Joe El-Khoury, PhD, DABCC, FACB
Laboratory Medicine
Titles
- Associate Professor of Laboratory Medicine
- Director, Clinical Chemistry, Laboratory Medicine
- Director, Clinical Chemistry Fellowship Program, Laboratory Medicine
Education & Training
- Postdoctoral FellowshipCleveland Clinic (2014)
- PhDCleveland State Univ (2012)
- BSAmerican University of Beirut (2008)
Languages Spoken
- العربية (Arabic)
- English
- Français (French)
Additional Information
Honors & Recognitions
- 2024 Mentor of the Year: Association for Diagnostics and Laboratory Medicine's Society for Young Clinical Laboratorians (SYCL) (2024)
- 2023 IFCC Young Investigator Award: International Federation for Clinical Chemistry and Laboratory Medicine (2023)
- Outstanding Teaching in Laboratory Medicine: Yale School of Medicine (2021)
- George Grannis Award for Excellence in Research and Scientific Publication: National Academy of Clinical Biochemistry (2016)
- Outstanding Teaching in Laboratory Medicine: Yale University School of Medicine (2015)
- First Place, F. Merlin Bumpus Ph.D. Junior Investigator Award in Clinical Research: Cleveland Clinic (2013)
- Young Investigator Award: Mass Spectrometry Applications to the Clinical Lab (2013)
- Domestic Travel Grant: Society for Young Clinical Laboratorians (2012)
- American Association for Clinical Chemistry Past-Presidents’ Scholarship: American Association for Clinical Chemistry (2012)
Professional Service
- Clinical Biochemistry (2022 - Present): Associate Editor
- International Federation of Clinical Chemistry Committee on Kidney Diseases (2021 - Present): Chair
- Clinical Chemistry (2021 - Present): Reviewer
- American Association for Clinical Chemistry (2021 - Present): Board of Directors
- Practical Laboratory Medicine (2021 - Present): Guest Editor
- American Association for Clinical Chemistry Annual Meeting Organizing Committee (2020 - 2021): Board Member
- Society for Young Clinical Laboratorians (2016 - 2021): Board Member
- The Journal of Applied Laboratory Medicine (2016 - Present): Reviewer
- Neuroscience (2015 - Present): Reviewer
- Northeast Ohio Local Section Executive Committee of the American Association for Clinical Chemistry (2013 - 2014): Coordinator
Publications
- Spies N, Militello L, Farnsworth C, El-Khoury J, Durant T, Zaydman M. Prospective and External Validation of an Ensemble Learning Approach to Sensitively Detect Intravenous Fluid Contamination in Basic Metabolic Panels. Clinical Chemistry 2024, hvae168. PMID: 39545815, DOI: 10.1093/clinchem/hvae168.
- Takieddine L, El-Khoury J. Laboratory Anomalies in the Basic Metabolic Panel: Core Curriculum 2025. American Journal Of Kidney Diseases 2024 PMID: 39396361, DOI: 10.1053/j.ajkd.2024.06.019.
- El-Khoury J. Breaking the Chain: Navigating the Pitfalls of Total Laboratory Automation. The Journal Of Applied Laboratory Medicine 2024, 9: 1095-1096. PMID: 39225460, DOI: 10.1093/jalm/jfae061.
- Cao J, Donato L, El-Khoury J, Goldberg A, Meeusen J, Remaley A. ADLM Guidance Document on the Measurement and Reporting of Lipids and Lipoproteins. The Journal Of Applied Laboratory Medicine 2024, 9: 1040-1056. PMID: 39225455, DOI: 10.1093/jalm/jfae057.
- Choucair I, Shang E, Tran M, Cassella-McLane G, El-Khoury J. Direct analysis in real time mass spectrometry (DART-MS/MS) for rapid urine opioid detection in a clinical setting. Clinica Chimica Acta 2024, 564: 119939. PMID: 39197698, DOI: 10.1016/j.cca.2024.119939.
- El-Khoury J. ChatGPT: A Reliable Laboratory Medicine Consult? Clinical Chemistry 2024, 70: 1089-1091. PMID: 39045739, DOI: 10.1093/clinchem/hvae100.
- Militello L, El-Khoury J, Durant T. Accounting for differences between serum and plasma: An indirect approach to derive reference intervals for total protein, albumin, and globulin. Clinica Chimica Acta 2024, 562: 119851. PMID: 38977172, DOI: 10.1016/j.cca.2024.119851.
- Chaves Rivera M, Choucair I, Vera M, El-Khoury J, Figueroa Villalba C. Puzzling undetectable haptoglobin in a transfused pregnant patient. Clinica Chimica Acta 2024, 561: 119829. PMID: 38917868, DOI: 10.1016/j.cca.2024.119829.
- El-Khoury J, Badrick T, Theodorsson E. Time to Reevaluate the 95% Inclusion Criteria for Defining Reference Intervals? Clinical Chemistry 2024, 70: 700-702. PMID: 38498011, DOI: 10.1093/clinchem/hvae026.
- Jiao J, Bernard P, Meeusen J, Militello L, El-Khoury J. Glycerol Kinase Deficiency with Increased Triglycerides and Weight Gain: Pseudo or Real? Clinical Chemistry 2024, 70: 703-706. PMID: 38692658, DOI: 10.1093/clinchem/hvae032.
- Ghazi L, Farhat K, Hoenig M, Durant T, El-Khoury J. Biomarkers vs Machines: The Race to Predict Acute Kidney Injury. Clinical Chemistry 2024, 70: 805-819. PMID: 38299927, DOI: 10.1093/clinchem/hvad217.
- Safdar B, Sobiesk M, Bertsimas D, Nowroozpoor A, Deng Y, D’Onofrio G, Dziura J, El-Khoury J, Guo X, Simonov M, Taylor R, Wang M, Desir G. Renalase Identified by Machine Learning Methods as A Novel Independent Predictor of Mortality in Hospitalized Patients with COVID-19. Journal Of Biotechnology And Biomedicine 2024, 07 DOI: 10.26502/jbb.2642-91280139.
- Malaeb H, Vera M, Sangal R, Venkatesh A, Possick S, Maciejak L, Oberle E, El-Khoury J. Rapid serum tubes reduce transport hemolysis and false positive rates for high-sensitivity troponin T. Clinica Chimica Acta 2023, 551: 117630. PMID: 37931733, DOI: 10.1016/j.cca.2023.117630.
- Shang E, Choucair I, El-Khoury J. Unexpected Negative Zolpidem Urine Drug Test in a Compliant Patient. Clinical Chemistry 2023, 69: 1435-1436. PMID: 38037440, DOI: 10.1093/clinchem/hvad149.
- Malaeb H, Vera M, Sangal R, Venkatesh A, Possick S, Maciejak L, Oberle E, El-Khoury J. Rapid serum tubes reduce transport hemolysis and false positive rates for high-sensitivity troponin T. Clinica Chimica Acta 2023, 551: 117630. PMID: 38420909, DOI: 10.1016/j.cca.2023.117630.
- El-Khoury J, Karger A, Cavalier E, Kalyesubula R, Teo B, Costa e Silva V, Inker L. International Perspectives on GFR Estimation and Race-Based Adjustments. Clinical Chemistry 2023, 69: 796-802. PMID: 37453046, DOI: 10.1093/clinchem/hvad095.
- El-Khoury J. Laboratory-developed tests: The forgotten majority. American Journal Of Clinical Pathology 2023, 160: 541-541. PMID: 37449363, DOI: 10.1093/ajcp/aqad080.
