Joao P. De Aquino, MD
Psychiatry, Addiction Medicine
Titles
- Assistant Professor of Psychiatry
- Assistant Chief of the Clinical Neuroscience Research Unit (CNRU), Psychiatry
Education & Training
- Advanced Research FellowshipYale University & VA VISN-1 Mental Illness Research, Education, and Clinical Center (MIRECC) (2021)
- Addiction Psychiatry FellowshipYale University (2019)
- Psychiatry ResidencyYale University (2018)
- MDFederal University of Ceara, School of Medicine (2012)
Languages Spoken
- English
- Français (French)
- Português (Portuguese)
- Español (Spanish)
Additional Information
Honors & Recognitions
- Associate Member: American College of Neuropsychopharmacology (ACNP) (2024)
- Leadership Academy: United States Association for the Study of Pain (USASP) (2024)
- MIT/NIDA Substance Use Disorder Ventures Program: Massachusetts Institute of Technology (MIT) and National Institute on Drug Abuse (NIDA) (2024)
- NIH R01 Research Project Grant Program : National Institute on Drug Abuse (NIDA) (2024)
- NIH Early Career Reviewer: National Institute of Health (NIH) Center for Scientific Review (2023)
- ASCP New Investigator Award: American Society of Clinical Psychopharmacology (ASCP) (2023)
- ISCTM New Investigator Award: International Society of CNS Clinical Trials and Methodology (ISCTM) (2023)
- COVID-19 Fund to Retain Clinical Scientists : Doris Duke Foundation and Yale Center for Clinical Investigation (YCCI) (2023)
- IMPOWR-YOU Pilot Award: Integrative Management of Chronic Pain and Opioid Use Disorder for Whole Recovery-Yale Organizations United (IMPOWR-YOU) Research Center (2022)
- ACNP Past Travel Awardee Progress Funding: American College of Neuropsychopharmacology (ACNP) (2022)
Board Certifications
- AB of Psychiatry & Neurology, Addiction Psychiatry (2020)
- AB of Psychiatry & Neurology, Psychiatry (2018)
Professional Service
- United States Association for the Study of Pain (2024 - Present): Membership Committee
- American Academy of Addiction Psychiatry (AAAP) (2024 - Present): Research Committee Co-Chair
- American Society of Clinical Psychopharmacology (ASCP) (2023 - Present): ASCP Early Career Committee
- National Institute of Health (NIH) (2023 - 2024): Neurobiology of Pain and Itch (NPI) Study Section
- British Journal of Clinical Psychopharmacology (2023 - Present): Guest Editor
- Experimental and Clinical Psychopharmacology (2022 - Present): Editorial Board Member
- Janeway Society (2022 - Present): Council Member
- College on Problems of Drug Dependence (CPDD) (2022 - Present): Human Research Committee
- Frontiers Psychiatry Addictive Disorders (2021 - Present): Editorial Board Member
Publications
- De Aquino JP, Parida S, Avila-Quintero VJ, Flores J, Compton P, Hickey T, Gómez O, Sofuoglu M. Opioid-induced analgesia among persons with opioid use disorder receiving methadone or buprenorphine: A systematic review of experimental pain studies. Drug And Alcohol Dependence 2021, 228: 109097. PMID: 34601272, PMCID: PMC8595687, DOI: 10.1016/j.drugalcdep.2021.109097.
- Ranganathan M, De Aquino JP, Cortes-Briones JA, Radhakrishnan R, Pittman B, Bhakta S, D’Souza D. Highs and lows of cannabinoid-dopamine interactions: effects of genetic variability and pharmacological modulation of catechol-O-methyl transferase on the acute response to delta-9-tetrahydrocannabinol in humans. Psychopharmacology 2019, 236: 3209-3219. PMID: 31187152, DOI: 10.1007/s00213-019-05273-5.
- De Aquino JP, Flores JM, Avila‐Quintero V, Compton P, Sofuoglu M. Pharmacological treatment of pain among persons with opioid addiction: A systematic review and meta‐analysis with implications for drug development. Addiction Biology 2020, 26: e12964. PMID: 32974993, DOI: 10.1111/adb.12964.
- Sugarman DE, De Aquino JP, Poling J, Sofuoglu M. Feasibility and effects of galantamine on cognition in humans with cannabis use disorder. Pharmacology Biochemistry And Behavior 2019, 181: 86-92. PMID: 31082417, PMCID: PMC6545124, DOI: 10.1016/j.pbb.2019.05.004.
- De Aquino J, Sloan M, Nunes J, Costa G, Katz J, de Oliveira D, Ra J, Tang V, Petrakis I. Alcohol Use Disorder and Chronic Pain: An Overlooked Epidemic. American Journal Of Psychiatry 2024, 181: 391-402. PMID: 38706339, PMCID: PMC11521207, DOI: 10.1176/appi.ajp.20230886.
- Weleff J, Nunes J, Costa G, Sofuoglu M, MacLean R, De Aquino J. From taboo to treatment: The emergence of psychedelics in the management of pain and opioid use disorder. British Journal Of Clinical Pharmacology 2024, 90: 3036-3053. PMID: 38627909, PMCID: PMC11480258, DOI: 10.1111/bcp.16045.
