1
1 of 2
- Yale Sleep Medicine Centers1291 Boston Post RoadMadison, CT 06443
- Yale Sleep Medicine Centers8 Devine StreetNorth Haven, CT 06473
Melissa Knauert, MD, PhD
she/her/hers
Pulmonary Critical Care , Sleep Medicine
Telehealth is available
Patient type treated
Adult
Accepting new patients
Yes
Referral required
MD to MD Consult
Board Certified in
Internal Medicine, Pulmonary Disease, Critical Care Medicine (Internal Medicine)
, and Sleep Medicine (Internal Medicine)
Biography
Melissa P. Knauert, MD, PhD, treats critically ill patients in the medical intensive care unit at Yale New Haven Hospital and is the program director of the Yale School of Medicine Critical Care Medicine Fellowship.
She is fascinated by critical illness and “how systemic intervention with each affected organ improves the overall health of a patient.”
An associate professor of medicine (pulmonary) at Yale School of Medicine, she also conducts research on sleep deprivation and circadian disruption in critically ill patients. “I would like to design interventions to improve patient outcomes in the intensive care unit via improvements in sleep and circadian alignment,” says Dr. Knauert.
Titles
- Associate Professor of Medicine (Pulmonary)
- Program Director, Critical Care Medicine Fellowship, Dept Clinical: Internal Medicine
Education & Training
- FellowshipYale University School of Medicine (2013)
- FellowshipYale University School of Medicine (2012)
- ResidencyHospital of the University of Pennsylvania (2009)
- InternshipHospital of the University of Pennsylvania (2007)
- MDYale School of Medicine (2006)
- PhDYale University (2005)
- ScBBrown University, Biochemistry (1996)
Additional Information
Honors & Recognitions
- PROSE Winner in the Textbook Category (Medicine and Clinical Science Sub-category): (2020)
- YCCI Scholar: Yale Center for Clinical Investigation, Yale School of Medicine (2015)
- Pepper Scholar: Yale Program on Aging, Yale School of Medicine (2014)
- Medical Scientist Training Program: Yale University School of Medicine (1998)
Publications
- Knauert M, Ayas N, Bosma K, Drouot X, Heavner M, Owens R, Watson P, Wilcox M, Anderson B, Cordoza M, Devlin J, Elliott R, Gehlbach B, Girard T, Kamdar B, Korwin A, Lusczek E, Parthasarathy S, Spies C, Sunderram J, Telias I, Weinhouse G, Zee P. Causes, Consequences, and Treatments of Sleep and Circadian Disruption in the ICU: An Official American Thoracic Society Research Statement. American Journal Of Respiratory And Critical Care Medicine 2023, 207: e49-e68. PMID: 36999950, PMCID: PMC10111990, DOI: 10.1164/rccm.202301-0184st.
- Knauert M, Adekolu O, Xu Z, Deng A, Chu J, Baldassarri S, Kushida C, Yaggi H, Zinchuk A. Morning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea. Annals Of The American Thoracic Society 2023, 20: 1182-1191. PMID: 36917194, PMCID: PMC10405611, DOI: 10.1513/annalsats.202210-885oc.
- Klerman E, Brager A, Carskadon M, Depner C, Foster R, Goel N, Harrington M, Holloway P, Knauert M, LeBourgeois M, Lipton J, Merrow M, Montagnese S, Ning M, Ray D, Scheer F, Shea S, Skene D, Spies C, Staels B, St‐Onge M, Tiedt S, Zee P, Burgess H. Keeping an eye on circadian time in clinical research and medicine. Clinical And Translational Medicine 2022, 12: e1131. PMID: 36567263, PMCID: PMC9790849, DOI: 10.1002/ctm2.1131.
- Dashti H, Wang Y, Knauert M. Feeding critically ill patients at the right time of day. Critical Care 2024, 28: 206. PMID: 38915028, PMCID: PMC11197374, DOI: 10.1186/s13054-024-04994-0.
- Powierza C, Doyle M, Wasden K, Intihar T, Korwin A, Honiden S, Knauert M. Early goal enteral nutrition associated with decreased in-hospital death in mechanically ventilated critically ill adults: a retrospective cohort study. BMJ Open Respiratory Research 2024, 11: e001962. PMID: 38749534, PMCID: PMC11097881, DOI: 10.1136/bmjresp-2023-001962.
- Adirim Z, Pan Y, Doyle M, Knauert M, Yaggi H, Miner B. 0680 Body Clock and Aging: Relationships of Circadian Rhythm with Sleep Quality, Mental Health and Geriatric Conditions. Sleep 2024, 47: a291-a291. DOI: 10.1093/sleep/zsae067.0680.
- Miner B, Pan Y, Cho G, Knauert M, Yaggi H, Gill T, Stone K, Ensrud K, Zeitzer J, Yaffe K, Doyle M. 0757 Association of Insomnia with Objective Short Sleep Duration and Other Phenotypes with Mortality in Older Persons. Sleep 2024, 47: a324-a325. DOI: 10.1093/sleep/zsae067.0757.
- Miner B, Pan Y, Cho G, Burzynski C, Polisetty L, Doyle M, Iannone L, Knauert M, Gill T, Yaggi H. 0309 Concordance in Electroencephalography-Headband versus Polysomnography by Demographics and Cognitive Status. Sleep 2024, 47: a133-a133. DOI: 10.1093/sleep/zsae067.0309.