- Tolan N, Krasowski M, Mathias P, Wiencek J, Babic N, Chai P, Chambliss A, Choucair I, Demetriou C, Erickson T, Feldhammer M, French D, Hayes B, Kang P, El-Khoury J, Knezevic C, Monte A, Nerenz R, Okorodudu A, Roper S, Saitman A, Thiriveedhi V, Uljon S, Vest A, Woodworth A, Yu M, Melanson S. Cannabis positivity rates in 17 emergency departments across the United States with varying degrees of marijuana legalization. Journal Of Toxicology Clinical Toxicology 2023, 61: 248-259. PMID: 37129223, PMCID: PMC10793079, DOI: 10.1080/15563650.2023.2177552.
- Malaeb H, Vera M, Figueroa Villalba C, El-Khoury J. Hemolysis or wine? A case of red-wine-colored plasma. Clinica Chimica Acta 2023, 542: 117277. PMID: 36870523, DOI: 10.1016/j.cca.2023.117277.
- El-Khoury J. Seasonal Variation and Thyroid Function Testing: Source of Misdiagnosis and Levothyroxine Over-Prescription. Clinical Chemistry 2023, 69: 537-538. PMID: 36857303, DOI: 10.1093/clinchem/hvad017.
- Malaeb H, El-Khoury J. Vitamin D and Bone Fractures Revisited. Clinical Chemistry 2023, 69: 209-209. PMID: 36724482, DOI: 10.1093/clinchem/hvac196.
- Choucair I, Villalba C, Vera M, Cassella-Mclane G, Durant T, El-Khoury J. A preliminary study of hydrocodone and hydromorphone to oxycodone ratios for distinguishing impurities from independent opioid use. Clinical Biochemistry 2022, 112: 6-10. PMID: 36535386, DOI: 10.1016/j.clinbiochem.2022.12.009.
- Villalba C, Choucair I, El-Khoury J. Compliance or Abuse? Detectable hydromorphone in patients taking oxycodone. American Journal Of Clinical Pathology 2022, 158: s5-s6. DOI: 10.1093/ajcp/aqac126.008.
- Villalba C, Choucair I, Vera M, Lee E, El-Khoury J. Low haptoglobin in pregnancy: physiological or intravascular hemolysis? American Journal Of Clinical Pathology 2022, 158: s6-s6. DOI: 10.1093/ajcp/aqac126.009.
- Knezevic CE, Das B, El-Khoury JM, Jannetto PJ, Lacbawan F, Winter WE. Rising to the Challenge: Shortages in Laboratory Medicine. Clinical Chemistry 2022, 68: 1486-1492. PMID: 36301321, DOI: 10.1093/clinchem/hvac179.
- Choucair I, Lee ES, Vera MA, Drongmebaro C, El-Khoury JM, Durant TJS. Contamination of clinical blood samples with crystalloid solutions: An experimental approach to derive multianalyte delta checks. Clinica Chimica Acta 2022, 538: 22-28. PMID: 36309069, DOI: 10.1016/j.cca.2022.10.011.
- Choucair I, Cassella-Mclane G, Rogers K, Durant T, El-Khoury J. An Unusual Case of High 6-Monoacetylmorphine and Low Morphine in Urine: Heroin Abuse or Analytical Error? Clinical Chemistry 2022, 68: 1344-1345. PMID: 37619530, DOI: 10.1093/clinchem/hvac110.
- Verma A, Figueroa Villalba C, Choucair I, El-Khoury JM. A case of spuriously low serum creatinine concentrations in a patient with acetaminophen poisoning. Clinica Chimica Acta 2022, 535: 195-196. PMID: 36075459, DOI: 10.1016/j.cca.2022.09.001.
- Vera MA, Koch CD, El-Khoury JM. Resolving icteric interference by a novel photoisomerization device: Bilibox. Clinical Biochemistry 2022, 115: 112-115. PMID: 35882276, DOI: 10.1016/j.clinbiochem.2022.07.004.
- Vera MA, El-Khoury JM, Thorp H, Tofel RJ, Ross JS, Mandavilli A, Topol E. Public Misinformation and Science Communication in Times of Public Health Crises. Clinical Chemistry 2022, 68: 1008-1014. PMID: 35675305, DOI: 10.1093/clinchem/hvac088.
- El-Khoury JM. Advances in laboratory detection of acute kidney injury. Practical Laboratory Medicine 2022, 31: e00287. PMID: 35965846, PMCID: PMC9363638, DOI: 10.1016/j.plabm.2022.e00287.
- El-Khoury J. Pandemic Reflections. Clinical Chemistry 2022, 68: 742-743. DOI: 10.1093/clinchem/hvab209.
- Vera MA, Eid T, El-Khoury JM. Effects of Bovine Hemoglobin on Chemistry Testing: Pseudohemolysis or Real? Clinical Chemistry 2022, 68: 607-608. PMID: 36103316, DOI: 10.1093/clinchem/hvab222.
- Jacobs JW, Gisriel SD, Iyer K, Hauser RG, El-Khoury JM. Unexpectedly low hemoglobin A1c in a patient with chronic lymphocytic leukemia. Clinica Chimica Acta 2022, 531: 91-93. PMID: 35351433, DOI: 10.1016/j.cca.2022.03.012.
- Koch CD, Vera MA, El-Khoury JM. Rapid serum clot tubes reduce haemolysis due to pneumatic tube transport. Journal Of Clinical Pathology 2022, 75: 643-645. PMID: 35273119, DOI: 10.1136/jclinpath-2021-208126.
- Safdar B, Wang M, Guo X, Cha C, Chun HJ, Deng Y, Dziura J, El-Khoury JM, Gorelick F, Ko AI, Lee AI, Safirstein R, Simonov M, Zhou B, Desir GV. Association of renalase with clinical outcomes in hospitalized patients with COVID-19. PLOS ONE 2022, 17: e0264178. PMID: 35259186, PMCID: PMC8903289, DOI: 10.1371/journal.pone.0264178.
- Vera MA, Sutphin A, Hansen L, El-Khoury JM. Resolving Pseudohyponatremia: Validation of Plasma Sodium on Radiometer ABL800 Blood Gas Analyzers for Immediate Reflex Testing. Lab Medicine 2022, 53: e105-e108. PMID: 35015890, DOI: 10.1093/labmed/lmab114.
- El-Khoury JM. A Horseback Riding Lesson in Leadership. The Journal Of Applied Laboratory Medicine 2022, 7: 629-631. PMID: 34993546, DOI: 10.1093/jalm/jfab160.
- Chen T, Coca S, Thiessen-Philbrook H, Heerspink H, Obeid W, Ix J, Fried L, Bonventre J, El-Khoury J, Shlipak M, Parikh C. Urinary Biomarkers of Tubular Health and Risk for Kidney Function Decline or Mortality in Diabetes. American Journal Of Nephrology 2022, 53: 775-785. PMID: 36630924, PMCID: PMC10006337, DOI: 10.1159/000528918.
- Vera MA, Koch CD, Liapakis A, Lim JK, El-Khoury JM. The ALT upper reference interval debate: Blame it on the alcohol. Clinica Chimica Acta 2021, 526: 62-65. PMID: 34973184, DOI: 10.1016/j.cca.2021.12.026.
- Hauser RG, Gisriel S, El-Khoury J. The Surprising Absence of a Laboratory Result Standard. American Journal Of Clinical Pathology 2021, 157: 642-643. PMID: 34871342, DOI: 10.1093/ajcp/aqab198.
- Li P, Koch CD, El-Khoury JM. Increased Lipemia Index in a Dark Green Sample from a Patient after Heart Transplant. Clinical Chemistry 2021, 67: 1575-1576. PMID: 36103299, DOI: 10.1093/clinchem/hvab080.