- Nunes J, Costa G, Weleff J, Rogan M, Compton P, De Aquino J. Assessing pain in persons with opioid use disorder: Approaches, techniques and special considerations. British Journal Of Clinical Pharmacology 2024, 90: 2985-3002. PMID: 38556851, DOI: 10.1111/bcp.16055.
- Schwartz E, De Aquino J, Sofuoglu M. Glial modulators as novel therapeutics for comorbid pain and opioid use disorder. British Journal Of Clinical Pharmacology 2024, 90: 3054-3066. PMID: 38752593, DOI: 10.1111/bcp.16094.
- Costa G, Nunes J, Heringer D, Anand A, De Aquino J. The impact of cannabis on non-medical opioid use among individuals receiving pharmacotherapies for opioid use disorder: a systematic review and meta-analysis of longitudinal studies. The American Journal Of Drug And Alcohol Abuse 2024, 50: 12-26. PMID: 38225727, DOI: 10.1080/00952990.2023.2287406.
- De Aquino J. Fatty Acid Amide Hydrolase, Neurodevelopment, and Alcohol: Illuminating the Intricacies of the Endocannabinoid System in Addiction Susceptibility. Biological Psychiatry 2023, 94: e19-e21. PMID: 37558315, DOI: 10.1016/j.biopsych.2023.06.027.
- Weleff J, Christian N, Wang J, Singh M, De Aquino J, Saxon A, Vassallo G. Navigating new norms: Addiction specialists' perspectives on opioid use disorder treatments and policy challenges in the fentanyl era. American Journal On Addictions 2024 PMID: 39364597, DOI: 10.1111/ajad.13653.
- Sofuoglu M, MacLean R, De Aquino J. Editorial for the themed issue: Addressing the dual challenges of opioid use disorder and chronic pain in the context of the opioid crisis. British Journal Of Clinical Pharmacology 2024, 90: 2960-2961. PMID: 39340184, PMCID: PMC11604519, DOI: 10.1111/bcp.16273.
- Jegede O, De Aquino J, Hsaio C, Caldwell E, Funaro M, Petrakis I, Muvvala S. The Impact of High-Potency Synthetic Opioids on Pharmacotherapies for Opioid Use Disorder: A Scoping Review. Journal Of Addiction Medicine 2024, 18: 499-510. PMID: 39356620, PMCID: PMC11449257, DOI: 10.1097/adm.0000000000001356.
- Nunes J, Jegede O, De Aquino J. Disentangling the effects of racism-related stress on opioid use disorder and chronic pain outcomes. The American Journal Of Drug And Alcohol Abuse 2024, 50: 455-461. PMID: 39018662, DOI: 10.1080/00952990.2024.2369866.
- Wolkowicz N, Sofuoglu M, De Aquino J, MacLean R. W82 Variation in Psychosocial Symptom Change: A Preliminary Examination of Veterans in Early Medication Treatment for Opioid Use Disorder. Drug And Alcohol Dependence 2024, 260: 110700. DOI: 10.1016/j.drugalcdep.2023.110700.
- Wolkowicz N, Sofuoglu M, Pittman B, Meyerovich J, MacLean R, De Aquino J. A preliminary investigation of the acute effects of delta-9-tetrahydrocannabinol on pain and opioid attentional bias among persons with opioid use disorder. Journal Of Psychiatric Research 2024, 177: 90-95. PMID: 38991269, PMCID: PMC11371499, DOI: 10.1016/j.jpsychires.2024.06.047.
- Mohammad Aghaei A, Urban Spillane L, Pittman B, Flynn L, De Aquino J, Bassir Nia A, Ranganathan M. Sex differences in the acute effects of oral THC: a randomized, placebo-controlled, crossover human laboratory study. Psychopharmacology 2024, 241: 2145-2155. PMID: 38832949, DOI: 10.1007/s00213-024-06625-6.
- Rogan M, Nunes J, Xie C, Sofuoglu M, Pittman B, De Aquino J. Brief report: The influence of childhood trauma on the effects of delta‐9‐tetrahydrocannabinol in persons with opioid use disorder. American Journal On Addictions 2023, 33: 343-346. PMID: 38059660, PMCID: PMC11032222, DOI: 10.1111/ajad.13504.
- De Aquino J, Meyerovich J, Xie C, Ranganathan M, Compton P, Pittman B, Rogan M, Sofuoglu M. Delta‐9‐tetrahydrocannabinol modulates pain sensitivity among persons receiving opioid agonist therapy for opioid use disorder: A within‐subject, randomized, placebo‐controlled laboratory study. Addiction Biology 2023, 28: e13317. PMID: 37644897, PMCID: PMC10468603, DOI: 10.1111/adb.13317.
- Oliveira D, Fontenele R, Weleff J, Sofuoglu M, De Aquino J. Developing non-opioid therapeutics to alleviate pain among persons with opioid use disorder: a review of the human evidence. International Review Of Psychiatry 2023, 35: 377-396. PMID: 38299655, PMCID: PMC10835074, DOI: 10.1080/09540261.2023.2229430.
