652.23.
- Vasudevan S, Seli E, Steitz JA. Metazoan oocyte and early embryo development program: a progression through translation regulatory cascades. Genes & Development 2006, 20: 138-146. PMID: 16418480, DOI: 10.1101/gad.1398906.
- Seli E, Kayisli UA, Cakmak H, Bukulmez O, Bildirici I, Guzeloglu-Kayisli O, Arici A. Removal of hydrosalpinges increases endometrial leukaemia inhibitory factor (LIF) expression at the time of the implantation window. Human Reproduction 2005, 20: 3012-3017. PMID: 16024536, DOI: 10.1093/humrep/dei188.
- Seli E, Tangir J. Fertility preservation options for female patients with malignancies. Current Opinion In Obstetrics & Gynecology 2005, 17: 299-308. PMID: 15870565, DOI: 10.1097/01.gco.0000169108.15623.34.
- Spano M, Seli E, Bizzaro D, Manicardi GC, Sakkas D. The significance of sperm nuclear DNA strand breaks on reproductive outcome. Current Opinion In Obstetrics & Gynecology 2005, 17: 255-260. PMID: 15870559, DOI: 10.1097/01.gco.0000169102.77504.66.
- Seli E, Sakkas D. Spermatozoal nuclear determinants of reproductive outcome: implications for ART. Human Reproduction Update 2005, 11: 337-349. PMID: 15863434, DOI: 10.1093/humupd/dmi011.
- Seli E, Lalioti MD, Flaherty SM, Sakkas D, Terzi N, Steitz JA. An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 367-372. PMID: 15630085, PMCID: PMC544294, DOI: 10.1073/pnas.0408378102.
- Seli E, Gardner DK, Schoolcraft WB, Moffatt O, Sakkas D. Extent of nuclear DNA damage in ejaculated spermatozoa impacts on blastocyst development after in vitro fertilization. Fertility And Sterility 2004, 82: 378-383. PMID: 15302287, DOI: 10.1016/j.fertnstert.2003.12.039.
- Kodaman PH, Arici A, Seli E. Evidence-based diagnosis and management of tubal factor infertility. Current Opinion In Obstetrics & Gynecology 2004, 16: 221-229. PMID: 15129051, DOI: 10.1097/00001703-200406000-00004.
- Sakkas D, Seli E, Manicardi GC, Nijs M, Ombelet W, Bizzaro D. The presence of abnormal spermatozoa in the ejaculate: Did apoptosis fail? Human Fertility 2004, 7: 99-103. PMID: 15223758, DOI: 10.1080/14647270410001720464.
- Seli E, Duleba AJ. Treatment of PCOS with metformin and other insulin-sensitizing agents. Current Diabetes Reports 2004, 4: 69-75. PMID: 14764283, DOI: 10.1007/s11892-004-0014-8.
- Seli E, Berkkanoglu M, Arici A. Pathogenesis of endometriosis. Obstetrics And Gynecology Clinics Of North America 2003, 30: 41-61. PMID: 12699257, DOI: 10.1016/s0889-8545(02)00052-9.
- Sakkas D, Seli E, Bizzaro D, Tarozzi N, Manicardi GC. Abnormal spermatozoa in the ejaculate: abortive apoptosis and faulty nuclear remodelling during spermatogenesis. Reproductive BioMedicine Online 2003, 7: 428-432. PMID: 14656403, DOI: 10.1016/s1472-6483(10)61886-x.
- Seli E, Arici A. Endometriosis: Interaction of Immune and Endocrine Systems. Seminars In Reproductive Medicine 2003, 21: 135-144. PMID: 12917783, DOI: 10.1055/s-2003-41320.
- Seli E, Kayisli UA, Selam B, Seli M, Arici A. Estradiol suppresses vascular monocyte chemotactic protein-1 expression during early atherogenesis. American Journal Of Obstetrics And Gynecology 2002, 187: 1544-1549. PMID: 12501061, DOI: 10.1067/mob.2002.127306.
- Seli E, Duleba AJ. Should patients with polycystic ovarian syndrome be treated with metformin? Human Reproduction 2002, 17: 2230-2236. PMID: 12202407, DOI: 10.1093/humrep/17.9.2230.
- Seli E, Duleba AJ. Optimizing ovulation induction in women with polycystic ovary syndrome. Current Opinion In Obstetrics & Gynecology 2002, 14: 245-254. PMID: 12032379, DOI: 10.1097/00001703-200206000-00002.
- Seli E, Pehlivan T, Selam B, Garcia-Velasco JA, Arici A. Estradiol down-regulates MCP-1 expression in human coronary artery endothelial cells. Fertility And Sterility 2002, 77: 542-547. PMID: 11872210, DOI: 10.1016/s0015-0282(01)03223-x.
- Senturk LM, Seli E, Gutierrez LS, Mor G, Zeyneloglu HB, Arici A. Monocyte chemotactic protein-1 expression in human corpus luteum. Molecular Human Reproduction 1999, 5: 697. PMID: 10421794, DOI: 10.1093/molehr/5.8.697.
- Bahtiyar MO, Seli E, Oral E, Senturk LM, Zreik TG, Arici A. Follicular fluid of women with endometriosis stimulates the proliferation of endometrial stromal cells. Human Reproduction 1998, 13: 3492-3495. PMID: 9886538, DOI: 10.1093/humrep/13.12.3492.
- Zeyneloglu HB, Senturk LM, Seli E, Oral E, Olive DL, Arici A. The role of monocyte chemotactic protein-1 in intraperitoneal adhesion formation. Human Reproduction 1998, 13: 1194-1199. PMID: 9647546, DOI: 10.1093/humrep/13.5.1194.
- Arici A, Oral E, Bahtiyar O, Engin O, Seli E, Jones EE. Leukaemia inhibitory factor expression in human follicular fluid and ovarian cells. Human Reproduction 1997, 12: 1233-1239. PMID: 9222008, DOI: 10.1093/humrep/12.6.1233.
- Oral E, Seli E, Bahtiyar MO, Olive DL, Arici A. Growth-regulated alpha expression in the peritoneal environment with endometriosis. Obstetrics And Gynecology 1996, 88: 1050-6. PMID: 8942852, DOI: 10.1016/s0029-7844(96)00361-4.
- Yale Fertiity Center125A Kings Highway NorthWestport, CT 06880
- Yale Medicine Fertility Center200 West Campus DriveFl 2Orange, CT 06477
Biography
Emre Seli, MD, specializes in treating complex infertility cases, including women and men who need egg donation or gestational surrogacy. Dr. Seli’s patients experience very high pregnancy rates, with 78 percent achieving live birth through egg donation in 2015. He also addresses the medical, psychological and legal needs of LGBTQ patients attempting parenthood.
Dr. Emre says the most exciting part of his work is combining biomedical research with advances in the field of infertility, including personalized medicine. “The first baby born through IVF (in vitro fertilization) is not even 40 years old,” he notes. “Since then, we have learned how to freeze embryos, eggs and perform diagnostic procedures in the embryo. Every day, a new experimental procedure is being offered to women and men with infertility.”
The Yale Medicine Fertility Center is at the forefront of these discoveries and, Dr. Seli says, “We are constantly collaborating with other leading researchers in the field. As a result, we provide our patients a critical assessment of all options to achieve the best possible outcome."
Dr. Seli is a professor of obstetrics, gynecology and reproductive sciences at Yale School of Medicine. In his laboratory, Dr. Seli researches determinants of egg and embryo health, and mechanisms of ovarian aging. He and his colleagues have made significant contributions within the field of in vitro fertilization (IVF), especially in understanding which embryos might result in a successful pregnancy and birth.
“We continually seek new and better ways of helping our patients,” Dr. Seli says. “One thing is for sure, three years from now, we’ll be doing things differently than we are doing now.”