- Pan Y, Cho G, Burzynski C, Polisetty L, Doyle M, Iannone L, Knauert M, Yaggi H, Gill T, Miner B. 0230 Comparing Subjective and Objective Measures of Chronotypes and Their Associations with Age in Older Adults. Sleep 2024, 47: a99-a99. DOI: 10.1093/sleep/zsae067.0230.
- Wilcox M, Burry L, Englesakis M, Coman B, Daou M, van Haren F, Ely E, Bosma K, Knauert M. Intensive care unit interventions to promote sleep and circadian biology in reducing incident delirium: a scoping review. Thorax 2024, 79: 988-997. PMID: 38350730, DOI: 10.1136/thorax-2023-220036.
- Allen C, Streiff M, Naik R, Knauert M, Goshua G. Consecutive Inpatient Hematology Consultation Service Utilization across 11 Years in the Medical Intensive Care Unit. Blood 2023, 142: 2323. DOI: 10.1182/blood-2023-184891.
- Ehrenberg M, Kongpakpaisarn K, Intihar T, Doyle M, Knauert M. 0846 Prevalence of Obstructive Sleep Apnea Among Medical ICU Patients. Sleep 2023, 46: a373-a373. DOI: 10.1093/sleep/zsad077.0846.
- Intihar T, Doyle M, Lukas M, Wright K, Redeker N, Pisani M, Yaggi H, Knauert M. 0842 Feasibility of daytime bright light exposure and urinary 6-sulfatoxymelatonin profiling in the medical ICU: A pilot study. Sleep 2023, 46: a371-a371. DOI: 10.1093/sleep/zsad077.0842.
- Lukas M, Doyle M, Intihar T, Wright K, Redeker N, Pisani M, Yaggi H, Knauert M. 0841 Feasibility of Actigraphy during a Daytime Bright Pilot Study in the Medical ICU. Sleep 2023, 46: a370-a371. DOI: 10.1093/sleep/zsad077.0841.
- Polisetty L, Pan Y, Iannone L, Knauert M, Yaggi K, Gill T, Miner B. 0733 The Association of Nocturia and Napping with Obstructive Sleep Apnea Among Older Adults with Insomnia and/or Daytime Sleepiness. Sleep 2023, 46: a322-a323. DOI: 10.1093/sleep/zsad077.0733.
- Miner B, Pan Y, Burzynski C, Iannone L, Knauert M, Gill T, Yaggi H. 0726 Agreement Between an Electroencephalography-Measuring Headband and Polysomnography in Older Adults with Sleep Disturbances. Sleep 2023, 46: a319-a320. DOI: 10.1093/sleep/zsad077.0726.
- Miner B, Doyle M, Knauert M, Yaggi H, Stone K, Ancoli‐Israel S, Cauley J, Redline S, Blackwell T, Gill T, Groups F. Insomnia with objective short sleep duration in community‐living older persons: A multifactorial geriatric health condition. Journal Of The American Geriatrics Society 2022, 71: 1198-1208. PMID: 36524599, PMCID: PMC10089942, DOI: 10.1111/jgs.18195.
- SAMOJEDNY V, INTIHAR T, KNAUERT M. INFLUENCE OF DEMOGRAPHIC FACTORS ON RESEARCH PARTICIPATION. CHEST Journal 2022, 162: a1479. DOI: 10.1016/j.chest.2022.08.1246.
- Knauert M, Parthasarathy S. Sleep in Critical Illness: Future Directions. 2022, 291-309. DOI: 10.1007/978-3-031-06447-0_17.
- Korwin A, Knauert M. Best Practice for Improving Sleep in the ICU. Part I: Non-pharmacologic. 2022, 231-248. DOI: 10.1007/978-3-031-06447-0_14.
- KNAUERT M. Sleep Deficiency and Health. Clinics In Chest Medicine 2022, 43: i. DOI: 10.1016/s0272-5231(22)00048-x.
- Knauert MP. Sleep Deficiency and Health. Clinics In Chest Medicine 2022, 43: xiii-xiv. PMID: 35659032, DOI: 10.1016/j.ccm.2022.02.014.
- Mansour W, Knauert M. Adding Insult to Injury Sleep Deficiency in Hospitalized Patients. Clinics In Chest Medicine 2022, 43: 287-303. PMID: 35659026, PMCID: PMC9177053, DOI: 10.1016/j.ccm.2022.02.009.
- Intihar T, Samojedny V, Korwin A, Knauert M. 0583 Tolerance and feasibility of daytime bright light in medical intensive care unit patients. Sleep 2022, 45: a256-a257. DOI: 10.1093/sleep/zsac079.580.
- Miner B, Yaggi H, Gill T, Doyle M, Stone K, Redline S, Ensrud K, Blackwell T, Knauert M. 0321 Poor Agreement Among Self-Reported and Objective Sleep Deficiency Assessments in Older Persons. Sleep 2022, 45: a144-a145. DOI: 10.1093/sleep/zsac079.319.
- Doyle MM, Murphy TE, Miner B, Pisani MA, Lusczek ER, Knauert MP. Enhancing cosinor analysis of circadian phase markers using the gamma distribution. Sleep Medicine 2022, 92: 1-3. PMID: 35306404, PMCID: PMC9356385, DOI: 10.1016/j.sleep.2022.01.015.