- Vera MA, Koch CD, Kavsak PA, El-Khoury JM. Determination of 97.5th and 99th percentile upper reference limits for heart-type fatty acid-binding protein (H-FABP) in a US population. Clinica Chimica Acta 2021, 523: 397-401. PMID: 34666029, DOI: 10.1016/j.cca.2021.10.011.
- Patel K, El-Khoury JM, Kataria Y, Wheeler S, Hackenmueller S. The 2021 PhD Board-Certified Clinical Chemist Compensation Survey. The Journal Of Applied Laboratory Medicine 2021, 6: 1655-1659. PMID: 34427677, DOI: 10.1093/jalm/jfab105.
- Li P, Koch CD, El-Khoury JM. Perimenopausal woman with elevated serum hCG and abdominal pain. Clinica Chimica Acta 2021, 522: 141-143. PMID: 34418366, DOI: 10.1016/j.cca.2021.08.018.
- Binns TC, Koch CD, Durant TJS, El-Khoury JM. CO-Oximetry Interference in a Patient with Dyspnea Refractory to Oxygen Therapy. The Journal Of Applied Laboratory Medicine 2021, 6: 1671-1676. PMID: 34383919, DOI: 10.1093/jalm/jfab071.
- El-Khoury JM, Schulz WL, Durant TJS. Longitudinal Assessment of SARS-CoV-2 Anti-Nucleocapsid and anti-Spike-1-RBD Antibody Testing Following PCR-Detected SARS-CoV-2 Infection. The Journal Of Applied Laboratory Medicine 2021, 6: jfab030-. PMID: 33822964, PMCID: PMC8083453, DOI: 10.1093/jalm/jfab030.
- Koch CD, Vera MA, Messina J, Price N, Durant TJS, El-Khoury JM. Preventing pseudohyponatremia: Intralipid®-based lipemia cutoffs for sodium are inappropriate. Clinica Chimica Acta 2021, 520: 63-66. PMID: 34077753, DOI: 10.1016/j.cca.2021.05.032.
- Koch CD, Vera MA, Paulson N, El-Khoury JM. The case of the hyponatremias. Clinica Chimica Acta 2021, 520: 76-77. PMID: 34048733, DOI: 10.1016/j.cca.2021.05.023.
- Patel K, El-Khoury JM, Aarsand AK, Badrick T, Jones GRD, Sikaris K, Parnas ML. Current Utility and Reliability of Biological Variability. Clinical Chemistry 2021, 67: 1050-1055. PMID: 33993263, DOI: 10.1093/clinchem/hvab055.
- El-Khoury JM, Hoenig MP, Jones GRD, Lamb EJ, Parikh CR, Tolan NV, Wilson FP. AACC Guidance Document on Laboratory Investigation of Acute Kidney Injury. The Journal Of Applied Laboratory Medicine 2021, 6: 1316-1337. PMID: 33973621, DOI: 10.1093/jalm/jfab020.
- Moderators:, El-Khoury JM, Ovalle AA, Cervinski MA, Experts:, Levey AS, Jones G, Eneanya ND, Lieske JC, Jha V. Is It Time to Move On? Reexamining Race in Glomerular Filtration Rate Equations. Clinical Chemistry 2021, 67: 585-591. PMID: 33686430, DOI: 10.1093/clinchem/hvaa333.
- Patel M, El-Khoury JM, Simundic E, Farnsworth CW, Broell F, Genzen JR, Amukele TK. Evolution of Blood Sample Transportation and Monitoring Technologies. Clinical Chemistry 2021, 67: 812-819. PMID: 33615326, DOI: 10.1093/clinchem/hvab001.
- El-Khoury JM. The Dimethylarginines (Asymmetric and Symmetric): A Deadly Combination in Sepsis. The Journal Of Applied Laboratory Medicine 2021, 6: 577-579. PMID: 33544823, DOI: 10.1093/jalm/jfaa241.
- Koch CD, Paulson N, Vera MA, Loza A, El-Khoury JM. Elevated Lipemia Index in Dark-Brown Plasma from a Bronze Baby. Clinical Chemistry 2020, 67: 447-448. PMID: 33523217, DOI: 10.1093/clinchem/hvaa146.
- Bunch DR, Firmender K, Harb R, El-Khoury JM. First- and Second-Trimester Reference Intervals for Thyroid Function Testing in a US Population. American Journal Of Clinical Pathology 2020, 155: 776-780. PMID: 33210132, DOI: 10.1093/ajcp/aqaa165.
- El-Khoury JM. Nephrocheck®: Checkmate or reality check? Annals Of Clinical Biochemistry International Journal Of Laboratory Medicine 2020, 58: 3-5. PMID: 33016084, DOI: 10.1177/0004563220967581.
- Koch CD, Xu L, Curtis SA, Roberts JD, Bunch DR, El-Khoury JM. Urinary cannabinoid mass spectrometry profiles differentiate dronabinol from cannabis use. Clinica Chimica Acta 2020, 510: 515-521. PMID: 32795544, DOI: 10.1016/j.cca.2020.08.014.
- Koch CD, El-Khoury JM. New Sampson Low-Density Lipoprotein Equation: Better Than Friedewald and Martin-Hopkins. Clinical Chemistry 2020, 66: 1120-1121. PMID: 32746460, DOI: 10.1093/clinchem/hvaa126.
- Mansour SG, Liu C, Jia Y, Reese PP, Hall IE, El-Achkar TM, LaFavers KA, Obeid W, Rosenberg AZ, Daneshpajouhnejad P, Doshi MD, Akalin E, Bromberg JS, Harhay MN, Mohan S, Muthukumar T, Schröppel B, Singh P, El-Khoury JM, Weng FL, Thiessen-Philbrook HR, Parikh CR. Uromodulin to Osteopontin Ratio in Deceased Donor Urine Is Associated With Kidney Graft Outcomes. Transplantation 2020, 105: 876-885. PMID: 32769629, PMCID: PMC8805736, DOI: 10.1097/tp.0000000000003299.
- Hultgren C, Rogers K, Bunch DR, El-Khoury JM. Investigating Interference with Lamotrigine Quantification by Liquid Chromatography–Tandem Mass Spectrometry. The Journal Of Applied Laboratory Medicine 2020, 5: 609-611. PMID: 32445366, DOI: 10.1093/jalm/jfaa007.
- Bunch DR, El-Khoury JM, Colby J, Colon-Franco J, Hackenmueller SA, Olson KN, Cotten SW, Kampfrath T, Chittiprol S, Suh-Lailam B, French D, Isbell TS, Nerenz RD, Parnas ML, Tolan NV. The 2018 AACC/SYCL PhD Clinical Chemist Compensation Survey. The Journal Of Applied Laboratory Medicine 2020, 5: 377-387. PMID: 32445390, DOI: 10.1093/jalm/jfaa001.
- El-Khoury JM, Remaley AT, Nordestgaard BG, Kaufman HW, Mora S, Cao J, Meeusen JW. Perspectives on the Changing Landscape of Measuring Cardiovascular Risk Related to LDL. Clinical Chemistry 2019, 65: 1487-1492. PMID: 31699699, DOI: 10.1373/clinchem.2019.307306.
- Practical Approach to Eliminate Bilirubin Interference in Icteric Samples for Creatinine MeasurementCharifa A, Bunch DR, El-Khoury JM. Practical Approach to Eliminate Bilirubin Interference in Icteric Samples for Creatinine Measurement. The Journal Of Applied Laboratory Medicine 2019, 4: 477-479. PMID: 31659092, DOI: 10.1373/jalm.2019.030247.
- Gall B, El-Khoury JM. Unusual Drug Test Results for a Patient on Buprenorphine and Naloxone. Clinical Chemistry 2019, 65: 1332-1333. PMID: 31570415, DOI: 10.1373/clinchem.2019.309484.