Titles
- Professor of Obstetrics, Gynecology & Reproductive Sciences
Education & Training
- FellowYale University School of Medicine (2004)
- ResidentYale University School of Medicine (2001)
- MDUniversity of Istanbul (1992)
Languages Spoken
- English
- Français (French)
- Türkçe (Turkish)
Additional Information
- ASRM Prize Paper: American Society for Reproductive Medicine (2019)
- ASRM SART Prize Paper: American Society for Reproductive Medicine (2019)
- Beacon Award: Frontiers in Stem Cells and Reproduction, ICRO, UNESCO (2018)
- President's Achievement Award: Society for Reproductive Investigation (SRI) (2016)
- SRI President's Presenter Award (mentor): Society for Reproductive Investigation (2016), (2017), (2018), (2019)
- Star Award: American Society for Reproductive Medicine (ASRM) (2015), (2016), (2017), (2018), (2019)
- Best Doctors in America: (2015), (2016), (2017), (2018), (2019)
- Excellence in Teaching Award: Association of Professors of Gynecology and Obstetrics (APGO) and Department of Obstetrics and Gynecology, Yale School of Medicine (2013)
- Ira and Ester Rosenwaks New Investigator Award: American Society for Reproductive Medicine (ASRM) (2009)
- ESHRE Basic Science Award: European Society for Human Reproduction and Embryology (ESHRE) (2008)
- AB of Obstetrics & Gynecology, Reproductive Endocrinology & Infertility (2009, recertified: 2020)
- AB of Obstetrics & Gynecology, Obstetrics & Gynecology (2005, recertified: 2020)
- Ata B, Gill P, Cimadomo D, Ubaldi F, Garcia-Velasco J, Seli E. Reply. Recurrent implantation failure in patients undergoing euploid embryo transfers are unlikely to be caused by unmodifiable extra-embryonic factors. Human Reproduction 2024, deae185. PMID: 39173607, DOI: 10.1093/humrep/deae185.
- Gill P, Ata B, Arnanz A, Cimadomo D, Vaiarelli A, Fatemi H, Ubaldi F, Garcia-Velasco J, Seli E. Does Recurrent Implantation Failure Exist? Prevalence and Outcomes of Five Consecutive Euploid Blastocyst Transfers in 123 987 Patients. Obstetrical & Gynecological Survey 2024, 79: 473-474. DOI: 10.1097/ogx.0000000000001310.
- Yildirim R, Seli E. Mitochondria as determinants of reproductive senescence and competence: implications for diagnosis of embryo competence in assisted reproduction. Human Reproduction 2024, deae171. PMID: 39066612, DOI: 10.1093/humrep/deae171.
- Yildirim R, Seli E. Mitochondria as therapeutic targets in assisted reproduction. Human Reproduction 2024, deae170. PMID: 39066614, DOI: 10.1093/humrep/deae170.
- Volovsky M, Scott R, Seli E. Non-invasive preimplantation genetic testing for aneuploidy: is the promise real? Human Reproduction 2024, 39: 1899-1908. PMID: 38970367, DOI: 10.1093/humrep/deae151.
- Dotterweich K, Gill P, Reig A, Whitehead C, Werner M, Seli E. EVALUATING DAY 5 VERSUS DAY 6 BLASTULATION RATES AMONG FRESH VERSUS FROZEN DONOR EGG CYCLES. Fertility And Sterility 2024, 122: e24-e25. DOI: 10.1016/j.fertnstert.2024.05.041.
- Rodríguez-Eguren A, Bueno-Fernandez C, Gómez-Álvarez M, Francés-Herrero E, Pellicer A, Bellver J, Seli E, Cervelló I. Evolution of biotechnological advances and regenerative therapies for endometrial disorders: a systematic review. Human Reproduction Update 2024, 30: 584-613. PMID: 38796750, PMCID: PMC11369227, DOI: 10.1093/humupd/dmae013.
- Ata B, Gill P, Cimadomo D, Ubaldi F, Garcia-Velasco J, Seli E. Reply: Consecutive euploid blastocyst transfers currently represent the best available model for investigating the true prevalence of recurrent implantation failure (RIF), a rare pathology at best. Human Reproduction 2024, 39: 1575-1576. PMID: 38741229, DOI: 10.1093/humrep/deae096.
- Herlihy N, Cakiroglu Y, Whitehead C, Reig A, Tiras B, Scott R, Seli E. Effect of intraovarian platelet-rich plasma injection on IVF outcomes in women with poor ovarian response: the PROVA randomized controlled trial. Human Reproduction 2024, 39: 1495-1503. PMID: 38725194, DOI: 10.1093/humrep/deae093.
- Gill P, Puchalt N, Molinaro T, Werner M, Seli E, Hotaling J, Cheng P. Leukocytospermia does not negatively impact outcomes in in vitro fertilization cycles with intracytoplasmic sperm injection and preimplantation genetic testing for aneuploidy: findings from 5435 cycles. Journal Of Assisted Reproduction And Genetics 2024, 41: 1213-1219. PMID: 38642270, PMCID: PMC11143111, DOI: 10.1007/s10815-024-03085-x.
- Reig A, Seli E. Poor ovarian response classification systems in the clinical setting – time for an update? Current Opinion In Obstetrics & Gynecology 2024, 36: 192-199. PMID: 38597510, DOI: 10.1097/gco.0000000000000950.
- Gill P, Ata B, Arnanz A, Cimadomo D, Vaiarelli A, Fatemi H, Ubaldi F, Garcia-Velasco J, Seli E. Does recurrent implantation failure exist? Prevalence and outcomes of five consecutive euploid blastocyst transfers in 123 987 patients. Human Reproduction 2024, 39: 974-980. PMID: 38452358, DOI: 10.1093/humrep/deae040.
- Cozzolino M, Ergun Y, Ristori E, Garg A, Imamoglu G, Seli E. Disruption of mitochondrial unfolded protein response results in telomere shortening in mouse oocytes and somatic cells. Aging 2024, 16: 2047-2060. PMID: 38349865, PMCID: PMC10911389, DOI: 10.18632/aging.205543.
- Yildirim R, Seli E. The role of mitochondrial dynamics in oocyte and early embryo development. Seminars In Cell And Developmental Biology 2024, 159: 52-61. PMID: 38330625, DOI: 10.1016/j.semcdb.2024.01.007.
- Ergun Y, Imamoglu A, Cozzolino M, Demirkiran C, Basar M, Garg A, Yildirim R, Seli E. Mitochondrial Unfolded Protein Response Gene Clpp Is Required for Oocyte Function and Female Fertility. International Journal Of Molecular Sciences 2024, 25: 1866. PMID: 38339144, PMCID: PMC10855406, DOI: 10.3390/ijms25031866.
- Esbert M, Tao X, Ballesteros A, Yildirim R, Scott R, Seli E. Addition of rapamycin or co-culture with cumulus cells from younger reproductive age women does not improve rescue in vitro oocyte maturation or euploidy rates in older reproductive age women. Molecular Human Reproduction 2024, 30: gaad048. PMID: 38180884, DOI: 10.1093/molehr/gaad048.
- Garg A, Seli E. Leukocyte telomere length and DNA methylome as biomarkers of ovarian reserve and embryo aneuploidy: the intricate relationship between somatic and reproductive aging. Fertility And Sterility 2023, 121: 26-33. PMID: 37979607, DOI: 10.1016/j.fertnstert.2023.11.011.