- Gohar A, Knauert M, Kalot M, Khan A, Sider D, Javed M, Wooldridge D, Eck L, Buckhold F, Colaco B, Bhat A, Castillo D, Newman R, Mustafa R. Influence of medical trainee sleep pattern (chronotype) on burn-out and satisfaction with work schedules: a multicentre observational study. Postgraduate Medical Journal 2021, 98: 936-941. PMID: 37062998, PMCID: PMC10074556, DOI: 10.1136/postgradmedj-2021-140975.
- Intihar T, Wasden K, Knauert M. LIGHT PATTERNS OF THE MEDICAL ICU: ARE WE DISRUPTING CIRCADIAN RHYTHMS? CHEST Journal 2021, 160: a2424. DOI: 10.1016/j.chest.2021.07.2095.
- Wasden K, Intihar T, Knauert M. LIGHT SPECTRA: AN IMPORTANT CONSIDERATION FOR CIRCADIAN ALIGNMENT IN THE MEDICAL ICU. CHEST Journal 2021, 160: a2425. DOI: 10.1016/j.chest.2021.07.2096.
- Doyle MM, Murphy TE, Pisani MA, Yaggi HK, Jeon S, Redeker NS, Knauert MP. A SAS macro for modelling periodic data using cosinor analysis. Computer Methods And Programs In Biomedicine 2021, 209: 106292. PMID: 34380075, PMCID: PMC8435001, DOI: 10.1016/j.cmpb.2021.106292.
- Mansour W, Knauert M. 681 Sleep Apnea Severity and COVID-19 Hospitalization Outcomes: Interim Analysis. Sleep 2021, 44: a266-a266. PMCID: PMC8135644, DOI: 10.1093/sleep/zsab072.679.
- Korwin A, Honiden S, Intihar T, Wasden K, Powierza C, Knauert M. Intermittent Feeding in Mechanically Ventilated Medical Intensive Care Unit Patients: Preliminary Outcomes. 2021, a2889-a2889. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2889.
- Korwin A, Honiden S, Intihar T, Wasden K, Heard A, Powierza C, Knauert M. A Pilot Protocol for Intermittent Feeding in Mechanically Ventilated Medical Intensive Care Unit Patients. 2021, a2879-a2879. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2879.
- Lusczek ER, Knauert MP. Light Levels in ICU Patient Rooms: Dimming of Daytime Light in Occupied Rooms. Journal Of Patient Experience 2021, 8: 23743735211033104. PMID: 34368424, PMCID: PMC8312159, DOI: 10.1177/23743735211033104.
- Doyle M, Murphy T, Knauert M. A SAS Macro for Cosinor Analysis of Automated Heart Rate Data in the ICU. Innovation In Aging 2020, 4: 210-210. PMCID: PMC7740472, DOI: 10.1093/geroni/igaa057.679.
- Lutchmansingh DD, Knauert MP, Antin-Ozerkis DE, Chupp G, Cohn L, Dela Cruz CS, Ferrante LE, Herzog EL, Koff J, Rochester CL, Ryu C, Singh I, Tickoo M, Winks V, Gulati M, Possick JD. A Clinic Blueprint for Post-Coronavirus Disease 2019 RECOVERY Learning From the Past, Looking to the Future. CHEST Journal 2020, 159: 949-958. PMID: 33159907, PMCID: PMC7641526, DOI: 10.1016/j.chest.2020.10.067.
- Knauert MP, Murphy TE, Doyle MM, Pisani MA, Redeker NS, Yaggi HK. Pilot Observational Study to Detect Diurnal Variation and Misalignment in Heart Rate Among Critically Ill Patients. Frontiers In Neurology 2020, 11: 637. PMID: 32760341, PMCID: PMC7373742, DOI: 10.3389/fneur.2020.00637.
- Gao C, Knauert M. Circadian Biology and Its Importance to Intensive Care Unit Care and Outcomes. Seminars In Respiratory And Critical Care Medicine 2019, 40: 629-637. PMID: 31826263, DOI: 10.1055/s-0039-1698394.
- Knauert MP, Pisani M, Redeker N, Murphy T, Araujo K, Jeon S, Yaggi H. Pilot study: an intensive care unit sleep promotion protocol. BMJ Open Respiratory Research 2019, 6: e000411. PMID: 31258916, PMCID: PMC6561389, DOI: 10.1136/bmjresp-2019-000411.
- Knauert M, Pisani M. Chapter 19 Sleep in Hospitalized Patients. 2019, 411-437. DOI: 10.1016/b978-0-12-813014-8.00019-6.
- Knauert MP, Gilmore EJ, Murphy TE, Yaggi HK, Van Ness PH, Han L, Hirsch LJ, Pisani MA. Association between death and loss of stage N2 sleep features among critically Ill patients with delirium. Journal Of Critical Care 2018, 48: 124-129. PMID: 30179762, PMCID: PMC6226351, DOI: 10.1016/j.jcrc.2018.08.028.
- Altman MT, Pulaski C, Mburu F, Pisani MA, Knauert MP. Non-circadian signals in the intensive care unit: Point prevalence morning, noon and night. Heart & Lung 2018, 47: 610-615. PMID: 30143362, PMCID: PMC6234066, DOI: 10.1016/j.hrtlng.2018.07.011.
