- Digestive Health Center8 Devine StreetFl 1st FloorNorth Haven, CT 06473
Xavier Llor, MD, PhD
Biography
Xavier Llor, MD, PhD, is a gastroenterologist at Yale Medicine with a specialty in gastrointestinal cancer genetics and colorectal cancer. He is co-director of the Gastrointestinal (GI) & Pancreatic Cancer Prevention Program, associate director for cancer screening at the Center for Community Engagement and Health Equity at Yale Cancer Center, and the medical director of the Colorectal Cancer Prevention Program.
After receiving a medical school education from the Autonomous University in Barcelona, Dr. Llor trained in basic research and internal medicine at the University of Chicago and completed his PhD in molecular biology from the University of Barcelona. Dr. Llor completed his GI fellowship at the University of Illinois at Chicago. His background as both a clinician and researcher led him to specialize in cancer genetics, where he works to identify specific genes that make a person more susceptible to gastrointestinal cancers. “One of the most rewarding things about this field is that every day we seem to discover more, and that knowledge is translated very quickly into patients’ lives,” says Dr. Llor.
As a physician, Dr. Llor uses his research to better care for his patients. The goal is to identify cancer risk as early as possible. This knowledge can help patients take measures to prevent cancer, or it can help doctors treat patients with cancer as early as possible. “The earlier a cancer is detected, the better the prognosis is,” says Dr. Llor.
In addition, genetic defects that are linked to gastrointestinal cancers may also be linked to cancers in other parts of the body. “We take a broad and comprehensive approach to patients in making sure that we prevent all cancers that are linked to those particular genetic defects,” says Dr. Llor.
As a researcher, Dr. Llor continues to identify new genetic defects that may be linked to colorectal and other GI cancer risk. Furthermore, he is exploring different approaches that lead to a wider identification of these diseases, with a particular emphasis in disseminating this specialized care among the underserved. He has made important contributions to the field of Lynch syndrome (a hereditary form of colorectal cancer).
Dr. Llor is a professor of medicine (digestive diseases) at Yale School of Medicine.
Titles
- Professor of Medicine
- Director, GI and Pancreatic Cancer Prevention Program, Digestive Diseases
Education & Training
- PhDUniversity of Barcelona, Molecular Biology (1999)
- FellowshipUniversity of Illinois (1997)
- ResidencyLutheran General Hospital-University of Chicago Program C (1994)
- MDUniversity of Barcelona (1986)
Languages Spoken
- Català (Catalan)
- English
- Español (Spanish)
Additional Information
- Mentor, Future Leaders Program: American Gastroenterological Association (2016)
- Distinguished Mentor: Hispanic Center of Excellence. University of Illinois at Chicago School of Medicine (2012)
- National Comprehensive Cancer Network Guidelines Committee (2021 - Present): Vice-Chair of the Colorectal Cancer Screening Panel
- Colorectal Cancer Alliance Chris4Life Research Program (2020 - Present): Grant Reviewer
- National Comprehensive Cancer Network (2019 - Present): Genetic Colorectal Cancer Screening Panel
- Gastroenterology (2018 - Present): Selected Summaries
- Yale University (2017 - 2019): Ambulatory Advisory Group, Yale Medicine
- American Cancer Society (2017 - 2018): Advisory Group: Primary care module on family history/early onset colorectal cancer, National Colorectal Cancer Round Table
- American Cancer Society (2017 - Present): Steering Committee: National Colorectal Cancer Round Table
- American Gastroenterolgical Association Institute (2017 - Present): Member; Advisory board, Academy of Educators
- National Comprehensive Cancer Network Guidelines Committee (2016 - Present): Member of the Guidelines Committee of the Genetics/High risk Colorectal Cancer Panel
- American Gastrointestinal Association (2016 - Present): Member, Nominating Committee
- Lerner B, Giner-Calabuig M, Carraway C, Richardson M, Krahn K, Susswein L, Heald B, Karam R, Xicola R, Llor X. 899 YALE CRITERIA FOR GENETIC TESTING IN CASES OF SUSPECTED HEREDITARY DIFFUSE GASTRIC CANCER (HDGC) ARE MORE SENSITIVE THAN IGCLC AND ERN GENTURIS CRITERIA IN A LARGE AMERICAN COHORT. Gastroenterology 2024, 166: s-215. DOI: 10.1016/s0016-5085(24)00984-3.
- Rajpara S, Buckley D, Xicola R, Mikaeel R, Yagle M, Kerimoglu B, Thorne C, Bellomo D, Padi M, Llor X, Ellis N, Salhia B. Abstract 7004: DNA Methylation analysis of African American colorectal cancers reveal race-specific alterations. Cancer Research 2024, 84: 7004-7004. DOI: 10.1158/1538-7445.am2024-7004.
- Mikaeel R, Bellomo D, Rajpara S, Buckley D, Yagle M, Kerimoglu B, Thorne C, Padi M, Salhia B, Ellis N, Llor X, Xicola R. Abstract 4409: FBXW7 and BCL9L altered pathways as hallmarks of early-onset colorectal cancer. Cancer Research 2024, 84: 4409-4409. DOI: 10.1158/1538-7445.am2024-4409.
- Buckley D, Xicola R, Reger M, Yagle M, Kerimoglu B, Thorne C, Bellomo D, Padi M, Llor X, Ellis N, Salhia B. Abstract C060: DNA Methylation analysis of African American colorectal cancers reveal race-specific alterations. Cancer Epidemiology Biomarkers & Prevention 2023, 32: c060-c060. DOI: 10.1158/1538-7755.disp23-c060.
- Soleymanjahi S, Hong Y, Lee J, Kvistad R, Hughes M, Llor X. 30 IMPACT OF THE COVID-19 PANDEMIC ON RACIAL AND SOCIOECONOMIC DISPARITIES ON RECEIVING COLORECTAL CANCER SCREENING RECOMMENDATIONS IN THE UNITED STATES. Gastroenterology 2023, 164: s-9-s-10. DOI: 10.1016/s0016-5085(23)00977-0.
- Soleymanjahi S, Singh V, Liu J, Brown Q, Brierley K, Healy C, Xicola R, Kashyap N, Llor X. 33 THE IMPLEMENTATION OF AN EMR-BASED AUTOMATED SYSTEM FOR IDENTIFICATION OF PATIENTS SUSPICIOUS FOR LYNCH SYNDROME HAS A DISPROPORTIONALLY POSITIVE IMPACT IN THE IDENTIFICATION OF DISADVANTAGED PATIENTS. Gastroenterology 2023, 164: s-11. DOI: 10.1016/s0016-5085(23)00980-0.
- Soleymanjahi S, Hong Y, Lee J, Mahmoudi-Rouhani R, Hughes M, Llor X. Sa1001 CHANGES IN USAGE OF STOOL-BASED AND NON-STOOL-BASED COLORECTAL CANCER SCREENING MODALITIES BEFORE AND DURING THE COVID-19 PANDEMIC IN THE UNITED STATES. Gastroenterology 2023, 164: s-268. DOI: 10.1016/s0016-5085(23)01605-0.
- Perez-Mayoral J, Gonzalez-Pons M, Centeno-Girona H, Montes-Rodríguez I, Soto-Salgado M, Suárez B, Rodríguez N, Colón G, Sevilla J, Jorge D, Llor X, Xicola R, Toro D, Tous-López L, Torres-Torres M, Reyes J, López-Acevedo N, Goel A, Rodríguez-Quilichini S, Cruz-Correa M. Molecular and Sociodemographic Colorectal Cancer Disparities in Latinos Living in Puerto Rico. Genes 2023, 14: 894. PMID: 37107652, PMCID: PMC10138302, DOI: 10.3390/genes14040894.
- Padi M, Bellomo D, Grant A, Xicola R, Thorne C, Salhia B, Llor X, Ellis N. Abstract 484: Molecular drivers of tumor progression in microsatellite stable APC mutation-negative colorectal cancers. Cancer Research 2022, 82: 484-484. DOI: 10.1158/1538-7445.am2022-484.
- Giner-Calabuig M, De Leon S, Vidal-Pedrola G, Fehlmann T, Ukaegbu C, Gibson J, Picó M, Alenda C, Reyes J, Ortega S, LLado C, de la Torre Rubio P, Obrador-Hevia A, Castillejo A, Soto J, Castellví-Bel S, Syngal S, Stoffel E, Ellis N, Jover R, Llor X, Xicola R. Tu1100: HETEROZYGOUS MUTATIONS IN DNA REPAIR GENES CONFER GENETIC SUSCEPTIILITY TO COLORECTAL CANCER AMONG LYNCH-LIKE CASES. Gastroenterology 2022, 162: s-883. DOI: 10.1016/s0016-5085(22)62088-2.
- Lerner BA, Xicola RM, Rodriguez NJ, Karam R, Llor X. Simplified and more sensitive criteria for identifying individuals with pathogenic CDH1 variants. Journal Of Medical Genetics 2022, 60: 36-40. PMID: 35078942, PMCID: PMC9661780, DOI: 10.1136/jmedgenet-2021-108169.
- Singh V, Ganzak A, Gershkovich P, Gibson J, Xicola R, Llor X. Abstract PO-052: A multisystem approach doubles the number of patients referred for genetic testing and diagnosed with Lynch syndrome with equally success among ethnic/racial groups. Cancer Epidemiology Biomarkers & Prevention 2022, 31: po-052-po-052. DOI: 10.1158/1538-7755.disp21-po-052.
- Grant A, Xicola RM, Nguyen V, Lim J, Thorne C, Salhia B, Llor X, Ellis N, Padi M. Molecular drivers of tumor progression in microsatellite stable APC mutation-negative colorectal cancers. Scientific Reports 2021, 11: 23507. PMID: 34873211, PMCID: PMC8648784, DOI: 10.1038/s41598-021-02806-x.
- Mezzacappa C, Llor X. Colorectal Cancer Risk in Lynch Syndrome: Of Genes and More. Gastroenterology 2021, 162: 1358-1360. PMID: 34863785, DOI: 10.1053/j.gastro.2021.11.032.
- Bustos A, Payá A, Torrubia A, Jover R, Llor X, Bessa X, Castells A, Carracedo Á, Alenda C. xDEEP-MSI: Explainable Bias-Rejecting Microsatellite Instability Deep Learning System in Colorectal Cancer. Biomolecules 2021, 11: 1786. PMID: 34944430, PMCID: PMC8699085, DOI: 10.3390/biom11121786.
- Weiss JM, Gupta S, Burke CA, Axell L, Chen LM, Chung DC, Clayback KM, Dallas S, Felder S, Gbolahan O, Giardiello FM, Grady W, Hall MJ, Hampel H, Hodan R, Idos G, Kanth P, Katona B, Lamps L, Llor X, Lynch PM, Markowitz AJ, Pirzadeh-Miller S, Samadder NJ, Shibata D, Swanson BJ, Szymaniak BM, Wiesner GL, Wolf A, Yurgelun MB, Zakhour M, Darlow SD, Dwyer MA, Campbell M. NCCN Guidelines® Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 1.2021. Journal Of The National Comprehensive Cancer Network 2021, 19: 1122-1132. PMID: 34666312, DOI: 10.1164/jnccn.2021.0048.
- Cheng E, Blackburn H, Ng K, Spiegelman D, Irwin M, Ma X, Gross C, Tabung F, Giovannucci E, Kunz P, Llor X, Billingsley K, Meyerhardt J, Ahuja N, Fuchs C. Abstract 898: Survival for patients with early-onset colorectal cancer - An overall survival analysis from the National Cancer Database, 2004-2015. Cancer Research 2021, 81: 898-898. DOI: 10.1158/1538-7445.am2021-898.
- Analysis of Survival Among Adults With Early-Onset Colorectal Cancer in the National Cancer DatabaseCheng E, Blackburn HN, Ng K, Spiegelman D, Irwin ML, Ma X, Gross CP, Tabung FK, Giovannucci EL, Kunz PL, Llor X, Billingsley K, Meyerhardt JA, Ahuja N, Fuchs CS. Analysis of Survival Among Adults With Early-Onset Colorectal Cancer in the National Cancer Database. JAMA Network Open 2021, 4: e2112539. PMID: 34132794, PMCID: PMC8209612, DOI: 10.1001/jamanetworkopen.2021.12539.
- Fernández-Rozadilla C, Álvarez-Barona M, Quintana I, López-Novo A, Amigo J, Cameselle-Teijeiro J, Roman E, Gonzalez D, Llor X, Bujanda L, Bessa X, Jover R, Balaguer F, Castells A, Castellví-Bel S, Capellá G, Carracedo A, Valle L, Ruiz-Ponte C. Exome sequencing of early-onset patients supports genetic heterogeneity in colorectal cancer. Scientific Reports 2021, 11: 11135. PMID: 34045552, PMCID: PMC8159954, DOI: 10.1038/s41598-021-90590-z.
- Shin JH, Jeong J, Choi J, Lim J, Dinesh RK, Braverman J, Hong JY, Maher SE, Vesely M, Kim W, Koo JH, Tang W, Wu D, Blackburn HN, Xicola RM, Llor X, Yilmaz O, Choi JM, Bothwell ALM. Dickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1. IScience 2021, 24: 102411. PMID: 33997693, PMCID: PMC8099562, DOI: 10.1016/j.isci.2021.102411.
- MacFarland SP, Ebrahimzadeh JE, Zelley K, Begum L, Bass LM, Brand RE, Dudley B, Fishman DS, Ganzak A, Karloski E, Latham A, Llor X, Plon S, Riordan MK, Scollon SR, Stadler ZK, Syngal S, Ukaegbu C, Weiss JM, Yurgelun MB, Brodeur GM, Mamula P, Katona BW. Phenotypic Differences in Juvenile Polyposis Syndrome With or Without a Disease-causing SMAD4/BMPR1A Variant. Cancer Prevention Research 2021, 14: 215-222. PMID: 33097490, PMCID: PMC8557953, DOI: 10.1158/1940-6207.capr-20-0348.
- Lerner BA, Llor X. Genetic Gastric Cancer Risk Syndromes. Current Treatment Options In Gastroenterology 2020, 18: 604-615. PMID: 33776403, PMCID: PMC7992355, DOI: 10.1007/s11938-020-00312-z.
- Provenzale D, Ness RM, Llor X, Weiss JM, Abbadessa B, Cooper G, Early DS, Friedman M, Giardiello FM, Glaser K, Gurudu S, Halverson AL, Issaka R, Jain R, Kanth P, Kidambi T, Lazenby AJ, Maguire L, Markowitz AJ, May FP, Mayer RJ, Mehta S, Patel S, Peter S, Stanich P, Terdiman J, Keller J, Dwyer MA, Ogba N. NCCN Guidelines Insights: Colorectal Cancer Screening, Version 2.2020. Journal Of The National Comprehensive Cancer Network 2020, 18: 1312-1320. PMID: 33022639, PMCID: PMC8311627, DOI: 10.6004/jnccn.2020.0048.
- Vilar-Sanchez E, Burke C, Correa M, Dekker E, Grady W, Grandval P, Katona B, Llor X, Riegert-Johnson D, Saurin J, Stanich P, Sussman D, Weinberg D, Attiyeh E, Joseph D, Raybold K, Borzillo G, Prior T, Smith M, Xie H, Bachman K, Infante J, Samadder N. Abstract CT236: A phase 1b, multicenter, randomized, blinded, placebo-controlled study to evaluate the efficacy of guselkumab in subjects with familial adenomatous polyposis. Cancer Research 2020, 80: ct236-ct236. DOI: 10.1158/1538-7445.am2020-ct236.
- Melson JE, Imperiale TF, Itzkowitz SH, Llor X, Kochman ML, Grady WM, Schoen RE, Burke CA, Shaukat A, Rabeneck L, Ladabaum U, Bresalier R, Spiegel B, Yee J, Wang T, Lieberman D, Komanduri S, Muthusamy VR, Dey N. AGA White Paper: Roadmap for the Future of Colorectal Cancer Screening in the United States. Clinical Gastroenterology And Hepatology 2020, 18: 2667-2678.e2. PMID: 32634626, DOI: 10.1016/j.cgh.2020.06.053.
- Xicola R, Manojlovic Z, Augustus G, Kupfer S, Emmadi R, Alagiozian-Angelova V, Triche T, Bodour S, Carpten J, Llor X, Ellis N. Abstract IA26: Mechanistic differences in early-onset colorectal cancer. Cancer Epidemiology Biomarkers & Prevention 2020, 29: ia26-ia26. DOI: 10.1158/1538-7755.disp18-ia26.
- Giner-Calabuig M, Ukaegbu C, Syngal S, Stoffel E, Jover R, Llor X, Xicola R. Tu1212 RELEVANT HETEROGENEITY IN MISMATCH REPAIR DEFICIENT TUMORS. Gastroenterology 2020, 158: s-1020. DOI: 10.1016/s0016-5085(20)33223-6.
- Singh V, Ganzak A, Gershkovich P, Gibson J, Llor X. 1 IMPROVING LYNCH SYNDROME IDENTIFICATION THROUGH THE IMPLEMENTATION OF ENHANCED TUMOR TESTING AND A COMPREHENSIVE SYSTEMS APPROACH. Gastroenterology 2020, 158: s-1. DOI: 10.1016/s0016-5085(20)30682-x.
- Augustus GJ, Xicola RM, Llor X, Ellis NA. Decreased copy‐neutral loss of heterozygosity in African American colorectal cancers. Genes Chromosomes And Cancer 2020, 59: 454-464. PMID: 32293075, PMCID: PMC8045478, DOI: 10.1002/gcc.22851.
- Llor X. Lynch Syndrome: Widening the Net. Gastroenterology 2019, 157: 1432-1434. PMID: 31586568, DOI: 10.1053/j.gastro.2019.09.028.
- Gupta S, Provenzale D, Llor X, Halverson AL, Grady W, Chung DC, Haraldsdottir S, Markowitz AJ, Slavin TP, Hampel H, Ness RM, Weiss JM, Ahnen DJ, Chen LM, Cooper G, Early DS, Giardiello FM, Hall MJ, Hamilton SR, Kanth P, Klapman JB, Lazenby AJ, Lynch PM, Mayer RJ, Mikkelson J, Peter S, Regenbogen SE, Dwyer MA, Ogba N. NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 2.2019. Journal Of The National Comprehensive Cancer Network : JNCCN 2019, 17: 1032-1041. PMID: 31487681, DOI: 10.6004/jnccn.2019.0044.
- Nartowt BJ, Hart GR, Roffman DA, Llor X, Ali I, Muhammad W, Liang Y, Deng J. Scoring colorectal cancer risk with an artificial neural network based on self-reportable personal health data. PLOS ONE 2019, 14: e0221421. PMID: 31437221, PMCID: PMC6705772, DOI: 10.1371/journal.pone.0221421.
- Xicola RM, Li S, Rodriguez N, Reinecke P, Karam R, Speare V, Black MH, LaDuca H, Llor X. Clinical features and cancer risk in families with pathogenic CDH1 variants irrespective of clinical criteria. Journal Of Medical Genetics 2019, 56: 838. PMID: 31296550, DOI: 10.1136/jmedgenet-2019-105991.
- Xicola RM, Clark JR, Carroll T, Alvikas J, Marwaha P, Regan MR, Lopez-Giraldez F, Choi J, Emmadi R, Alagiozian-Angelova V, Kupfer SS, Ellis NA, Llor X. Implication of DNA repair genes in Lynch-like syndrome. Familial Cancer 2019, 18: 331-342. PMID: 30989425, PMCID: PMC6561810, DOI: 10.1007/s10689-019-00128-6.
- Xicola RM, Manojlovic Z, Augustus GJ, Kupfer SS, Emmadi R, Alagiozian-Angelova V, Triche T, Salhia B, Carpten J, Llor X, Ellis NA. Lack of APC somatic mutation is associated with early-onset colorectal cancer in African Americans. Carcinogenesis 2018, 39: 1331-1341. PMID: 30239619, PMCID: PMC6292413, DOI: 10.1093/carcin/bgy122.
- Murcia O, Juárez M, Rodríguez-Soler M, Hernández-Illán E, Giner-Calabuig M, Alustiza M, Egoavil C, Castillejo A, Alenda C, Barberá V, Mangas-Sanjuan C, Yuste A, Bujanda L, Clofent J, Andreu M, Castells A, Llor X, Zapater P, Jover R. Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability and CIMP status: Prognostic implications and response to chemotherapy. PLOS ONE 2018, 13: e0203051. PMID: 30188916, PMCID: PMC6126803, DOI: 10.1371/journal.pone.0203051.
- Provenzale D, Gupta S, Ahnen DJ, Markowitz AJ, Chung DC, Mayer RJ, Regenbogen SE, Blanco AM, Bray T, Cooper G, Early DS, Ford JM, Giardiello FM, Grady W, Hall MJ, Halverson AL, Hamilton SR, Hampel H, Klapman JB, Larson DW, Lazenby AJ, Llor X, Lynch PM, Mikkelson J, Ness RM, Slavin TP, Sugandha S, Weiss JM, Dwyer MA, Ogba N. NCCN Guidelines Insights: Colorectal Cancer Screening, Version 1.2018. Journal Of The National Comprehensive Cancer Network : JNCCN 2018, 16: 939-949. PMID: 30099370, DOI: 10.6004/jnccn.2018.0067.
- Murcia O, Jover R, Egoavil C, Perez-Carbonell L, Juárez M, Hernández-Illán E, Rojas E, Alenda C, Balaguer F, Andreu M, Llor X, Castells A, Boland CR, Goel A. TFAP2E Methylation and Expression Status Does Not Predict Response to 5-FU-based Chemotherapy in Colorectal Cancer. Clinical Cancer Research 2018, 24: 2820-2827. PMID: 29535127, PMCID: PMC7396148, DOI: 10.1158/1078-0432.ccr-17-2940.
- Rodriguez N, Reineke P, LaDuca H, Xicola R, Llor X. 1066 - Phenotypic Expression of Cdh1 Germline Mutations Unselected for Hereditary Diffuse Gastric Cancer. Gastroenterology 2018, 154: s-204. DOI: 10.1016/s0016-5085(18)31081-3.
- Zhen JT, Syed J, Nguyen KA, Leapman MS, Agarwal N, Brierley K, Llor X, Hofstatter E, Shuch B. Genetic testing for hereditary prostate cancer: Current status and limitations. Cancer 2018, 124: 3105-3117. PMID: 29669169, DOI: 10.1002/cncr.31316.
- Murcia O, Juárez M, Hernández-Illán E, Rodriguez-Soler M, Giner-Calabuig M, Alustiza M, Egoavil C, Castillejo A, Alenda C, Mangas C, Barberá V, Yuste A, Bujanda L, Clofent J, Andreu M, Castells A, Llor X, Zapater P, Jover R. Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability, and CIMP status: Prognostic implications and response to chemotherapy. Journal Of Clinical Oncology 2018, 36: 668-668. DOI: 10.1200/jco.2018.36.4_suppl.668.