- Cakiroglu Y, Tohma Y, Yuceturk A, Karaosmanoglu O, Kopuk S, Korun Z, Yazicioglu C, Scott R, Tiras B, Zeyneloglu H, Seli E. SUBENDOMETRIAL AUTOLOGOUS PLATELET RICH PLASMA INJECTION IN PATIENTS WITH UNRESPONSIVE THIN ENDOMETRIUM UNDERGOING FROZEN-THAWED EMBRYO TRANSFER. Fertility And Sterility 2022, 118: e170. DOI: 10.1016/j.fertnstert.2022.08.489.
- Cozzolino M, Herraiz S, Cakiroglu Y, Garcia-Velasco JA, Tiras B, Pacheco A, Rabadan S, Kohls G, Barrio AI, Pellicer A, Seli E. Distress response in granulosa cells of women affected by PCOS with or without insulin resistance. Endocrine 2022, 79: 200-207. PMID: 36149529, DOI: 10.1007/s12020-022-03192-8.
- Cozzolino M, Ergun Y, Seli E. Targeted Deletion of Mitofusin 1 and Mitofusin 2 Causes Female Infertility and Loss of Follicular Reserve. Reproductive Sciences 2022, 30: 560-568. PMID: 35739352, DOI: 10.1007/s43032-022-01014-w.
- Cozzolino M, Seli E. Mitochondrial dysfunction caused by targeted deletion of Mfn1 does not result in telomere shortening in oocytes. Zygote 2022, 30: 735-737. PMID: 35730364, DOI: 10.1017/s0967199422000089.
- Herlihy NS, Klimczak AM, Cheung JKW, Seli E, Scott RT. The chances of obtaining a euploid embryo and subsequent live birth remain consistent with national age-based rates after an in vitro fertilization cycle that produced only aneuploid embryos. Fertility And Sterility 2022, 118: 484-491. PMID: 35691719, DOI: 10.1016/j.fertnstert.2022.05.026.
- Herlihy NS, Seli E. The use of intraovarian injection of autologous platelet rich plasma (PRP) in patients with poor ovarian response and premature ovarian insufficiency. Current Opinion In Obstetrics & Gynecology 2022, 34: 133-137. PMID: 35645011, DOI: 10.1097/gco.0000000000000784.
- Cozzolino M, Herraiz S, Titus S, Roberts L, Romeu M, Peinado I, Scott RT, Pellicer A, Seli E. Transcriptomic landscape of granulosa cells and peripheral blood mononuclear cells in women with PCOS compared to young poor responders and women with normal response. Human Reproduction 2022, 37: 1274-1286. PMID: 35451009, PMCID: PMC9156844, DOI: 10.1093/humrep/deac069.
- Díaz-García C, Herraiz S, Pamplona L, Subirá J, Soriano MJ, Simon C, Seli E, Pellicer A. Follicular activation in women previously diagnosed with poor ovarian response: a randomized, controlled trial. Fertility And Sterility 2022, 117: 747-755. PMID: 35367015, DOI: 10.1016/j.fertnstert.2021.12.034.
- Cakiroglu Y, Yuceturk A, Karaosmanoglu O, Kopuk SY, Korun ZEU, Herlihy N, Scott RT, Tiras B, Seli E. Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP). Aging 2022, 14: 2513-2523. PMID: 35320118, PMCID: PMC9004561, DOI: 10.18632/aging.203972.
- Klimczak AM, Herlihy NS, Scott CS, Hanson BM, Kim JG, Titus S, Seli E, Scott RT. B-cell lymphoma 6 expression is not associated with live birth in a normal responder in vitro fertilization population. Fertility And Sterility 2021, 117: 351-358. PMID: 34809978, DOI: 10.1016/j.fertnstert.2021.09.036.
- Franasiak JM, Alecsandru D, Forman EJ, Gemmell LC, Goldberg JM, Llarena N, Margolis C, Laven J, Schoenmakers S, Seli E. A review of the pathophysiology of recurrent implantation failure. Fertility And Sterility 2021, 116: 1436-1448. PMID: 34674825, DOI: 10.1016/j.fertnstert.2021.09.014.
- Hanson BM, Kim JG, Suarez SI, Ackerman BK, Comito CE, Pangasnan R, Seli E, Hong KH, Scott RT. Embryology outcomes after oocyte vitrification with super-cooled slush nitrogen are similar to outcomes with conventional liquid nitrogen: a randomized controlled trial. Fertility And Sterility 2021, 117: 106-114. PMID: 34654569, DOI: 10.1016/j.fertnstert.2021.08.043.
- Zhu M, Shahbazi M, Martin A, Zhang C, Sozen B, Borsos M, Mandelbaum RS, Paulson RJ, Mole MA, Esbert M, Titus S, Scott RT, Campbell A, Fishel S, Gradinaru V, Zhao H, Wu K, Chen ZJ, Seli E, de los Santos MJ, Goetz M. Human embryo polarization requires PLC signaling to mediate trophectoderm specification. ELife 2021, 10: e65068. PMID: 34569938, PMCID: PMC8514238, DOI: 10.7554/elife.65068.
- Tiegs AW, Titus S, Mehta S, Garcia-Milian R, Seli E, Scott RT. Cumulus cells of euploid versus whole chromosome 21 aneuploid embryos reveal differentially expressed genes. Reproductive BioMedicine Online 2021, 43: 614-626. PMID: 34417138, DOI: 10.1016/j.rbmo.2021.06.015.
- Glatthorn HN, Hanson BM, Kim JG, Herlihy NS, Klimczak AM, Hong KH, Seli E, Scott RT. Individual culture leads to decreased blastocyst formation but does not affect pregnancy outcomes in the setting of a single, vitrified-warmed euploid blastocyst transfer. Journal Of Assisted Reproduction And Genetics 2021, 38: 2157-2164. PMID: 34086147, PMCID: PMC8417170, DOI: 10.1007/s10815-021-02252-8.
- Seli E, Garcia-Velasco JA. Editorial: Assisted reproductive technology (ART) in a changing world. Current Opinion In Obstetrics & Gynecology 2021, 33: 157-158. PMID: 33896914, DOI: 10.1097/gco.0000000000000699.
- Reig A, Herraiz S, Pellicer A, Seli E. Emerging follicular activation strategies to treat women with poor ovarian response and primary ovarian insufficiency. Current Opinion In Obstetrics & Gynecology 2021, 33: 241-248. PMID: 33896920, DOI: 10.1097/gco.0000000000000703.
- Yang M, Tao X, Scott K, Zhan Y, Scott RT, Seli E. Evaluation of genome-wide DNA methylation profile of human embryos with different developmental competences. Human Reproduction 2021, 36: 1682-1690. PMID: 33846747, DOI: 10.1093/humrep/deab074.
- Klimczak AM, Seli E, Scott RT. Noninvasive prenatal testing in women undergoing in vitro fertilization with preimplantation genetic testing. Current Opinion In Obstetrics & Gynecology 2021, 33: 184-187. PMID: 33797422, DOI: 10.1097/gco.0000000000000707.
- Esencan E, Simsek B, Seli E. Analysis of female demographics in the United States: life expectancy, education, employment, family building decisions, and fertility service utilization. Current Opinion In Obstetrics & Gynecology 2021, 33: 170-177. PMID: 33797423, DOI: 10.1097/gco.0000000000000704.
- Hanson BM, Seli E. Preimplantation genetic testing to evaluate for mitochondrial deoxyribonucleic acid disease and aneuploidy: a two-birds-with-one-stone approach. Fertility And Sterility 2021, 115: 1439-1440. PMID: 33795137, DOI: 10.1016/j.fertnstert.2021.03.006.
- Hanson BM, Tao X, Hong KH, Comito CE, Pangasnan R, Seli E, Jalas C, Scott RT. Noninvasive preimplantation genetic testing for aneuploidy exhibits high rates of deoxyribonucleic acid amplification failure and poor correlation with results obtained using trophectoderm biopsy. Fertility And Sterility 2021, 115: 1461-1470. PMID: 33745720, DOI: 10.1016/j.fertnstert.2021.01.028.