- Heavner M, Nguyen N, Knauert M, Verceles A, Pisani M, Seung H, Gonzales J. Survey of clinical pharmacist perceptions and practices in promoting sleep in intensive care unit patients. JACCP JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY 2018, 2: 46-52. DOI: 10.1002/jac5.1027.
- Altman MT, Knauert MP, Murphy TE, Ahasic AM, Chauhan Z, Pisani MA. Association of intensive care unit delirium with sleep disturbance and functional disability after critical illness: an observational cohort study. Annals Of Intensive Care 2018, 8: 63. PMID: 29740704, PMCID: PMC5940933, DOI: 10.1186/s13613-018-0408-4.
- Knauert MP, Redeker NS, Yaggi HK, Bennick M, Pisani MA. Creating Naptime. Journal Of Patient Experience 2018, 5: 180-187. PMID: 30214923, PMCID: PMC6134539, DOI: 10.1177/2374373517747242.
- Nguyen N, Heavner M, Gonzales J, Verceles A, Pisani M, Knauert M. 940. Critical Care Medicine 2018, 46: 453. DOI: 10.1097/01.ccm.0000528947.29749.ed.
- Perkins M, Knauert M, Honiden S, Siner J, Ma J, Lee D, Pinker E, Pisani M. Rothman Index Predicts ICU Mortality at 24 Hours. CHEST Journal 2017, 152: a332. DOI: 10.1016/j.chest.2017.08.358.
- Altman M, Knauert M, Ahasic A, Chauhan Z, Pisani M. Delirium is Associated With Sleep Disturbance After Critical Illness. CHEST Journal 2017, 152: a1066. DOI: 10.1016/j.chest.2017.08.1100.
- Ding Q, Redeker NS, Pisani MA, Yaggi HK, Knauert MP. Factors Influencing Patients' Sleep in the Intensive Care Unit: Perceptions of Patients and Clinical Staff. American Journal Of Critical Care 2017, 26: 278-286. PMID: 28668912, PMCID: PMC5559223, DOI: 10.4037/ajcc2017333.
- Altman MT, Knauert MP, Pisani MA. Sleep Disturbance after Hospitalization and Critical Illness: A Systematic Review. Annals Of The American Thoracic Society 2017, 14: 1457-1468. PMID: 28644698, PMCID: PMC5711402, DOI: 10.1513/annalsats.201702-148sr.
- Knauert MP, Kamdar BB. Reply: Sleep in the Intensive Care Unit Is a Priority. Annals Of The American Thoracic Society 2016, 13: 1868-1869. PMID: 27726437, PMCID: PMC5122496, DOI: 10.1513/annalsats.201607-578le.
- Kamdar BB, Knauert MP, Jones SF, Parsons EC, Parthasarathy S, Pisani MA. Perceptions and Practices Regarding Sleep in the Intensive Care Unit. A Survey of 1,223 Critical Care Providers. Annals Of The American Thoracic Society 2016, 13: 1370-7. PMID: 27104770, PMCID: PMC5021080, DOI: 10.1513/annalsats.201601-087oc.
- Knauert M, Jeon S, Murphy TE, Yaggi HK, Pisani MA, Redeker NS. Comparing average levels and peak occurrence of overnight sound in the medical intensive care unit on A-weighted and C-weighted decibel scales. Journal Of Critical Care 2016, 36: 1-7. PMID: 27546739, PMCID: PMC5097003, DOI: 10.1016/j.jcrc.2016.06.005.
- Knauert MP, Haspel JA, Pisani MA. Sleep Loss and Circadian Rhythm Disruption in the Intensive Care Unit. Clinics In Chest Medicine 2015, 36: 419-429. PMID: 26304279, DOI: 10.1016/j.ccm.2015.05.008.
- Knauert MP, Malik V, Kamdar BB. Sleep and Sleep Disordered Breathing in Hospitalized Patients. Seminars In Respiratory And Critical Care Medicine 2014, 35: 582-592. PMID: 25353103, DOI: 10.1055/s-0034-1390080.
- Knauert MP, Yaggi HK, Redeker NS, Murphy TE, Araujo KL, Pisani MA. Feasibility study of unattended polysomnography in medical intensive care unit patients. Heart & Lung 2014, 43: 445-452. PMID: 25023504, PMCID: PMC4150840, DOI: 10.1016/j.hrtlng.2014.06.049.
- Knauert M, Yaggi H, Redeker N, Murphy T, Araujo K, Pisani M. Sources of Overnight Patient Sleep Disruption in the Medical Intensive Care Unit. CHEST Journal 2012, 142: 547a-547b. DOI: 10.1378/chest.1383037.
- Kalish J, Knauert M, Hegan D, Glazer P. 708. Gene Targeting with Triplex-Forming Oligonucletides in the Pyrimidine Motif. Molecular Therapy 2006, 13: s273-s274. DOI: 10.1016/j.ymthe.2006.08.787.
- Knauert M, Glazer P. Triplex forming oligonucleotides: sequence-specific tools for gene targeting. Human Molecular Genetics 2001, 10: 2243-2251. PMID: 11673407, DOI: 10.1093/hmg/10.20.2243.
- Zhao H, Sheffield L, Pakstis A, Knauert M, Kidd K. A more powerful method to evaluate p‐values in GENEHUNTER. Genetic Epidemiology 1999, 17: s415-s420. PMID: 10597472, DOI: 10.1002/gepi.1370170770.