- Mansour SG, Martin TG, Obeid W, Pata RW, Myrick KM, Kukova L, Jia Y, Bjornstad P, El-Khoury JM, Parikh CR. The Role of Volume Regulation and Thermoregulation in AKI during Marathon Running. Clinical Journal Of The American Society Of Nephrology 2019, 14: 1297-1305. PMID: 31413064, PMCID: PMC6730516, DOI: 10.2215/cjn.01400219.
- Charifa A, El-Khoury JM. Hyperhomocysteinemia in a Gammopathy Patient: Malnutrition or Interference? Clinical Chemistry 2019, 65: 1063-1064. PMID: 31358504, DOI: 10.1373/clinchem.2019.302752.
- Kukova LZ, Mansour SG, Coca SG, de Fontnouvelle CA, Thiessen-Philbrook HR, Shlipak MG, El-Khoury JM, Parikh CR. Comparison of Urine and Plasma Biomarker Concentrations Measured by Aptamer-Based versus Immunoassay Methods in Cardiac Surgery Patients. The Journal Of Applied Laboratory Medicine 2019, 4: 331-342. PMID: 31659071, DOI: 10.1373/jalm.2018.028621.
- Charifa A, Bunch DR, El-Khoury JM. Erratic Serum Creatinine Concentrations in a Cardiac Patient. Clinical Chemistry 2018, 64: 1543-1544. PMID: 30266720, DOI: 10.1373/clinchem.2017.285858.
- Bunch DR, El-Khoury JM. Emerging Biomarker of Kidney Disease: suPAR or Subpar? Clinical Chemistry 2018, 64: 1545-1547. PMID: 32100860, DOI: 10.1373/clinchem.2018.293167.
- El-Khoury JM. Commentary. Clinical Chemistry 2018, 64: 445-445. PMID: 29490996, DOI: 10.1373/clinchem.2017.273714.
- El-Khoury JM. Networking and the Career Opportunities It Affords in Clinical Chemistry. The Journal Of Applied Laboratory Medicine 2017, 2: 284-285. PMID: 32630974, DOI: 10.1373/jalm.2016.022210.
- Nadkarni GN, Coca SG, Meisner A, Patel S, Kerr KF, Patel UD, Koyner JL, Garg AX, Philbrook HT, Edelstein CL, Shlipak M, El-Khoury J, Parikh CR, on behalf of the TRIBE-AKI Consortium Investigators. Urinalysis findings and urinary kidney injury biomarker concentrations. BMC Nephrology 2017, 18: 218. PMID: 28683730, PMCID: PMC5499057, DOI: 10.1186/s12882-017-0629-z.
- Roy LD, Dillon LM, Zhou R, Moore LJ, Livasy C, El-Khoury JM, Puri R, Mukherjee P. A tumor specific antibody to aid breast cancer screening in women with dense breast tissue. Genes & Cancer 2017, 8: 536-549. PMID: 28680538, PMCID: PMC5489651, DOI: 10.18632/genesandcancer.134.
- El-Khoury JM, Bunch DR, Hu B, Payto D, Reineks EZ, Wang S. Comparison of symmetric dimethylarginine with creatinine, cystatin C and their eGFR equations as markers of kidney function. Clinical Biochemistry 2016, 49: 1140-1143. PMID: 27452178, DOI: 10.1016/j.clinbiochem.2016.07.009.
- Yang Y, Rogers K, Wardle R, El-Khoury JM. High-throughput measurement of 25-hydroxyvitamin D by LC–MS/MS with separation of the C3-epimer interference for pediatric populations. Clinica Chimica Acta 2016, 454: 102-106. PMID: 26772722, DOI: 10.1016/j.cca.2016.01.004.
- El-Khoury J, Reineks E, Wang S. 1. Angiotensin converting enzyme. 2014, 1-18. DOI: 10.1515/9783110227802.1.
- Reineks E, El-Khoury J, Wang S. 3. Aldolase. 2014, 41-56. DOI: 10.1515/9783110227802.41.
- El-Khoury J, Wang S. 5. Aspartate aminotransferase and alanine aminotransferase. 2014, 81-104. DOI: 10.1515/9783110227802.81.
- Zhang W, Reineks E, El-Khoury J, Wang S. 9. Pancreatic lipase. 2014, 153-180. DOI: 10.1515/9783110227802.153.
- Ansari M, El-Khoury J, Daly T. Screen-Only Tests for Anti-Nuclear Antibodies Lead to Inappropriate Follow-Up in Majority of Cases. American Journal Of Clinical Pathology 2014, 142: a032-a032. DOI: 10.1093/ajcp/142.suppl1.032.
- El-Khoury JM, Wang S. Recent advances in MS methods for nicotine and metabolite analysis in human matrices: clinical perspectives. Bioanalysis 2014, 6: 2171-2183. PMID: 25331861, DOI: 10.4155/bio.14.176.
- El-Khoury JM, Gabler J, Wang S. Measurement of GFR for children and an LC–MS/MS method for nonradioactive iothalamate. Clinical Biochemistry 2014, 47: 749-750. PMID: 24858210, DOI: 10.1016/j.clinbiochem.2014.05.042.
- Abbadi A, El-Khoury JM, Wang S. Stability of serum and plasma osmolality in common clinical laboratory storage conditions. Clinical Biochemistry 2014, 47: 686-687. PMID: 24631174, DOI: 10.1016/j.clinbiochem.2014.02.024.
- Bunch DR, El-Khoury JM, Gabler J, Wang S. Do deuterium labeled internal standards correct for matrix effects in LC-MS/MS assays? A case study using plasma free metanephrine and normetanephrine. Clinica Chimica Acta 2013, 429: 4-5. PMID: 24269502, DOI: 10.1016/j.cca.2013.11.013.
- El-Khoury JM, Bicer F, Bunch DR, Yuan C, Wang S. Does Paricalcitol (Zemplar®) interfere with 1,25-dihydroxyvitamin D measurement by liquid chromatography–tandem mass spectrometry assays? Clinica Chimica Acta 2012, 415: 230-232. PMID: 23142648, DOI: 10.1016/j.cca.2012.10.050.
- Yuan C, Gabler J, El-Khoury JM, Spatholt R, Wang S. Highly sensitive and selective measurement of underivatized methylmalonic acid in serum and plasma by liquid chromatography-tandem mass spectrometry. Analytical And Bioanalytical Chemistry 2012, 404: 133-140. PMID: 22618327, DOI: 10.1007/s00216-012-6099-z.
- El-Khoury JM, Bunch DR, Wang S. Is the Effect of Hemolysis on Plasma Ammonia Measurement Overrated? Archives Of Pathology & Laboratory Medicine 2012, 136: 471-2. PMID: 22540295, DOI: 10.5858/arpa.2011-0445-le.
- El-Khoury JM, Wang S. Stability of 1,25-dihydroxyvitamin D2 and 1,25-dihydroxyvitamin D3 in human serum. Clinical Biochemistry 2012, 45: 707-708. PMID: 22465273, DOI: 10.1016/j.clinbiochem.2012.03.016.
- El-Khoury JM, Bunch DR, Reineks E, Jackson R, Steinle R, Wang S. A simple and fast liquid chromatography–tandem mass spectrometry method for measurement of underivatized l-arginine, symmetric dimethylarginine, and asymmetric dimethylarginine and establishment of the reference ranges. Analytical And Bioanalytical Chemistry 2011, 402: 771-779. PMID: 22124751, DOI: 10.1007/s00216-011-5462-9.
- El-Khoury JM, Reineks EZ, Wang S. Progress of liquid chromatography-mass spectrometry in measurement of vitamin D metabolites and analogues. Clinical Biochemistry 2010, 44: 66-76. PMID: 20493831, DOI: 10.1016/j.clinbiochem.2010.05.007.