- Practice Update
- Gupta S, Provenzale D, Regenbogen SE, Hampel H, Slavin TP, Hall MJ, Llor X, Chung DC, Ahnen DJ, Bray T, Cooper G, Early DS, Ford JM, Giardiello FM, Grady W, Halverson AL, Hamilton SR, Klapman JB, Larson DW, Lazenby AJ, Lynch PM, Markowitz AJ, Mayer RJ, Ness RM, Samadder NJ, Shike M, Sugandha S, Weiss JM, Dwyer MA, Ogba N. NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 3.2017. Journal Of The National Comprehensive Cancer Network : JNCCN 2017, 15: 1465-1475. PMID: 29223984, DOI: 10.6004/jnccn.2017.0176.
- Perez-Mayoral J, Rivera-Lynch C, Soto-Salgado M, Llor X, Tous-Lopez L, Torres-Torres M, Reyes J, Torres C, Goel A, Rodriguez-Quillichini S, Cruz-Correa M. Abstract 1759: Description of molecular marker disparities and KRAS mutational spectrum of colorectal tumors from Puerto Rican Hispanics. Cancer Research 2017, 77: 1759-1759. DOI: 10.1158/1538-7445.am2017-1759.
- Llor X. Abdominal Pain With Boring-Like Character: The Revolution Is Yet to Come. Journal Of The National Comprehensive Cancer Network : JNCCN 2017, 15: 969-970. PMID: 28687583, DOI: 10.6004/jnccn.2017.0128.
- Kandimalla R, Linnekamp JF, van Hooff S, Castells A, Llor X, Andreu M, Jover R, Goel A, Medema JP. Methylation of WNT target genes AXIN2 and DKK1 as robust biomarkers for recurrence prediction in stage II colon cancer. Oncogenesis 2017, 6: e308-e308. PMID: 28368388, PMCID: PMC5520503, DOI: 10.1038/oncsis.2017.9.
- Wolf P, Yazici C, Kim H, Liu T, Carroll T, Augustus G, Mutlu E, Tussing‐Humphreys L, Braunschweig C, Xicola R, Jung B, Llor X, Ellis N, Gaskins H. Race‐dependent Association of Sulfidogenic Bacteria with Colorectal Cancer. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.315.2.
- Gomez‐Perez S, Yazici C, Wolf P, Braunschweig C, Xicola R, Llor X, Ellis N, Tussing‐Humphreys L, Mutlu E, Gaskins R. Correlations of Abdominal Fat and Colonic Sulfidogenic Bacteria in African Americans and Non‐Hispanic Whites with Newly Diagnosed Colorectal Cancer. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.138.7.
- Marquez J, Pérez-Mayoral J, Gonzalez-Pons M, Rodriguez-Mañon N, Rivera-Lynch C, Soto M, Llor X, Xicola R, Lopez L, Torres-Torres M, Reyes J, Goel A, Torres-Cintrón C, Rodriguez-Quilichini S, Cruz-Correa M. Tu1974 Molecular Disparities and Kras Mutational Spectrum of Colorectal Tumors from Puerto Rican Hispanic Subjects. Gastroenterology 2017, 152: s1022. DOI: 10.1016/s0016-5085(17)33461-3.
- Kwak Y, Alvarenga J, Vazquez-Gillamet L, Vega M, Vargas-Torres M, Lagarde S, McCloskey B, Xicola R, Llor X. Su1014 Resource Utilization and Colorectal Cancer Screening Compliance with Patient Navigation in Under-Screened Populations. Gastroenterology 2017, 152: s443. DOI: 10.1016/s0016-5085(17)31692-x.
- Alvarenga J, Kwak Y, Vazquez-Gillamet L, Vargas-Torres M, Vega M, Lagarde S, McCloskey B, Xicola R, Llor X. 86 Outcomes and Cost Analysis of a Colonoscopy-Based Colorectal Cancer Screening Program in a Lower Income us Hispanic Cohort. Gastroenterology 2017, 152: s23. DOI: 10.1016/s0016-5085(17)30447-x.
- Xicola R, Manojlovic Z, Augustus G, Kupfer S, Carpten J, Ellis N, Llor X. 235 Mutational and Epigenetic Spectrum of Colorectal Cancers in African Americans. Gastroenterology 2017, 152: s60. DOI: 10.1016/s0016-5085(17)30558-9.
- Yazici C, Wolf PG, Kim H, Cross TL, Vermillion K, Carroll T, Augustus GJ, Mutlu E, Tussing-Humphreys L, Braunschweig C, Xicola RM, Jung B, Llor X, Ellis NA, Gaskins HR. Race-dependent association of sulfidogenic bacteria with colorectal cancer. Gut 2017, 66: 1983. PMID: 28153960, PMCID: PMC5575988, DOI: 10.1136/gutjnl-2016-313321.
- Yazici C, Wolf P, Liu T, Vermillion K, Carroll T, Mutlu E, Tussing-Humphreys L, Braunschweig C, Xicola R, Jung B, Llor X, Ellis N, Gaskins H. Abstract B31: Sulfidogenic bacteria are an important diet-driven exposure promoting colorectal cancer in African Americans. Cancer Epidemiology Biomarkers & Prevention 2017, 26: b31-b31. DOI: 10.1158/1538-7755.disp16-b31.
- Brea-Fernandez AJ, Fernandez-Rozadilla C, Alvarez-Barona M, Azuara D, Ginesta MM, Clofent J, de Castro L, Gonzalez D, Andreu M, Bessa X, Llor X, Xicola R, Jover R, Castells A, Castellvi-Bel S, Capella G, Carracedo A, Ruiz-Ponte C. Candidate predisposing germline copy number variants in early onset colorectal cancer patients. Clinical And Translational Oncology 2016, 19: 625-632. PMID: 27888432, DOI: 10.1007/s12094-016-1576-z.
- Llor X. Building a Cancer Genetics and Prevention Program. Clinical Gastroenterology And Hepatology 2016, 14: 1516-1520. PMID: 27531499, DOI: 10.1016/j.cgh.2016.06.012.
- Ashktorab H, Ahuja S, Kannan L, Llor X, Ellis N, Xicola R, Laiyemo A, Carethers J, Brim H, Nouraie M. Abstract 5013: A meta-analysis of MSI frequency and race in colorectal cancer. Cancer Research 2016, 76: 5013-5013. DOI: 10.1158/1538-7445.am2016-5013.
- Mathur PS, Gierut JJ, Guzman G, Xie H, Xicola RM, Llor X, Chastkofsky MI, Perekatt AO, Tyner AL. Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer. Molecular Cancer Research 2016, 14: 563-573. PMID: 26983689, PMCID: PMC4912439, DOI: 10.1158/1541-7786.mcr-15-0450.
- Xicola RM, Bontu S, Doyle BJ, Rawson J, Garre P, Lee E, de la Hoya M, Bessa X, Clofent J, Bujanda L, Balaguer F, Castellví-Bel S, Alenda C, Jover R, Ruiz-Ponte C, Syngal S, Andreu M, Carracedo A, Castells A, Newcomb PA, Lindor N, Potter JD, Baron JA, Ellis NA, Caldes T, LLor X. Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC). Carcinogenesis 2016, 37: 751-758. PMID: 27234654, PMCID: PMC4967215, DOI: 10.1093/carcin/bgw064.
- Ashktorab H, Ahuja S, Kannan L, Llor X, Ellis NA, Xicola RM, Laiyemo AO, Carethers JM, Brim H, Nouraie M. A meta-analysis of MSI frequency and race in colorectal cancer. Oncotarget 2016, 7: 34546-34557. PMID: 27120810, PMCID: PMC5085175, DOI: 10.18632/oncotarget.8945.
- Xicola R, Clark J, Carroll T, Alvikas J, Marwaha P, Regan M, Emmadi R, Alagiozian-Angelova V, Kupfer S, Ellis N, Llor X. 775 Unveiling New Colorectal Cancer Phenotypes With Mismatch Repair Deficiency. Gastroenterology 2016, 150: s160. DOI: 10.1016/s0016-5085(16)30630-8.
- Augustus G, Xicola R, Brothman A, Llor X, Ellis N. Abstract PR02: Homologous recombination drives African American colorectal carcinogenesis. Cancer Epidemiology Biomarkers & Prevention 2016, 25: pr02-pr02. DOI: 10.1158/1538-7755.disp15-pr02.
- Díaz-Algorri Y, Pérez-Mayoral J, González-Pons M, Rodríguez N, Suárez B, Colón G, Sevilla J, Jorge D, Llor X, Xicola R, Tous L, Reyes J, Torres M, Goel A, Rodriguez S, Cruz-Correa M. Abstract B35: Molecular characterization of colorectal tumors from Puerto Rican Hispanic patients. Cancer Epidemiology Biomarkers & Prevention 2016, 25: b35-b35. DOI: 10.1158/1538-7755.disp15-b35.
- Xicola R, Kupfer S, Braunschweig C, Ellis N, Llor X. Abstract A75: Excess of proximal microsatellite-stable colorectal cancer in African Americans from a multiethnic study. Cancer Epidemiology Biomarkers & Prevention 2015, 24: a75-a75. DOI: 10.1158/1538-7755.disp14-a75.
- Santa Cruz Guindalini R, Win AK, Gulden C, Lindor NM, Newcomb PA, Haile RW, Raymond V, Stoffel E, Hall M, Llor X, Ukaegbu CI, Solomon I, Weitzel J, Kalady M, Blanco A, Terdiman J, Shuttlesworth GA, Lynch PM, Hampel H, Lynch HT, Jenkins MA, Olopade OI, Kupfer SS. Mutation Spectrum and Risk of Colorectal Cancer in African American Families with Lynch Syndrome. Gastroenterology 2015, 149: 1446-1453. PMID: 26248088, PMCID: PMC4648287, DOI: 10.1053/j.gastro.2015.07.052.
- Mathur P, Gierut J, Xicola R, Llor X, Tyner A. Abstract LB-059: Opposing roles for protein tyrosine kinase 6 (PTK6) in colon cancer. 2015, lb-059-lb-059. DOI: 10.1158/1538-7445.am2015-lb-059.
- Kupfer S, Hulur I, Gamazon E, Skol A, Llor X, Onel K, Ellis N. Abstract 4582: Enrichment of colorectal cancer and inflammatory bowel disease risk variants in colon expression quantitative trait loci in African Americans. 2015, 4582-4582. DOI: 10.1158/1538-7445.am2015-4582.
- Hamaya Y, Guarinos C, Tseng-Rogenski SS, Iwaizumi M, Das R, Jover R, Castells A, Llor X, Andreu M, Carethers JM. Efficacy of Adjuvant 5-Fluorouracil Therapy for Patients with EMAST-Positive Stage II/III Colorectal Cancer. PLOS ONE 2015, 10: e0127591. PMID: 25996601, PMCID: PMC4440728, DOI: 10.1371/journal.pone.0127591.
- Castillejo A, Hernández-Illán E, Rodriguez-Soler M, Pérez-Carbonell L, Egoavil C, Barberá VM, Castillejo MI, Guarinos C, Martínez-de-Dueñas E, Juan MJ, Sánchez-Heras AB, García-Casado Z, Ruiz-Ponte C, Brea-Fernández A, Juárez M, Bujanda L, Clofent J, Llor X, Andreu M, Castells A, Carracedo A, Alenda C, Payá A, Jover R, Soto JL. Prevalence of MLH1 constitutional epimutations as a cause of Lynch syndrome in unselected versus selected consecutive series of patients with colorectal cancer. Journal Of Medical Genetics 2015, 52: 498. PMID: 25908759, DOI: 10.1136/jmedgenet-2015-103076.
- Yazici C, Wolf P, Carroll T, Mutlu E, Xicola R, Llor X, Jung B, Ellis N, Gaskins H. 511 Bilophila wadsworthia Is More Abundant in the Colonic Microbiome of Colorectal Cancer Cases Compared to Healthy Controls. Gastroenterology 2015, 148: s-100. DOI: 10.1016/s0016-5085(15)30343-7.
- Murcia O, Rodriguez-Soler M, Juarez-Quesada M, Guarinos C, Hernandez-Illan E, Andreu M, Castells A, Llor X, Carracedo A, Jover R. Su1997 Colorectal Cancer With Methylator Phenotype. Clinical Characterisitics, Prognosis and Response to Adjuvant Chemotherapy. Gastroenterology 2015, 148: s-570-s-571. DOI: 10.1016/s0016-5085(15)31926-0.
- Xicola R, Carroll T, Emmadi R, Alagiozian-Angelova V, Alvikas J, Marwaha P, Regan M, Gibson J, Mitchell K, Kupfer S, Ellis N, Llor X. Su1993 Somatic Mutations in the Mismatch Repair System Are Responsible for a Majority of Unexplained Lynch Syndrome Cases: Time to Revise Lynch Syndrome Screening? Gastroenterology 2015, 148: s-570. DOI: 10.1016/s0016-5085(15)31922-3.
- Hulur I, Gamazon ER, Skol AD, Xicola RM, Llor X, Onel K, Ellis NA, Kupfer SS. Enrichment of inflammatory bowel disease and colorectal cancer risk variants in colon expression quantitative trait loci. BMC Genomics 2015, 16: 138. PMID: 25766683, PMCID: PMC4351699, DOI: 10.1186/s12864-015-1292-z.
- Commentary
- Commentary
- Moreira L, Muñoz J, Cuatrecasas M, Quintanilla I, Leoz ML, Carballal S, Ocaña T, López‐Cerón M, Pellise M, Castellví‐Bel S, Jover R, Andreu M, Carracedo A, Xicola RM, Llor X, Boland CR, Goel A, Castells A, Balaguer F. Prevalence of somatic mutl homolog 1 promoter hypermethylation in Lynch syndrome colorectal cancer. Cancer 2014, 121: 1395-1404. PMID: 25557234, PMCID: PMC10508888, DOI: 10.1002/cncr.29190.
- Pibiri F, Rechenmacher R, Xicola R, Kittles R, Sandler R, Keku T, Llor X, Carpten J, Kupfer S, Ellis N. Abstract 2191: Identification of functional risk alleles in colorectal cancer-associated regions in African Americans. 2014, 2191-2191. DOI: 10.1158/1538-7445.am2014-2191.
- Siddiqi S, Pibiri F, Xicola R, Kittles R, Llor X, Kupfer S, Ellis N. Abstract 1279: Association between vitamin D levels and colorectal cancer in African Americans. 2014, 1279-1279. DOI: 10.1158/1538-7445.am2014-1279.
- Xicola RM, Gagnon M, Clark JR, Carroll T, Gao W, Fernandez C, Mijic D, Rawson JB, Janoski A, Pusatcioglu CK, Rajaram P, Gluskin AB, Regan M, Chaudhry V, Abcarian H, Blumetti J, Cintron J, Melson J, Xie H, Guzman G, Emmadi R, Alagiozian-Angelova V, Kupfer SS, Braunschweig C, Ellis NA, Llor X. Excess of Proximal Microsatellite-Stable Colorectal Cancer in African Americans from a Multiethnic Study. Clinical Cancer Research 2014, 20: 4962-4970. PMID: 25013126, PMCID: PMC4167473, DOI: 10.1158/1078-0432.ccr-14-0353.
- Perez-Carbonell L, Balaguer F, Toiyama Y, Egoavil C, Rojas E, Guarinos C, Andreu M, Llor X, Castells A, Jover R, Boland CR, Goel A. IGFBP3 Methylation Is a Novel Diagnostic and Predictive Biomarker in Colorectal Cancer. PLOS ONE 2014, 9: e104285. PMID: 25127039, PMCID: PMC4134211, DOI: 10.1371/journal.pone.0104285.
- Pusatcioglu CK, Nemeth E, Fantuzzi G, Llor X, Freels S, Tussing-Humphreys L, Cabay RJ, Linzmeier R, Ng D, Clark J, Braunschweig C. Systemic and tumor level iron regulation in men with colorectal cancer: a case control study. Nutrition & Metabolism 2014, 11: 21. PMID: 24872837, PMCID: PMC4037273, DOI: 10.1186/1743-7075-11-21.
- Hulur I, Skol A, Llor X, Onel K, Ellis N, Kupfer S. 719 Expression Quantitative Trait Loci Mapping in the Human Colon. Gastroenterology 2014, 146: s-125-s-126. DOI: 10.1016/s0016-5085(14)60451-0.
- Marwaha P, Xicola R, Kim Y, Snyder C, Carroll T, Syngal S, Buxbaum S, Zhang M, Want S, Lynch H, Bessa X, Andreu M, Jover R, Carracedo A, Castells A, Caldes T, Ellis N, Llor X. 675 Unveiling of DNA Repair Gene Alterations in Non-Lynch Hereditary Colorectal Cancer Through Exome Sequencing. Gastroenterology 2014, 146: s-119. DOI: 10.1016/s0016-5085(14)60429-7.
- Pérez-Carbonell L, Egoavil C, Rojas E, Alenda C, Rodriguez-Soler M, Guarinos C, Juarez-Quesada M, Andreu M, Llor X, Castells A, Jover R, Boland C, Goel A. Sa1897 Novel Evidence for Interleukin-8 (IL-8) As a Predictive Biomarker of Response to 5fluorouracil Based Chemotherapy in Colorectal Cancer. Gastroenterology 2014, 146: s-323. DOI: 10.1016/s0016-5085(14)61166-5.
- Mathur P, Xicola R, Llor X, Tyner A. 50 PTK6 Antagonizes the EMT in Colon Cancer Cell Lines. Gastroenterology 2014, 146: s-14. DOI: 10.1016/s0016-5085(14)60050-0.
- Ravella S, Xicola R, Pibiri F, Carroll T, Sandler R, Kupfer S, Ellis N, Llor X. Mo1153 Association of a Variant in FADS2 the Gene Encoding the Polyunsaturated Fatty Acid Metabolizing Enzyme FADS2 With Colorectal Cancer in African Americans. Gastroenterology 2014, 146: s-571. DOI: 10.1016/s0016-5085(14)62069-2.
- Abulí A, Bujanda L, Muñoz J, Buch S, Schafmayer C, Valeria Maiorana M, Veneroni S, van Wezel T, Liu T, Westers H, Esteban-Jurado C, Ocaña T, Piqué JM, Andreu M, Jover R, Carracedo A, Xicola RM, Llor X, Castells A, , Dunlop M, Hofstra R, Lindblom A, Wijnen J, Peterlongo P, Hampe J, Ruiz-Ponte C, Castellví-Bel S. The MLH1 c.1852_1853delinsGC (p.K618A) Variant in Colorectal Cancer: Genetic Association Study in 18,723 Individuals. PLOS ONE 2014, 9: e95022. PMID: 24743384, PMCID: PMC3990597, DOI: 10.1371/journal.pone.0095022.
- Llor X. Colorectal cancer: From the laboratory to the patient, a now indispensable step. Revista De Gastroenterología De México (English Edition) 2014, 79: 71-72. DOI: 10.1016/j.rgmxen.2014.05.012.
- Llor X. Cáncer colorrectal: del laboratorio al paciente, un paso ya imprescindible. Revista De Gastroenterología De México 2014, 79: 71-72. PMID: 24934514, DOI: 10.1016/j.rgmx.2014.05.005.
- Gonzalo V, Lozano JJ, Alonso-Espinaco V, Moreira L, Muñoz J, Pellisé M, Castellví-Bel S, Bessa X, Andreu M, Xicola RM, Llor X, Ruiz-Ponte C, Carracedo A, Jover R, Castells A, Balaguer F, . Multiple Sporadic Colorectal Cancers Display a Unique Methylation Phenotype. PLOS ONE 2014, 9: e91033. PMID: 24643221, PMCID: PMC3958343, DOI: 10.1371/journal.pone.0091033.
- Pibiri F, Kittles RA, Sandler RS, Keku TO, Kupfer SS, Xicola RM, Llor X, Ellis NA. Genetic variation in vitamin D-related genes and risk of colorectal cancer in African Americans. Cancer Causes & Control 2014, 25: 561-570. PMID: 24562971, PMCID: PMC3978221, DOI: 10.1007/s10552-014-0361-y.
- Fernandez-Rozadilla C, Cazier JB, Tomlinson I, Brea-Fernández A, Lamas MJ, Baiget M, López-Fernández LA, Clofent J, Bujanda L, Gonzalez D, de Castro L, The EPICOLON Consortium, Hemminki K, Bessa X, Andreu M, Jover R, Xicola R, Llor X, Moreno V, Castells A, Castellví-Bel S, Carracedo A, Ruiz-Ponte C. A genome-wide association study on copy-number variation identifies a 11q11 loss as a candidate susceptibility variant for colorectal cancer. Human Genetics 2013, 133: 525-534. PMID: 24218287, DOI: 10.1007/s00439-013-1390-4.
- Montero-Meléndez T, Llor X, García-Planella E, Perretti M, Suárez A. Identification of Novel Predictor Classifiers for Inflammatory Bowel Disease by Gene Expression Profiling. PLOS ONE 2013, 8: e76235. PMID: 24155895, PMCID: PMC3796518, DOI: 10.1371/journal.pone.0076235.
- Parepally M, Rajaram P, Xicola R, Ellis N, Llor X, Venepalli N. Racial Differences in Colorectal Cancer: A Large Single Institution Experience. The American Journal Of Gastroenterology 2013, 108: s180. DOI: 10.14309/00000434-201310001-00613.
- Abulí A, Lozano JJ, Rodríguez-Soler M, Jover R, Bessa X, Muñoz J, Esteban-Jurado C, Fernández-Rozadilla C, Carracedo A, Ruiz-Ponte C, Cubiella J, Balaguer F, Bujanda L, Reñé JM, Clofent J, Morillas JD, Nicolás-Pérez D, Xicola RM, Llor X, Piqué JM, Andreu M, Castells A, Castellví-Bel S. Genetic susceptibility variants associated with colorectal cancer prognosis. Carcinogenesis 2013, 34: 2286-2291. PMID: 23712746, DOI: 10.1093/carcin/bgt179.
- Pérez-Carbonell L, Egoavil C, Toiyama Y, Guarinos C, Rojas E, Alenda C, Balaguer F, Hur K, Andreu M, Llor X, Castells A, Jover R, Boland C, Goel A. 470 TFAP2E Methylation and Expression Status Do Not Serve As Predictors of Response to 5-FU Based Chemotherapy in Colorectal Cancer. Gastroenterology 2013, 144: s-84-s-85. DOI: 10.1016/s0016-5085(13)60314-5.
- Pérez-Carbonell L, Toiyama Y, Balaguer F, Guarinos C, Hur K, Andreu M, Llor X, Castells A, Jover R, Boland C, Goel A. Sa2002 IGFBP3 Methylation As a Novel Diagnostic and Prognostic Marker in Colorectal Cancer. Gastroenterology 2013, 144: s-356. DOI: 10.1016/s0016-5085(13)61311-6.