Departments and Programs
Locations
1
1 of 2
- Yale Sleep Medicine Centers1291 Boston Post RoadMadison, CT 06443
- Yale Sleep Medicine Centers8 Devine StreetNorth Haven, CT 06473
Biography
Melissa P. Knauert, MD, PhD, treats critically ill patients in the medical intensive care unit at Yale New Haven Hospital and is the program director of the Yale School of Medicine Critical Care Medicine Fellowship.
She is fascinated by critical illness and “how systemic intervention with each affected organ improves the overall health of a patient.”
An associate professor of medicine (pulmonary) at Yale School of Medicine, she also conducts research on sleep deprivation and circadian disruption in critically ill patients. “I would like to design interventions to improve patient outcomes in the intensive care unit via improvements in sleep and circadian alignment,” says Dr. Knauert.
Titles
- Associate Professor of Medicine (Pulmonary)
- Program Director, Critical Care Medicine Fellowship, Dept Clinical: Internal Medicine
Education & Training
- FellowshipYale University School of Medicine (2013)
- FellowshipYale University School of Medicine (2012)
- ResidencyHospital of the University of Pennsylvania (2009)
- InternshipHospital of the University of Pennsylvania (2007)
- MDYale School of Medicine (2006)
- PhDYale University (2005)
- ScBBrown University, Biochemistry (1996)
Additional Information
Honors & Recognitions
- PROSE Winner in the Textbook Category (Medicine and Clinical Science Sub-category): (2020)
- YCCI Scholar: Yale Center for Clinical Investigation, Yale School of Medicine (2015)
- Pepper Scholar: Yale Program on Aging, Yale School of Medicine (2014)
- Medical Scientist Training Program: Yale University School of Medicine (1998)
Publications
- Knauert M, Ayas N, Bosma K, Drouot X, Heavner M, Owens R, Watson P, Wilcox M, Anderson B, Cordoza M, Devlin J, Elliott R, Gehlbach B, Girard T, Kamdar B, Korwin A, Lusczek E, Parthasarathy S, Spies C, Sunderram J, Telias I, Weinhouse G, Zee P. Causes, Consequences, and Treatments of Sleep and Circadian Disruption in the ICU: An Official American Thoracic Society Research Statement. American Journal Of Respiratory And Critical Care Medicine 2023, 207: e49-e68. PMID: 36999950, PMCID: PMC10111990, DOI: 10.1164/rccm.202301-0184st.
- Knauert M, Adekolu O, Xu Z, Deng A, Chu J, Baldassarri S, Kushida C, Yaggi H, Zinchuk A. Morning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea. Annals Of The American Thoracic Society 2023, 20: 1182-1191. PMID: 36917194, PMCID: PMC10405611, DOI: 10.1513/annalsats.202210-885oc.
- Klerman E, Brager A, Carskadon M, Depner C, Foster R, Goel N, Harrington M, Holloway P, Knauert M, LeBourgeois M, Lipton J, Merrow M, Montagnese S, Ning M, Ray D, Scheer F, Shea S, Skene D, Spies C, Staels B, St‐Onge M, Tiedt S, Zee P, Burgess H. Keeping an eye on circadian time in clinical research and medicine. Clinical And Translational Medicine 2022, 12: e1131. PMID: 36567263, PMCID: PMC9790849, DOI: 10.1002/ctm2.1131.
- Dashti H, Wang Y, Knauert M. Feeding critically ill patients at the right time of day. Critical Care 2024, 28: 206. PMID: 38915028, PMCID: PMC11197374, DOI: 10.1186/s13054-024-04994-0.
- Powierza C, Doyle M, Wasden K, Intihar T, Korwin A, Honiden S, Knauert M. Early goal enteral nutrition associated with decreased in-hospital death in mechanically ventilated critically ill adults: a retrospective cohort study. BMJ Open Respiratory Research 2024, 11: e001962. PMID: 38749534, PMCID: PMC11097881, DOI: 10.1136/bmjresp-2023-001962.
- Adirim Z, Pan Y, Doyle M, Knauert M, Yaggi H, Miner B. 0680 Body Clock and Aging: Relationships of Circadian Rhythm with Sleep Quality, Mental Health and Geriatric Conditions. Sleep 2024, 47: a291-a291. DOI: 10.1093/sleep/zsae067.0680.
- Miner B, Pan Y, Cho G, Knauert M, Yaggi H, Gill T, Stone K, Ensrud K, Zeitzer J, Yaffe K, Doyle M. 0757 Association of Insomnia with Objective Short Sleep Duration and Other Phenotypes with Mortality in Older Persons. Sleep 2024, 47: a324-a325. DOI: 10.1093/sleep/zsae067.0757.
- Miner B, Pan Y, Cho G, Burzynski C, Polisetty L, Doyle M, Iannone L, Knauert M, Gill T, Yaggi H. 0309 Concordance in Electroencephalography-Headband versus Polysomnography by Demographics and Cognitive Status. Sleep 2024, 47: a133-a133. DOI: 10.1093/sleep/zsae067.0309.
- Pan Y, Cho G, Burzynski C, Polisetty L, Doyle M, Iannone L, Knauert M, Yaggi H, Gill T, Miner B. 0230 Comparing Subjective and Objective Measures of Chronotypes and Their Associations with Age in Older Adults. Sleep 2024, 47: a99-a99. DOI: 10.1093/sleep/zsae067.0230.