Departments and Programs
Titles
- Associate Professor of Laboratory Medicine
- Director, Clinical Chemistry, Laboratory Medicine
- Director, Clinical Chemistry Fellowship Program, Laboratory Medicine
Education & Training
- Postdoctoral FellowshipCleveland Clinic (2014)
- PhDCleveland State Univ (2012)
- BSAmerican University of Beirut (2008)
Languages Spoken
- العربية (Arabic)
- English
- Français (French)
Additional Information
Honors & Recognitions
- 2024 Mentor of the Year: Association for Diagnostics and Laboratory Medicine's Society for Young Clinical Laboratorians (SYCL) (2024)
- 2023 IFCC Young Investigator Award: International Federation for Clinical Chemistry and Laboratory Medicine (2023)
- Outstanding Teaching in Laboratory Medicine: Yale School of Medicine (2021)
- George Grannis Award for Excellence in Research and Scientific Publication: National Academy of Clinical Biochemistry (2016)
- Outstanding Teaching in Laboratory Medicine: Yale University School of Medicine (2015)
- First Place, F. Merlin Bumpus Ph.D. Junior Investigator Award in Clinical Research: Cleveland Clinic (2013)
- Young Investigator Award: Mass Spectrometry Applications to the Clinical Lab (2013)
- Domestic Travel Grant: Society for Young Clinical Laboratorians (2012)
- American Association for Clinical Chemistry Past-Presidents’ Scholarship: American Association for Clinical Chemistry (2012)
Professional Service
- Clinical Biochemistry (2022 - Present): Associate Editor
- International Federation of Clinical Chemistry Committee on Kidney Diseases (2021 - Present): Chair
- Clinical Chemistry (2021 - Present): Reviewer
- American Association for Clinical Chemistry (2021 - Present): Board of Directors
- Practical Laboratory Medicine (2021 - Present): Guest Editor
- American Association for Clinical Chemistry Annual Meeting Organizing Committee (2020 - 2021): Board Member
- Society for Young Clinical Laboratorians (2016 - 2021): Board Member
- The Journal of Applied Laboratory Medicine (2016 - Present): Reviewer
- Neuroscience (2015 - Present): Reviewer
- Northeast Ohio Local Section Executive Committee of the American Association for Clinical Chemistry (2013 - 2014): Coordinator
Publications
- Spies N, Militello L, Farnsworth C, El-Khoury J, Durant T, Zaydman M. Prospective and External Validation of an Ensemble Learning Approach to Sensitively Detect Intravenous Fluid Contamination in Basic Metabolic Panels. Clinical Chemistry 2024, hvae168. PMID: 39545815, DOI: 10.1093/clinchem/hvae168.
- Takieddine L, El-Khoury J. Laboratory Anomalies in the Basic Metabolic Panel: Core Curriculum 2025. American Journal Of Kidney Diseases 2024 PMID: 39396361, DOI: 10.1053/j.ajkd.2024.06.019.
- El-Khoury J. Breaking the Chain: Navigating the Pitfalls of Total Laboratory Automation. The Journal Of Applied Laboratory Medicine 2024, 9: 1095-1096. PMID: 39225460, DOI: 10.1093/jalm/jfae061.
- Cao J, Donato L, El-Khoury J, Goldberg A, Meeusen J, Remaley A. ADLM Guidance Document on the Measurement and Reporting of Lipids and Lipoproteins. The Journal Of Applied Laboratory Medicine 2024, 9: 1040-1056. PMID: 39225455, DOI: 10.1093/jalm/jfae057.
- Choucair I, Shang E, Tran M, Cassella-McLane G, El-Khoury J. Direct analysis in real time mass spectrometry (DART-MS/MS) for rapid urine opioid detection in a clinical setting. Clinica Chimica Acta 2024, 564: 119939. PMID: 39197698, DOI: 10.1016/j.cca.2024.119939.
- El-Khoury J. ChatGPT: A Reliable Laboratory Medicine Consult? Clinical Chemistry 2024, 70: 1089-1091. PMID: 39045739, DOI: 10.1093/clinchem/hvae100.
- Militello L, El-Khoury J, Durant T. Accounting for differences between serum and plasma: An indirect approach to derive reference intervals for total protein, albumin, and globulin. Clinica Chimica Acta 2024, 562: 119851. PMID: 38977172, DOI: 10.1016/j.cca.2024.119851.
- Chaves Rivera M, Choucair I, Vera M, El-Khoury J, Figueroa Villalba C. Puzzling undetectable haptoglobin in a transfused pregnant patient. Clinica Chimica Acta 2024, 561: 119829. PMID: 38917868, DOI: 10.1016/j.cca.2024.119829.
- El-Khoury J, Badrick T, Theodorsson E. Time to Reevaluate the 95% Inclusion Criteria for Defining Reference Intervals? Clinical Chemistry 2024, 70: 700-702. PMID: 38498011, DOI: 10.1093/clinchem/hvae026.
- Jiao J, Bernard P, Meeusen J, Militello L, El-Khoury J. Glycerol Kinase Deficiency with Increased Triglycerides and Weight Gain: Pseudo or Real? Clinical Chemistry 2024, 70: 703-706. PMID: 38692658, DOI: 10.1093/clinchem/hvae032.
- Ghazi L, Farhat K, Hoenig M, Durant T, El-Khoury J. Biomarkers vs Machines: The Race to Predict Acute Kidney Injury. Clinical Chemistry 2024, 70: 805-819. PMID: 38299927, DOI: 10.1093/clinchem/hvad217.
- Safdar B, Sobiesk M, Bertsimas D, Nowroozpoor A, Deng Y, D’Onofrio G, Dziura J, El-Khoury J, Guo X, Simonov M, Taylor R, Wang M, Desir G. Renalase Identified by Machine Learning Methods as A Novel Independent Predictor of Mortality in Hospitalized Patients with COVID-19. Journal Of Biotechnology And Biomedicine 2024, 07 DOI: 10.26502/jbb.2642-91280139.
- Malaeb H, Vera M, Sangal R, Venkatesh A, Possick S, Maciejak L, Oberle E, El-Khoury J. Rapid serum tubes reduce transport hemolysis and false positive rates for high-sensitivity troponin T. Clinica Chimica Acta 2023, 551: 117630. PMID: 37931733, DOI: 10.1016/j.cca.2023.117630.
- Shang E, Choucair I, El-Khoury J. Unexpected Negative Zolpidem Urine Drug Test in a Compliant Patient. Clinical Chemistry 2023, 69: 1435-1436. PMID: 38037440, DOI: 10.1093/clinchem/hvad149.
- Malaeb H, Vera M, Sangal R, Venkatesh A, Possick S, Maciejak L, Oberle E, El-Khoury J. Rapid serum tubes reduce transport hemolysis and false positive rates for high-sensitivity troponin T. Clinica Chimica Acta 2023, 551: 117630. PMID: 38420909, DOI: 10.1016/j.cca.2023.117630.
- El-Khoury J, Karger A, Cavalier E, Kalyesubula R, Teo B, Costa e Silva V, Inker L. International Perspectives on GFR Estimation and Race-Based Adjustments. Clinical Chemistry 2023, 69: 796-802. PMID: 37453046, DOI: 10.1093/clinchem/hvad095.
- El-Khoury J. Laboratory-developed tests: The forgotten majority. American Journal Of Clinical Pathology 2023, 160: 541-541. PMID: 37449363, DOI: 10.1093/ajcp/aqad080.