- Moreira L, Munoz J, Cuatrecasas M, Quintanilla I, Leoz M, Carballal S, Ocana T, Fernandez P, Arnold M, Pellise M, Jover R, Andreu M, Carracedo A, Llor X, Boland C, Goel A, Castells A, Balaguer F. 107 Somatic MLH1 Promoter Hypermethylation Is a Frequent Event in Lynch Syndrome Colorectal Cancers. Gastroenterology 2013, 144: s-25. DOI: 10.1016/s0016-5085(13)60087-6.
- Diaz-Algorri Y, Xicola R, Llor X, Tucker K, Cruz-Correa M. Su1087 Clinicopathological Characterization and Nutritional Assessment of Hispanics With Sporadic Microsatellite Unstable Colorectal Cancers. Gastroenterology 2013, 144: s-395. DOI: 10.1016/s0016-5085(13)61454-7.
- Xicola R, Doyle B, Rawson J, Garre P, Abulí A, Murugappan S, Lee J, Bessa X, Clofent J, Bujanda L, Balaguer F, Castellvi-Bel S, Alenda C, Jover R, Ruiz-Ponte C, Syngal S, Andreu M, Carracedo A, Castells A, Ellis N, Caldes T, Llor X. 106 Implication of the 3′Utr Region of TGFβR1 With MSS HNPCC and Sporadic Colorectal Cancer. Gastroenterology 2013, 144: s-25. DOI: 10.1016/s0016-5085(13)60086-4.
- Munoz Xicola R, Doyle B, Rawson J, Garre P, Abuli A, Lee E, Murugappan S, Bessa X, Bujanda L, Balaguer F, Castellvi-Bel S, Clofent J, Alenda C, Jover R, Ruiz-Ponte C, Singal S, Andreu M, Carracedo A, Castells A, Ellis N, Caldes T, LLor X. Abstract 1334: Implication of the 3′UTR region of TGFβR1 with MSS HNPCC and sporadic colorectal cancer. Cancer Research 2013, 73: 1334-1334. DOI: 10.1158/1538-7445.am2013-1334.
- Pibiri F, Ellis N, Kittles R, LLor X, Xicola R, Kupfer S, Sandler R, Keku T. Abstract 1330: Genetic variation in the vitamin D pathway and risk for colorectal cancer in African Americans. Cancer Research 2013, 73: 1330-1330. DOI: 10.1158/1538-7445.am2013-1330.
- Fernandez-Rozadilla C, Cazier JB, Tomlinson IP, Carvajal-Carmona LG, Palles C, Lamas MJ, Baiget M, López-Fernández LA, Brea-Fernández A, Abulí A, Bujanda L, Clofent J, Gonzalez D, Xicola R, Andreu M, Bessa X, Jover R, Llor X, The EPICOLON Consortium, Moreno V, Castells A, Carracedo Á, Castellvi-Bel S, Ruiz-Ponte C. A colorectal cancer genome-wide association study in a Spanish cohort identifies two variants associated with colorectal cancer risk at 1p33 and 8p12. BMC Genomics 2013, 14: 55. PMID: 23350875, PMCID: PMC3616862, DOI: 10.1186/1471-2164-14-55.
- Rodríguez–Soler M, Pérez–Carbonell L, Guarinos C, Zapater P, Castillejo A, Barberá VM, Juárez M, Bessa X, Xicola RM, Clofent J, Bujanda L, Balaguer F, Reñé J, de–Castro L, Marín–Gabriel J, Lanas A, Cubiella J, Nicolás–Pérez D, Brea–Fernández A, Castellví–Bel S, Alenda C, Ruiz–Ponte C, Carracedo A, Castells A, Andreu M, Llor X, Soto JL, Payá A, Jover R. Risk of Cancer in Cases of Suspected Lynch Syndrome Without Germline Mutation. Gastroenterology 2013, 144: 926-932.e1. PMID: 23354017, DOI: 10.1053/j.gastro.2013.01.044.
- Fernandez-Rozadilla C, Palles C, Carvajal-Carmona L, Peterlongo P, Nici C, Veneroni S, Pinheiro M, Teixeira MR, Moreno V, Lamas MJ, Baiget M, Lopez-Fernandez L, Gonzalez D, Brea-Fernandez A, Clofent J, Bujanda L, Bessa X, Andreu M, Xicola R, Llor X, Jover R, Consortium T, Castells A, Castellvi-Bel S, Carracedo A, Tomlinson I, Ruiz-Ponte C. BMP2 / BMP4 colorectal cancer susceptibility loci in northern and southern European populations. Carcinogenesis 2012, 34: 314-318. PMID: 23161572, DOI: 10.1093/carcin/bgs357.
- Fernandez‐Rozadilla C, Brea‐Fernández A, Bessa X, Álvarez‐Urturi C, Abulí A, Clofent J, Payá A, Consortium T, Jover R, Xicola R, Llor X, Andreu M, Castells A, Carracedo Á, Castellví‐Bel S, Ruiz‐Ponte C. BMPR1A mutations in early‐onset colorectal cancer with mismatch repair proficiency. Clinical Genetics 2012, 84: 94-96. PMID: 23057600, DOI: 10.1111/cge.12023.
- Pibiri F, Kittles R, Sandler R, Keku T, Kupfer S, Xicola R, Llor X, Ellis N. Abstract PR02: Genetic variation in the vitamin D pathway and risk for colorectal cancer in African Americans. Cancer Epidemiology Biomarkers & Prevention 2012, 21: pr02-pr02. DOI: 10.1158/1055-9965.disp12-pr02.
- Antelo M, Balaguer F, Shia J, Shen Y, Hur K, Moreira L, Cuatrecasas M, Bujanda L, Giraldez MD, Takahashi M, Cabanne A, Barugel ME, Arnold M, Roca EL, Andreu M, Castellvi-Bel S, Llor X, Jover R, Castells A, Boland CR, Goel A. A High Degree of LINE-1 Hypomethylation Is a Unique Feature of Early-Onset Colorectal Cancer. PLOS ONE 2012, 7: e45357. PMID: 23049789, PMCID: PMC3458035, DOI: 10.1371/journal.pone.0045357.
- Giráldez M, López-Dóriga A, Bujanda L, Abulí A, Bessa X, Fernandez-Rozadilla C, Munoz J, Cuatrecasas M, Jover R, Xicola R, Llor X, Piqué J, Carracedo A, Ruiz-Ponte C, Cosme A, Enriquez-Navascués J, Moreno V, Andreu M, Castells A, Balaguer F, Castellvi-Bel S. Su1813 Susceptibility Genetic Variants Associated With Early-Onset Colorectal Cancer. Gastroenterology 2012, 142: s-510. DOI: 10.1016/s0016-5085(12)61954-4.
- Rodriguez-Soler M, Pérez-Carbonell L, Guarinos C, Castillejo A, Egoavil C, Barberà V, Martinez-Dueńas E, Castillejo M, Martinez-Canto A, Sanchez-Heras A, Ruiz-Ponte C, Brea A, Alenda C, Paya A, Sanchez-Fortun C, Juarez-Quesada M, Bujanda L, Clofent J, Llor X, Andreu M, Castells A, Carracedo A, Soto J, Jover R. Sa1774 Prevalence of MLH1 Constitutional Epimutations as a Cause of Lynch Syndrome in Unselected Consecutive Cases of Colorectal Cancer. Gastroenterology 2012, 142: s-322. DOI: 10.1016/s0016-5085(12)61211-6.
- Xicola R, Gagnon M, Shaw J, Rodriguez G, Pusatcioglu C, Clark J, James R, Ravella S, Guzman G, Janoski A, Morrissey M, Mraz K, Cerye K, Chaudhry V, Kupfer S, Melson J, Freeman V, Xie H, Braunchweig C, Ellis N, Llor X. Abstract 3597: The Chicago Colorectal Cancer Consortium (CCCC) experience: Understanding colorectal cancer disparities. Cancer Research 2012, 72: 3597-3597. DOI: 10.1158/1538-7445.am2012-3597.
- Pibiri F, Kittles R, Sandler R, Keku T, Kupfer S, LLor X, Ellis N. Abstract 1653: Genetic variation in the vitamin D pathway and risk for colorectal cancer in African Americans. Cancer Research 2012, 72: 1653-1653. DOI: 10.1158/1538-7445.am2012-1653.
- Xicola RM, Llor X. Defectos de la metilación del ADN en el cáncer colorrectal esporádico y hereditario. Gastroenterología Y Hepatología 2012, 35: 480-487. PMID: 22459641, DOI: 10.1016/j.gastrohep.2012.01.010.
- Fernandez-Rozadilla C, Cazier JB, Moreno V, Crous-Bou M, Guinó E, Durán G, Lamas MJ, López R, Candamio S, Gallardo E, Paré L, Baiget M, Páez D, López-Fernández LA, Cortejoso L, García MI, Bujanda L, González D, Gonzalo V, Rodrigo L, Reñé JM, Jover R, Brea-Fernández A, Andreu M, Bessa X, Llor X, Xicola R, Palles C, Tomlinson I, Castellví-Bel S, Castells A, Ruiz-Ponte C, Carracedo A. Pharmacogenomics in colorectal cancer: a genome-wide association study to predict toxicity after 5-fluorouracil or FOLFOX administration. The Pharmacogenomics Journal 2012, 13: 209-217. PMID: 22310351, DOI: 10.1038/tpj.2012.2.
- Castellví-Bel S, Ruiz-Ponte C, Fernández-Rozadilla C, Abulí A, Muñoz J, Bessa X, Brea-Fernández A, Ferro M, Giráldez MD, Xicola RM, Llor X, Jover R, Piqué JM, Andreu M, Castells A, Carracedo A, Association F. Seeking genetic susceptibility variants for colorectal cancer: the EPICOLON consortium experience. Mutagenesis 2012, 27: 153-159. PMID: 22294762, DOI: 10.1093/mutage/ger047.
- Giráldez MD, López-Dóriga A, Bujanda L, Abulí A, Bessa X, Fernández-Rozadilla C, Muñoz J, Cuatrecasas M, Jover R, Xicola RM, Llor X, Piqué JM, Carracedo A, Ruiz-Ponte C, Cosme A, Enríquez-Navascués JM, Moreno V, Andreu M, Castells A, Balaguer F, Castellví-Bel S, Association T. Susceptibility genetic variants associated with early-onset colorectal cancer. Carcinogenesis 2012, 33: 613-619. PMID: 22235025, DOI: 10.1093/carcin/bgs009.
- Llor X. When Should We Suspect Hereditary Colorectal Cancer Syndrome? Clinical Gastroenterology And Hepatology 2011, 10: 363-367. PMID: 22178459, DOI: 10.1016/j.cgh.2011.12.022.
- Balaguer F, Moreira L, Lozano JJ, Link A, Ramirez G, Shen Y, Cuatrecasas M, Arnold M, Meltzer SJ, Syngal S, Stoffel E, Jover R, Llor X, Castells A, Boland CR, Gironella M, Goel A. Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles. Clinical Cancer Research 2011, 17: 6239-6249. PMID: 21844009, PMCID: PMC3186834, DOI: 10.1158/1078-0432.ccr-11-1424.
- Sohn VR, Giros A, Xicola RM, Fluvià L, Grzybowski M, Anguera A, Llor X. Stool-fermented Plantago ovata husk induces apoptosis in colorectal cancer cells independently of molecular phenotype. British Journal Of Nutrition 2011, 107: 1591-1602. PMID: 22018732, DOI: 10.1017/s0007114511004910.
- Pérez-Carbonell L, Ruiz-Ponte C, Guarinos C, Alenda C, Payá A, Brea A, Egoavil CM, Castillejo A, Barberá VM, Bessa X, Xicola RM, Rodríguez-Soler M, Sánchez-Fortún C, Acame N, Castellví-Bel S, Piñol V, Balaguer F, Bujanda L, De-Castro ML, Llor X, Andreu M, Carracedo A, Soto JL, Castells A, Jover R. Comparison between universal molecular screening for Lynch syndrome and revised Bethesda guidelines in a large population-based cohort of patients with colorectal cancer. Gut 2011, 61: 865. PMID: 21868491, DOI: 10.1136/gutjnl-2011-300041.
- Abulí A, Fernández-Rozadilla C, Alonso-Espinaco V, Muñoz J, Gonzalo V, Bessa X, González D, Clofent J, Cubiella J, Morillas JD, Rigau J, Latorre M, Fernández-Bañares F, Peña E, Riestra S, Payá A, Jover R, Xicola RM, Llor X, Carvajal-Carmona L, Villanueva CM, Moreno V, Piqué JM, Carracedo A, Castells A, Andreu M, Ruiz-Ponte C, Castellví-Bel S, for the Gastrointestinal Oncology Group of the Spanish Gastroenterological Association. Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins. BMC Cancer 2011, 11: 339. PMID: 21819567, PMCID: PMC3176240, DOI: 10.1186/1471-2407-11-339.
- Abulí A, Fernández-Rozadilla C, Giráldez MD, Muñoz J, Gonzalo V, Bessa X, Bujanda L, Reñé JM, Lanas A, García AM, Saló J, Argüello L, Vilella À, Carreño R, Jover R, Xicola RM, Llor X, Carvajal-Carmona L, Tomlinson IP, Kerr DJ, Houlston RS, Piqué JM, Carracedo A, Castells A, Andreu M, Ruiz-Ponte C, Castellví-Bel S, for the Gastrointestinal Oncology Group of the Spanish Gastroenterological Association. A two-phase case–control study for colorectal cancer genetic susceptibility: candidate genes from chromosomal regions 9q22 and 3q22. British Journal Of Cancer 2011, 105: 870-875. PMID: 21811255, PMCID: PMC3171011, DOI: 10.1038/bjc.2011.296.
- Validation Microsatellite Path Score in a Population-Based Cohort of Patients With Colorectal CancerBessa X, Alenda C, Paya A, Álvarez C, Iglesias M, Seoane A, Dedeu JM, Abulí A, Ilzarbe L, Navarro G, Pellise M, Balaguer F, Castellvi-Bel S, LLor X, Castells A, Jover R, Andreu M. Validation Microsatellite Path Score in a Population-Based Cohort of Patients With Colorectal Cancer. Journal Of Clinical Oncology 2011, 29: 3374-3380. PMID: 21788563, DOI: 10.1200/jco.2010.34.3947.
- Xicola RM, Llor X. Cancer Risk Assessment in Lynch Syndrome: Does the Gene Matter? JAMA 2011, 305: 2351-2352. PMID: 21642691, DOI: 10.1001/jama.2011.771.
- Soler M, Pérez-Carbonell L, Guarinos C, Ruiz-Ponte C, Brea A, Castillejo A, Barberá V, Sanchez-Fortun C, Sempere-Robles L, Bujanda L, Clofent J, Llor X, Andreu M, Castells A, Carracedo A, Soto J, Payá A, Alenda C, Jover R. Differential Features of Colorectal Cancer (CRC) in Patients With Probable Non-Sporadic Mismatch Repair Deficiency Without Germline Mutation. Gastroenterology 2011, 140: s-190-s-191. DOI: 10.1016/s0016-5085(11)60767-1.
- Pérez-Carbonell L, Guarinos C, Soler M, Sanchez-Fortun C, Sempere-Robles L, Ruiz-Ponte C, Castillejo A, Brea A, Carracedo A, Barberá V, Rojas E, Bujanda L, Clofent J, Andreu M, Llor X, Castells A, Soto J, Jover R. Comparison Between Universal Immunohistochemistry for Mismatch Repair Proteins Versus Revised Bethesda Guidelines in the Detection of Patients With Lynch Syndrome. Gastroenterology 2011, 140: s-97. DOI: 10.1016/s0016-5085(11)60394-6.
- Balaguer F, Antelo M, Shen Y, Hur K, Giraldez M, Bujanda L, Takahashi M, Cabanne A, Barugel M, Arnold M, Roca E, Andreu M, Llor X, Jover R, Castells A, Boland C, Goel A. Increased Line-1 Hypomethylation is a Unique Feature of Early-Onset Colorectal Cancer (CRC). Gastroenterology 2011, 140: s-820-s-821. DOI: 10.1016/s0016-5085(11)63397-0.
- Xicola R, Mu W, Huang L, Sohn V, Doyle B, Jover R, Carracedo A, Andreu M, Bessa X, Castells A, Boland C, Goel A, Investigators E, Dai Y, Llor X. Identification of Mirnas and Their Gene Targets Differentially Expressed in Microsatellite Stable and Unstable Colorectal Cancers Through an Integrated Analysis. Gastroenterology 2011, 140: s-819. DOI: 10.1016/s0016-5085(11)63391-x.
- Xicola R, Below J, Doyle B, Garre P, Zhang W, Caldes T, Cox N, Llor X. Identification of a Chromosome 10 Region Potentially Implicated in Hereditary Non-Polyposis Colorectal Cancer Without Mismatch Repair Mutations. Gastroenterology 2011, 140: s-97. DOI: 10.1016/s0016-5085(11)60395-8.
- Garre P, Briceño V, Xicola RM, Doyle BJ, de la Hoya M, Sanz J, Llovet P, Pescador P, Puente J, Díaz-Rubio E, Llor X, Caldés T. Analysis of the Oxidative Damage Repair Genes NUDT1, OGG1, and MUTYH in Patients from Mismatch Repair Proficient HNPCC Families (MSS-HNPCC). Clinical Cancer Research 2011, 17: 1701-1712. PMID: 21355073, DOI: 10.1158/1078-0432.ccr-10-2491.
- Castillejo A, Guarinos C, Martinez-Canto A, Barbera VM, Egoavil C, Castillejo MI, Perez-Carbonell L, Sanchez-Heras AB, Segura A, Ochoa E, Lazaro R, Ruiz-Ponte C, Bujanda L, Andreu M, Castells A, Carracedo A, Llor X, Clofent J, Alenda C, Paya A, Jover R, Soto JL. Evidence for classification of c.1852_1853AA>GC in MLH1 as a neutral variant for Lynch syndrome. BMC Medical Genomics 2011, 12: 12. PMID: 21247423, PMCID: PMC3034663, DOI: 10.1186/1471-2350-12-12.
- Jover R, Nguyen T, Pérez–Carbonell L, Zapater P, Payá A, Alenda C, Rojas E, Cubiella J, Balaguer F, Morillas JD, Clofent J, Bujanda L, Reñé JM, Bessa X, Xicola RM, Nicolás–Pérez D, Castells A, Andreu M, Llor X, Boland CR, Goel A. 5-Fluorouracil Adjuvant Chemotherapy Does Not Increase Survival in Patients With CpG Island Methylator Phenotype Colorectal Cancer. Gastroenterology 2010, 140: 1174-1181. PMID: 21185836, PMCID: PMC3073650, DOI: 10.1053/j.gastro.2010.12.035.
- Fernández-Rozadilla C, de Castro L, Clofent J, Brea-Fernández A, Bessa X, Abulí A, Andreu M, Jover R, Xicola R, Llor X, Castells A, Castellví-Bel S, Carracedo A, Ruiz-Ponte C, . Single Nucleotide Polymorphisms in the Wnt and BMP Pathways and Colorectal Cancer Risk in a Spanish Cohort. PLOS ONE 2010, 5: e12673. PMID: 20844743, PMCID: PMC2936577, DOI: 10.1371/journal.pone.0012673.
- Abulí A, Bessa X, González JR, Ruiz–Ponte C, Cáceres A, Muñoz J, Gonzalo V, Balaguer F, Fernández–Rozadilla C, González D, de Castro L, Clofent J, Bujanda L, Cubiella J, Reñé J, Morillas JD, Lanas Á, Rigau J, García A, Latorre M, Saló J, Bañares F, Argüello L, Peña E, Vilella À, Riestra S, Carreño R, Paya A, Alenda C, Xicola RM, Doyle BJ, Jover R, Llor X, Carracedo A, Castells A, Castellví–Bel S, Andreu M, Association G. Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype. Gastroenterology 2010, 139: 788-796.e6. PMID: 20638935, DOI: 10.1053/j.gastro.2010.05.072.
- Pérez-Carbonell L, Alenda C, Payá A, Castillejo A, Barberá VM, Guillén C, Rojas E, Acame N, Gutiérrez-Aviñó FJ, Castells A, Llor X, Andreu M, Soto JL, Jover R. Methylation Analysis of MLH1 Improves the Selection of Patients for Genetic Testing in Lynch Syndrome. Journal Of Molecular Diagnostics 2010, 12: 498-504. PMID: 20489114, PMCID: PMC2893635, DOI: 10.2353/jmoldx.2010.090212.
- Jover R, Nguyen T, Pérez-Carbonell L, Payá A, Alenda C, Rojas E, Castells A, Andreu M, Llor X, Boland C, Goel A. 745 Colorectal Cancers (CRCs) With the CpG Island Methylator Phenotype (CIMP) Do Not Show Improved Survival With 5-Fluorouracil (5FU)-Based Adjuvant Chemotherapy. Gastroenterology 2010, 138: s-102. DOI: 10.1016/s0016-5085(10)60466-0.
- Abulí A, Fernandez-Rozadilla C, Alonso-Espinaco V, Giráldez M, Muñoz J, Bessa X, Llor X, Jover R, Carvajal-Carmona L, Tomlinson I, Moreno V, Carracedo A, Castells A, Andreu M, Ruiz-Ponte C, Castellvi-Bel S. S1984 Case-Control Genetic Association Study of Candidates Genes for Genetic Susceptibility to Colorectal Cancer. Gastroenterology 2010, 138: s-295. DOI: 10.1016/s0016-5085(10)61355-8.
- Pérez-Carbonell L, Ruiz-Ponte C, Bessa X, Soto J, Castillejo A, Barberá V, Brea A, Sempere L, Sánchez-Fortún C, Castellvi-Bel S, Balaguer F, Xicola R, Llor X, Abulí A, Andreu M, Alenda C, Payá A, Carracedo A, Castells A, Jover R. S1993 Comparison Between Routine Immunohistochemistry for Mismatch Repair Proteins Versus Revised Bethesda Guidelines in the Diagnosis of Lynch Syndrome in a Non-Selected Population of Colorectal Cancer Patients. Gastroenterology 2010, 138: s-297. DOI: 10.1016/s0016-5085(10)61364-9.
- Xicola R, Garre P, Doyle B, Bandipalliam P, Sapoznik V, Syngal S, Castells A, Jover R, Andreu M, Boland C, Goel A, Caldes T, Llor X. S1994 Base Excision Repair Genes MYH, Ogg1 and Nudt1 and Mismatch Repair Gene Variants in Hereditary Non-Polyposis Colorectal Cancer Without Mismatch Repair Deficiency (MSS HNPCC). Gastroenterology 2010, 138: s-297. DOI: 10.1016/s0016-5085(10)61365-0.