- Wilcox M, Burry L, Englesakis M, Coman B, Daou M, van Haren F, Ely E, Bosma K, Knauert M. Intensive care unit interventions to promote sleep and circadian biology in reducing incident delirium: a scoping review. Thorax 2024, 79: 988-997. PMID: 38350730, DOI: 10.1136/thorax-2023-220036.
- Allen C, Streiff M, Naik R, Knauert M, Goshua G. Consecutive Inpatient Hematology Consultation Service Utilization across 11 Years in the Medical Intensive Care Unit. Blood 2023, 142: 2323. DOI: 10.1182/blood-2023-184891.
- Ehrenberg M, Kongpakpaisarn K, Intihar T, Doyle M, Knauert M. 0846 Prevalence of Obstructive Sleep Apnea Among Medical ICU Patients. Sleep 2023, 46: a373-a373. DOI: 10.1093/sleep/zsad077.0846.
- Intihar T, Doyle M, Lukas M, Wright K, Redeker N, Pisani M, Yaggi H, Knauert M. 0842 Feasibility of daytime bright light exposure and urinary 6-sulfatoxymelatonin profiling in the medical ICU: A pilot study. Sleep 2023, 46: a371-a371. DOI: 10.1093/sleep/zsad077.0842.
- Lukas M, Doyle M, Intihar T, Wright K, Redeker N, Pisani M, Yaggi H, Knauert M. 0841 Feasibility of Actigraphy during a Daytime Bright Pilot Study in the Medical ICU. Sleep 2023, 46: a370-a371. DOI: 10.1093/sleep/zsad077.0841.
- Polisetty L, Pan Y, Iannone L, Knauert M, Yaggi K, Gill T, Miner B. 0733 The Association of Nocturia and Napping with Obstructive Sleep Apnea Among Older Adults with Insomnia and/or Daytime Sleepiness. Sleep 2023, 46: a322-a323. DOI: 10.1093/sleep/zsad077.0733.
- Miner B, Pan Y, Burzynski C, Iannone L, Knauert M, Gill T, Yaggi H. 0726 Agreement Between an Electroencephalography-Measuring Headband and Polysomnography in Older Adults with Sleep Disturbances. Sleep 2023, 46: a319-a320. DOI: 10.1093/sleep/zsad077.0726.
- Miner B, Doyle M, Knauert M, Yaggi H, Stone K, Ancoli‐Israel S, Cauley J, Redline S, Blackwell T, Gill T, Groups F. Insomnia with objective short sleep duration in community‐living older persons: A multifactorial geriatric health condition. Journal Of The American Geriatrics Society 2022, 71: 1198-1208. PMID: 36524599, PMCID: PMC10089942, DOI: 10.1111/jgs.18195.
- SAMOJEDNY V, INTIHAR T, KNAUERT M. INFLUENCE OF DEMOGRAPHIC FACTORS ON RESEARCH PARTICIPATION. CHEST Journal 2022, 162: a1479. DOI: 10.1016/j.chest.2022.08.1246.
- Knauert M, Parthasarathy S. Sleep in Critical Illness: Future Directions. 2022, 291-309. DOI: 10.1007/978-3-031-06447-0_17.
- Korwin A, Knauert M. Best Practice for Improving Sleep in the ICU. Part I: Non-pharmacologic. 2022, 231-248. DOI: 10.1007/978-3-031-06447-0_14.
- KNAUERT M. Sleep Deficiency and Health. Clinics In Chest Medicine 2022, 43: i. DOI: 10.1016/s0272-5231(22)00048-x.
- Knauert MP. Sleep Deficiency and Health. Clinics In Chest Medicine 2022, 43: xiii-xiv. PMID: 35659032, DOI: 10.1016/j.ccm.2022.02.014.
- Mansour W, Knauert M. Adding Insult to Injury Sleep Deficiency in Hospitalized Patients. Clinics In Chest Medicine 2022, 43: 287-303. PMID: 35659026, PMCID: PMC9177053, DOI: 10.1016/j.ccm.2022.02.009.
- Intihar T, Samojedny V, Korwin A, Knauert M. 0583 Tolerance and feasibility of daytime bright light in medical intensive care unit patients. Sleep 2022, 45: a256-a257. DOI: 10.1093/sleep/zsac079.580.
- Miner B, Yaggi H, Gill T, Doyle M, Stone K, Redline S, Ensrud K, Blackwell T, Knauert M. 0321 Poor Agreement Among Self-Reported and Objective Sleep Deficiency Assessments in Older Persons. Sleep 2022, 45: a144-a145. DOI: 10.1093/sleep/zsac079.319.
- Doyle MM, Murphy TE, Miner B, Pisani MA, Lusczek ER, Knauert MP. Enhancing cosinor analysis of circadian phase markers using the gamma distribution. Sleep Medicine 2022, 92: 1-3. PMID: 35306404, PMCID: PMC9356385, DOI: 10.1016/j.sleep.2022.01.015.
- Gohar A, Knauert M, Kalot M, Khan A, Sider D, Javed M, Wooldridge D, Eck L, Buckhold F, Colaco B, Bhat A, Castillo D, Newman R, Mustafa R. Influence of medical trainee sleep pattern (chronotype) on burn-out and satisfaction with work schedules: a multicentre observational study. Postgraduate Medical Journal 2021, 98: 936-941. PMID: 37062998, PMCID: PMC10074556, DOI: 10.1136/postgradmedj-2021-140975.