- Tolan N, Krasowski M, Mathias P, Wiencek J, Babic N, Chai P, Chambliss A, Choucair I, Demetriou C, Erickson T, Feldhammer M, French D, Hayes B, Kang P, El-Khoury J, Knezevic C, Monte A, Nerenz R, Okorodudu A, Roper S, Saitman A, Thiriveedhi V, Uljon S, Vest A, Woodworth A, Yu M, Melanson S. Cannabis positivity rates in 17 emergency departments across the United States with varying degrees of marijuana legalization. Journal Of Toxicology Clinical Toxicology 2023, 61: 248-259. PMID: 37129223, PMCID: PMC10793079, DOI: 10.1080/15563650.2023.2177552.
- Malaeb H, Vera M, Figueroa Villalba C, El-Khoury J. Hemolysis or wine? A case of red-wine-colored plasma. Clinica Chimica Acta 2023, 542: 117277. PMID: 36870523, DOI: 10.1016/j.cca.2023.117277.
- El-Khoury J. Seasonal Variation and Thyroid Function Testing: Source of Misdiagnosis and Levothyroxine Over-Prescription. Clinical Chemistry 2023, 69: 537-538. PMID: 36857303, DOI: 10.1093/clinchem/hvad017.
- Malaeb H, El-Khoury J. Vitamin D and Bone Fractures Revisited. Clinical Chemistry 2023, 69: 209-209. PMID: 36724482, DOI: 10.1093/clinchem/hvac196.
- Choucair I, Villalba C, Vera M, Cassella-Mclane G, Durant T, El-Khoury J. A preliminary study of hydrocodone and hydromorphone to oxycodone ratios for distinguishing impurities from independent opioid use. Clinical Biochemistry 2022, 112: 6-10. PMID: 36535386, DOI: 10.1016/j.clinbiochem.2022.12.009.
- Villalba C, Choucair I, El-Khoury J. Compliance or Abuse? Detectable hydromorphone in patients taking oxycodone. American Journal Of Clinical Pathology 2022, 158: s5-s6. DOI: 10.1093/ajcp/aqac126.008.
- Villalba C, Choucair I, Vera M, Lee E, El-Khoury J. Low haptoglobin in pregnancy: physiological or intravascular hemolysis? American Journal Of Clinical Pathology 2022, 158: s6-s6. DOI: 10.1093/ajcp/aqac126.009.
- Knezevic CE, Das B, El-Khoury JM, Jannetto PJ, Lacbawan F, Winter WE. Rising to the Challenge: Shortages in Laboratory Medicine. Clinical Chemistry 2022, 68: 1486-1492. PMID: 36301321, DOI: 10.1093/clinchem/hvac179.
- Choucair I, Lee ES, Vera MA, Drongmebaro C, El-Khoury JM, Durant TJS. Contamination of clinical blood samples with crystalloid solutions: An experimental approach to derive multianalyte delta checks. Clinica Chimica Acta 2022, 538: 22-28. PMID: 36309069, DOI: 10.1016/j.cca.2022.10.011.
- Choucair I, Cassella-Mclane G, Rogers K, Durant T, El-Khoury J. An Unusual Case of High 6-Monoacetylmorphine and Low Morphine in Urine: Heroin Abuse or Analytical Error? Clinical Chemistry 2022, 68: 1344-1345. PMID: 37619530, DOI: 10.1093/clinchem/hvac110.
- Verma A, Figueroa Villalba C, Choucair I, El-Khoury JM. A case of spuriously low serum creatinine concentrations in a patient with acetaminophen poisoning. Clinica Chimica Acta 2022, 535: 195-196. PMID: 36075459, DOI: 10.1016/j.cca.2022.09.001.
- Vera MA, Koch CD, El-Khoury JM. Resolving icteric interference by a novel photoisomerization device: Bilibox. Clinical Biochemistry 2022, 115: 112-115. PMID: 35882276, DOI: 10.1016/j.clinbiochem.2022.07.004.
- Vera MA, El-Khoury JM, Thorp H, Tofel RJ, Ross JS, Mandavilli A, Topol E. Public Misinformation and Science Communication in Times of Public Health Crises. Clinical Chemistry 2022, 68: 1008-1014. PMID: 35675305, DOI: 10.1093/clinchem/hvac088.
- El-Khoury JM. Advances in laboratory detection of acute kidney injury. Practical Laboratory Medicine 2022, 31: e00287. PMID: 35965846, PMCID: PMC9363638, DOI: 10.1016/j.plabm.2022.e00287.
- El-Khoury J. Pandemic Reflections. Clinical Chemistry 2022, 68: 742-743. DOI: 10.1093/clinchem/hvab209.
- Vera MA, Eid T, El-Khoury JM. Effects of Bovine Hemoglobin on Chemistry Testing: Pseudohemolysis or Real? Clinical Chemistry 2022, 68: 607-608. PMID: 36103316, DOI: 10.1093/clinchem/hvab222.
- Jacobs JW, Gisriel SD, Iyer K, Hauser RG, El-Khoury JM. Unexpectedly low hemoglobin A1c in a patient with chronic lymphocytic leukemia. Clinica Chimica Acta 2022, 531: 91-93. PMID: 35351433, DOI: 10.1016/j.cca.2022.03.012.
- Koch CD, Vera MA, El-Khoury JM. Rapid serum clot tubes reduce haemolysis due to pneumatic tube transport. Journal Of Clinical Pathology 2022, 75: 643-645. PMID: 35273119, DOI: 10.1136/jclinpath-2021-208126.
- Safdar B, Wang M, Guo X, Cha C, Chun HJ, Deng Y, Dziura J, El-Khoury JM, Gorelick F, Ko AI, Lee AI, Safirstein R, Simonov M, Zhou B, Desir GV. Association of renalase with clinical outcomes in hospitalized patients with COVID-19. PLOS ONE 2022, 17: e0264178. PMID: 35259186, PMCID: PMC8903289, DOI: 10.1371/journal.pone.0264178.
- Vera MA, Sutphin A, Hansen L, El-Khoury JM. Resolving Pseudohyponatremia: Validation of Plasma Sodium on Radiometer ABL800 Blood Gas Analyzers for Immediate Reflex Testing. Lab Medicine 2022, 53: e105-e108. PMID: 35015890, DOI: 10.1093/labmed/lmab114.
- El-Khoury JM. A Horseback Riding Lesson in Leadership. The Journal Of Applied Laboratory Medicine 2022, 7: 629-631. PMID: 34993546, DOI: 10.1093/jalm/jfab160.
- Chen T, Coca S, Thiessen-Philbrook H, Heerspink H, Obeid W, Ix J, Fried L, Bonventre J, El-Khoury J, Shlipak M, Parikh C. Urinary Biomarkers of Tubular Health and Risk for Kidney Function Decline or Mortality in Diabetes. American Journal Of Nephrology 2022, 53: 775-785. PMID: 36630924, PMCID: PMC10006337, DOI: 10.1159/000528918.
- Vera MA, Koch CD, Liapakis A, Lim JK, El-Khoury JM. The ALT upper reference interval debate: Blame it on the alcohol. Clinica Chimica Acta 2021, 526: 62-65. PMID: 34973184, DOI: 10.1016/j.cca.2021.12.026.
- Hauser RG, Gisriel S, El-Khoury J. The Surprising Absence of a Laboratory Result Standard. American Journal Of Clinical Pathology 2021, 157: 642-643. PMID: 34871342, DOI: 10.1093/ajcp/aqab198.
- Li P, Koch CD, El-Khoury JM. Increased Lipemia Index in a Dark Green Sample from a Patient after Heart Transplant. Clinical Chemistry 2021, 67: 1575-1576. PMID: 36103299, DOI: 10.1093/clinchem/hvab080.
- Vera MA, Koch CD, Kavsak PA, El-Khoury JM. Determination of 97.5th and 99th percentile upper reference limits for heart-type fatty acid-binding protein (H-FABP) in a US population. Clinica Chimica Acta 2021, 523: 397-401. PMID: 34666029, DOI: 10.1016/j.cca.2021.10.011.