- T1710 MicroRNA Expression Profiles Distinguish Various Molecular Subtypes of Colorectal Cancer (CRC)Balaguer F, Moreira L, Lozano J, Link A, Ramirez G, Cuatrecasas M, Arnold M, Stoffel E, Syngal S, Jover R, Llor X, Castells A, Boland C, Gironella M, Goel A. T1710 MicroRNA Expression Profiles Distinguish Various Molecular Subtypes of Colorectal Cancer (CRC). Gastroenterology 2010, 138: s-562-s-563. DOI: 10.1016/s0016-5085(10)62588-7.
- Kim J, Rami P, O’Toole J, Llor X, Carroll RE, Benya RV. Extent of prevalence and size of flat neoplasms in a heterogeneous population undergoing routine colorectal cancer screening. Colorectal Disease 2010, 12: 471-476. PMID: 19298579, DOI: 10.1111/j.1463-1318.2009.01822.x.
- Bujanda L, Sarasqueta C, Hijona E, Hijona L, Cosme A, Gil I, Elorza JL, Asensio JI, Larburu S, Enríquez-Navascués JM, Jover R, Balaguer F, Llor X, Bessa X, Andreu M, Paya A, Castells A, Association G. Colorectal cancer prognosis twenty years later. World Journal Of Gastroenterology 2010, 16: 862-867. PMID: 20143465, PMCID: PMC2825333, DOI: 10.3748/wjg.v16.i7.862.
- Fernández-Rozadilla C, Tarrío R, Clofent J, de Castro L, Brea-Fernández A, Bessa X, Abulí A, Andreu M, Jover R, Xicola R, Llor X, Castells A, Castellví-Bel S, Carracedo A, Ruiz-Ponte C, Association F. Colorectal Cancer Susceptibility Quantitative Trait Loci in Mice as a Novel Approach to Detect Low-Penetrance Variants in Humans: A Two-Stage Case-Control Study. Cancer Epidemiology Biomarkers & Prevention 2010, 19: 619-623. PMID: 20142256, DOI: 10.1158/1055-9965.epi-09-1175.
- Goel A, Xicola RM, Nguyen T, Doyle BJ, Sohn VR, Bandipalliam P, Rozek LS, Reyes J, Cordero C, Balaguer F, Castells A, Jover R, Andreu M, Syngal S, Boland CR, Llor X. Aberrant DNA Methylation in Hereditary Nonpolyposis Colorectal Cancer Without Mismatch Repair Deficiency. Gastroenterology 2010, 138: 1854-1862.e1. PMID: 20102720, PMCID: PMC2859993, DOI: 10.1053/j.gastro.2010.01.035.
- Gonzalo V, Lozano JJ, Muñoz J, Balaguer F, Pellisé M, de Miguel C, Andreu M, Jover R, Llor X, Giráldez MD, Ocaña T, Serradesanferm A, Alonso-Espinaco V, Jimeno M, Cuatrecasas M, Sendino O, Castellví-Bel S, Castells A, . Aberrant Gene Promoter Methylation Associated with Sporadic Multiple Colorectal Cancer. PLOS ONE 2010, 5: e8777. PMID: 20098741, PMCID: PMC2808250, DOI: 10.1371/journal.pone.0008777.
- Giráldez MD, Balaguer F, Caldés T, Sanchez-de-Abajo A, Gómez-Fernández N, Ruiz-Ponte C, Muñoz J, Garre P, Gonzalo V, Moreira L, Ocaña T, Clofent J, Carracedo A, Andreu M, Jover R, Llor X, Castells A, Castellví-Bel S, Gastrointestinal Oncology Group of the Spanish Gastroenterological Association. Association of MUTYH and MSH6 germline mutations in colorectal cancer patients. Familial Cancer 2009, 8: 525. PMID: 19685280, DOI: 10.1007/s10689-009-9282-4.
- Giros A, Grzybowski M, Sohn VR, Pons E, Fernandez-Morales J, Xicola RM, Sethi P, Grzybowski J, Goel A, Boland CR, Gassull MA, Llor X. Regulation of Colorectal Cancer Cell Apoptosis by the n-3 Polyunsaturated Fatty Acids Docosahexaenoic and Eicosapentaenoic. Cancer Prevention Research 2009, 2: 732-742. PMID: 19638488, PMCID: PMC3793343, DOI: 10.1158/1940-6207.capr-08-0197.
- Sapoznik V, Grzybowski M, Xicola R, Doyle B, Grzybowski J, Martinez T, Anguera A, Llor X. S1271 Plantago Ovata Husk Regulates Cell Cycle Progression and Wnt Signaling Pathway, Crucial Elements Implicated in Colorectal Carcinogenesis. Gastroenterology 2009, 136: a-226. DOI: 10.1016/s0016-5085(09)61020-9.
- Kim J, Ewing R, Llor X, Carroll R, Benya R. W1975 African Americans Fail to Undergo Screening for Colorectal Cancer Independently of Insurance or Self-Reported Income. Gastroenterology 2009, 136: a-765. DOI: 10.1016/s0016-5085(09)63533-2.
- Bessa X, Gonzalez D, Roman E, Bujanda L, Enriquez-Navascués J, Reñe J, Gonzalo V, Jover R, Llor X, Peña E, Latorre M, de Castro Parga M, Carracedo A, Castells A, Andreu M. M1953 Frequency and Characteristics of Hereditary Non-Polyposis Colorectal Cancer (HNPCC) and Other Non-Syndromic Colorectal Cancer (CRC) Familial Forms in Spain. Preliminary Data of a Prospective, Multicenter, Population-Based Study (Epicolon-II). Gastroenterology 2009, 136: a-454. DOI: 10.1016/s0016-5085(09)62088-6.
- Abulí A, Bessa X, Ruiz-Ponte C, Fernandez-Rozadilla C, Carracedo A, Ilzarbe L, Llor X, Jover R, Muñoz J, Castells A, Castellvi-Bel S, Andreu M. 767 Genotype-Phenotype Correlation of Genetic Susceptibility Variants Identified Through Genome-Wide Association Studies for Colorectal Cancer. Gastroenterology 2009, 136: a-120. DOI: 10.1016/s0016-5085(09)60537-0.
- Xicola R, Nguyen T, Doyle B, Bandipalliam P, Syngal S, Reyes J, Cordero C, Grzybowski J, Sapoznik V, Grzybowski M, Castells A, Jover R, Andreu M, Boland C, Llor X, Goel A. 198 CpG-Island Methylator Phenotype (CIMP) and Alterations in RAS-Raf Signaling in Hereditary Non-Polyposis Colorectal Cancers Without Mismatch Repair Deficiency (MSS HNPCC). Gastroenterology 2009, 136: a-37. DOI: 10.1016/s0016-5085(09)60169-4.
- Xicola R, Caldes T, Garre P, Doyle B, Bandipalliam P, Syngal S, Grzybowski J, Sapoznik V, Grzybowski M, Martinez T, Murugappan S, Castells A, Jover R, Andreu M, Goel A, Llor X. M1930 Identification of Genomic Variants in Hereditary Non-Polyposis Colorectal Cancer Without Mismatch Repair Deficiency (MSS HNPCC). Gastroenterology 2009, 136: a-449. DOI: 10.1016/s0016-5085(09)62065-5.
- Grzybowski M, Sapoznik V, Xicola R, Doyle B, Grzybowski J, Martinez T, Anguera A, Llor X. S1272 Differential Regulation of Apoptosis Induction By Plantago Ovata Husk in Colorectal Cancer Cells. Induction of the TNF-Alpha Apoptosis Cascade in Metastatic Cells. Gastroenterology 2009, 136: a-226. DOI: 10.1016/s0016-5085(09)61021-0.
- Kim J, Ewing R, Llor X, Carroll R, Benya R. W1891 Smoking Promotes the Formation of Hyperplastic, But Not Adenomatous, Polyps. Gastroenterology 2009, 136: a-748. DOI: 10.1016/s0016-5085(09)63450-8.
- Payá A, Alenda C, Pérez-Carbonell L, Rojas E, Soto J, Guillén C, Castillejo A, Barberá V, Carrato A, Castells A, Llor X, Andreu M, Koh J, Enders GH, Benlloch S, Jover R. Utility of p16 Immunohistochemistry for the Identification of Lynch Syndrome. Clinical Cancer Research 2009, 15: 3156-3162. PMID: 19383812, PMCID: PMC2825754, DOI: 10.1158/1078-0432.ccr-08-3116.
- Abulí A, Bessa X, Ruiz-Ponte C, Fernández-Gómez C, Carracedo A, Ilzarbe L, Llor X, Jover R, Muñoz J, Castells A, Castellví-Bel S, Andreu M, de Gastroenterología G. CORRELACIÓN GENOTIPO-FENOTIP EN EL CÁNCER COLORRECTAL EN RELACIÓN A VARIANTES GENÉTICAS DE SUSCEPTIBILIDAD. Gastroenterología Y Hepatología 2009, 32: 181-182. DOI: 10.1016/j.gastrohep.2009.01.006.
- Bessa X, Gonzalez D, Roman E, Bujanda L, Enriquez-Navascués J, Reñe J, Gonzalo V, Jover R, Xicolà R, Llor X, Peña E, Latorre M, De Castro L, Carracedo A, Castells A, Andreu M, de Oncología E. FRECUENCIA Y CARACTERÍSTICAS DEL CÁNCER COLORRECTAL HEREDITARIO NO POLIPOSIS (CCHNP) Y OTROS CÁNCERES COLORRECTALES NO SINDRÓMICOS EN ESPAÑA. DATOS PRELIMINARES DE UN ESTUDIO POBLACIONAL, PROSPECTIVO Y MULTICÉNTRICO (EPICOLON-II). Gastroenterología Y Hepatología 2009, 32: 232-233. DOI: 10.1016/j.gastrohep.2009.01.118.
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- "Hereditary Colorectal Cancer"Colorectal Cancer: Early detection and prevention. Editor: Kim, K. Slack Inc. New Jersey. 2009: pp. 149-166
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- Kim J, Ng J, Arozulllah A, Ewing R, Llor X, Carroll RE, Benya RV. Aberrant Crypt Focus Size Predicts Distal Polyp Histopathology. Cancer Epidemiology Biomarkers & Prevention 2008, 17: 1155-1162. PMID: 18483337, DOI: 10.1158/1055-9965.epi-07-2731.
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- Montero T, Llor X, Gil A, Gassull M, Suarez A. M2051 Genome-Wide Expression Profiling Reveals a Common Biomarker Gene Signature in Colitis. Gastroenterology 2008, 134: a-458-a-459. DOI: 10.1016/s0016-5085(08)62144-7.
- Mutlu E, Glover S, Gillevet P, Llor X, Quander C, Sikaroodi M, Engen P, Bracamonte S, Keshavarzian A. S2007 Bacterial Microbiota Fingerprints Are Altered in Colon Cancer. Gastroenterology 2008, 134: a-296. DOI: 10.1016/s0016-5085(08)61377-3.
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- Giros A, Sapoznik V, Fernandez-Morales J, Xicola R, Llor X. 151 Docosahexaenoic and Eicosahexaenoic N-3 Fatty Acids Inhibit DNA Synthesis and Cell Proliferation in Colorectal Cancer Cells Independent of the Responsible Underlying Molecular Pathways. Gastroenterology 2008, 134: a-27. DOI: 10.1016/s0016-5085(08)60133-x.
- Bessa X, Ballesté B, Andreu M, Castells A, Bellosillo B, Balaguer F, Castellví–bel S, Paya A, Jover R, Alenda C, Titó L, Martinez–Villacampa M, Vilella A, Xicola RM, Pons E, Llor X, Association G. A Prospective, Multicenter, Population-Based Study of BRAF Mutational Analysis for Lynch Syndrome Screening. Clinical Gastroenterology And Hepatology 2007, 6: 206-214. PMID: 18096441, DOI: 10.1016/j.cgh.2007.10.011.
- Balaguer F, Balmaña J, Castellví–Bel S, Steyerberg EW, Andreu M, Llor X, Jover R, Syngal S, Castells A, Association G. Validation and Extension of the PREMM1,2 Model in a Population-Based Cohort of Colorectal Cancer Patients. Gastroenterology 2007, 134: 39-46. PMID: 18061181, PMCID: PMC2542581, DOI: 10.1053/j.gastro.2007.10.042.
- Ballesté B, Bessa X, Piñol V, CastellvíBel S, Castells A, Alenda C, Paya A, Jover R, Xicola RM, Pons E, Llor X, Cordero C, FernandezBañares F, de Castro L, Reñé JM, Andreu M. Detection of Metachronous Neoplasms in Colorectal Cancer Patients: Identification of Risk Factors. Diseases Of The Colon & Rectum 2007, 50: 971-980. PMID: 17468913, DOI: 10.1007/s10350-007-0237-2.
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- Hommes T, Giros A, Llor X, Pons E, Fernandez-Morales J, Xicola R, Gassull M. P079 IMPLICATION OF BCL-2 FAMILY PROTEINS IN THE INDUCTION OF JURKAT T LYMPHOCYTE APOPTOSIS BY THE MAIN N-3 FATTY ACIDS PRESENT IN FISH OIL DOCOSAHEXAENOIC AND EICOSAPENTAENOIC ACID. Journal Of Crohn's And Colitis 2007, 1: 23. DOI: 10.1016/s1873-9954(07)70091-5.
- Balaguer F, Castellví–Bel S, Castells A, Andreu M, Muñoz J, Gisbert JP, Llor X, Jover R, de Cid R, Gonzalo V, Bessa X, Xicola RM, Pons E, Alenda C, Payá A, Piqué JM, Association G. Identification of MYH Mutation Carriers in Colorectal Cancer: A Multicenter, Case-Control, Population-Based Study. Clinical Gastroenterology And Hepatology 2007, 5: 379-387. PMID: 17368238, DOI: 10.1016/j.cgh.2006.12.025.
- Xicola RM, Llor X, Pons E, Castells A, Alenda C, Piñol V, Andreu M, Castellví-Bel S, Payá A, Jover R, Bessa X, Girós A, Duque JM, Nicolás-Pérez D, Garcia AM, Rigau J, Gassull MA. Performance of Different Microsatellite Marker Panels for Detection of Mismatch Repair–Deficient Colorectal Tumors. Journal Of The National Cancer Institute 2007, 99: 244-252. PMID: 17284719, DOI: 10.1093/jnci/djk033.
- "Inner and outer environment"Intestinal Inflammation and Colorectal Cancer. Editors: Gasche, Gassull, Herrerias Gutierrez, Monterio. Springer Science. Lancaster, UK. 2007: pp. 185-192.
- "Cancer and Inflammatory Bowel DiseasesInflammatory bowel diseases. 3rd Edition. Editors: Gassull, Gomollon, Hinojosa, Obrador. Aran Publishing. Madrid. Spain. 2007: 475-480.
- Jover R, Castells A, Llor X, Andreu M. Authors’ reply. Gut 2006, 55: 1819. PMID: 17124161, PMCID: PMC1856450, DOI: 10.1136/gut.2006.105627.
- Benlloch S, Payá A, Alenda C, Bessa X, Andreu M, Jover R, Castells A, Llor X, Aranda FI, Massutí B. Detection of BRAF V600E Mutation in Colorectal Cancer Comparison of Automatic Sequencing and Real-Time Chemistry Methodology. Journal Of Molecular Diagnostics 2006, 8: 540-543. PMID: 17065421, PMCID: PMC1876165, DOI: 10.2353/jmoldx.2006.060070.
- Rodríguez-Moranta F, Castells A, Andreu M, Piñol V, Castellví-Bel S, Alenda C, Llor X, Xicola RM, Jover R, Payá A, Bessa X, Balaguer F, Cubiella J, Argüello L, Morillas JD, Bujanda L. Clinical Performance of Original and Revised Bethesda Guidelines for the Identification of MSH2/MLH1 Gene Carriers in Patients with Newly Diagnosed Colorectal Cancer: Proposal of a New and Simpler Set of Recommendations. The American Journal Of Gastroenterology 2006, 101: ajg2006204. PMID: 16696788, DOI: 10.1111/j.1572-0241.2006.00522.x.
- Castells A, Payá A, Alenda C, Rodríguez-Moranta F, Agrelo R, Andreu M, Piñol V, Castellví-Bel S, Jover R, Llor X, Pons E, Elizalde JI, Bessa X, Alcedo J, Saló J, Medina E, Naranjo A, Esteller M, Piqué J, Association F. Cyclooxygenase 2 Expression in Colorectal Cancer with DNA Mismatch Repair Deficiency. Clinical Cancer Research 2006, 12: 1686-1692. PMID: 16551850, DOI: 10.1158/1078-0432.ccr-05-1581.
- "The Effect of Olive Oil in Inflammatory Bowel Disease"Olive Oil and Health, pp. 309-16
- Llor X, Cabré E, Gassull M. The effect of olive oil on inflammatory bowel disease. 2006, 309-316. DOI: 10.1079/9781845930684.0309.
- Jover R, Zapater P, Castells A, Llor X, Andreu M, Cubiella J, Piñol V, Xicola RM, Bujanda L, Reñé JM, Clofent J, Bessa X, Morillas JD, Nicolás-Pérez D, Payá A, Alenda C. Mismatch repair status in the prediction of benefit from adjuvant fluorouracil chemotherapy in colorectal cancer. Gut 2005, 55: 848. PMID: 16299036, PMCID: PMC1856227, DOI: 10.1136/gut.2005.073015.
- Llor X, Pons E, Xicola RM, Castells A, Alenda C, Piñol V, Andreu M, Castellví-Bel S, Payá A, Jover R, Bessa X, Girós A, Roca A, Gassull MA, Association F. Differential Features of Colorectal Cancers Fulfilling Amsterdam Criteria without Involvement of the Mutator Pathway. Clinical Cancer Research 2005, 11: 7304-7310. PMID: 16243801, DOI: 10.1158/1078-0432.ccr-05-0965.
- Piñol V, Castells A, Andreu M, Castellví-Bel S, Alenda C, Llor X, Xicola RM, Rodríguez-Moranta F, Payá A, Jover R, Bessa X, Association F. Accuracy of Revised Bethesda Guidelines, Microsatellite Instability, and Immunohistochemistry for the Identification of Patients With Hereditary Nonpolyposis Colorectal Cancer. JAMA 2005, 293: 1986-1994. PMID: 15855432, DOI: 10.1001/jama.293.16.1986.
- "New Familial Colorectal Cancer Forms"Latest gastroenterology advances. Gastroenterol Hepatol. 2005; 3(1):54-58. Latest gastroenterology advances. Gastroenterol Hepatol. 2005; 3(1):54-58. Latest gastroenterology advances. Gastroenterol Hepatol. 2005; 3(1):54-58. Latest Gastroenterology Advances. Gastroenterol Hepatol. 2005; 3(1):54-58
- LLOR X, PONS E, ROCA A, ÀLVAREZ M, MAÑÉ J, FERNÁNDEZ-BAÑARES F, GASSULL MA. The effects of fish oil, olive oil, oleic acid and linoleic acid on colorectal neoplastic processes. Clinical Nutrition 2003, 22: 71-79. PMID: 12553953, DOI: 10.1054/clnu.2002.0627.
- Llor X. Papel de los lípidos de la dieta en los mecanismos de inflamación, proliferación, diferenciación y muerte celular en el tracto intestinal. Gastroenterología Y Hepatología 2003, 26: 507-513. PMID: 14534023, DOI: 10.1016/s0210-5705(03)70402-6.
- Llor X, Pons E, Alvarez M, Fernandez-Banares F, Gassull M. Olive oil induces apoptosis and cell differentiation in Caco-2 cells. Gastroenterology 2000, 118: a536-a537. DOI: 10.1016/s0016-5085(00)84276-6.
- Llor X, Serfas MS, Bie W, Vasioukhin V, Polonskaia M, Derry J, Abbott CM, Tyner AL. BRK/Sik expression in the gastrointestinal tract and in colon tumors. Clinical Cancer Research 1999, 5: 1767-77. PMID: 10430081.
- "Characterization of the novel breast tumor kinase Brk"Book chapter. Breast Cancer Research Program. Department of Defense, USA. Era of Hope. Vol II. 1997; 2:121-127
- Tyner A, Vasioukhin V, Serfas M, Siyanova E, Llor X. Expression of Tyrosine Kinases in the Mouse Small Intestine. NATO ASI Series 1996, 309-318. DOI: 10.1007/978-3-642-61180-3_28.
- "Expression of Tyrosine Kinases in the Mouse Small Intestine"Proceedings on Regulation of Cell Growth, Differentiation and Genetics in Cancer, pp. 308-318
- Davidson NO, Ifkovits CA, Skarosi SF, Hausman AM, Llor X, Sitrin MD, Montag A, Brasitus TA. Tissue and cell-specific patterns of expression of rat liver and intestinal fatty acid binding protein during development and in experimental colonic and small intestinal adenocarcinomas. Laboratory Investigation; A Journal Of Technical Methods And Pathology 1993, 68: 663-75. PMID: 8515653.
- Llor X, Jacoby RF, Teng BB, Davidson NO, Sitrin MD, Brasitus TA. K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors: effects of supplemental dietary calcium and vitamin D deficiency. Cancer Research 1991, 51: 4305-9. PMID: 1868452.
- Jacoby RF, Llor X, Teng BB, Davidson NO, Brasitus TA. Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa. The Journal Of Clinical Investigation 1991, 87: 624-30. PMID: 1991846, PMCID: PMC296352, DOI: 10.1172/JCI115039.
- Halline AG, Dudeja PK, Jacoby RF, Llor X, Teng BB, Chowdhury LN, Davidson NO, Brasitus TA. Effect of polyamine oxidase inhibition on the colonic malignant transformation process induced by 1,2-dimethylhydrazine. Carcinogenesis 1990, 11: 2127-32. PMID: 2265465, DOI: 10.1093/carcin/11.12.2127.
- Digestive Health Center8 Devine StreetFl 1st FloorNorth Haven, CT 06473
Biography
Xavier Llor, MD, PhD, is a gastroenterologist at Yale Medicine with a specialty in gastrointestinal cancer genetics and colorectal cancer. He is co-director of the Gastrointestinal (GI) & Pancreatic Cancer Prevention Program, associate director for cancer screening at the Center for Community Engagement and Health Equity at Yale Cancer Center, and the medical director of the Colorectal Cancer Prevention Program.
After receiving a medical school education from the Autonomous University in Barcelona, Dr. Llor trained in basic research and internal medicine at the University of Chicago and completed his PhD in molecular biology from the University of Barcelona. Dr. Llor completed his GI fellowship at the University of Illinois at Chicago. His background as both a clinician and researcher led him to specialize in cancer genetics, where he works to identify specific genes that make a person more susceptible to gastrointestinal cancers. “One of the most rewarding things about this field is that every day we seem to discover more, and that knowledge is translated very quickly into patients’ lives,” says Dr. Llor.