- Intihar T, Wasden K, Knauert M. LIGHT PATTERNS OF THE MEDICAL ICU: ARE WE DISRUPTING CIRCADIAN RHYTHMS? CHEST Journal 2021, 160: a2424. DOI: 10.1016/j.chest.2021.07.2095.
- Wasden K, Intihar T, Knauert M. LIGHT SPECTRA: AN IMPORTANT CONSIDERATION FOR CIRCADIAN ALIGNMENT IN THE MEDICAL ICU. CHEST Journal 2021, 160: a2425. DOI: 10.1016/j.chest.2021.07.2096.
- Doyle MM, Murphy TE, Pisani MA, Yaggi HK, Jeon S, Redeker NS, Knauert MP. A SAS macro for modelling periodic data using cosinor analysis. Computer Methods And Programs In Biomedicine 2021, 209: 106292. PMID: 34380075, PMCID: PMC8435001, DOI: 10.1016/j.cmpb.2021.106292.
- Mansour W, Knauert M. 681 Sleep Apnea Severity and COVID-19 Hospitalization Outcomes: Interim Analysis. Sleep 2021, 44: a266-a266. PMCID: PMC8135644, DOI: 10.1093/sleep/zsab072.679.
- Korwin A, Honiden S, Intihar T, Wasden K, Powierza C, Knauert M. Intermittent Feeding in Mechanically Ventilated Medical Intensive Care Unit Patients: Preliminary Outcomes. 2021, a2889-a2889. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2889.
- Korwin A, Honiden S, Intihar T, Wasden K, Heard A, Powierza C, Knauert M. A Pilot Protocol for Intermittent Feeding in Mechanically Ventilated Medical Intensive Care Unit Patients. 2021, a2879-a2879. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2879.
- Lusczek ER, Knauert MP. Light Levels in ICU Patient Rooms: Dimming of Daytime Light in Occupied Rooms. Journal Of Patient Experience 2021, 8: 23743735211033104. PMID: 34368424, PMCID: PMC8312159, DOI: 10.1177/23743735211033104.
- Doyle M, Murphy T, Knauert M. A SAS Macro for Cosinor Analysis of Automated Heart Rate Data in the ICU. Innovation In Aging 2020, 4: 210-210. PMCID: PMC7740472, DOI: 10.1093/geroni/igaa057.679.
- Lutchmansingh DD, Knauert MP, Antin-Ozerkis DE, Chupp G, Cohn L, Dela Cruz CS, Ferrante LE, Herzog EL, Koff J, Rochester CL, Ryu C, Singh I, Tickoo M, Winks V, Gulati M, Possick JD. A Clinic Blueprint for Post-Coronavirus Disease 2019 RECOVERY Learning From the Past, Looking to the Future. CHEST Journal 2020, 159: 949-958. PMID: 33159907, PMCID: PMC7641526, DOI: 10.1016/j.chest.2020.10.067.
- Knauert MP, Murphy TE, Doyle MM, Pisani MA, Redeker NS, Yaggi HK. Pilot Observational Study to Detect Diurnal Variation and Misalignment in Heart Rate Among Critically Ill Patients. Frontiers In Neurology 2020, 11: 637. PMID: 32760341, PMCID: PMC7373742, DOI: 10.3389/fneur.2020.00637.
- Gao C, Knauert M. Circadian Biology and Its Importance to Intensive Care Unit Care and Outcomes. Seminars In Respiratory And Critical Care Medicine 2019, 40: 629-637. PMID: 31826263, DOI: 10.1055/s-0039-1698394.
- Knauert MP, Pisani M, Redeker N, Murphy T, Araujo K, Jeon S, Yaggi H. Pilot study: an intensive care unit sleep promotion protocol. BMJ Open Respiratory Research 2019, 6: e000411. PMID: 31258916, PMCID: PMC6561389, DOI: 10.1136/bmjresp-2019-000411.
- Knauert M, Pisani M. Chapter 19 Sleep in Hospitalized Patients. 2019, 411-437. DOI: 10.1016/b978-0-12-813014-8.00019-6.
- Knauert MP, Gilmore EJ, Murphy TE, Yaggi HK, Van Ness PH, Han L, Hirsch LJ, Pisani MA. Association between death and loss of stage N2 sleep features among critically Ill patients with delirium. Journal Of Critical Care 2018, 48: 124-129. PMID: 30179762, PMCID: PMC6226351, DOI: 10.1016/j.jcrc.2018.08.028.
- Altman MT, Pulaski C, Mburu F, Pisani MA, Knauert MP. Non-circadian signals in the intensive care unit: Point prevalence morning, noon and night. Heart & Lung 2018, 47: 610-615. PMID: 30143362, PMCID: PMC6234066, DOI: 10.1016/j.hrtlng.2018.07.011.
- Heavner M, Nguyen N, Knauert M, Verceles A, Pisani M, Seung H, Gonzales J. Survey of clinical pharmacist perceptions and practices in promoting sleep in intensive care unit patients. JACCP JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY 2018, 2: 46-52. DOI: 10.1002/jac5.1027.