- Kim J, Patounakis G, Juneau C, Morin S, Neal S, Bergh P, Seli E, Scott R. The Appraisal of Body Content (ABC) trial: Increased male or female adiposity does not significantly impact in vitro fertilization laboratory or clinical outcomes. Fertility And Sterility 2021, 116: 444-452. PMID: 33581854, DOI: 10.1016/j.fertnstert.2020.12.037.
- Esencan E, Cozzolino M, Imamoglu G, Seli E. Mitochondrial Stress Response Gene Clpp Is Not Required for Granulosa Cell Function. Antioxidants 2020, 10: 1. PMID: 33374937, PMCID: PMC7821922, DOI: 10.3390/antiox10010001.
- Hanson BM, Tao X, Zhan Y, Kim JG, Klimczak AM, Herlihy NS, Scott RT, Seli E. Shorter telomere length of white blood cells is associated with higher rates of aneuploidy among infertile women undergoing in vitro fertilization. Fertility And Sterility 2020, 115: 957-965. PMID: 33272640, DOI: 10.1016/j.fertnstert.2020.09.164.
- Pirtea P, De Ziegler D, Tao X, Sun L, Zhan Y, Ayoubi JM, Seli E, Franasiak JM, Scott RT. Rate of true recurrent implantation failure is low: results of three successive frozen euploid single embryo transfers. Fertility And Sterility 2020, 115: 45-53. PMID: 33077239, DOI: 10.1016/j.fertnstert.2020.07.002.
- Hanson BM, Tao X, Zhan Y, Jenkins TG, Morin SJ, Scott RT, Seli EU. Young women with poor ovarian response exhibit epigenetic age acceleration based on evaluation of white blood cells using a DNA methylation-derived age prediction model. Human Reproduction 2020, 35: 2579-2588. PMID: 33049778, DOI: 10.1093/humrep/deaa206.
- Klimczak AM, Reig A, Neal SA, Seli E, Scott RT. Interpretation of noninvasive prenatal testing results following in vitro fertilization and preimplantation genetic testing for aneuploidy. American Journal Of Obstetrics & Gynecology MFM 2020, 2: 100232. PMID: 33345935, DOI: 10.1016/j.ajogmf.2020.100232.
- Tiegs AW, Tao X, Zhan Y, Whitehead C, Kim J, Hanson B, Osman E, Kim TJ, Patounakis G, Gutmann J, Castelbaum A, Seli E, Jalas C, Scott RT. A multicenter, prospective, blinded, nonselection study evaluating the predictive value of an aneuploid diagnosis using a targeted next-generation sequencing–based preimplantation genetic testing for aneuploidy assay and impact of biopsy. Fertility And Sterility 2020, 115: 627-637. PMID: 32863013, DOI: 10.1016/j.fertnstert.2020.07.052.
- Kim J, Juneau C, Patounakis G, Morin S, Neal S, Seli E, Scott R. The appraisal of body content (ABC) trial: obesity does not significantly impact gamete production in infertile men and women. Journal Of Assisted Reproduction And Genetics 2020, 37: 2733-2742. PMID: 32827101, PMCID: PMC7642175, DOI: 10.1007/s10815-020-01930-3.
- Shahbazi MN, Wang T, Tao X, Weatherbee BAT, Sun L, Zhan Y, Keller L, Smith GD, Pellicer A, Scott RT, Seli E, Zernicka-Goetz M. Developmental potential of aneuploid human embryos cultured beyond implantation. Nature Communications 2020, 11: 3987. PMID: 32778678, PMCID: PMC7418029, DOI: 10.1038/s41467-020-17764-7.
- Yang M, Tao X, Titus S, Zhao T, Scott RT, Seli E. Analysis of accessible chromatin landscape in the inner cell mass and trophectoderm of human blastocysts. Molecular Human Reproduction 2020, 26: 702-711. PMID: 32663300, DOI: 10.1093/molehr/gaaa048.
- Cakiroglu Y, Saltik A, Yuceturk A, Karaosmanoglu O, Kopuk SY, Scott RT, Tiras B, Seli E. Effects of intraovarian injection of autologous platelet rich plasma on ovarian reserve and IVF outcome parameters in women with primary ovarian insufficiency. Aging 2020, 12: 10211-10222. PMID: 32507764, PMCID: PMC7346073, DOI: 10.18632/aging.103403.
- Jalas C, Seli E, Scott RT. Key metrics and processes for validating embryo diagnostics. Fertility And Sterility 2020, 114: 16-23. PMID: 32505382, DOI: 10.1016/j.fertnstert.2020.04.053.
- Cozzolino M, Seli E. Mitochondrial function in women with polycystic ovary syndrome. Current Opinion In Obstetrics & Gynecology 2020, 32: 205-212. PMID: 32068544, DOI: 10.1097/gco.0000000000000619.
- Garcia Velasco JA, Seli E. Editorial: Challenges in ART diagnostics. Current Opinion In Obstetrics & Gynecology 2020, 32: 167-168. PMID: 32168032, DOI: 10.1097/gco.0000000000000622.
- Klimczak A, Seli E. Timing of frozen-thawed embryo transfers—does it really matter? Annals Of Translational Medicine 2020, 8: 731. PMID: 32647656, PMCID: PMC7333132, DOI: 10.21037/atm.2020.03.223.
- Pérez-Sánchez M, Díez-Juan A, Beltrán D, Mifsud A, Mercader A, Vidal C, Labarta E, Pellicer A, Seli E, De Los Santos MJ. Mitochondrial DNA content decreases during in vitro human embryo development: insights into mitochondrial DNA variation in preimplantation embryos donated for research. F&S Science 2020, 1: 36-45. PMID: 35559739, DOI: 10.1016/j.xfss.2020.05.001.
- Scott RT, Sun L, Zhan Y, Marin D, Tao X, Seli E. Mitochondrial DNA content is not predictive of reproductive competence in euploid blastocysts. Reproductive BioMedicine Online 2020, 41: 183-190. PMID: 32600944, DOI: 10.1016/j.rbmo.2020.04.011.
- Tiegs AW, Tao X, Landis J, Zhan Y, Franasiak JM, Seli E, Wells D, Fragouli E, Scott RT. Sperm Mitochondrial DNA Copy Number Is Not a Predictor of Intracytoplasmic Sperm Injection (ICSI) Cycle Outcomes. Reproductive Sciences 2020, 27: 1350-1356. PMID: 31994001, DOI: 10.1007/s43032-020-00163-0.
- Esencan E, Jiang Z, Wang T, Zhang M, Soylemez-Imamoglu G, Seli E. Impaired Mitochondrial Stress Response due to CLPP Deletion Is Associated with Altered Mitochondrial Dynamics and Increased Apoptosis in Cumulus Cells. Reproductive Sciences 2020, 27: 621-630. PMID: 31939198, DOI: 10.1007/s43032-019-00063-y.
- Kasapoğlu I, Seli E. Mitochondrial Dysfunction and Ovarian Aging. Endocrinology 2020, 161: bqaa001. PMID: 31927571, DOI: 10.1210/endocr/bqaa001.
- Lara-Molina EE, Franasiak JM, Marin D, Tao X, Díaz-Gimeno P, Florensa M, Martin M, Seli E, Pellicer A. Cumulus cells have longer telomeres than leukocytes in reproductive-age women. Fertility And Sterility 2019, 113: 217-223. PMID: 31594634, DOI: 10.1016/j.fertnstert.2019.08.089.
- Zhang M, Bener MB, Jiang Z, Wang T, Esencan E, Scott III R, Horvath T, Seli E. Mitofusin 1 is required for female fertility and to maintain ovarian follicular reserve. Cell Death & Disease 2019, 10: 560. PMID: 31332167, PMCID: PMC6646343, DOI: 10.1038/s41419-019-1799-3.