- Patel K, El-Khoury JM, Kataria Y, Wheeler S, Hackenmueller S. The 2021 PhD Board-Certified Clinical Chemist Compensation Survey. The Journal Of Applied Laboratory Medicine 2021, 6: 1655-1659. PMID: 34427677, DOI: 10.1093/jalm/jfab105.
- Li P, Koch CD, El-Khoury JM. Perimenopausal woman with elevated serum hCG and abdominal pain. Clinica Chimica Acta 2021, 522: 141-143. PMID: 34418366, DOI: 10.1016/j.cca.2021.08.018.
- Binns TC, Koch CD, Durant TJS, El-Khoury JM. CO-Oximetry Interference in a Patient with Dyspnea Refractory to Oxygen Therapy. The Journal Of Applied Laboratory Medicine 2021, 6: 1671-1676. PMID: 34383919, DOI: 10.1093/jalm/jfab071.
- El-Khoury JM, Schulz WL, Durant TJS. Longitudinal Assessment of SARS-CoV-2 Anti-Nucleocapsid and anti-Spike-1-RBD Antibody Testing Following PCR-Detected SARS-CoV-2 Infection. The Journal Of Applied Laboratory Medicine 2021, 6: jfab030-. PMID: 33822964, PMCID: PMC8083453, DOI: 10.1093/jalm/jfab030.
- Koch CD, Vera MA, Messina J, Price N, Durant TJS, El-Khoury JM. Preventing pseudohyponatremia: Intralipid®-based lipemia cutoffs for sodium are inappropriate. Clinica Chimica Acta 2021, 520: 63-66. PMID: 34077753, DOI: 10.1016/j.cca.2021.05.032.
- Koch CD, Vera MA, Paulson N, El-Khoury JM. The case of the hyponatremias. Clinica Chimica Acta 2021, 520: 76-77. PMID: 34048733, DOI: 10.1016/j.cca.2021.05.023.
- Patel K, El-Khoury JM, Aarsand AK, Badrick T, Jones GRD, Sikaris K, Parnas ML. Current Utility and Reliability of Biological Variability. Clinical Chemistry 2021, 67: 1050-1055. PMID: 33993263, DOI: 10.1093/clinchem/hvab055.
- El-Khoury JM, Hoenig MP, Jones GRD, Lamb EJ, Parikh CR, Tolan NV, Wilson FP. AACC Guidance Document on Laboratory Investigation of Acute Kidney Injury. The Journal Of Applied Laboratory Medicine 2021, 6: 1316-1337. PMID: 33973621, DOI: 10.1093/jalm/jfab020.
- Moderators:, El-Khoury JM, Ovalle AA, Cervinski MA, Experts:, Levey AS, Jones G, Eneanya ND, Lieske JC, Jha V. Is It Time to Move On? Reexamining Race in Glomerular Filtration Rate Equations. Clinical Chemistry 2021, 67: 585-591. PMID: 33686430, DOI: 10.1093/clinchem/hvaa333.
- Patel M, El-Khoury JM, Simundic E, Farnsworth CW, Broell F, Genzen JR, Amukele TK. Evolution of Blood Sample Transportation and Monitoring Technologies. Clinical Chemistry 2021, 67: 812-819. PMID: 33615326, DOI: 10.1093/clinchem/hvab001.
- El-Khoury JM. The Dimethylarginines (Asymmetric and Symmetric): A Deadly Combination in Sepsis. The Journal Of Applied Laboratory Medicine 2021, 6: 577-579. PMID: 33544823, DOI: 10.1093/jalm/jfaa241.
- Koch CD, Paulson N, Vera MA, Loza A, El-Khoury JM. Elevated Lipemia Index in Dark-Brown Plasma from a Bronze Baby. Clinical Chemistry 2020, 67: 447-448. PMID: 33523217, DOI: 10.1093/clinchem/hvaa146.
- Bunch DR, Firmender K, Harb R, El-Khoury JM. First- and Second-Trimester Reference Intervals for Thyroid Function Testing in a US Population. American Journal Of Clinical Pathology 2020, 155: 776-780. PMID: 33210132, DOI: 10.1093/ajcp/aqaa165.
- El-Khoury JM. Nephrocheck®: Checkmate or reality check? Annals Of Clinical Biochemistry International Journal Of Laboratory Medicine 2020, 58: 3-5. PMID: 33016084, DOI: 10.1177/0004563220967581.
- Koch CD, Xu L, Curtis SA, Roberts JD, Bunch DR, El-Khoury JM. Urinary cannabinoid mass spectrometry profiles differentiate dronabinol from cannabis use. Clinica Chimica Acta 2020, 510: 515-521. PMID: 32795544, DOI: 10.1016/j.cca.2020.08.014.
- Koch CD, El-Khoury JM. New Sampson Low-Density Lipoprotein Equation: Better Than Friedewald and Martin-Hopkins. Clinical Chemistry 2020, 66: 1120-1121. PMID: 32746460, DOI: 10.1093/clinchem/hvaa126.
- Mansour SG, Liu C, Jia Y, Reese PP, Hall IE, El-Achkar TM, LaFavers KA, Obeid W, Rosenberg AZ, Daneshpajouhnejad P, Doshi MD, Akalin E, Bromberg JS, Harhay MN, Mohan S, Muthukumar T, Schröppel B, Singh P, El-Khoury JM, Weng FL, Thiessen-Philbrook HR, Parikh CR. Uromodulin to Osteopontin Ratio in Deceased Donor Urine Is Associated With Kidney Graft Outcomes. Transplantation 2020, 105: 876-885. PMID: 32769629, PMCID: PMC8805736, DOI: 10.1097/tp.0000000000003299.
- Hultgren C, Rogers K, Bunch DR, El-Khoury JM. Investigating Interference with Lamotrigine Quantification by Liquid Chromatography–Tandem Mass Spectrometry. The Journal Of Applied Laboratory Medicine 2020, 5: 609-611. PMID: 32445366, DOI: 10.1093/jalm/jfaa007.
- Bunch DR, El-Khoury JM, Colby J, Colon-Franco J, Hackenmueller SA, Olson KN, Cotten SW, Kampfrath T, Chittiprol S, Suh-Lailam B, French D, Isbell TS, Nerenz RD, Parnas ML, Tolan NV. The 2018 AACC/SYCL PhD Clinical Chemist Compensation Survey. The Journal Of Applied Laboratory Medicine 2020, 5: 377-387. PMID: 32445390, DOI: 10.1093/jalm/jfaa001.
- El-Khoury JM, Remaley AT, Nordestgaard BG, Kaufman HW, Mora S, Cao J, Meeusen JW. Perspectives on the Changing Landscape of Measuring Cardiovascular Risk Related to LDL. Clinical Chemistry 2019, 65: 1487-1492. PMID: 31699699, DOI: 10.1373/clinchem.2019.307306.
- Practical Approach to Eliminate Bilirubin Interference in Icteric Samples for Creatinine MeasurementCharifa A, Bunch DR, El-Khoury JM. Practical Approach to Eliminate Bilirubin Interference in Icteric Samples for Creatinine Measurement. The Journal Of Applied Laboratory Medicine 2019, 4: 477-479. PMID: 31659092, DOI: 10.1373/jalm.2019.030247.
- Gall B, El-Khoury JM. Unusual Drug Test Results for a Patient on Buprenorphine and Naloxone. Clinical Chemistry 2019, 65: 1332-1333. PMID: 31570415, DOI: 10.1373/clinchem.2019.309484.