As a physician, Dr. Llor uses his research to better care for his patients. The goal is to identify cancer risk as early as possible. This knowledge can help patients take measures to prevent cancer, or it can help doctors treat patients with cancer as early as possible. “The earlier a cancer is detected, the better the prognosis is,” says Dr. Llor.
In addition, genetic defects that are linked to gastrointestinal cancers may also be linked to cancers in other parts of the body. “We take a broad and comprehensive approach to patients in making sure that we prevent all cancers that are linked to those particular genetic defects,” says Dr. Llor.
As a researcher, Dr. Llor continues to identify new genetic defects that may be linked to colorectal and other GI cancer risk. Furthermore, he is exploring different approaches that lead to a wider identification of these diseases, with a particular emphasis in disseminating this specialized care among the underserved. He has made important contributions to the field of Lynch syndrome (a hereditary form of colorectal cancer).
Dr. Llor is a professor of medicine (digestive diseases) at Yale School of Medicine.
Titles
- Professor of Medicine
- Director, GI and Pancreatic Cancer Prevention Program, Digestive Diseases
Education & Training
- PhDUniversity of Barcelona, Molecular Biology (1999)
- FellowshipUniversity of Illinois (1997)
- ResidencyLutheran General Hospital-University of Chicago Program C (1994)
- MDUniversity of Barcelona (1986)
Languages Spoken
- Català (Catalan)
- English
- Español (Spanish)
Additional Information
- Mentor, Future Leaders Program: American Gastroenterological Association (2016)
- Distinguished Mentor: Hispanic Center of Excellence. University of Illinois at Chicago School of Medicine (2012)
- National Comprehensive Cancer Network Guidelines Committee (2021 - Present): Vice-Chair of the Colorectal Cancer Screening Panel
- Colorectal Cancer Alliance Chris4Life Research Program (2020 - Present): Grant Reviewer
- National Comprehensive Cancer Network (2019 - Present): Genetic Colorectal Cancer Screening Panel
- Gastroenterology (2018 - Present): Selected Summaries
- Yale University (2017 - 2019): Ambulatory Advisory Group, Yale Medicine
- American Cancer Society (2017 - 2018): Advisory Group: Primary care module on family history/early onset colorectal cancer, National Colorectal Cancer Round Table
- American Cancer Society (2017 - Present): Steering Committee: National Colorectal Cancer Round Table
- American Gastroenterolgical Association Institute (2017 - Present): Member; Advisory board, Academy of Educators
- National Comprehensive Cancer Network Guidelines Committee (2016 - Present): Member of the Guidelines Committee of the Genetics/High risk Colorectal Cancer Panel
- American Gastrointestinal Association (2016 - Present): Member, Nominating Committee
- Lerner B, Giner-Calabuig M, Carraway C, Richardson M, Krahn K, Susswein L, Heald B, Karam R, Xicola R, Llor X. 899 YALE CRITERIA FOR GENETIC TESTING IN CASES OF SUSPECTED HEREDITARY DIFFUSE GASTRIC CANCER (HDGC) ARE MORE SENSITIVE THAN IGCLC AND ERN GENTURIS CRITERIA IN A LARGE AMERICAN COHORT. Gastroenterology 2024, 166: s-215. DOI: 10.1016/s0016-5085(24)00984-3.
- Rajpara S, Buckley D, Xicola R, Mikaeel R, Yagle M, Kerimoglu B, Thorne C, Bellomo D, Padi M, Llor X, Ellis N, Salhia B. Abstract 7004: DNA Methylation analysis of African American colorectal cancers reveal race-specific alterations. Cancer Research 2024, 84: 7004-7004. DOI: 10.1158/1538-7445.am2024-7004.
- Mikaeel R, Bellomo D, Rajpara S, Buckley D, Yagle M, Kerimoglu B, Thorne C, Padi M, Salhia B, Ellis N, Llor X, Xicola R. Abstract 4409: FBXW7 and BCL9L altered pathways as hallmarks of early-onset colorectal cancer. Cancer Research 2024, 84: 4409-4409. DOI: 10.1158/1538-7445.am2024-4409.
- Buckley D, Xicola R, Reger M, Yagle M, Kerimoglu B, Thorne C, Bellomo D, Padi M, Llor X, Ellis N, Salhia B. Abstract C060: DNA Methylation analysis of African American colorectal cancers reveal race-specific alterations. Cancer Epidemiology Biomarkers & Prevention 2023, 32: c060-c060. DOI: 10.1158/1538-7755.disp23-c060.
- Soleymanjahi S, Hong Y, Lee J, Kvistad R, Hughes M, Llor X. 30 IMPACT OF THE COVID-19 PANDEMIC ON RACIAL AND SOCIOECONOMIC DISPARITIES ON RECEIVING COLORECTAL CANCER SCREENING RECOMMENDATIONS IN THE UNITED STATES. Gastroenterology 2023, 164: s-9-s-10. DOI: 10.1016/s0016-5085(23)00977-0.
- Soleymanjahi S, Singh V, Liu J, Brown Q, Brierley K, Healy C, Xicola R, Kashyap N, Llor X. 33 THE IMPLEMENTATION OF AN EMR-BASED AUTOMATED SYSTEM FOR IDENTIFICATION OF PATIENTS SUSPICIOUS FOR LYNCH SYNDROME HAS A DISPROPORTIONALLY POSITIVE IMPACT IN THE IDENTIFICATION OF DISADVANTAGED PATIENTS. Gastroenterology 2023, 164: s-11. DOI: 10.1016/s0016-5085(23)00980-0.
- Soleymanjahi S, Hong Y, Lee J, Mahmoudi-Rouhani R, Hughes M, Llor X. Sa1001 CHANGES IN USAGE OF STOOL-BASED AND NON-STOOL-BASED COLORECTAL CANCER SCREENING MODALITIES BEFORE AND DURING THE COVID-19 PANDEMIC IN THE UNITED STATES. Gastroenterology 2023, 164: s-268. DOI: 10.1016/s0016-5085(23)01605-0.
- Perez-Mayoral J, Gonzalez-Pons M, Centeno-Girona H, Montes-Rodríguez I, Soto-Salgado M, Suárez B, Rodríguez N, Colón G, Sevilla J, Jorge D, Llor X, Xicola R, Toro D, Tous-López L, Torres-Torres M, Reyes J, López-Acevedo N, Goel A, Rodríguez-Quilichini S, Cruz-Correa M. Molecular and Sociodemographic Colorectal Cancer Disparities in Latinos Living in Puerto Rico. Genes 2023, 14: 894. PMID: 37107652, PMCID: PMC10138302, DOI: 10.3390/genes14040894.
- Padi M, Bellomo D, Grant A, Xicola R, Thorne C, Salhia B, Llor X, Ellis N. Abstract 484: Molecular drivers of tumor progression in microsatellite stable APC mutation-negative colorectal cancers. Cancer Research 2022, 82: 484-484. DOI: 10.1158/1538-7445.am2022-484.
- Giner-Calabuig M, De Leon S, Vidal-Pedrola G, Fehlmann T, Ukaegbu C, Gibson J, Picó M, Alenda C, Reyes J, Ortega S, LLado C, de la Torre Rubio P, Obrador-Hevia A, Castillejo A, Soto J, Castellví-Bel S, Syngal S, Stoffel E, Ellis N, Jover R, Llor X, Xicola R. Tu1100: HETEROZYGOUS MUTATIONS IN DNA REPAIR GENES CONFER GENETIC SUSCEPTIILITY TO COLORECTAL CANCER AMONG LYNCH-LIKE CASES. Gastroenterology 2022, 162: s-883. DOI: 10.1016/s0016-5085(22)62088-2.
- Lerner BA, Xicola RM, Rodriguez NJ, Karam R, Llor X. Simplified and more sensitive criteria for identifying individuals with pathogenic CDH1 variants. Journal Of Medical Genetics 2022, 60: 36-40. PMID: 35078942, PMCID: PMC9661780, DOI: 10.1136/jmedgenet-2021-108169.
- Singh V, Ganzak A, Gershkovich P, Gibson J, Xicola R, Llor X. Abstract PO-052: A multisystem approach doubles the number of patients referred for genetic testing and diagnosed with Lynch syndrome with equally success among ethnic/racial groups. Cancer Epidemiology Biomarkers & Prevention 2022, 31: po-052-po-052. DOI: 10.1158/1538-7755.disp21-po-052.
- Grant A, Xicola RM, Nguyen V, Lim J, Thorne C, Salhia B, Llor X, Ellis N, Padi M. Molecular drivers of tumor progression in microsatellite stable APC mutation-negative colorectal cancers. Scientific Reports 2021, 11: 23507. PMID: 34873211, PMCID: PMC8648784, DOI: 10.1038/s41598-021-02806-x.
- Mezzacappa C, Llor X. Colorectal Cancer Risk in Lynch Syndrome: Of Genes and More. Gastroenterology 2021, 162: 1358-1360. PMID: 34863785, DOI: 10.1053/j.gastro.2021.11.032.
- Bustos A, Payá A, Torrubia A, Jover R, Llor X, Bessa X, Castells A, Carracedo Á, Alenda C. xDEEP-MSI: Explainable Bias-Rejecting Microsatellite Instability Deep Learning System in Colorectal Cancer. Biomolecules 2021, 11: 1786. PMID: 34944430, PMCID: PMC8699085, DOI: 10.3390/biom11121786.
- Weiss JM, Gupta S, Burke CA, Axell L, Chen LM, Chung DC, Clayback KM, Dallas S, Felder S, Gbolahan O, Giardiello FM, Grady W, Hall MJ, Hampel H, Hodan R, Idos G, Kanth P, Katona B, Lamps L, Llor X, Lynch PM, Markowitz AJ, Pirzadeh-Miller S, Samadder NJ, Shibata D, Swanson BJ, Szymaniak BM, Wiesner GL, Wolf A, Yurgelun MB, Zakhour M, Darlow SD, Dwyer MA, Campbell M. NCCN Guidelines® Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 1.2021. Journal Of The National Comprehensive Cancer Network 2021, 19: 1122-1132. PMID: 34666312, DOI: 10.1164/jnccn.2021.0048.
- Cheng E, Blackburn H, Ng K, Spiegelman D, Irwin M, Ma X, Gross C, Tabung F, Giovannucci E, Kunz P, Llor X, Billingsley K, Meyerhardt J, Ahuja N, Fuchs C. Abstract 898: Survival for patients with early-onset colorectal cancer - An overall survival analysis from the National Cancer Database, 2004-2015. Cancer Research 2021, 81: 898-898. DOI: 10.1158/1538-7445.am2021-898.
- Analysis of Survival Among Adults With Early-Onset Colorectal Cancer in the National Cancer DatabaseCheng E, Blackburn HN, Ng K, Spiegelman D, Irwin ML, Ma X, Gross CP, Tabung FK, Giovannucci EL, Kunz PL, Llor X, Billingsley K, Meyerhardt JA, Ahuja N, Fuchs CS. Analysis of Survival Among Adults With Early-Onset Colorectal Cancer in the National Cancer Database. JAMA Network Open 2021, 4: e2112539. PMID: 34132794, PMCID: PMC8209612, DOI: 10.1001/jamanetworkopen.2021.12539.
- Fernández-Rozadilla C, Álvarez-Barona M, Quintana I, López-Novo A, Amigo J, Cameselle-Teijeiro J, Roman E, Gonzalez D, Llor X, Bujanda L, Bessa X, Jover R, Balaguer F, Castells A, Castellví-Bel S, Capellá G, Carracedo A, Valle L, Ruiz-Ponte C. Exome sequencing of early-onset patients supports genetic heterogeneity in colorectal cancer. Scientific Reports 2021, 11: 11135. PMID: 34045552, PMCID: PMC8159954, DOI: 10.1038/s41598-021-90590-z.
- Shin JH, Jeong J, Choi J, Lim J, Dinesh RK, Braverman J, Hong JY, Maher SE, Vesely M, Kim W, Koo JH, Tang W, Wu D, Blackburn HN, Xicola RM, Llor X, Yilmaz O, Choi JM, Bothwell ALM. Dickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1. IScience 2021, 24: 102411. PMID: 33997693, PMCID: PMC8099562, DOI: 10.1016/j.isci.2021.102411.
- MacFarland SP, Ebrahimzadeh JE, Zelley K, Begum L, Bass LM, Brand RE, Dudley B, Fishman DS, Ganzak A, Karloski E, Latham A, Llor X, Plon S, Riordan MK, Scollon SR, Stadler ZK, Syngal S, Ukaegbu C, Weiss JM, Yurgelun MB, Brodeur GM, Mamula P, Katona BW. Phenotypic Differences in Juvenile Polyposis Syndrome With or Without a Disease-causing SMAD4/BMPR1A Variant. Cancer Prevention Research 2021, 14: 215-222. PMID: 33097490, PMCID: PMC8557953, DOI: 10.1158/1940-6207.capr-20-0348.
- Lerner BA, Llor X. Genetic Gastric Cancer Risk Syndromes. Current Treatment Options In Gastroenterology 2020, 18: 604-615. PMID: 33776403, PMCID: PMC7992355, DOI: 10.1007/s11938-020-00312-z.
- Provenzale D, Ness RM, Llor X, Weiss JM, Abbadessa B, Cooper G, Early DS, Friedman M, Giardiello FM, Glaser K, Gurudu S, Halverson AL, Issaka R, Jain R, Kanth P, Kidambi T, Lazenby AJ, Maguire L, Markowitz AJ, May FP, Mayer RJ, Mehta S, Patel S, Peter S, Stanich P, Terdiman J, Keller J, Dwyer MA, Ogba N. NCCN Guidelines Insights: Colorectal Cancer Screening, Version 2.2020. Journal Of The National Comprehensive Cancer Network 2020, 18: 1312-1320. PMID: 33022639, PMCID: PMC8311627, DOI: 10.6004/jnccn.2020.0048.
- Vilar-Sanchez E, Burke C, Correa M, Dekker E, Grady W, Grandval P, Katona B, Llor X, Riegert-Johnson D, Saurin J, Stanich P, Sussman D, Weinberg D, Attiyeh E, Joseph D, Raybold K, Borzillo G, Prior T, Smith M, Xie H, Bachman K, Infante J, Samadder N. Abstract CT236: A phase 1b, multicenter, randomized, blinded, placebo-controlled study to evaluate the efficacy of guselkumab in subjects with familial adenomatous polyposis. Cancer Research 2020, 80: ct236-ct236. DOI: 10.1158/1538-7445.am2020-ct236.
- Melson JE, Imperiale TF, Itzkowitz SH, Llor X, Kochman ML, Grady WM, Schoen RE, Burke CA, Shaukat A, Rabeneck L, Ladabaum U, Bresalier R, Spiegel B, Yee J, Wang T, Lieberman D, Komanduri S, Muthusamy VR, Dey N. AGA White Paper: Roadmap for the Future of Colorectal Cancer Screening in the United States. Clinical Gastroenterology And Hepatology 2020, 18: 2667-2678.e2. PMID: 32634626, DOI: 10.1016/j.cgh.2020.06.053.
- Xicola R, Manojlovic Z, Augustus G, Kupfer S, Emmadi R, Alagiozian-Angelova V, Triche T, Bodour S, Carpten J, Llor X, Ellis N. Abstract IA26: Mechanistic differences in early-onset colorectal cancer. Cancer Epidemiology Biomarkers & Prevention 2020, 29: ia26-ia26. DOI: 10.1158/1538-7755.disp18-ia26.
- Giner-Calabuig M, Ukaegbu C, Syngal S, Stoffel E, Jover R, Llor X, Xicola R. Tu1212 RELEVANT HETEROGENEITY IN MISMATCH REPAIR DEFICIENT TUMORS. Gastroenterology 2020, 158: s-1020. DOI: 10.1016/s0016-5085(20)33223-6.
- Singh V, Ganzak A, Gershkovich P, Gibson J, Llor X. 1 IMPROVING LYNCH SYNDROME IDENTIFICATION THROUGH THE IMPLEMENTATION OF ENHANCED TUMOR TESTING AND A COMPREHENSIVE SYSTEMS APPROACH. Gastroenterology 2020, 158: s-1. DOI: 10.1016/s0016-5085(20)30682-x.
- Augustus GJ, Xicola RM, Llor X, Ellis NA. Decreased copy‐neutral loss of heterozygosity in African American colorectal cancers. Genes Chromosomes And Cancer 2020, 59: 454-464. PMID: 32293075, PMCID: PMC8045478, DOI: 10.1002/gcc.22851.
- Llor X. Lynch Syndrome: Widening the Net. Gastroenterology 2019, 157: 1432-1434. PMID: 31586568, DOI: 10.1053/j.gastro.2019.09.028.
- Gupta S, Provenzale D, Llor X, Halverson AL, Grady W, Chung DC, Haraldsdottir S, Markowitz AJ, Slavin TP, Hampel H, Ness RM, Weiss JM, Ahnen DJ, Chen LM, Cooper G, Early DS, Giardiello FM, Hall MJ, Hamilton SR, Kanth P, Klapman JB, Lazenby AJ, Lynch PM, Mayer RJ, Mikkelson J, Peter S, Regenbogen SE, Dwyer MA, Ogba N. NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 2.2019. Journal Of The National Comprehensive Cancer Network : JNCCN 2019, 17: 1032-1041. PMID: 31487681, DOI: 10.6004/jnccn.2019.0044.
- Nartowt BJ, Hart GR, Roffman DA, Llor X, Ali I, Muhammad W, Liang Y, Deng J. Scoring colorectal cancer risk with an artificial neural network based on self-reportable personal health data. PLOS ONE 2019, 14: e0221421. PMID: 31437221, PMCID: PMC6705772, DOI: 10.1371/journal.pone.0221421.
- Xicola RM, Li S, Rodriguez N, Reinecke P, Karam R, Speare V, Black MH, LaDuca H, Llor X. Clinical features and cancer risk in families with pathogenic CDH1 variants irrespective of clinical criteria. Journal Of Medical Genetics 2019, 56: 838. PMID: 31296550, DOI: 10.1136/jmedgenet-2019-105991.
- Xicola RM, Clark JR, Carroll T, Alvikas J, Marwaha P, Regan MR, Lopez-Giraldez F, Choi J, Emmadi R, Alagiozian-Angelova V, Kupfer SS, Ellis NA, Llor X. Implication of DNA repair genes in Lynch-like syndrome. Familial Cancer 2019, 18: 331-342. PMID: 30989425, PMCID: PMC6561810, DOI: 10.1007/s10689-019-00128-6.
- Xicola RM, Manojlovic Z, Augustus GJ, Kupfer SS, Emmadi R, Alagiozian-Angelova V, Triche T, Salhia B, Carpten J, Llor X, Ellis NA. Lack of APC somatic mutation is associated with early-onset colorectal cancer in African Americans. Carcinogenesis 2018, 39: 1331-1341. PMID: 30239619, PMCID: PMC6292413, DOI: 10.1093/carcin/bgy122.
- Murcia O, Juárez M, Rodríguez-Soler M, Hernández-Illán E, Giner-Calabuig M, Alustiza M, Egoavil C, Castillejo A, Alenda C, Barberá V, Mangas-Sanjuan C, Yuste A, Bujanda L, Clofent J, Andreu M, Castells A, Llor X, Zapater P, Jover R. Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability and CIMP status: Prognostic implications and response to chemotherapy. PLOS ONE 2018, 13: e0203051. PMID: 30188916, PMCID: PMC6126803, DOI: 10.1371/journal.pone.0203051.
- Provenzale D, Gupta S, Ahnen DJ, Markowitz AJ, Chung DC, Mayer RJ, Regenbogen SE, Blanco AM, Bray T, Cooper G, Early DS, Ford JM, Giardiello FM, Grady W, Hall MJ, Halverson AL, Hamilton SR, Hampel H, Klapman JB, Larson DW, Lazenby AJ, Llor X, Lynch PM, Mikkelson J, Ness RM, Slavin TP, Sugandha S, Weiss JM, Dwyer MA, Ogba N. NCCN Guidelines Insights: Colorectal Cancer Screening, Version 1.2018. Journal Of The National Comprehensive Cancer Network : JNCCN 2018, 16: 939-949. PMID: 30099370, DOI: 10.6004/jnccn.2018.0067.
- Murcia O, Jover R, Egoavil C, Perez-Carbonell L, Juárez M, Hernández-Illán E, Rojas E, Alenda C, Balaguer F, Andreu M, Llor X, Castells A, Boland CR, Goel A. TFAP2E Methylation and Expression Status Does Not Predict Response to 5-FU-based Chemotherapy in Colorectal Cancer. Clinical Cancer Research 2018, 24: 2820-2827. PMID: 29535127, PMCID: PMC7396148, DOI: 10.1158/1078-0432.ccr-17-2940.
- Rodriguez N, Reineke P, LaDuca H, Xicola R, Llor X. 1066 - Phenotypic Expression of Cdh1 Germline Mutations Unselected for Hereditary Diffuse Gastric Cancer. Gastroenterology 2018, 154: s-204. DOI: 10.1016/s0016-5085(18)31081-3.
- Zhen JT, Syed J, Nguyen KA, Leapman MS, Agarwal N, Brierley K, Llor X, Hofstatter E, Shuch B. Genetic testing for hereditary prostate cancer: Current status and limitations. Cancer 2018, 124: 3105-3117. PMID: 29669169, DOI: 10.1002/cncr.31316.
- Murcia O, Juárez M, Hernández-Illán E, Rodriguez-Soler M, Giner-Calabuig M, Alustiza M, Egoavil C, Castillejo A, Alenda C, Mangas C, Barberá V, Yuste A, Bujanda L, Clofent J, Andreu M, Castells A, Llor X, Zapater P, Jover R. Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability, and CIMP status: Prognostic implications and response to chemotherapy. Journal Of Clinical Oncology 2018, 36: 668-668. DOI: 10.1200/jco.2018.36.4_suppl.668.
- Practice Update
- Gupta S, Provenzale D, Regenbogen SE, Hampel H, Slavin TP, Hall MJ, Llor X, Chung DC, Ahnen DJ, Bray T, Cooper G, Early DS, Ford JM, Giardiello FM, Grady W, Halverson AL, Hamilton SR, Klapman JB, Larson DW, Lazenby AJ, Lynch PM, Markowitz AJ, Mayer RJ, Ness RM, Samadder NJ, Shike M, Sugandha S, Weiss JM, Dwyer MA, Ogba N. NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 3.2017. Journal Of The National Comprehensive Cancer Network : JNCCN 2017, 15: 1465-1475. PMID: 29223984, DOI: 10.6004/jnccn.2017.0176.
- Perez-Mayoral J, Rivera-Lynch C, Soto-Salgado M, Llor X, Tous-Lopez L, Torres-Torres M, Reyes J, Torres C, Goel A, Rodriguez-Quillichini S, Cruz-Correa M. Abstract 1759: Description of molecular marker disparities and KRAS mutational spectrum of colorectal tumors from Puerto Rican Hispanics. Cancer Research 2017, 77: 1759-1759. DOI: 10.1158/1538-7445.am2017-1759.