- Sofiyeva N, Siepmann T, Barlinn K, Seli E, Ata B. Gonadotropin-Releasing Hormone Analogs for Gonadal Protection During Gonadotoxic Chemotherapy: A Systematic Review and Meta-Analysis. Reproductive Sciences 2019, 26: 939-953. PMID: 30270741, DOI: 10.1177/1933719118799203.
- Zhang M, Bener MB, Jiang Z, Wang T, Esencan E, Scott R, Horvath T, Seli E. Mitofusin 2 plays a role in oocyte and follicle development, and is required to maintain ovarian follicular reserve during reproductive aging. Aging 2019, 11: 3919-3938. PMID: 31204316, PMCID: PMC6628992, DOI: 10.18632/aging.102024.
- Ata B, Seyhan A, Seli E. Diminished ovarian reserve versus ovarian aging: overlaps and differences. Current Opinion In Obstetrics & Gynecology 2019, 31: 139-147. PMID: 30870184, DOI: 10.1097/gco.0000000000000536.
- Kim J, Seli E. Mitochondria as a Biomarker for IVF Outcome. Reproduction 2019, -1: r235-r242. PMID: 30844752, DOI: 10.1530/rep-18-0580.
- Reig A, Seli E. The association between assisted reproductive technologies and low birth weight. Current Opinion In Obstetrics & Gynecology 2019, 31: 183-187. PMID: 30893135, DOI: 10.1097/gco.0000000000000535.
- Esencan E, Kallen A, Zhang M, Seli E. Translational activation of maternally derived mRNAs in oocytes and early embryos and the role of embryonic poly(A) binding protein (EPAB). Biology Of Reproduction 2019, 100: 1147-1157. PMID: 30806655, PMCID: PMC8127035, DOI: 10.1093/biolre/ioz034.
- Marin D, Seli E. In vitro fertilization and infertility do not cause a significant alteration in placental gene expression at the end of the first trimester. Fertility And Sterility 2019, 111: 463-464. PMID: 30737004, DOI: 10.1016/j.fertnstert.2018.12.006.
- Sanchez T, Zhang M, Needleman D, Seli E. Metabolic imaging via fluorescence lifetime imaging microscopy for egg and embryo assessment. Fertility And Sterility 2019, 111: 212-218. PMID: 30691624, DOI: 10.1016/j.fertnstert.2018.12.014.
- Seli E, Wang T, Horvath TL. Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging. Fertility And Sterility 2019, 111: 197-204. PMID: 30691623, DOI: 10.1016/j.fertnstert.2018.11.048.
- Morin SJ, Tao X, Marin D, Zhan Y, Landis J, Bedard J, Scott RT, Seli E. DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation. Aging 2018, 10: 3761-3773. PMID: 30530921, PMCID: PMC6326671, DOI: 10.18632/aging.101670.
- Sanchez T, Wang T, Pedro MV, Zhang M, Esencan E, Sakkas D, Needleman D, Seli E. Metabolic imaging with the use of fluorescence lifetime imaging microscopy (FLIM) accurately detects mitochondrial dysfunction in mouse oocytes. Fertility And Sterility 2018, 110: 1387-1397. PMID: 30446247, PMCID: PMC6289735, DOI: 10.1016/j.fertnstert.2018.07.022.
- Morin SJ, Patounakis G, Juneau CR, Neal SA, Scott RT, Seli E. Diminished ovarian reserve and poor response to stimulation in patients <38 years old: a quantitative but not qualitative reduction in performance. Human Reproduction 2018, 33: 1489-1498. PMID: 30010882, DOI: 10.1093/humrep/dey238.
- Scott R, Zhang M, Seli E. Metabolism of the oocyte and the preimplantation embryo. Current Opinion In Obstetrics & Gynecology 2018, 30: 163-170. PMID: 29708901, DOI: 10.1097/gco.0000000000000455.
- García-Velasco JA, Seli E. How new technical knowledge impacts clinical approach to infertile patients. Current Opinion In Obstetrics & Gynecology 2018, 30: 137-138. PMID: 29652726, DOI: 10.1097/gco.0000000000000461.
- Wang T, Babayev E, Jiang Z, Li G, Zhang M, Esencan E, Horvath T, Seli E. Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging, for oocyte competence, and development of pre‐implantation embryos. Aging Cell 2018, 17: e12784. PMID: 29851234, PMCID: PMC6052477, DOI: 10.1111/acel.12784.
- Morin SJ, Seli E. Assisted Reproductive Technology and Origins of Disease: The Clinical Realities and Implications. Seminars In Reproductive Medicine 2018, 36: 195-203. PMID: 30866006, DOI: 10.1055/s-0038-1677048.
- Cecchino GN, Seli E, Alves da Motta E, García-Velasco J. The role of mitochondrial activity in female fertility and assisted reproductive technologies: overview and current insights. Reproductive BioMedicine Online 2018, 36: 686-697. PMID: 29598846, DOI: 10.1016/j.rbmo.2018.02.007.
- Ata B, Seli E. A universal freeze all strategy. Current Opinion In Obstetrics & Gynecology 2017, 29: 136-145. PMID: 28333696, DOI: 10.1097/gco.0000000000000362.
- Wang T, Zhang M, Jiang Z, Seli E. Mitochondrial dysfunction and ovarian aging. American Journal Of Reproductive Immunology 2017, 77 PMID: 28194828, DOI: 10.1111/aji.12651.
- Lowther KM, Favero F, Yang CR, Taylor HS, Seli E. Embryonic poly(A)-binding protein is required at the preantral stage of mouse folliculogenesis for oocyte–somatic communication†. Biology Of Reproduction 2017, 96: 341-351. PMID: 28203794, DOI: 10.1095/biolreprod.116.141234.
- Babayev E, Wang T, Szigeti-Buck K, Lowther K, Taylor HS, Horvath T, Seli E. Reproductive aging is associated with changes in oocyte mitochondrial dynamics, function, and mtDNA quantity. Maturitas 2016, 93: 121-130. PMID: 27523387, PMCID: PMC5064871, DOI: 10.1016/j.maturitas.2016.06.015.
- Seli E, Garcia-Velasco J. IVF. Current Opinion In Obstetrics & Gynecology 2016, 28: 149-150. PMID: 27077470, DOI: 10.1097/gco.0000000000000275.
- Greenfeld DA, Seli E. Same-sex reproduction. Current Opinion In Obstetrics & Gynecology 2016, 28: 202-205. PMID: 27077473, DOI: 10.1097/gco.0000000000000266.
- Seli E. Mitochondrial DNA as a biomarker for in-vitro fertilization outcome. Current Opinion In Obstetrics & Gynecology 2016, 28: 158-163. PMID: 27077472, DOI: 10.1097/gco.0000000000000274.
- Babayev E, Lalioti MD, Favero F, Seli E. Cross-Talk Between FSH and Endoplasmic Reticulum Stress: A Mutually Suppressive Relationship. Reproductive Sciences 2016, 23: 352-364. PMID: 26342052, PMCID: PMC5933091, DOI: 10.1177/1933719115602770.
- Seli E. Ovarian Aging. Seminars In Reproductive Medicine 2015, 33: 375-376. PMID: 26565386, DOI: 10.1055/s-0035-1567817.
- Ata B, Seli E. Strategies for Controlled Ovarian Stimulation in the Setting of Ovarian Aging. Seminars In Reproductive Medicine 2015, 33: 436-448. PMID: 26562286, DOI: 10.1055/s-0035-1567818.
- Cil AP, Turkgeldi L, Seli E. Oocyte Cryopreservation as a Preventive Measure for Age-Related Fertility Loss. Seminars In Reproductive Medicine 2015, 33: 429-435. PMID: 26562287, DOI: 10.1055/s-0035-1567819.