- Mansour SG, Martin TG, Obeid W, Pata RW, Myrick KM, Kukova L, Jia Y, Bjornstad P, El-Khoury JM, Parikh CR. The Role of Volume Regulation and Thermoregulation in AKI during Marathon Running. Clinical Journal Of The American Society Of Nephrology 2019, 14: 1297-1305. PMID: 31413064, PMCID: PMC6730516, DOI: 10.2215/cjn.01400219.
- Charifa A, El-Khoury JM. Hyperhomocysteinemia in a Gammopathy Patient: Malnutrition or Interference? Clinical Chemistry 2019, 65: 1063-1064. PMID: 31358504, DOI: 10.1373/clinchem.2019.302752.
- Kukova LZ, Mansour SG, Coca SG, de Fontnouvelle CA, Thiessen-Philbrook HR, Shlipak MG, El-Khoury JM, Parikh CR. Comparison of Urine and Plasma Biomarker Concentrations Measured by Aptamer-Based versus Immunoassay Methods in Cardiac Surgery Patients. The Journal Of Applied Laboratory Medicine 2019, 4: 331-342. PMID: 31659071, DOI: 10.1373/jalm.2018.028621.
- Charifa A, Bunch DR, El-Khoury JM. Erratic Serum Creatinine Concentrations in a Cardiac Patient. Clinical Chemistry 2018, 64: 1543-1544. PMID: 30266720, DOI: 10.1373/clinchem.2017.285858.
- Bunch DR, El-Khoury JM. Emerging Biomarker of Kidney Disease: suPAR or Subpar? Clinical Chemistry 2018, 64: 1545-1547. PMID: 32100860, DOI: 10.1373/clinchem.2018.293167.
- El-Khoury JM. Commentary. Clinical Chemistry 2018, 64: 445-445. PMID: 29490996, DOI: 10.1373/clinchem.2017.273714.
- El-Khoury JM. Networking and the Career Opportunities It Affords in Clinical Chemistry. The Journal Of Applied Laboratory Medicine 2017, 2: 284-285. PMID: 32630974, DOI: 10.1373/jalm.2016.022210.
- Nadkarni GN, Coca SG, Meisner A, Patel S, Kerr KF, Patel UD, Koyner JL, Garg AX, Philbrook HT, Edelstein CL, Shlipak M, El-Khoury J, Parikh CR, on behalf of the TRIBE-AKI Consortium Investigators. Urinalysis findings and urinary kidney injury biomarker concentrations. BMC Nephrology 2017, 18: 218. PMID: 28683730, PMCID: PMC5499057, DOI: 10.1186/s12882-017-0629-z.
- Roy LD, Dillon LM, Zhou R, Moore LJ, Livasy C, El-Khoury JM, Puri R, Mukherjee P. A tumor specific antibody to aid breast cancer screening in women with dense breast tissue. Genes & Cancer 2017, 8: 536-549. PMID: 28680538, PMCID: PMC5489651, DOI: 10.18632/genesandcancer.134.
- El-Khoury JM, Bunch DR, Hu B, Payto D, Reineks EZ, Wang S. Comparison of symmetric dimethylarginine with creatinine, cystatin C and their eGFR equations as markers of kidney function. Clinical Biochemistry 2016, 49: 1140-1143. PMID: 27452178, DOI: 10.1016/j.clinbiochem.2016.07.009.
- Yang Y, Rogers K, Wardle R, El-Khoury JM. High-throughput measurement of 25-hydroxyvitamin D by LC–MS/MS with separation of the C3-epimer interference for pediatric populations. Clinica Chimica Acta 2016, 454: 102-106. PMID: 26772722, DOI: 10.1016/j.cca.2016.01.004.
- El-Khoury J, Reineks E, Wang S. 1. Angiotensin converting enzyme. 2014, 1-18. DOI: 10.1515/9783110227802.1.
- Reineks E, El-Khoury J, Wang S. 3. Aldolase. 2014, 41-56. DOI: 10.1515/9783110227802.41.
- El-Khoury J, Wang S. 5. Aspartate aminotransferase and alanine aminotransferase. 2014, 81-104. DOI: 10.1515/9783110227802.81.
- Zhang W, Reineks E, El-Khoury J, Wang S. 9. Pancreatic lipase. 2014, 153-180. DOI: 10.1515/9783110227802.153.
- Ansari M, El-Khoury J, Daly T. Screen-Only Tests for Anti-Nuclear Antibodies Lead to Inappropriate Follow-Up in Majority of Cases. American Journal Of Clinical Pathology 2014, 142: a032-a032. DOI: 10.1093/ajcp/142.suppl1.032.
- El-Khoury JM, Wang S. Recent advances in MS methods for nicotine and metabolite analysis in human matrices: clinical perspectives. Bioanalysis 2014, 6: 2171-2183. PMID: 25331861, DOI: 10.4155/bio.14.176.
- El-Khoury JM, Gabler J, Wang S. Measurement of GFR for children and an LC–MS/MS method for nonradioactive iothalamate. Clinical Biochemistry 2014, 47: 749-750. PMID: 24858210, DOI: 10.1016/j.clinbiochem.2014.05.042.
- Abbadi A, El-Khoury JM, Wang S. Stability of serum and plasma osmolality in common clinical laboratory storage conditions. Clinical Biochemistry 2014, 47: 686-687. PMID: 24631174, DOI: 10.1016/j.clinbiochem.2014.02.024.
- Bunch DR, El-Khoury JM, Gabler J, Wang S. Do deuterium labeled internal standards correct for matrix effects in LC-MS/MS assays? A case study using plasma free metanephrine and normetanephrine. Clinica Chimica Acta 2013, 429: 4-5. PMID: 24269502, DOI: 10.1016/j.cca.2013.11.013.
- El-Khoury JM, Bicer F, Bunch DR, Yuan C, Wang S. Does Paricalcitol (Zemplar®) interfere with 1,25-dihydroxyvitamin D measurement by liquid chromatography–tandem mass spectrometry assays? Clinica Chimica Acta 2012, 415: 230-232. PMID: 23142648, DOI: 10.1016/j.cca.2012.10.050.
- Yuan C, Gabler J, El-Khoury JM, Spatholt R, Wang S. Highly sensitive and selective measurement of underivatized methylmalonic acid in serum and plasma by liquid chromatography-tandem mass spectrometry. Analytical And Bioanalytical Chemistry 2012, 404: 133-140. PMID: 22618327, DOI: 10.1007/s00216-012-6099-z.
- El-Khoury JM, Bunch DR, Wang S. Is the Effect of Hemolysis on Plasma Ammonia Measurement Overrated? Archives Of Pathology & Laboratory Medicine 2012, 136: 471-2. PMID: 22540295, DOI: 10.5858/arpa.2011-0445-le.
- El-Khoury JM, Wang S. Stability of 1,25-dihydroxyvitamin D2 and 1,25-dihydroxyvitamin D3 in human serum. Clinical Biochemistry 2012, 45: 707-708. PMID: 22465273, DOI: 10.1016/j.clinbiochem.2012.03.016.
- El-Khoury JM, Bunch DR, Reineks E, Jackson R, Steinle R, Wang S. A simple and fast liquid chromatography–tandem mass spectrometry method for measurement of underivatized l-arginine, symmetric dimethylarginine, and asymmetric dimethylarginine and establishment of the reference ranges. Analytical And Bioanalytical Chemistry 2011, 402: 771-779. PMID: 22124751, DOI: 10.1007/s00216-011-5462-9.
- El-Khoury JM, Reineks EZ, Wang S. Progress of liquid chromatography-mass spectrometry in measurement of vitamin D metabolites and analogues. Clinical Biochemistry 2010, 44: 66-76. PMID: 20493831, DOI: 10.1016/j.clinbiochem.2010.05.007.
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