- Llor X. Abdominal Pain With Boring-Like Character: The Revolution Is Yet to Come. Journal Of The National Comprehensive Cancer Network : JNCCN 2017, 15: 969-970. PMID: 28687583, DOI: 10.6004/jnccn.2017.0128.
- Kandimalla R, Linnekamp JF, van Hooff S, Castells A, Llor X, Andreu M, Jover R, Goel A, Medema JP. Methylation of WNT target genes AXIN2 and DKK1 as robust biomarkers for recurrence prediction in stage II colon cancer. Oncogenesis 2017, 6: e308-e308. PMID: 28368388, PMCID: PMC5520503, DOI: 10.1038/oncsis.2017.9.
- Wolf P, Yazici C, Kim H, Liu T, Carroll T, Augustus G, Mutlu E, Tussing‐Humphreys L, Braunschweig C, Xicola R, Jung B, Llor X, Ellis N, Gaskins H. Race‐dependent Association of Sulfidogenic Bacteria with Colorectal Cancer. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.315.2.
- Gomez‐Perez S, Yazici C, Wolf P, Braunschweig C, Xicola R, Llor X, Ellis N, Tussing‐Humphreys L, Mutlu E, Gaskins R. Correlations of Abdominal Fat and Colonic Sulfidogenic Bacteria in African Americans and Non‐Hispanic Whites with Newly Diagnosed Colorectal Cancer. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.138.7.
- Marquez J, Pérez-Mayoral J, Gonzalez-Pons M, Rodriguez-Mañon N, Rivera-Lynch C, Soto M, Llor X, Xicola R, Lopez L, Torres-Torres M, Reyes J, Goel A, Torres-Cintrón C, Rodriguez-Quilichini S, Cruz-Correa M. Tu1974 Molecular Disparities and Kras Mutational Spectrum of Colorectal Tumors from Puerto Rican Hispanic Subjects. Gastroenterology 2017, 152: s1022. DOI: 10.1016/s0016-5085(17)33461-3.
- Kwak Y, Alvarenga J, Vazquez-Gillamet L, Vega M, Vargas-Torres M, Lagarde S, McCloskey B, Xicola R, Llor X. Su1014 Resource Utilization and Colorectal Cancer Screening Compliance with Patient Navigation in Under-Screened Populations. Gastroenterology 2017, 152: s443. DOI: 10.1016/s0016-5085(17)31692-x.
- Alvarenga J, Kwak Y, Vazquez-Gillamet L, Vargas-Torres M, Vega M, Lagarde S, McCloskey B, Xicola R, Llor X. 86 Outcomes and Cost Analysis of a Colonoscopy-Based Colorectal Cancer Screening Program in a Lower Income us Hispanic Cohort. Gastroenterology 2017, 152: s23. DOI: 10.1016/s0016-5085(17)30447-x.
- Xicola R, Manojlovic Z, Augustus G, Kupfer S, Carpten J, Ellis N, Llor X. 235 Mutational and Epigenetic Spectrum of Colorectal Cancers in African Americans. Gastroenterology 2017, 152: s60. DOI: 10.1016/s0016-5085(17)30558-9.
- Yazici C, Wolf PG, Kim H, Cross TL, Vermillion K, Carroll T, Augustus GJ, Mutlu E, Tussing-Humphreys L, Braunschweig C, Xicola RM, Jung B, Llor X, Ellis NA, Gaskins HR. Race-dependent association of sulfidogenic bacteria with colorectal cancer. Gut 2017, 66: 1983. PMID: 28153960, PMCID: PMC5575988, DOI: 10.1136/gutjnl-2016-313321.
- Yazici C, Wolf P, Liu T, Vermillion K, Carroll T, Mutlu E, Tussing-Humphreys L, Braunschweig C, Xicola R, Jung B, Llor X, Ellis N, Gaskins H. Abstract B31: Sulfidogenic bacteria are an important diet-driven exposure promoting colorectal cancer in African Americans. Cancer Epidemiology Biomarkers & Prevention 2017, 26: b31-b31. DOI: 10.1158/1538-7755.disp16-b31.
- Brea-Fernandez AJ, Fernandez-Rozadilla C, Alvarez-Barona M, Azuara D, Ginesta MM, Clofent J, de Castro L, Gonzalez D, Andreu M, Bessa X, Llor X, Xicola R, Jover R, Castells A, Castellvi-Bel S, Capella G, Carracedo A, Ruiz-Ponte C. Candidate predisposing germline copy number variants in early onset colorectal cancer patients. Clinical And Translational Oncology 2016, 19: 625-632. PMID: 27888432, DOI: 10.1007/s12094-016-1576-z.
- Llor X. Building a Cancer Genetics and Prevention Program. Clinical Gastroenterology And Hepatology 2016, 14: 1516-1520. PMID: 27531499, DOI: 10.1016/j.cgh.2016.06.012.
- Ashktorab H, Ahuja S, Kannan L, Llor X, Ellis N, Xicola R, Laiyemo A, Carethers J, Brim H, Nouraie M. Abstract 5013: A meta-analysis of MSI frequency and race in colorectal cancer. Cancer Research 2016, 76: 5013-5013. DOI: 10.1158/1538-7445.am2016-5013.
- Mathur PS, Gierut JJ, Guzman G, Xie H, Xicola RM, Llor X, Chastkofsky MI, Perekatt AO, Tyner AL. Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer. Molecular Cancer Research 2016, 14: 563-573. PMID: 26983689, PMCID: PMC4912439, DOI: 10.1158/1541-7786.mcr-15-0450.
- Xicola RM, Bontu S, Doyle BJ, Rawson J, Garre P, Lee E, de la Hoya M, Bessa X, Clofent J, Bujanda L, Balaguer F, Castellví-Bel S, Alenda C, Jover R, Ruiz-Ponte C, Syngal S, Andreu M, Carracedo A, Castells A, Newcomb PA, Lindor N, Potter JD, Baron JA, Ellis NA, Caldes T, LLor X. Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC). Carcinogenesis 2016, 37: 751-758. PMID: 27234654, PMCID: PMC4967215, DOI: 10.1093/carcin/bgw064.
- Ashktorab H, Ahuja S, Kannan L, Llor X, Ellis NA, Xicola RM, Laiyemo AO, Carethers JM, Brim H, Nouraie M. A meta-analysis of MSI frequency and race in colorectal cancer. Oncotarget 2016, 7: 34546-34557. PMID: 27120810, PMCID: PMC5085175, DOI: 10.18632/oncotarget.8945.
- Xicola R, Clark J, Carroll T, Alvikas J, Marwaha P, Regan M, Emmadi R, Alagiozian-Angelova V, Kupfer S, Ellis N, Llor X. 775 Unveiling New Colorectal Cancer Phenotypes With Mismatch Repair Deficiency. Gastroenterology 2016, 150: s160. DOI: 10.1016/s0016-5085(16)30630-8.
- Augustus G, Xicola R, Brothman A, Llor X, Ellis N. Abstract PR02: Homologous recombination drives African American colorectal carcinogenesis. Cancer Epidemiology Biomarkers & Prevention 2016, 25: pr02-pr02. DOI: 10.1158/1538-7755.disp15-pr02.
- Díaz-Algorri Y, Pérez-Mayoral J, González-Pons M, Rodríguez N, Suárez B, Colón G, Sevilla J, Jorge D, Llor X, Xicola R, Tous L, Reyes J, Torres M, Goel A, Rodriguez S, Cruz-Correa M. Abstract B35: Molecular characterization of colorectal tumors from Puerto Rican Hispanic patients. Cancer Epidemiology Biomarkers & Prevention 2016, 25: b35-b35. DOI: 10.1158/1538-7755.disp15-b35.
- Xicola R, Kupfer S, Braunschweig C, Ellis N, Llor X. Abstract A75: Excess of proximal microsatellite-stable colorectal cancer in African Americans from a multiethnic study. Cancer Epidemiology Biomarkers & Prevention 2015, 24: a75-a75. DOI: 10.1158/1538-7755.disp14-a75.
- Santa Cruz Guindalini R, Win AK, Gulden C, Lindor NM, Newcomb PA, Haile RW, Raymond V, Stoffel E, Hall M, Llor X, Ukaegbu CI, Solomon I, Weitzel J, Kalady M, Blanco A, Terdiman J, Shuttlesworth GA, Lynch PM, Hampel H, Lynch HT, Jenkins MA, Olopade OI, Kupfer SS. Mutation Spectrum and Risk of Colorectal Cancer in African American Families with Lynch Syndrome. Gastroenterology 2015, 149: 1446-1453. PMID: 26248088, PMCID: PMC4648287, DOI: 10.1053/j.gastro.2015.07.052.
- Mathur P, Gierut J, Xicola R, Llor X, Tyner A. Abstract LB-059: Opposing roles for protein tyrosine kinase 6 (PTK6) in colon cancer. 2015, lb-059-lb-059. DOI: 10.1158/1538-7445.am2015-lb-059.
- Kupfer S, Hulur I, Gamazon E, Skol A, Llor X, Onel K, Ellis N. Abstract 4582: Enrichment of colorectal cancer and inflammatory bowel disease risk variants in colon expression quantitative trait loci in African Americans. 2015, 4582-4582. DOI: 10.1158/1538-7445.am2015-4582.
- Hamaya Y, Guarinos C, Tseng-Rogenski SS, Iwaizumi M, Das R, Jover R, Castells A, Llor X, Andreu M, Carethers JM. Efficacy of Adjuvant 5-Fluorouracil Therapy for Patients with EMAST-Positive Stage II/III Colorectal Cancer. PLOS ONE 2015, 10: e0127591. PMID: 25996601, PMCID: PMC4440728, DOI: 10.1371/journal.pone.0127591.
- Castillejo A, Hernández-Illán E, Rodriguez-Soler M, Pérez-Carbonell L, Egoavil C, Barberá VM, Castillejo MI, Guarinos C, Martínez-de-Dueñas E, Juan MJ, Sánchez-Heras AB, García-Casado Z, Ruiz-Ponte C, Brea-Fernández A, Juárez M, Bujanda L, Clofent J, Llor X, Andreu M, Castells A, Carracedo A, Alenda C, Payá A, Jover R, Soto JL. Prevalence of MLH1 constitutional epimutations as a cause of Lynch syndrome in unselected versus selected consecutive series of patients with colorectal cancer. Journal Of Medical Genetics 2015, 52: 498. PMID: 25908759, DOI: 10.1136/jmedgenet-2015-103076.
- Yazici C, Wolf P, Carroll T, Mutlu E, Xicola R, Llor X, Jung B, Ellis N, Gaskins H. 511 Bilophila wadsworthia Is More Abundant in the Colonic Microbiome of Colorectal Cancer Cases Compared to Healthy Controls. Gastroenterology 2015, 148: s-100. DOI: 10.1016/s0016-5085(15)30343-7.
- Murcia O, Rodriguez-Soler M, Juarez-Quesada M, Guarinos C, Hernandez-Illan E, Andreu M, Castells A, Llor X, Carracedo A, Jover R. Su1997 Colorectal Cancer With Methylator Phenotype. Clinical Characterisitics, Prognosis and Response to Adjuvant Chemotherapy. Gastroenterology 2015, 148: s-570-s-571. DOI: 10.1016/s0016-5085(15)31926-0.
- Xicola R, Carroll T, Emmadi R, Alagiozian-Angelova V, Alvikas J, Marwaha P, Regan M, Gibson J, Mitchell K, Kupfer S, Ellis N, Llor X. Su1993 Somatic Mutations in the Mismatch Repair System Are Responsible for a Majority of Unexplained Lynch Syndrome Cases: Time to Revise Lynch Syndrome Screening? Gastroenterology 2015, 148: s-570. DOI: 10.1016/s0016-5085(15)31922-3.
- Hulur I, Gamazon ER, Skol AD, Xicola RM, Llor X, Onel K, Ellis NA, Kupfer SS. Enrichment of inflammatory bowel disease and colorectal cancer risk variants in colon expression quantitative trait loci. BMC Genomics 2015, 16: 138. PMID: 25766683, PMCID: PMC4351699, DOI: 10.1186/s12864-015-1292-z.
- Commentary
- Commentary
- Moreira L, Muñoz J, Cuatrecasas M, Quintanilla I, Leoz ML, Carballal S, Ocaña T, López‐Cerón M, Pellise M, Castellví‐Bel S, Jover R, Andreu M, Carracedo A, Xicola RM, Llor X, Boland CR, Goel A, Castells A, Balaguer F. Prevalence of somatic mutl homolog 1 promoter hypermethylation in Lynch syndrome colorectal cancer. Cancer 2014, 121: 1395-1404. PMID: 25557234, PMCID: PMC10508888, DOI: 10.1002/cncr.29190.
- Pibiri F, Rechenmacher R, Xicola R, Kittles R, Sandler R, Keku T, Llor X, Carpten J, Kupfer S, Ellis N. Abstract 2191: Identification of functional risk alleles in colorectal cancer-associated regions in African Americans. 2014, 2191-2191. DOI: 10.1158/1538-7445.am2014-2191.
- Siddiqi S, Pibiri F, Xicola R, Kittles R, Llor X, Kupfer S, Ellis N. Abstract 1279: Association between vitamin D levels and colorectal cancer in African Americans. 2014, 1279-1279. DOI: 10.1158/1538-7445.am2014-1279.
- Xicola RM, Gagnon M, Clark JR, Carroll T, Gao W, Fernandez C, Mijic D, Rawson JB, Janoski A, Pusatcioglu CK, Rajaram P, Gluskin AB, Regan M, Chaudhry V, Abcarian H, Blumetti J, Cintron J, Melson J, Xie H, Guzman G, Emmadi R, Alagiozian-Angelova V, Kupfer SS, Braunschweig C, Ellis NA, Llor X. Excess of Proximal Microsatellite-Stable Colorectal Cancer in African Americans from a Multiethnic Study. Clinical Cancer Research 2014, 20: 4962-4970. PMID: 25013126, PMCID: PMC4167473, DOI: 10.1158/1078-0432.ccr-14-0353.
- Perez-Carbonell L, Balaguer F, Toiyama Y, Egoavil C, Rojas E, Guarinos C, Andreu M, Llor X, Castells A, Jover R, Boland CR, Goel A. IGFBP3 Methylation Is a Novel Diagnostic and Predictive Biomarker in Colorectal Cancer. PLOS ONE 2014, 9: e104285. PMID: 25127039, PMCID: PMC4134211, DOI: 10.1371/journal.pone.0104285.
- Pusatcioglu CK, Nemeth E, Fantuzzi G, Llor X, Freels S, Tussing-Humphreys L, Cabay RJ, Linzmeier R, Ng D, Clark J, Braunschweig C. Systemic and tumor level iron regulation in men with colorectal cancer: a case control study. Nutrition & Metabolism 2014, 11: 21. PMID: 24872837, PMCID: PMC4037273, DOI: 10.1186/1743-7075-11-21.
- Hulur I, Skol A, Llor X, Onel K, Ellis N, Kupfer S. 719 Expression Quantitative Trait Loci Mapping in the Human Colon. Gastroenterology 2014, 146: s-125-s-126. DOI: 10.1016/s0016-5085(14)60451-0.
- Marwaha P, Xicola R, Kim Y, Snyder C, Carroll T, Syngal S, Buxbaum S, Zhang M, Want S, Lynch H, Bessa X, Andreu M, Jover R, Carracedo A, Castells A, Caldes T, Ellis N, Llor X. 675 Unveiling of DNA Repair Gene Alterations in Non-Lynch Hereditary Colorectal Cancer Through Exome Sequencing. Gastroenterology 2014, 146: s-119. DOI: 10.1016/s0016-5085(14)60429-7.
- Pérez-Carbonell L, Egoavil C, Rojas E, Alenda C, Rodriguez-Soler M, Guarinos C, Juarez-Quesada M, Andreu M, Llor X, Castells A, Jover R, Boland C, Goel A. Sa1897 Novel Evidence for Interleukin-8 (IL-8) As a Predictive Biomarker of Response to 5fluorouracil Based Chemotherapy in Colorectal Cancer. Gastroenterology 2014, 146: s-323. DOI: 10.1016/s0016-5085(14)61166-5.
- Mathur P, Xicola R, Llor X, Tyner A. 50 PTK6 Antagonizes the EMT in Colon Cancer Cell Lines. Gastroenterology 2014, 146: s-14. DOI: 10.1016/s0016-5085(14)60050-0.
- Ravella S, Xicola R, Pibiri F, Carroll T, Sandler R, Kupfer S, Ellis N, Llor X. Mo1153 Association of a Variant in FADS2 the Gene Encoding the Polyunsaturated Fatty Acid Metabolizing Enzyme FADS2 With Colorectal Cancer in African Americans. Gastroenterology 2014, 146: s-571. DOI: 10.1016/s0016-5085(14)62069-2.
- Abulí A, Bujanda L, Muñoz J, Buch S, Schafmayer C, Valeria Maiorana M, Veneroni S, van Wezel T, Liu T, Westers H, Esteban-Jurado C, Ocaña T, Piqué JM, Andreu M, Jover R, Carracedo A, Xicola RM, Llor X, Castells A, , Dunlop M, Hofstra R, Lindblom A, Wijnen J, Peterlongo P, Hampe J, Ruiz-Ponte C, Castellví-Bel S. The MLH1 c.1852_1853delinsGC (p.K618A) Variant in Colorectal Cancer: Genetic Association Study in 18,723 Individuals. PLOS ONE 2014, 9: e95022. PMID: 24743384, PMCID: PMC3990597, DOI: 10.1371/journal.pone.0095022.
- Llor X. Colorectal cancer: From the laboratory to the patient, a now indispensable step. Revista De Gastroenterología De México (English Edition) 2014, 79: 71-72. DOI: 10.1016/j.rgmxen.2014.05.012.
- Llor X. Cáncer colorrectal: del laboratorio al paciente, un paso ya imprescindible. Revista De Gastroenterología De México 2014, 79: 71-72. PMID: 24934514, DOI: 10.1016/j.rgmx.2014.05.005.
- Gonzalo V, Lozano JJ, Alonso-Espinaco V, Moreira L, Muñoz J, Pellisé M, Castellví-Bel S, Bessa X, Andreu M, Xicola RM, Llor X, Ruiz-Ponte C, Carracedo A, Jover R, Castells A, Balaguer F, . Multiple Sporadic Colorectal Cancers Display a Unique Methylation Phenotype. PLOS ONE 2014, 9: e91033. PMID: 24643221, PMCID: PMC3958343, DOI: 10.1371/journal.pone.0091033.
- Pibiri F, Kittles RA, Sandler RS, Keku TO, Kupfer SS, Xicola RM, Llor X, Ellis NA. Genetic variation in vitamin D-related genes and risk of colorectal cancer in African Americans. Cancer Causes & Control 2014, 25: 561-570. PMID: 24562971, PMCID: PMC3978221, DOI: 10.1007/s10552-014-0361-y.
- Fernandez-Rozadilla C, Cazier JB, Tomlinson I, Brea-Fernández A, Lamas MJ, Baiget M, López-Fernández LA, Clofent J, Bujanda L, Gonzalez D, de Castro L, The EPICOLON Consortium, Hemminki K, Bessa X, Andreu M, Jover R, Xicola R, Llor X, Moreno V, Castells A, Castellví-Bel S, Carracedo A, Ruiz-Ponte C. A genome-wide association study on copy-number variation identifies a 11q11 loss as a candidate susceptibility variant for colorectal cancer. Human Genetics 2013, 133: 525-534. PMID: 24218287, DOI: 10.1007/s00439-013-1390-4.
- Montero-Meléndez T, Llor X, García-Planella E, Perretti M, Suárez A. Identification of Novel Predictor Classifiers for Inflammatory Bowel Disease by Gene Expression Profiling. PLOS ONE 2013, 8: e76235. PMID: 24155895, PMCID: PMC3796518, DOI: 10.1371/journal.pone.0076235.
- Parepally M, Rajaram P, Xicola R, Ellis N, Llor X, Venepalli N. Racial Differences in Colorectal Cancer: A Large Single Institution Experience. The American Journal Of Gastroenterology 2013, 108: s180. DOI: 10.14309/00000434-201310001-00613.
- Abulí A, Lozano JJ, Rodríguez-Soler M, Jover R, Bessa X, Muñoz J, Esteban-Jurado C, Fernández-Rozadilla C, Carracedo A, Ruiz-Ponte C, Cubiella J, Balaguer F, Bujanda L, Reñé JM, Clofent J, Morillas JD, Nicolás-Pérez D, Xicola RM, Llor X, Piqué JM, Andreu M, Castells A, Castellví-Bel S. Genetic susceptibility variants associated with colorectal cancer prognosis. Carcinogenesis 2013, 34: 2286-2291. PMID: 23712746, DOI: 10.1093/carcin/bgt179.
- Pérez-Carbonell L, Egoavil C, Toiyama Y, Guarinos C, Rojas E, Alenda C, Balaguer F, Hur K, Andreu M, Llor X, Castells A, Jover R, Boland C, Goel A. 470 TFAP2E Methylation and Expression Status Do Not Serve As Predictors of Response to 5-FU Based Chemotherapy in Colorectal Cancer. Gastroenterology 2013, 144: s-84-s-85. DOI: 10.1016/s0016-5085(13)60314-5.
- Pérez-Carbonell L, Toiyama Y, Balaguer F, Guarinos C, Hur K, Andreu M, Llor X, Castells A, Jover R, Boland C, Goel A. Sa2002 IGFBP3 Methylation As a Novel Diagnostic and Prognostic Marker in Colorectal Cancer. Gastroenterology 2013, 144: s-356. DOI: 10.1016/s0016-5085(13)61311-6.
- Moreira L, Munoz J, Cuatrecasas M, Quintanilla I, Leoz M, Carballal S, Ocana T, Fernandez P, Arnold M, Pellise M, Jover R, Andreu M, Carracedo A, Llor X, Boland C, Goel A, Castells A, Balaguer F. 107 Somatic MLH1 Promoter Hypermethylation Is a Frequent Event in Lynch Syndrome Colorectal Cancers. Gastroenterology 2013, 144: s-25. DOI: 10.1016/s0016-5085(13)60087-6.
- Diaz-Algorri Y, Xicola R, Llor X, Tucker K, Cruz-Correa M. Su1087 Clinicopathological Characterization and Nutritional Assessment of Hispanics With Sporadic Microsatellite Unstable Colorectal Cancers. Gastroenterology 2013, 144: s-395. DOI: 10.1016/s0016-5085(13)61454-7.