- Yang CR, Lowther KM, Lalioti MD, Seli E. Embryonic Poly(A)-Binding Protein (EPAB) Is Required for Granulosa Cell EGF Signaling and Cumulus Expansion in Female Mice. Endocrinology 2015, 157: 405-416. PMID: 26492470, PMCID: PMC4701890, DOI: 10.1210/en.2015-1135.
- Babayev E, Seli E. Oocyte mitochondrial function and reproduction. Current Opinion In Obstetrics & Gynecology 2015, 27: 175-181. PMID: 25719756, PMCID: PMC4590773, DOI: 10.1097/gco.0000000000000164.
- Velasco J, Seli E. IVF. Current Opinion In Obstetrics & Gynecology 2015, 27: 165-166. PMID: 25919232, PMCID: PMC4593514, DOI: 10.1097/gco.0000000000000178.
- Karakaya C, Guzeloglu-Kayisli O, Uyar A, Kallen AN, Babayev E, Bozkurt N, Unsal E, Karabacak O, Seli E. Poor ovarian response in women undergoing in vitro fertilization is associated with altered microRNA expression in cumulus cells. Fertility And Sterility 2015, 103: 1469-1476.e3. PMID: 25910568, PMCID: PMC5648585, DOI: 10.1016/j.fertnstert.2015.02.035.
- Karalok HM, Aydin E, Saglam O, Torun A, Guzeloglu-Kayisli O, Lalioti MD, Kristiansson H, Duke CM, Choe G, Flannery C, Kallen CB, Seli E. mRNA-Binding Protein TIA-1 Reduces Cytokine Expression in Human Endometrial Stromal Cells and Is Down-Regulated in Ectopic Endometrium. The Journal Of Clinical Endocrinology & Metabolism 2014, 99: e2610-e2619. PMID: 25140393, PMCID: PMC4255110, DOI: 10.1210/jc.2013-3488.
- Muñoz M, Uyar A, Correia E, Díez C, Fernandez-Gonzalez A, Caamaño JN, Martínez-Bello D, Trigal B, Humblot P, Ponsart C, Guyader-Joly C, Carrocera S, Martin D, Le Guienne B, Seli E, Gomez E. Prediction of pregnancy viability in bovine in vitro-produced embryos and recipient plasma with Fourier transform infrared spectroscopy. Journal Of Dairy Science 2014, 97: 5497-5507. PMID: 24997663, PMCID: PMC4208725, DOI: 10.3168/jds.2014-8067.
- Uyar A, Seli E. The impact of assisted reproductive technologies on genomic imprinting and imprinting disorders. Current Opinion In Obstetrics & Gynecology 2014, 26: 210-221. PMID: 24752003, PMCID: PMC4123998, DOI: 10.1097/gco.0000000000000071.
- Muñoz M, Uyar A, Correia E, Ponsart C, Guyader-Joly C, Martínez-Bello D, Guienne B, Fernandez-Gonzalez A, Díez C, Caamaño JN, Trigal B, Humblot P, Carrocera S, Martin D, Seli E, Gomez E. Metabolomic Prediction of Pregnancy Viability in Superovulated Cattle Embryos and Recipients with Fourier Transform Infrared Spectroscopy. BioMed Research International 2014, 2014: 608579. PMID: 24834432, PMCID: PMC4009133, DOI: 10.1155/2014/608579.
- Ozturk S, Guzeloglu-Kayisli O, Lowther KM, Lalioti MD, Sakkas D, Seli E. Epab is dispensable for mouse spermatogenesis and male fertility. Molecular Reproduction And Development 2014, 81: 390-390. PMID: 24599567, PMCID: PMC4079073, DOI: 10.1002/mrd.22319.
- Seli E, Babayev E, Collins SC, Nemeth G, Horvath TL. Minireview: Metabolism of Female Reproduction: Regulatory Mechanisms and Clinical Implications. Endocrinology 2014, 28: 790-804. PMID: 24678733, PMCID: PMC4042071, DOI: 10.1210/me.2013-1413.
- Karakaya C, Guzeloglu-Kayisli O, Hobbs RJ, Gerasimova T, Uyar A, Erdem M, Oktem M, Erdem A, Gumuslu S, Ercan D, Sakkas D, Comizzoli P, Seli E, Lalioti MD. Follicle-stimulating hormone receptor (FSHR) alternative skipping of exon 2 or 3 affects ovarian response to FSH. Molecular Human Reproduction 2014, 20: 630-643. PMID: 24670307, PMCID: PMC4072182, DOI: 10.1093/molehr/gau024.
- Uyar A, Seli E. Metabolomic Assessment of Embryo Viability. Seminars In Reproductive Medicine 2014, 32: 141-152. PMID: 24515909, PMCID: PMC4109799, DOI: 10.1055/s-0033-1363556.
- Guzeloglu-Kayisli O, Lalioti MD, Babayev E, Torrealday S, Karakaya C, Seli E. Human embryonic poly(A)-binding protein (EPAB) alternative splicing is differentially regulated in human oocytes and embryos. Molecular Human Reproduction 2013, 20: 59-65. PMID: 24002949, DOI: 10.1093/molehr/gat061.
- Seli E, Horvath TL. Natural birth-induced UCP2 in brain development. Reviews In Endocrine And Metabolic Disorders 2013, 14: 347-350. PMID: 23979530, DOI: 10.1007/s11154-013-9262-8.
- Torrealday S, Lalioti MD, Guzeloglu-Kayisli O, Seli E. Characterization of the Gonadotropin Releasing Hormone Receptor (GnRHR) Expression and Activity in the Female Mouse Ovary. Endocrinology 2013, 154: 3877-3887. PMID: 23913446, PMCID: PMC3776864, DOI: 10.1210/en.2013-1341.
- Cil AP, Seli E. Current trends and progress in clinical applications of oocyte cryopreservation. Current Opinion In Obstetrics & Gynecology 2013, 25: 247-254. PMID: 23562954, PMCID: PMC3869229, DOI: 10.1097/gco.0b013e32836091f4.
- Zhang H, Taylor WR, Joseph G, Caracciolo V, Gonzales DM, Sidell N, Seli E, Blackshear PJ, Kallen CB. mRNA-Binding Protein ZFP36 Is Expressed in Atherosclerotic Lesions and Reduces Inflammation in Aortic Endothelial Cells. Arteriosclerosis Thrombosis And Vascular Biology 2013, 33: 1212-1220. PMID: 23559629, PMCID: PMC3844532, DOI: 10.1161/atvbaha.113.301496.
- Uyar A, Torrealday S, Seli E. Cumulus and granulosa cell markers of oocyte and embryo quality. Fertility And Sterility 2013, 99: 979-997. PMID: 23498999, PMCID: PMC3866131, DOI: 10.1016/j.fertnstert.2013.01.129.
- Ozturk S, Guzeloglu-Kayisli O, Demir N, Sozen B, Ilbay O, Lalioti MD, Seli E. Epab and Pabpc1 Are Differentially Expressed During Male Germ Cell Development. Reproductive Sciences 2012, 19: 911-922. PMID: 22814100, PMCID: PMC4046314, DOI: 10.1177/1933719112446086.
- Guzeloglu-Kayisli O, Lalioti MD, Aydiner F, Sasson I, Ilbay O, Sakkas D, Lowther KM, Mehlmann LM, Seli E. Embryonic poly(A)-binding protein (EPAB) is required for oocyte maturation and female fertility in mice. Biochemical Journal 2012, 446: 47-58. PMID: 22621333, PMCID: PMC3955213, DOI: 10.1042/bj20120467.