- Altman MT, Knauert MP, Murphy TE, Ahasic AM, Chauhan Z, Pisani MA. Association of intensive care unit delirium with sleep disturbance and functional disability after critical illness: an observational cohort study. Annals Of Intensive Care 2018, 8: 63. PMID: 29740704, PMCID: PMC5940933, DOI: 10.1186/s13613-018-0408-4.
- Knauert MP, Redeker NS, Yaggi HK, Bennick M, Pisani MA. Creating Naptime. Journal Of Patient Experience 2018, 5: 180-187. PMID: 30214923, PMCID: PMC6134539, DOI: 10.1177/2374373517747242.
- Nguyen N, Heavner M, Gonzales J, Verceles A, Pisani M, Knauert M. 940. Critical Care Medicine 2018, 46: 453. DOI: 10.1097/01.ccm.0000528947.29749.ed.
- Perkins M, Knauert M, Honiden S, Siner J, Ma J, Lee D, Pinker E, Pisani M. Rothman Index Predicts ICU Mortality at 24 Hours. CHEST Journal 2017, 152: a332. DOI: 10.1016/j.chest.2017.08.358.
- Altman M, Knauert M, Ahasic A, Chauhan Z, Pisani M. Delirium is Associated With Sleep Disturbance After Critical Illness. CHEST Journal 2017, 152: a1066. DOI: 10.1016/j.chest.2017.08.1100.
- Ding Q, Redeker NS, Pisani MA, Yaggi HK, Knauert MP. Factors Influencing Patients' Sleep in the Intensive Care Unit: Perceptions of Patients and Clinical Staff. American Journal Of Critical Care 2017, 26: 278-286. PMID: 28668912, PMCID: PMC5559223, DOI: 10.4037/ajcc2017333.
- Altman MT, Knauert MP, Pisani MA. Sleep Disturbance after Hospitalization and Critical Illness: A Systematic Review. Annals Of The American Thoracic Society 2017, 14: 1457-1468. PMID: 28644698, PMCID: PMC5711402, DOI: 10.1513/annalsats.201702-148sr.
- Knauert MP, Kamdar BB. Reply: Sleep in the Intensive Care Unit Is a Priority. Annals Of The American Thoracic Society 2016, 13: 1868-1869. PMID: 27726437, PMCID: PMC5122496, DOI: 10.1513/annalsats.201607-578le.
- Kamdar BB, Knauert MP, Jones SF, Parsons EC, Parthasarathy S, Pisani MA. Perceptions and Practices Regarding Sleep in the Intensive Care Unit. A Survey of 1,223 Critical Care Providers. Annals Of The American Thoracic Society 2016, 13: 1370-7. PMID: 27104770, PMCID: PMC5021080, DOI: 10.1513/annalsats.201601-087oc.
- Knauert M, Jeon S, Murphy TE, Yaggi HK, Pisani MA, Redeker NS. Comparing average levels and peak occurrence of overnight sound in the medical intensive care unit on A-weighted and C-weighted decibel scales. Journal Of Critical Care 2016, 36: 1-7. PMID: 27546739, PMCID: PMC5097003, DOI: 10.1016/j.jcrc.2016.06.005.
- Knauert MP, Haspel JA, Pisani MA. Sleep Loss and Circadian Rhythm Disruption in the Intensive Care Unit. Clinics In Chest Medicine 2015, 36: 419-429. PMID: 26304279, DOI: 10.1016/j.ccm.2015.05.008.
- Knauert MP, Malik V, Kamdar BB. Sleep and Sleep Disordered Breathing in Hospitalized Patients. Seminars In Respiratory And Critical Care Medicine 2014, 35: 582-592. PMID: 25353103, DOI: 10.1055/s-0034-1390080.
- Knauert MP, Yaggi HK, Redeker NS, Murphy TE, Araujo KL, Pisani MA. Feasibility study of unattended polysomnography in medical intensive care unit patients. Heart & Lung 2014, 43: 445-452. PMID: 25023504, PMCID: PMC4150840, DOI: 10.1016/j.hrtlng.2014.06.049.
- Knauert M, Yaggi H, Redeker N, Murphy T, Araujo K, Pisani M. Sources of Overnight Patient Sleep Disruption in the Medical Intensive Care Unit. CHEST Journal 2012, 142: 547a-547b. DOI: 10.1378/chest.1383037.
- Kalish J, Knauert M, Hegan D, Glazer P. 708. Gene Targeting with Triplex-Forming Oligonucletides in the Pyrimidine Motif. Molecular Therapy 2006, 13: s273-s274. DOI: 10.1016/j.ymthe.2006.08.787.
- Knauert M, Glazer P. Triplex forming oligonucleotides: sequence-specific tools for gene targeting. Human Molecular Genetics 2001, 10: 2243-2251. PMID: 11673407, DOI: 10.1093/hmg/10.20.2243.
- Zhao H, Sheffield L, Pakstis A, Knauert M, Kidd K. A more powerful method to evaluate p‐values in GENEHUNTER. Genetic Epidemiology 1999, 17: s415-s420. PMID: 10597472, DOI: 10.1002/gepi.1370170770.
Departments and Programs
Locations
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- Yale Sleep Medicine Centers1291 Boston Post RoadMadison, CT 06443
- Yale Sleep Medicine Centers8 Devine StreetNorth Haven, CT 06473
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1 of 2
- Yale Sleep Medicine Centers1291 Boston Post RoadMadison, CT 06443
- Yale Sleep Medicine Centers8 Devine StreetNorth Haven, CT 06473