- Xicola R, Doyle B, Rawson J, Garre P, Abulí A, Murugappan S, Lee J, Bessa X, Clofent J, Bujanda L, Balaguer F, Castellvi-Bel S, Alenda C, Jover R, Ruiz-Ponte C, Syngal S, Andreu M, Carracedo A, Castells A, Ellis N, Caldes T, Llor X. 106 Implication of the 3′Utr Region of TGFβR1 With MSS HNPCC and Sporadic Colorectal Cancer. Gastroenterology 2013, 144: s-25. DOI: 10.1016/s0016-5085(13)60086-4.
- Munoz Xicola R, Doyle B, Rawson J, Garre P, Abuli A, Lee E, Murugappan S, Bessa X, Bujanda L, Balaguer F, Castellvi-Bel S, Clofent J, Alenda C, Jover R, Ruiz-Ponte C, Singal S, Andreu M, Carracedo A, Castells A, Ellis N, Caldes T, LLor X. Abstract 1334: Implication of the 3′UTR region of TGFβR1 with MSS HNPCC and sporadic colorectal cancer. Cancer Research 2013, 73: 1334-1334. DOI: 10.1158/1538-7445.am2013-1334.
- Pibiri F, Ellis N, Kittles R, LLor X, Xicola R, Kupfer S, Sandler R, Keku T. Abstract 1330: Genetic variation in the vitamin D pathway and risk for colorectal cancer in African Americans. Cancer Research 2013, 73: 1330-1330. DOI: 10.1158/1538-7445.am2013-1330.
- Fernandez-Rozadilla C, Cazier JB, Tomlinson IP, Carvajal-Carmona LG, Palles C, Lamas MJ, Baiget M, López-Fernández LA, Brea-Fernández A, Abulí A, Bujanda L, Clofent J, Gonzalez D, Xicola R, Andreu M, Bessa X, Jover R, Llor X, The EPICOLON Consortium, Moreno V, Castells A, Carracedo Á, Castellvi-Bel S, Ruiz-Ponte C. A colorectal cancer genome-wide association study in a Spanish cohort identifies two variants associated with colorectal cancer risk at 1p33 and 8p12. BMC Genomics 2013, 14: 55. PMID: 23350875, PMCID: PMC3616862, DOI: 10.1186/1471-2164-14-55.
- Rodríguez–Soler M, Pérez–Carbonell L, Guarinos C, Zapater P, Castillejo A, Barberá VM, Juárez M, Bessa X, Xicola RM, Clofent J, Bujanda L, Balaguer F, Reñé J, de–Castro L, Marín–Gabriel J, Lanas A, Cubiella J, Nicolás–Pérez D, Brea–Fernández A, Castellví–Bel S, Alenda C, Ruiz–Ponte C, Carracedo A, Castells A, Andreu M, Llor X, Soto JL, Payá A, Jover R. Risk of Cancer in Cases of Suspected Lynch Syndrome Without Germline Mutation. Gastroenterology 2013, 144: 926-932.e1. PMID: 23354017, DOI: 10.1053/j.gastro.2013.01.044.
- Fernandez-Rozadilla C, Palles C, Carvajal-Carmona L, Peterlongo P, Nici C, Veneroni S, Pinheiro M, Teixeira MR, Moreno V, Lamas MJ, Baiget M, Lopez-Fernandez L, Gonzalez D, Brea-Fernandez A, Clofent J, Bujanda L, Bessa X, Andreu M, Xicola R, Llor X, Jover R, Consortium T, Castells A, Castellvi-Bel S, Carracedo A, Tomlinson I, Ruiz-Ponte C. BMP2 / BMP4 colorectal cancer susceptibility loci in northern and southern European populations. Carcinogenesis 2012, 34: 314-318. PMID: 23161572, DOI: 10.1093/carcin/bgs357.
- Fernandez‐Rozadilla C, Brea‐Fernández A, Bessa X, Álvarez‐Urturi C, Abulí A, Clofent J, Payá A, Consortium T, Jover R, Xicola R, Llor X, Andreu M, Castells A, Carracedo Á, Castellví‐Bel S, Ruiz‐Ponte C. BMPR1A mutations in early‐onset colorectal cancer with mismatch repair proficiency. Clinical Genetics 2012, 84: 94-96. PMID: 23057600, DOI: 10.1111/cge.12023.
- Pibiri F, Kittles R, Sandler R, Keku T, Kupfer S, Xicola R, Llor X, Ellis N. Abstract PR02: Genetic variation in the vitamin D pathway and risk for colorectal cancer in African Americans. Cancer Epidemiology Biomarkers & Prevention 2012, 21: pr02-pr02. DOI: 10.1158/1055-9965.disp12-pr02.
- Antelo M, Balaguer F, Shia J, Shen Y, Hur K, Moreira L, Cuatrecasas M, Bujanda L, Giraldez MD, Takahashi M, Cabanne A, Barugel ME, Arnold M, Roca EL, Andreu M, Castellvi-Bel S, Llor X, Jover R, Castells A, Boland CR, Goel A. A High Degree of LINE-1 Hypomethylation Is a Unique Feature of Early-Onset Colorectal Cancer. PLOS ONE 2012, 7: e45357. PMID: 23049789, PMCID: PMC3458035, DOI: 10.1371/journal.pone.0045357.
- Giráldez M, López-Dóriga A, Bujanda L, Abulí A, Bessa X, Fernandez-Rozadilla C, Munoz J, Cuatrecasas M, Jover R, Xicola R, Llor X, Piqué J, Carracedo A, Ruiz-Ponte C, Cosme A, Enriquez-Navascués J, Moreno V, Andreu M, Castells A, Balaguer F, Castellvi-Bel S. Su1813 Susceptibility Genetic Variants Associated With Early-Onset Colorectal Cancer. Gastroenterology 2012, 142: s-510. DOI: 10.1016/s0016-5085(12)61954-4.
- Rodriguez-Soler M, Pérez-Carbonell L, Guarinos C, Castillejo A, Egoavil C, Barberà V, Martinez-Dueńas E, Castillejo M, Martinez-Canto A, Sanchez-Heras A, Ruiz-Ponte C, Brea A, Alenda C, Paya A, Sanchez-Fortun C, Juarez-Quesada M, Bujanda L, Clofent J, Llor X, Andreu M, Castells A, Carracedo A, Soto J, Jover R. Sa1774 Prevalence of MLH1 Constitutional Epimutations as a Cause of Lynch Syndrome in Unselected Consecutive Cases of Colorectal Cancer. Gastroenterology 2012, 142: s-322. DOI: 10.1016/s0016-5085(12)61211-6.
- Xicola R, Gagnon M, Shaw J, Rodriguez G, Pusatcioglu C, Clark J, James R, Ravella S, Guzman G, Janoski A, Morrissey M, Mraz K, Cerye K, Chaudhry V, Kupfer S, Melson J, Freeman V, Xie H, Braunchweig C, Ellis N, Llor X. Abstract 3597: The Chicago Colorectal Cancer Consortium (CCCC) experience: Understanding colorectal cancer disparities. Cancer Research 2012, 72: 3597-3597. DOI: 10.1158/1538-7445.am2012-3597.
- Pibiri F, Kittles R, Sandler R, Keku T, Kupfer S, LLor X, Ellis N. Abstract 1653: Genetic variation in the vitamin D pathway and risk for colorectal cancer in African Americans. Cancer Research 2012, 72: 1653-1653. DOI: 10.1158/1538-7445.am2012-1653.
- Xicola RM, Llor X. Defectos de la metilación del ADN en el cáncer colorrectal esporádico y hereditario. Gastroenterología Y Hepatología 2012, 35: 480-487. PMID: 22459641, DOI: 10.1016/j.gastrohep.2012.01.010.
- Fernandez-Rozadilla C, Cazier JB, Moreno V, Crous-Bou M, Guinó E, Durán G, Lamas MJ, López R, Candamio S, Gallardo E, Paré L, Baiget M, Páez D, López-Fernández LA, Cortejoso L, García MI, Bujanda L, González D, Gonzalo V, Rodrigo L, Reñé JM, Jover R, Brea-Fernández A, Andreu M, Bessa X, Llor X, Xicola R, Palles C, Tomlinson I, Castellví-Bel S, Castells A, Ruiz-Ponte C, Carracedo A. Pharmacogenomics in colorectal cancer: a genome-wide association study to predict toxicity after 5-fluorouracil or FOLFOX administration. The Pharmacogenomics Journal 2012, 13: 209-217. PMID: 22310351, DOI: 10.1038/tpj.2012.2.
- Castellví-Bel S, Ruiz-Ponte C, Fernández-Rozadilla C, Abulí A, Muñoz J, Bessa X, Brea-Fernández A, Ferro M, Giráldez MD, Xicola RM, Llor X, Jover R, Piqué JM, Andreu M, Castells A, Carracedo A, Association F. Seeking genetic susceptibility variants for colorectal cancer: the EPICOLON consortium experience. Mutagenesis 2012, 27: 153-159. PMID: 22294762, DOI: 10.1093/mutage/ger047.
- Giráldez MD, López-Dóriga A, Bujanda L, Abulí A, Bessa X, Fernández-Rozadilla C, Muñoz J, Cuatrecasas M, Jover R, Xicola RM, Llor X, Piqué JM, Carracedo A, Ruiz-Ponte C, Cosme A, Enríquez-Navascués JM, Moreno V, Andreu M, Castells A, Balaguer F, Castellví-Bel S, Association T. Susceptibility genetic variants associated with early-onset colorectal cancer. Carcinogenesis 2012, 33: 613-619. PMID: 22235025, DOI: 10.1093/carcin/bgs009.
- Llor X. When Should We Suspect Hereditary Colorectal Cancer Syndrome? Clinical Gastroenterology And Hepatology 2011, 10: 363-367. PMID: 22178459, DOI: 10.1016/j.cgh.2011.12.022.
- Balaguer F, Moreira L, Lozano JJ, Link A, Ramirez G, Shen Y, Cuatrecasas M, Arnold M, Meltzer SJ, Syngal S, Stoffel E, Jover R, Llor X, Castells A, Boland CR, Gironella M, Goel A. Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles. Clinical Cancer Research 2011, 17: 6239-6249. PMID: 21844009, PMCID: PMC3186834, DOI: 10.1158/1078-0432.ccr-11-1424.
- Sohn VR, Giros A, Xicola RM, Fluvià L, Grzybowski M, Anguera A, Llor X. Stool-fermented Plantago ovata husk induces apoptosis in colorectal cancer cells independently of molecular phenotype. British Journal Of Nutrition 2011, 107: 1591-1602. PMID: 22018732, DOI: 10.1017/s0007114511004910.
- Pérez-Carbonell L, Ruiz-Ponte C, Guarinos C, Alenda C, Payá A, Brea A, Egoavil CM, Castillejo A, Barberá VM, Bessa X, Xicola RM, Rodríguez-Soler M, Sánchez-Fortún C, Acame N, Castellví-Bel S, Piñol V, Balaguer F, Bujanda L, De-Castro ML, Llor X, Andreu M, Carracedo A, Soto JL, Castells A, Jover R. Comparison between universal molecular screening for Lynch syndrome and revised Bethesda guidelines in a large population-based cohort of patients with colorectal cancer. Gut 2011, 61: 865. PMID: 21868491, DOI: 10.1136/gutjnl-2011-300041.
- Abulí A, Fernández-Rozadilla C, Alonso-Espinaco V, Muñoz J, Gonzalo V, Bessa X, González D, Clofent J, Cubiella J, Morillas JD, Rigau J, Latorre M, Fernández-Bañares F, Peña E, Riestra S, Payá A, Jover R, Xicola RM, Llor X, Carvajal-Carmona L, Villanueva CM, Moreno V, Piqué JM, Carracedo A, Castells A, Andreu M, Ruiz-Ponte C, Castellví-Bel S, for the Gastrointestinal Oncology Group of the Spanish Gastroenterological Association. Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins. BMC Cancer 2011, 11: 339. PMID: 21819567, PMCID: PMC3176240, DOI: 10.1186/1471-2407-11-339.
- Abulí A, Fernández-Rozadilla C, Giráldez MD, Muñoz J, Gonzalo V, Bessa X, Bujanda L, Reñé JM, Lanas A, García AM, Saló J, Argüello L, Vilella À, Carreño R, Jover R, Xicola RM, Llor X, Carvajal-Carmona L, Tomlinson IP, Kerr DJ, Houlston RS, Piqué JM, Carracedo A, Castells A, Andreu M, Ruiz-Ponte C, Castellví-Bel S, for the Gastrointestinal Oncology Group of the Spanish Gastroenterological Association. A two-phase case–control study for colorectal cancer genetic susceptibility: candidate genes from chromosomal regions 9q22 and 3q22. British Journal Of Cancer 2011, 105: 870-875. PMID: 21811255, PMCID: PMC3171011, DOI: 10.1038/bjc.2011.296.
- Validation Microsatellite Path Score in a Population-Based Cohort of Patients With Colorectal CancerBessa X, Alenda C, Paya A, Álvarez C, Iglesias M, Seoane A, Dedeu JM, Abulí A, Ilzarbe L, Navarro G, Pellise M, Balaguer F, Castellvi-Bel S, LLor X, Castells A, Jover R, Andreu M. Validation Microsatellite Path Score in a Population-Based Cohort of Patients With Colorectal Cancer. Journal Of Clinical Oncology 2011, 29: 3374-3380. PMID: 21788563, DOI: 10.1200/jco.2010.34.3947.
- Xicola RM, Llor X. Cancer Risk Assessment in Lynch Syndrome: Does the Gene Matter? JAMA 2011, 305: 2351-2352. PMID: 21642691, DOI: 10.1001/jama.2011.771.
- Soler M, Pérez-Carbonell L, Guarinos C, Ruiz-Ponte C, Brea A, Castillejo A, Barberá V, Sanchez-Fortun C, Sempere-Robles L, Bujanda L, Clofent J, Llor X, Andreu M, Castells A, Carracedo A, Soto J, Payá A, Alenda C, Jover R. Differential Features of Colorectal Cancer (CRC) in Patients With Probable Non-Sporadic Mismatch Repair Deficiency Without Germline Mutation. Gastroenterology 2011, 140: s-190-s-191. DOI: 10.1016/s0016-5085(11)60767-1.
- Pérez-Carbonell L, Guarinos C, Soler M, Sanchez-Fortun C, Sempere-Robles L, Ruiz-Ponte C, Castillejo A, Brea A, Carracedo A, Barberá V, Rojas E, Bujanda L, Clofent J, Andreu M, Llor X, Castells A, Soto J, Jover R. Comparison Between Universal Immunohistochemistry for Mismatch Repair Proteins Versus Revised Bethesda Guidelines in the Detection of Patients With Lynch Syndrome. Gastroenterology 2011, 140: s-97. DOI: 10.1016/s0016-5085(11)60394-6.
- Balaguer F, Antelo M, Shen Y, Hur K, Giraldez M, Bujanda L, Takahashi M, Cabanne A, Barugel M, Arnold M, Roca E, Andreu M, Llor X, Jover R, Castells A, Boland C, Goel A. Increased Line-1 Hypomethylation is a Unique Feature of Early-Onset Colorectal Cancer (CRC). Gastroenterology 2011, 140: s-820-s-821. DOI: 10.1016/s0016-5085(11)63397-0.
- Xicola R, Mu W, Huang L, Sohn V, Doyle B, Jover R, Carracedo A, Andreu M, Bessa X, Castells A, Boland C, Goel A, Investigators E, Dai Y, Llor X. Identification of Mirnas and Their Gene Targets Differentially Expressed in Microsatellite Stable and Unstable Colorectal Cancers Through an Integrated Analysis. Gastroenterology 2011, 140: s-819. DOI: 10.1016/s0016-5085(11)63391-x.
- Xicola R, Below J, Doyle B, Garre P, Zhang W, Caldes T, Cox N, Llor X. Identification of a Chromosome 10 Region Potentially Implicated in Hereditary Non-Polyposis Colorectal Cancer Without Mismatch Repair Mutations. Gastroenterology 2011, 140: s-97. DOI: 10.1016/s0016-5085(11)60395-8.
- Garre P, Briceño V, Xicola RM, Doyle BJ, de la Hoya M, Sanz J, Llovet P, Pescador P, Puente J, Díaz-Rubio E, Llor X, Caldés T. Analysis of the Oxidative Damage Repair Genes NUDT1, OGG1, and MUTYH in Patients from Mismatch Repair Proficient HNPCC Families (MSS-HNPCC). Clinical Cancer Research 2011, 17: 1701-1712. PMID: 21355073, DOI: 10.1158/1078-0432.ccr-10-2491.
- Castillejo A, Guarinos C, Martinez-Canto A, Barbera VM, Egoavil C, Castillejo MI, Perez-Carbonell L, Sanchez-Heras AB, Segura A, Ochoa E, Lazaro R, Ruiz-Ponte C, Bujanda L, Andreu M, Castells A, Carracedo A, Llor X, Clofent J, Alenda C, Paya A, Jover R, Soto JL. Evidence for classification of c.1852_1853AA>GC in MLH1 as a neutral variant for Lynch syndrome. BMC Medical Genomics 2011, 12: 12. PMID: 21247423, PMCID: PMC3034663, DOI: 10.1186/1471-2350-12-12.
- Jover R, Nguyen T, Pérez–Carbonell L, Zapater P, Payá A, Alenda C, Rojas E, Cubiella J, Balaguer F, Morillas JD, Clofent J, Bujanda L, Reñé JM, Bessa X, Xicola RM, Nicolás–Pérez D, Castells A, Andreu M, Llor X, Boland CR, Goel A. 5-Fluorouracil Adjuvant Chemotherapy Does Not Increase Survival in Patients With CpG Island Methylator Phenotype Colorectal Cancer. Gastroenterology 2010, 140: 1174-1181. PMID: 21185836, PMCID: PMC3073650, DOI: 10.1053/j.gastro.2010.12.035.
- Fernández-Rozadilla C, de Castro L, Clofent J, Brea-Fernández A, Bessa X, Abulí A, Andreu M, Jover R, Xicola R, Llor X, Castells A, Castellví-Bel S, Carracedo A, Ruiz-Ponte C, . Single Nucleotide Polymorphisms in the Wnt and BMP Pathways and Colorectal Cancer Risk in a Spanish Cohort. PLOS ONE 2010, 5: e12673. PMID: 20844743, PMCID: PMC2936577, DOI: 10.1371/journal.pone.0012673.
- Abulí A, Bessa X, González JR, Ruiz–Ponte C, Cáceres A, Muñoz J, Gonzalo V, Balaguer F, Fernández–Rozadilla C, González D, de Castro L, Clofent J, Bujanda L, Cubiella J, Reñé J, Morillas JD, Lanas Á, Rigau J, García A, Latorre M, Saló J, Bañares F, Argüello L, Peña E, Vilella À, Riestra S, Carreño R, Paya A, Alenda C, Xicola RM, Doyle BJ, Jover R, Llor X, Carracedo A, Castells A, Castellví–Bel S, Andreu M, Association G. Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype. Gastroenterology 2010, 139: 788-796.e6. PMID: 20638935, DOI: 10.1053/j.gastro.2010.05.072.
- Pérez-Carbonell L, Alenda C, Payá A, Castillejo A, Barberá VM, Guillén C, Rojas E, Acame N, Gutiérrez-Aviñó FJ, Castells A, Llor X, Andreu M, Soto JL, Jover R. Methylation Analysis of MLH1 Improves the Selection of Patients for Genetic Testing in Lynch Syndrome. Journal Of Molecular Diagnostics 2010, 12: 498-504. PMID: 20489114, PMCID: PMC2893635, DOI: 10.2353/jmoldx.2010.090212.
- Jover R, Nguyen T, Pérez-Carbonell L, Payá A, Alenda C, Rojas E, Castells A, Andreu M, Llor X, Boland C, Goel A. 745 Colorectal Cancers (CRCs) With the CpG Island Methylator Phenotype (CIMP) Do Not Show Improved Survival With 5-Fluorouracil (5FU)-Based Adjuvant Chemotherapy. Gastroenterology 2010, 138: s-102. DOI: 10.1016/s0016-5085(10)60466-0.
- Abulí A, Fernandez-Rozadilla C, Alonso-Espinaco V, Giráldez M, Muñoz J, Bessa X, Llor X, Jover R, Carvajal-Carmona L, Tomlinson I, Moreno V, Carracedo A, Castells A, Andreu M, Ruiz-Ponte C, Castellvi-Bel S. S1984 Case-Control Genetic Association Study of Candidates Genes for Genetic Susceptibility to Colorectal Cancer. Gastroenterology 2010, 138: s-295. DOI: 10.1016/s0016-5085(10)61355-8.
- Pérez-Carbonell L, Ruiz-Ponte C, Bessa X, Soto J, Castillejo A, Barberá V, Brea A, Sempere L, Sánchez-Fortún C, Castellvi-Bel S, Balaguer F, Xicola R, Llor X, Abulí A, Andreu M, Alenda C, Payá A, Carracedo A, Castells A, Jover R. S1993 Comparison Between Routine Immunohistochemistry for Mismatch Repair Proteins Versus Revised Bethesda Guidelines in the Diagnosis of Lynch Syndrome in a Non-Selected Population of Colorectal Cancer Patients. Gastroenterology 2010, 138: s-297. DOI: 10.1016/s0016-5085(10)61364-9.
- Xicola R, Garre P, Doyle B, Bandipalliam P, Sapoznik V, Syngal S, Castells A, Jover R, Andreu M, Boland C, Goel A, Caldes T, Llor X. S1994 Base Excision Repair Genes MYH, Ogg1 and Nudt1 and Mismatch Repair Gene Variants in Hereditary Non-Polyposis Colorectal Cancer Without Mismatch Repair Deficiency (MSS HNPCC). Gastroenterology 2010, 138: s-297. DOI: 10.1016/s0016-5085(10)61365-0.
- T1710 MicroRNA Expression Profiles Distinguish Various Molecular Subtypes of Colorectal Cancer (CRC)Balaguer F, Moreira L, Lozano J, Link A, Ramirez G, Cuatrecasas M, Arnold M, Stoffel E, Syngal S, Jover R, Llor X, Castells A, Boland C, Gironella M, Goel A. T1710 MicroRNA Expression Profiles Distinguish Various Molecular Subtypes of Colorectal Cancer (CRC). Gastroenterology 2010, 138: s-562-s-563. DOI: 10.1016/s0016-5085(10)62588-7.
- Kim J, Rami P, O’Toole J, Llor X, Carroll RE, Benya RV. Extent of prevalence and size of flat neoplasms in a heterogeneous population undergoing routine colorectal cancer screening. Colorectal Disease 2010, 12: 471-476. PMID: 19298579, DOI: 10.1111/j.1463-1318.2009.01822.x.
- Bujanda L, Sarasqueta C, Hijona E, Hijona L, Cosme A, Gil I, Elorza JL, Asensio JI, Larburu S, Enríquez-Navascués JM, Jover R, Balaguer F, Llor X, Bessa X, Andreu M, Paya A, Castells A, Association G. Colorectal cancer prognosis twenty years later. World Journal Of Gastroenterology 2010, 16: 862-867. PMID: 20143465, PMCID: PMC2825333, DOI: 10.3748/wjg.v16.i7.862.