- Friend K, Brook M, Bezirci FB, Sheets MD, Gray NK, Seli E. Embryonic poly(A)-binding protein (ePAB) phosphorylation is required for Xenopus oocyte maturation. Biochemical Journal 2012, 445: 93-100. PMID: 22497250, PMCID: PMC3955212, DOI: 10.1042/bj20120304.
- Uyar A, Seli E. Embryo assessment strategies and their validation for clinical use. Current Opinion In Obstetrics & Gynecology 2012, 24: 141-150. PMID: 22487726, DOI: 10.1097/gco.0b013e328352cd17.
- Gong D, Seli E. The association between fertility clinic performance and cycle volume: implications for public reporting of provider performance data. Fertility And Sterility 2012, 98: 55-62.e1. PMID: 22521157, DOI: 10.1016/j.fertnstert.2012.03.036.
- Brahma PK, Zhang H, Murray BS, Shu F, Sidell N, Seli E, Kallen CB. The mRNA‐Binding Protein Zfp36 Is Upregulated by β‐Adrenergic Stimulation and Represses IL‐6 Production in 3T3‐L1 Adipocytes. Obesity 2012, 20: 40-47. PMID: 21818148, PMCID: PMC4127993, DOI: 10.1038/oby.2011.259.
- Murk W, Seli E. Fertility preservation as a public health issue: an epidemiological perspective. Current Opinion In Obstetrics & Gynecology 2011, 23: 143-150. PMID: 21415745, DOI: 10.1097/gco.0b013e3283455270.
- Bromer JG, Ata B, Seli M, Lockwood CJ, Seli E. Preterm deliveries that result from multiple pregnancies associated with assisted reproductive technologies in the USA: a cost analysis. Current Opinion In Obstetrics & Gynecology 2011, 23: 168-173. PMID: 21372712, DOI: 10.1097/gco.0b013e32834551cd.
- Karipcin FS, Ensari TA, Kayisli UA, Guzel E, Kallen CB, Seli E. The mRNA-Binding Protein HuR is Regulated in the Menstrual Cycle and Repressed in Ectopic Endometrium. Reproductive Sciences 2011, 18: 145-155. PMID: 20889954, PMCID: PMC3343139, DOI: 10.1177/1933719110382307.
- Schober CS, Aydiner F, Booth CJ, Seli E, Reinke V. The kinase VRK1 is required for normal meiotic progression in mammalian oogenesis. Cells And Development 2011, 128: 178-190. PMID: 21277975, DOI: 10.1016/j.mod.2011.01.004.
- Martin JR, Pels SG, Paidas M, Seli E. Assisted reproduction in a patient with Klippel-Trenaunay syndrome: management of thrombophilia and consumptive coagulopathy. Journal Of Assisted Reproduction And Genetics 2010, 28: 217-219. PMID: 21188495, PMCID: PMC3082665, DOI: 10.1007/s10815-010-9526-0.
- Seli E, Bruce C, Botros L, Henson M, Roos P, Judge K, Hardarson T, Ahlström A, Harrison P, Henman M, Go K, Acevedo N, Siques J, Tucker M, Sakkas D. Receiver operating characteristic (ROC) analysis of day 5 morphology grading and metabolomic Viability Score on predicting implantation outcome. Journal Of Assisted Reproduction And Genetics 2010, 28: 137-144. PMID: 21063765, PMCID: PMC3059520, DOI: 10.1007/s10815-010-9501-9.
- Greenfeld DA, Seli E. Gay men choosing parenthood through assisted reproduction: medical and psychosocial considerations. Fertility And Sterility 2010, 95: 225-229. PMID: 20643400, DOI: 10.1016/j.fertnstert.2010.05.053.
- Seli E, Robert C, Sirard MA. OMICS in assisted reproduction: possibilities and pitfalls. Molecular Human Reproduction 2010, 16: 513-530. PMID: 20538894, DOI: 10.1093/molehr/gaq041.
- Ata B, Seli E. Economics of assisted reproductive technologies. Current Opinion In Obstetrics & Gynecology 2010, 22: 183-188. PMID: 20125015, DOI: 10.1097/gco.0b013e3283373c13.
- Luk J, Greenfeld DA, Seli E. Third party reproduction and the aging couple. Maturitas 2010, 66: 389-396. PMID: 20451337, DOI: 10.1016/j.maturitas.2010.03.024.
- Aydiner F, Yetkin CE, Seli E. Perspectives on emerging biomarkers for non-invasive assessment of embryo viability in assisted reproduction. 2010, 10: 206-15. PMID: 20196727, DOI: 10.2174/156652410790963349.
- Gerasimova T, Thanasoula MN, Zattas D, Seli E, Sakkas D, Lalioti MD. Identification and in Vitro Characterization of Follicle Stimulating Hormone (FSH) Receptor Variants Associated with Abnormal Ovarian Response to FSH. The Journal Of Clinical Endocrinology & Metabolism 2010, 95: 529-536. PMID: 20061434, PMCID: PMC2840851, DOI: 10.1210/jc.2009-1304.
- Seli E, Vergouw CG, Morita H, Botros L, Roos P, Lambalk CB, Yamashita N, Kato O, Sakkas D. Noninvasive metabolomic profiling as an adjunct to morphology for noninvasive embryo assessment in women undergoing single embryo transfer. Fertility And Sterility 2009, 94: 535-542. PMID: 19589524, DOI: 10.1016/j.fertnstert.2009.03.078.
- Botros L, Sakkas D, Seli E. Metabolomics and its application for non-invasive embryo assessment in IVF. Molecular Human Reproduction 2008, 14: 679-690. PMID: 19129367, PMCID: PMC2639446, DOI: 10.1093/molehr/gan066.
- Seli E, Botros L, Sakkas D, Burns DH. Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization. Fertility And Sterility 2008, 90: 2183-2189. PMID: 18842260, DOI: 10.1016/j.fertnstert.2008.07.1739.
- Guzeloglu-Kayisli O, Pauli S, Demir H, Lalioti MD, Sakkas D, Seli E. Identification and characterization of human embryonic poly(A) binding protein (EPAB). Molecular Human Reproduction 2008, 14: 581-588. PMID: 18716053, DOI: 10.1093/molehr/gan047.
- Bromer JG, Seli E. Assessment of embryo viability in assisted reproductive technology: shortcomings of current approaches and the emerging role of metabolomics. Current Opinion In Obstetrics & Gynecology 2008, 20: 234-241. PMID: 18460937, DOI: 10.1097/gco.0b013e3282fe723d.
- Seli E, Yaba A, Guzeloglu-Kayisli O, Lalioti MD. Alternative splicing of the mouse embryonic poly(A) binding protein (Epab) mRNA is regulated by an exonic splicing enhancer: a model for post-transcriptional control of gene expression in the oocyte. Molecular Human Reproduction 2008, 14: 393-398. PMID: 18492745, PMCID: PMC2453241, DOI: 10.1093/molehr/gan028.
- Scott R, Seli E, Miller K, Sakkas D, Scott K, Burns DH. Noninvasive metabolomic profiling of human embryo culture media using Raman spectroscopy predicts embryonic reproductive potential: a prospective blinded pilot study. Fertility And Sterility 2008, 90: 77-83. PMID: 18281045, DOI: 10.1016/j.fertnstert.2007.11.058.
- Seli E, Sakkas D, Scott R, Kwok SC, Rosendahl SM, Burns DH. Noninvasive metabolomic profiling of embryo culture media using Raman and near-infrared spectroscopy correlates with reproductive potential of embryos in women undergoing in vitro fertilization. Fertility And Sterility 2007, 88: 1350-1357. PMID: 17923129, DOI: 10.1016/j.fertnstert.2007.07.1390.
- Seli E, Guzeloglu-Kayisli O, Kayisli UA, Kizilay G, Arici A. Estrogen increases apoptosis in the arterial wall in a murine atherosclerosis model. Fertility And Sterility 2007, 88: 1190-1196. PMID: 17498707, DOI: 10.1016/j.fertnstert.2007.01.132.
- Daftary GS, Kayisli U, Seli E, Bukulmez O, Arici A, Taylor HS. Salpingectomy increases peri-implantation endometrial HOXA10 expression in women with hydrosalpinx. Fertility And Sterility 2006, 87: 367-372. PMID: 17173899, DOI: 10.1016/j.fertnstert.2006.06.041.
- Seli E, Guzeloglu-Kayisli O, Cakmak H, Kayisli UA, Selam B, Arici A. Estradiol increases apoptosis in human coronary artery endothelial cells by up-regulating Fas and Fas ligand expression. The Journal Of Clinical Endocrinology & Metabolism 2006, 91: 4995-5001. PMID: 17003091, DOI: 10.1210/jc.2006-1225.
- Kayisli UA, Seli E. Stem cells and fertility: what does the future hold? Current Opinion In Obstetrics & Gynecology 2006, 18: 338-343. PMID: 16735836, DOI: 10.1097/01.gco.0000193008.88652.23.
- Vasudevan S, Seli E, Steitz JA. Metazoan oocyte and early embryo development program: a progression through translation regulatory cascades. Genes & Development 2006, 20: 138-146. PMID: 16418480, DOI: 10.1101/gad.1398906.
- Seli E, Kayisli UA, Cakmak H, Bukulmez O, Bildirici I, Guzeloglu-Kayisli O, Arici A. Removal of hydrosalpinges increases endometrial leukaemia inhibitory factor (LIF) expression at the time of the implantation window. Human Reproduction 2005, 20: 3012-3017. PMID: 16024536, DOI: 10.1093/humrep/dei188.
- Seli E, Tangir J. Fertility preservation options for female patients with malignancies. Current Opinion In Obstetrics & Gynecology 2005, 17: 299-308. PMID: 15870565, DOI: 10.1097/01.gco.0000169108.15623.34.
- Spano M, Seli E, Bizzaro D, Manicardi GC, Sakkas D. The significance of sperm nuclear DNA strand breaks on reproductive outcome. Current Opinion In Obstetrics & Gynecology 2005, 17: 255-260. PMID: 15870559, DOI: 10.1097/01.gco.0000169102.77504.66.
- Seli E, Sakkas D. Spermatozoal nuclear determinants of reproductive outcome: implications for ART. Human Reproduction Update 2005, 11: 337-349. PMID: 15863434, DOI: 10.1093/humupd/dmi011.
- Seli E, Lalioti MD, Flaherty SM, Sakkas D, Terzi N, Steitz JA. An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 367-372. PMID: 15630085, PMCID: PMC544294, DOI: 10.1073/pnas.0408378102.
- Seli E, Gardner DK, Schoolcraft WB, Moffatt O, Sakkas D. Extent of nuclear DNA damage in ejaculated spermatozoa impacts on blastocyst development after in vitro fertilization. Fertility And Sterility 2004, 82: 378-383. PMID: 15302287, DOI: 10.1016/j.fertnstert.2003.12.039.
- Kodaman PH, Arici A, Seli E. Evidence-based diagnosis and management of tubal factor infertility. Current Opinion In Obstetrics & Gynecology 2004, 16: 221-229. PMID: 15129051, DOI: 10.1097/00001703-200406000-00004.
- Sakkas D, Seli E, Manicardi GC, Nijs M, Ombelet W, Bizzaro D. The presence of abnormal spermatozoa in the ejaculate: Did apoptosis fail? Human Fertility 2004, 7: 99-103. PMID: 15223758, DOI: 10.1080/14647270410001720464.
- Seli E, Duleba AJ. Treatment of PCOS with metformin and other insulin-sensitizing agents. Current Diabetes Reports 2004, 4: 69-75. PMID: 14764283, DOI: 10.1007/s11892-004-0014-8.
- Seli E, Berkkanoglu M, Arici A. Pathogenesis of endometriosis. Obstetrics And Gynecology Clinics Of North America 2003, 30: 41-61. PMID: 12699257, DOI: 10.1016/s0889-8545(02)00052-9.
- Sakkas D, Seli E, Bizzaro D, Tarozzi N, Manicardi GC. Abnormal spermatozoa in the ejaculate: abortive apoptosis and faulty nuclear remodelling during spermatogenesis. Reproductive BioMedicine Online 2003, 7: 428-432. PMID: 14656403, DOI: 10.1016/s1472-6483(10)61886-x.
- Seli E, Arici A. Endometriosis: Interaction of Immune and Endocrine Systems. Seminars In Reproductive Medicine 2003, 21: 135-144. PMID: 12917783, DOI: 10.1055/s-2003-41320.
- Seli E, Kayisli UA, Selam B, Seli M, Arici A. Estradiol suppresses vascular monocyte chemotactic protein-1 expression during early atherogenesis. American Journal Of Obstetrics And Gynecology 2002, 187: 1544-1549. PMID: 12501061, DOI: 10.1067/mob.2002.127306.
- Seli E, Duleba AJ. Should patients with polycystic ovarian syndrome be treated with metformin? Human Reproduction 2002, 17: 2230-2236. PMID: 12202407, DOI: 10.1093/humrep/17.9.2230.
- Seli E, Duleba AJ. Optimizing ovulation induction in women with polycystic ovary syndrome. Current Opinion In Obstetrics & Gynecology 2002, 14: 245-254. PMID: 12032379, DOI: 10.1097/00001703-200206000-00002.
- Seli E, Pehlivan T, Selam B, Garcia-Velasco JA, Arici A. Estradiol down-regulates MCP-1 expression in human coronary artery endothelial cells. Fertility And Sterility 2002, 77: 542-547. PMID: 11872210, DOI: 10.1016/s0015-0282(01)03223-x.
- Senturk LM, Seli E, Gutierrez LS, Mor G, Zeyneloglu HB, Arici A. Monocyte chemotactic protein-1 expression in human corpus luteum. Molecular Human Reproduction 1999, 5: 697. PMID: 10421794, DOI: 10.1093/molehr/5.8.697.
- Bahtiyar MO, Seli E, Oral E, Senturk LM, Zreik TG, Arici A. Follicular fluid of women with endometriosis stimulates the proliferation of endometrial stromal cells. Human Reproduction 1998, 13: 3492-3495. PMID: 9886538, DOI: 10.1093/humrep/13.12.3492.
- Zeyneloglu HB, Senturk LM, Seli E, Oral E, Olive DL, Arici A. The role of monocyte chemotactic protein-1 in intraperitoneal adhesion formation. Human Reproduction 1998, 13: 1194-1199. PMID: 9647546, DOI: 10.1093/humrep/13.5.1194.
- Arici A, Oral E, Bahtiyar O, Engin O, Seli E, Jones EE. Leukaemia inhibitory factor expression in human follicular fluid and ovarian cells. Human Reproduction 1997, 12: 1233-1239. PMID: 9222008, DOI: 10.1093/humrep/12.6.1233.
- Oral E, Seli E, Bahtiyar MO, Olive DL, Arici A. Growth-regulated alpha expression in the peritoneal environment with endometriosis. Obstetrics And Gynecology 1996, 88: 1050-6. PMID: 8942852, DOI: 10.1016/s0029-7844(96)00361-4.
- Yale Fertiity Center125A Kings Highway NorthWestport, CT 06880
- Yale Medicine Fertility Center200 West Campus DriveFl 2Orange, CT 06477
- Yale Fertiity Center125A Kings Highway NorthWestport, CT 06880
- Yale Medicine Fertility Center200 West Campus DriveFl 2Orange, CT 06477