- Fernández-Rozadilla C, Tarrío R, Clofent J, de Castro L, Brea-Fernández A, Bessa X, Abulí A, Andreu M, Jover R, Xicola R, Llor X, Castells A, Castellví-Bel S, Carracedo A, Ruiz-Ponte C, Association F. Colorectal Cancer Susceptibility Quantitative Trait Loci in Mice as a Novel Approach to Detect Low-Penetrance Variants in Humans: A Two-Stage Case-Control Study. Cancer Epidemiology Biomarkers & Prevention 2010, 19: 619-623. PMID: 20142256, DOI: 10.1158/1055-9965.epi-09-1175.
- Goel A, Xicola RM, Nguyen T, Doyle BJ, Sohn VR, Bandipalliam P, Rozek LS, Reyes J, Cordero C, Balaguer F, Castells A, Jover R, Andreu M, Syngal S, Boland CR, Llor X. Aberrant DNA Methylation in Hereditary Nonpolyposis Colorectal Cancer Without Mismatch Repair Deficiency. Gastroenterology 2010, 138: 1854-1862.e1. PMID: 20102720, PMCID: PMC2859993, DOI: 10.1053/j.gastro.2010.01.035.
- Gonzalo V, Lozano JJ, Muñoz J, Balaguer F, Pellisé M, de Miguel C, Andreu M, Jover R, Llor X, Giráldez MD, Ocaña T, Serradesanferm A, Alonso-Espinaco V, Jimeno M, Cuatrecasas M, Sendino O, Castellví-Bel S, Castells A, . Aberrant Gene Promoter Methylation Associated with Sporadic Multiple Colorectal Cancer. PLOS ONE 2010, 5: e8777. PMID: 20098741, PMCID: PMC2808250, DOI: 10.1371/journal.pone.0008777.
- Giráldez MD, Balaguer F, Caldés T, Sanchez-de-Abajo A, Gómez-Fernández N, Ruiz-Ponte C, Muñoz J, Garre P, Gonzalo V, Moreira L, Ocaña T, Clofent J, Carracedo A, Andreu M, Jover R, Llor X, Castells A, Castellví-Bel S, Gastrointestinal Oncology Group of the Spanish Gastroenterological Association. Association of MUTYH and MSH6 germline mutations in colorectal cancer patients. Familial Cancer 2009, 8: 525. PMID: 19685280, DOI: 10.1007/s10689-009-9282-4.
- Giros A, Grzybowski M, Sohn VR, Pons E, Fernandez-Morales J, Xicola RM, Sethi P, Grzybowski J, Goel A, Boland CR, Gassull MA, Llor X. Regulation of Colorectal Cancer Cell Apoptosis by the n-3 Polyunsaturated Fatty Acids Docosahexaenoic and Eicosapentaenoic. Cancer Prevention Research 2009, 2: 732-742. PMID: 19638488, PMCID: PMC3793343, DOI: 10.1158/1940-6207.capr-08-0197.
- Sapoznik V, Grzybowski M, Xicola R, Doyle B, Grzybowski J, Martinez T, Anguera A, Llor X. S1271 Plantago Ovata Husk Regulates Cell Cycle Progression and Wnt Signaling Pathway, Crucial Elements Implicated in Colorectal Carcinogenesis. Gastroenterology 2009, 136: a-226. DOI: 10.1016/s0016-5085(09)61020-9.
- Kim J, Ewing R, Llor X, Carroll R, Benya R. W1975 African Americans Fail to Undergo Screening for Colorectal Cancer Independently of Insurance or Self-Reported Income. Gastroenterology 2009, 136: a-765. DOI: 10.1016/s0016-5085(09)63533-2.
- Bessa X, Gonzalez D, Roman E, Bujanda L, Enriquez-Navascués J, Reñe J, Gonzalo V, Jover R, Llor X, Peña E, Latorre M, de Castro Parga M, Carracedo A, Castells A, Andreu M. M1953 Frequency and Characteristics of Hereditary Non-Polyposis Colorectal Cancer (HNPCC) and Other Non-Syndromic Colorectal Cancer (CRC) Familial Forms in Spain. Preliminary Data of a Prospective, Multicenter, Population-Based Study (Epicolon-II). Gastroenterology 2009, 136: a-454. DOI: 10.1016/s0016-5085(09)62088-6.
- Abulí A, Bessa X, Ruiz-Ponte C, Fernandez-Rozadilla C, Carracedo A, Ilzarbe L, Llor X, Jover R, Muñoz J, Castells A, Castellvi-Bel S, Andreu M. 767 Genotype-Phenotype Correlation of Genetic Susceptibility Variants Identified Through Genome-Wide Association Studies for Colorectal Cancer. Gastroenterology 2009, 136: a-120. DOI: 10.1016/s0016-5085(09)60537-0.
- Xicola R, Nguyen T, Doyle B, Bandipalliam P, Syngal S, Reyes J, Cordero C, Grzybowski J, Sapoznik V, Grzybowski M, Castells A, Jover R, Andreu M, Boland C, Llor X, Goel A. 198 CpG-Island Methylator Phenotype (CIMP) and Alterations in RAS-Raf Signaling in Hereditary Non-Polyposis Colorectal Cancers Without Mismatch Repair Deficiency (MSS HNPCC). Gastroenterology 2009, 136: a-37. DOI: 10.1016/s0016-5085(09)60169-4.
- Xicola R, Caldes T, Garre P, Doyle B, Bandipalliam P, Syngal S, Grzybowski J, Sapoznik V, Grzybowski M, Martinez T, Murugappan S, Castells A, Jover R, Andreu M, Goel A, Llor X. M1930 Identification of Genomic Variants in Hereditary Non-Polyposis Colorectal Cancer Without Mismatch Repair Deficiency (MSS HNPCC). Gastroenterology 2009, 136: a-449. DOI: 10.1016/s0016-5085(09)62065-5.
- Grzybowski M, Sapoznik V, Xicola R, Doyle B, Grzybowski J, Martinez T, Anguera A, Llor X. S1272 Differential Regulation of Apoptosis Induction By Plantago Ovata Husk in Colorectal Cancer Cells. Induction of the TNF-Alpha Apoptosis Cascade in Metastatic Cells. Gastroenterology 2009, 136: a-226. DOI: 10.1016/s0016-5085(09)61021-0.
- Kim J, Ewing R, Llor X, Carroll R, Benya R. W1891 Smoking Promotes the Formation of Hyperplastic, But Not Adenomatous, Polyps. Gastroenterology 2009, 136: a-748. DOI: 10.1016/s0016-5085(09)63450-8.
- Payá A, Alenda C, Pérez-Carbonell L, Rojas E, Soto J, Guillén C, Castillejo A, Barberá V, Carrato A, Castells A, Llor X, Andreu M, Koh J, Enders GH, Benlloch S, Jover R. Utility of p16 Immunohistochemistry for the Identification of Lynch Syndrome. Clinical Cancer Research 2009, 15: 3156-3162. PMID: 19383812, PMCID: PMC2825754, DOI: 10.1158/1078-0432.ccr-08-3116.
- Abulí A, Bessa X, Ruiz-Ponte C, Fernández-Gómez C, Carracedo A, Ilzarbe L, Llor X, Jover R, Muñoz J, Castells A, Castellví-Bel S, Andreu M, de Gastroenterología G. CORRELACIÓN GENOTIPO-FENOTIP EN EL CÁNCER COLORRECTAL EN RELACIÓN A VARIANTES GENÉTICAS DE SUSCEPTIBILIDAD. Gastroenterología Y Hepatología 2009, 32: 181-182. DOI: 10.1016/j.gastrohep.2009.01.006.
- Bessa X, Gonzalez D, Roman E, Bujanda L, Enriquez-Navascués J, Reñe J, Gonzalo V, Jover R, Xicolà R, Llor X, Peña E, Latorre M, De Castro L, Carracedo A, Castells A, Andreu M, de Oncología E. FRECUENCIA Y CARACTERÍSTICAS DEL CÁNCER COLORRECTAL HEREDITARIO NO POLIPOSIS (CCHNP) Y OTROS CÁNCERES COLORRECTALES NO SINDRÓMICOS EN ESPAÑA. DATOS PRELIMINARES DE UN ESTUDIO POBLACIONAL, PROSPECTIVO Y MULTICÉNTRICO (EPICOLON-II). Gastroenterología Y Hepatología 2009, 32: 232-233. DOI: 10.1016/j.gastrohep.2009.01.118.
- Bujanda L, Sarasqueta C, Beraza M, Hijona L, Cosme A, Elorza J, Jover R, Balaguer F, Llor X, Andreu M, Bessa X, Paya A, Castells A, de Gastroenterología G. EVOLUCIÓN DEL PRONÓSTICO DEL CÁNCER DE COLON EN LOS ÚLTIMOS 20 AÑOS. Gastroenterología Y Hepatología 2009, 32: 232. DOI: 10.1016/j.gastrohep.2009.01.116.
- "Hereditary Colorectal Cancer"Colorectal Cancer: Early detection and prevention. Editor: Kim, K. Slack Inc. New Jersey. 2009: pp. 149-166
- "What the Primary Care Provider Needs to Know About Hereditary Colorectal Cancer"J Clin Outcomes Manage,16(12):1-9
- Jover R, Zapater P, Castells A, Llor X, Andreu M, Cubiella J, Balaguer F, Sempere L, Xicola RM, Bujanda L, Reñé JM, Clofent J, Bessa X, Morillas JD, Nicolás-Pérez D, Pons E, Payá A, Alenda C, Association G. The efficacy of adjuvant chemotherapy with 5-fluorouracil in colorectal cancer depends on the mismatch repair status. European Journal Of Cancer 2008, 45: 365-373. PMID: 18722765, DOI: 10.1016/j.ejca.2008.07.016.
- Balmaña J, Balaguer F, Castellví-Bel S, Steyerberg EW, Andreu M, Llor X, Jover R, Castells A, Syngal S, Association F. Comparison of predictive models, clinical criteria and molecular tumour screening for the identification of patients with Lynch syndrome in a population-based cohort of colorectal cancer patients. Journal Of Medical Genetics 2008, 45: 557. PMID: 18603628, DOI: 10.1136/jmg.2008.059311.
- Kim J, Ng J, Arozulllah A, Ewing R, Llor X, Carroll RE, Benya RV. Aberrant Crypt Focus Size Predicts Distal Polyp Histopathology. Cancer Epidemiology Biomarkers & Prevention 2008, 17: 1155-1162. PMID: 18483337, DOI: 10.1158/1055-9965.epi-07-2731.
- Montero T, Llor X, Suarez A. M1636 Gene-Expression Signature-Based Approach Identifies Pro-Apoptotic Compounds in CACO-2 Cell Line. Gastroenterology 2008, 134: a-387. DOI: 10.1016/s0016-5085(08)61806-5.
- Balmaña J, Balaguer F, Castellvi-Bel S, Steyerberg E, Andreu M, Llor X, Jover R, Castells A, Syngal S. T2027 Comparison of Predictive Models and Clinical Criteria for the Identification of Patients with Lynch Syndrome in a Population-Based Cohort of Colorectal Cancer (CRC) Patients. Gastroenterology 2008, 134: a-603. DOI: 10.1016/s0016-5085(08)62817-6.
- Montero T, Llor X, Gil A, Gassull M, Suarez A. M2051 Genome-Wide Expression Profiling Reveals a Common Biomarker Gene Signature in Colitis. Gastroenterology 2008, 134: a-458-a-459. DOI: 10.1016/s0016-5085(08)62144-7.
- Mutlu E, Glover S, Gillevet P, Llor X, Quander C, Sikaroodi M, Engen P, Bracamonte S, Keshavarzian A. S2007 Bacterial Microbiota Fingerprints Are Altered in Colon Cancer. Gastroenterology 2008, 134: a-296. DOI: 10.1016/s0016-5085(08)61377-3.
- Kim J, Ewing R, Carroll R, Llor X, Benya R. T1093 Aberrant Crypt Focus Size Predicts Distal Polyp Histopathology. Gastroenterology 2008, 134: a-482. DOI: 10.1016/s0016-5085(08)62254-4.
- Giros A, Sapoznik V, Fernandez-Morales J, Xicola R, Llor X. 151 Docosahexaenoic and Eicosahexaenoic N-3 Fatty Acids Inhibit DNA Synthesis and Cell Proliferation in Colorectal Cancer Cells Independent of the Responsible Underlying Molecular Pathways. Gastroenterology 2008, 134: a-27. DOI: 10.1016/s0016-5085(08)60133-x.
- Bessa X, Ballesté B, Andreu M, Castells A, Bellosillo B, Balaguer F, Castellví–bel S, Paya A, Jover R, Alenda C, Titó L, Martinez–Villacampa M, Vilella A, Xicola RM, Pons E, Llor X, Association G. A Prospective, Multicenter, Population-Based Study of BRAF Mutational Analysis for Lynch Syndrome Screening. Clinical Gastroenterology And Hepatology 2007, 6: 206-214. PMID: 18096441, DOI: 10.1016/j.cgh.2007.10.011.
- Balaguer F, Balmaña J, Castellví–Bel S, Steyerberg EW, Andreu M, Llor X, Jover R, Syngal S, Castells A, Association G. Validation and Extension of the PREMM1,2 Model in a Population-Based Cohort of Colorectal Cancer Patients. Gastroenterology 2007, 134: 39-46. PMID: 18061181, PMCID: PMC2542581, DOI: 10.1053/j.gastro.2007.10.042.
- Ballesté B, Bessa X, Piñol V, CastellvíBel S, Castells A, Alenda C, Paya A, Jover R, Xicola RM, Pons E, Llor X, Cordero C, FernandezBañares F, de Castro L, Reñé JM, Andreu M. Detection of Metachronous Neoplasms in Colorectal Cancer Patients: Identification of Risk Factors. Diseases Of The Colon & Rectum 2007, 50: 971-980. PMID: 17468913, DOI: 10.1007/s10350-007-0237-2.
- Castellví-Bel S, Castells A, de Cid R, Muñoz J, Balaguer F, Gonzalo V, Ruiz-Ponte C, Andreu M, Llor X, Jover R, Bessa X, Xicola RM, Pons E, Alenda C, Payá A, Carracedo A, Piqué JM. Association of the ARLTS1 Cys148Arg variant with sporadic and familial colorectal cancer. Carcinogenesis 2007, 28: 1687-1691. PMID: 17449901, DOI: 10.1093/carcin/bgm098.
- Bujanda L, Sarasqueta C, Zubiaurre L, Cosme A, Muñoz C, Sánchez A, Martín C, Tito L, Piñol V, Castells A, Llor X, Xicola RM, Pons E, Clofent J, de Castro ML, Cuquerella J, Medina E, Gutierrez A, Arenas JI, Jover R. Low adherence to colonoscopy in the screening of first-degree relatives of patients with colorectal cancer. Gut 2007, 56: 1714. PMID: 17400596, PMCID: PMC2095719, DOI: 10.1136/gut.2007.120709.
- Hommes T, Giros A, Llor X, Pons E, Fernandez-Morales J, Xicola R, Gassull M. P079 IMPLICATION OF BCL-2 FAMILY PROTEINS IN THE INDUCTION OF JURKAT T LYMPHOCYTE APOPTOSIS BY THE MAIN N-3 FATTY ACIDS PRESENT IN FISH OIL DOCOSAHEXAENOIC AND EICOSAPENTAENOIC ACID. Journal Of Crohn's And Colitis 2007, 1: 23. DOI: 10.1016/s1873-9954(07)70091-5.
- Balaguer F, Castellví–Bel S, Castells A, Andreu M, Muñoz J, Gisbert JP, Llor X, Jover R, de Cid R, Gonzalo V, Bessa X, Xicola RM, Pons E, Alenda C, Payá A, Piqué JM, Association G. Identification of MYH Mutation Carriers in Colorectal Cancer: A Multicenter, Case-Control, Population-Based Study. Clinical Gastroenterology And Hepatology 2007, 5: 379-387. PMID: 17368238, DOI: 10.1016/j.cgh.2006.12.025.
- Xicola RM, Llor X, Pons E, Castells A, Alenda C, Piñol V, Andreu M, Castellví-Bel S, Payá A, Jover R, Bessa X, Girós A, Duque JM, Nicolás-Pérez D, Garcia AM, Rigau J, Gassull MA. Performance of Different Microsatellite Marker Panels for Detection of Mismatch Repair–Deficient Colorectal Tumors. Journal Of The National Cancer Institute 2007, 99: 244-252. PMID: 17284719, DOI: 10.1093/jnci/djk033.
- "Inner and outer environment"Intestinal Inflammation and Colorectal Cancer. Editors: Gasche, Gassull, Herrerias Gutierrez, Monterio. Springer Science. Lancaster, UK. 2007: pp. 185-192.
- "Cancer and Inflammatory Bowel DiseasesInflammatory bowel diseases. 3rd Edition. Editors: Gassull, Gomollon, Hinojosa, Obrador. Aran Publishing. Madrid. Spain. 2007: 475-480.
- Jover R, Castells A, Llor X, Andreu M. Authors’ reply. Gut 2006, 55: 1819. PMID: 17124161, PMCID: PMC1856450, DOI: 10.1136/gut.2006.105627.
- Benlloch S, Payá A, Alenda C, Bessa X, Andreu M, Jover R, Castells A, Llor X, Aranda FI, Massutí B. Detection of BRAF V600E Mutation in Colorectal Cancer Comparison of Automatic Sequencing and Real-Time Chemistry Methodology. Journal Of Molecular Diagnostics 2006, 8: 540-543. PMID: 17065421, PMCID: PMC1876165, DOI: 10.2353/jmoldx.2006.060070.
- Rodríguez-Moranta F, Castells A, Andreu M, Piñol V, Castellví-Bel S, Alenda C, Llor X, Xicola RM, Jover R, Payá A, Bessa X, Balaguer F, Cubiella J, Argüello L, Morillas JD, Bujanda L. Clinical Performance of Original and Revised Bethesda Guidelines for the Identification of MSH2/MLH1 Gene Carriers in Patients with Newly Diagnosed Colorectal Cancer: Proposal of a New and Simpler Set of Recommendations. The American Journal Of Gastroenterology 2006, 101: ajg2006204. PMID: 16696788, DOI: 10.1111/j.1572-0241.2006.00522.x.
- Castells A, Payá A, Alenda C, Rodríguez-Moranta F, Agrelo R, Andreu M, Piñol V, Castellví-Bel S, Jover R, Llor X, Pons E, Elizalde JI, Bessa X, Alcedo J, Saló J, Medina E, Naranjo A, Esteller M, Piqué J, Association F. Cyclooxygenase 2 Expression in Colorectal Cancer with DNA Mismatch Repair Deficiency. Clinical Cancer Research 2006, 12: 1686-1692. PMID: 16551850, DOI: 10.1158/1078-0432.ccr-05-1581.
- "The Effect of Olive Oil in Inflammatory Bowel Disease"Olive Oil and Health, pp. 309-16
- Llor X, Cabré E, Gassull M. The effect of olive oil on inflammatory bowel disease. 2006, 309-316. DOI: 10.1079/9781845930684.0309.
- Jover R, Zapater P, Castells A, Llor X, Andreu M, Cubiella J, Piñol V, Xicola RM, Bujanda L, Reñé JM, Clofent J, Bessa X, Morillas JD, Nicolás-Pérez D, Payá A, Alenda C. Mismatch repair status in the prediction of benefit from adjuvant fluorouracil chemotherapy in colorectal cancer. Gut 2005, 55: 848. PMID: 16299036, PMCID: PMC1856227, DOI: 10.1136/gut.2005.073015.
- Llor X, Pons E, Xicola RM, Castells A, Alenda C, Piñol V, Andreu M, Castellví-Bel S, Payá A, Jover R, Bessa X, Girós A, Roca A, Gassull MA, Association F. Differential Features of Colorectal Cancers Fulfilling Amsterdam Criteria without Involvement of the Mutator Pathway. Clinical Cancer Research 2005, 11: 7304-7310. PMID: 16243801, DOI: 10.1158/1078-0432.ccr-05-0965.
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- LLOR X, PONS E, ROCA A, ÀLVAREZ M, MAÑÉ J, FERNÁNDEZ-BAÑARES F, GASSULL MA. The effects of fish oil, olive oil, oleic acid and linoleic acid on colorectal neoplastic processes. Clinical Nutrition 2003, 22: 71-79. PMID: 12553953, DOI: 10.1054/clnu.2002.0627.
- Llor X. Papel de los lípidos de la dieta en los mecanismos de inflamación, proliferación, diferenciación y muerte celular en el tracto intestinal. Gastroenterología Y Hepatología 2003, 26: 507-513. PMID: 14534023, DOI: 10.1016/s0210-5705(03)70402-6.
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- Llor X, Serfas MS, Bie W, Vasioukhin V, Polonskaia M, Derry J, Abbott CM, Tyner AL. BRK/Sik expression in the gastrointestinal tract and in colon tumors. Clinical Cancer Research 1999, 5: 1767-77. PMID: 10430081.
- "Characterization of the novel breast tumor kinase Brk"Book chapter. Breast Cancer Research Program. Department of Defense, USA. Era of Hope. Vol II. 1997; 2:121-127
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- "Expression of Tyrosine Kinases in the Mouse Small Intestine"Proceedings on Regulation of Cell Growth, Differentiation and Genetics in Cancer, pp. 308-318
- Davidson NO, Ifkovits CA, Skarosi SF, Hausman AM, Llor X, Sitrin MD, Montag A, Brasitus TA. Tissue and cell-specific patterns of expression of rat liver and intestinal fatty acid binding protein during development and in experimental colonic and small intestinal adenocarcinomas. Laboratory Investigation; A Journal Of Technical Methods And Pathology 1993, 68: 663-75. PMID: 8515653.
- Llor X, Jacoby RF, Teng BB, Davidson NO, Sitrin MD, Brasitus TA. K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors: effects of supplemental dietary calcium and vitamin D deficiency. Cancer Research 1991, 51: 4305-9. PMID: 1868452.
- Jacoby RF, Llor X, Teng BB, Davidson NO, Brasitus TA. Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa. The Journal Of Clinical Investigation 1991, 87: 624-30. PMID: 1991846, PMCID: PMC296352, DOI: 10.1172/JCI115039.
- Halline AG, Dudeja PK, Jacoby RF, Llor X, Teng BB, Chowdhury LN, Davidson NO, Brasitus TA. Effect of polyamine oxidase inhibition on the colonic malignant transformation process induced by 1,2-dimethylhydrazine. Carcinogenesis 1990, 11: 2127-32. PMID: 2265465, DOI: 10.1093/carcin/11.12.2127.
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