- De Aquino J, Bahji A, Gómez O, Sofuoglu M. Alleviation of opioid withdrawal by cannabis and delta-9-tetrahydrocannabinol: A systematic review of observational and experimental human studies. Drug And Alcohol Dependence 2022, 241: 109702. PMID: 36434879, PMCID: PMC9772106, DOI: 10.1016/j.drugalcdep.2022.109702.
- Lassi D, Malbergier A, Negrão A, Florio L, De Aquino J, Castaldelli-Maia J. Pharmacological Treatments for Cocaine Craving: What Is the Way Forward? A Systematic Review. Brain Sciences 2022, 12: 1546. PMID: 36421870, PMCID: PMC9688748, DOI: 10.3390/brainsci12111546.
- Schwartz EKC, Wolkowicz NR, De Aquino JP, MacLean RR, Sofuoglu M. Cocaine Use Disorder (CUD): Current Clinical Perspectives. Substance Abuse And Rehabilitation 2022, 13: 25-46. PMID: 36093428, PMCID: PMC9451050, DOI: 10.2147/sar.s337338.
- Martins B, Rutland W, De Aquino JP, Kazer BL, Funaro M, Potenza MN, Angarita GA. Helpful or Harmful? The Therapeutic Potential of Medications with Varying Degrees of Abuse Liability in the Treatment of Substance Use Disorders. Current Addiction Reports 2022, 9: 647-659. PMID: 35990796, PMCID: PMC9376579, DOI: 10.1007/s40429-022-00432-9.
- De Aquino JP, DeVito EE, Xie C, Meyerovich J, Parida S, Gueorguieva R, Sofuoglu M. Development of pulsed intravenous nicotine infusions as a model for inhaled nicotine in humans. Psychopharmacology 2022, 239: 2809-2818. PMID: 35554617, DOI: 10.1007/s00213-022-06162-0.
- Jegede O, Parida S, De Aquino JP. Buprenorphine Treatment of Fentanyl-Related Opioid Use Disorder. The Primary Care Companion For CNS Disorders 2022, 24 PMID: 35486939, DOI: 10.4088/pcc.21cr03163.
- Selloni A, Bhatia G, Ranganathan M, De Aquino JP. Multimodal Correlates of Cannabis Use among U.S. Veterans with Bipolar Disorder: An Integrated Study of Clinical, Cognitive, and Functional Outcomes. Journal Of Dual Diagnosis 2022, 18: 81-91. PMID: 35430960, PMCID: PMC9794455, DOI: 10.1080/15504263.2022.2053264.
- Florence L, Lassi D, Kortas G, Lima D, de Azevedo-Marques Périco C, Andrade A, Torales J, Ventriglio A, De Berardis D, De Aquino J, Castaldelli-Maia J. Brain Correlates of the Alcohol Use Disorder Pharmacotherapy Response: A Systematic Review of Neuroimaging Studies. Brain Sciences 2022, 12: 386. PMID: 35326342, PMCID: PMC8946664, DOI: 10.3390/brainsci12030386.
- De Aquino JP, MacLean RR, Gueorguieva R, DeVito EE, Eid T, Sofuoglu M. Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science. Addiction Biology 2022, 27: e13161. PMID: 35229960, PMCID: PMC8903077, DOI: 10.1111/adb.13161.
- De Aquino JP, Bahji A, D'Souza DC. Letter to the Editor: Cannabis as a Solution to the Opioid Crisis: Is the Cart Before the Horse Again? Cannabis And Cannabinoid Research 2021, 7: 898-900. PMID: 34714101, PMCID: PMC9784580, DOI: 10.1089/can.2021.0155.
- Wright M, De Aquino J, Bystrak T. Case Report: Increasing the Frequency of Intramuscular Naltrexone Administration in a High Risk Patient with Opioid use Disorder. Substance Use & Addiction Journal 2021, 42: 493-496. PMID: 33689592, DOI: 10.1080/08897077.2021.1876811.
- De Aquino JP, Parida S, Sofuoglu M. Buprenorphine Microinduction: Logistical Barriers and the Need for Convergent Evidence. Clinical Drug Investigation 2021, 41: 665-665. PMID: 34106434, DOI: 10.1007/s40261-021-01049-y.
- De Aquino JP, Parida S, Sofuoglu M. The Pharmacology of Buprenorphine Microinduction for Opioid Use Disorder. Clinical Drug Investigation 2021, 41: 425-436. PMID: 33818748, PMCID: PMC8020374, DOI: 10.1007/s40261-021-01032-7.
- De Aquino JP, Sofuoglu M, Stefanovics EA, Rosenheck RA. Impact of cannabis on non-medical opioid use and symptoms of posttraumatic stress disorder: a nationwide longitudinal VA study. The American Journal Of Drug And Alcohol Abuse 2020, 46: 812-822. PMID: 33035104, DOI: 10.1080/00952990.2020.1818248.
- De Aquino J, Arnaout B. Cannabinoids. 2020, 153-167. DOI: 10.1007/978-3-030-33404-8_10.
- De Aquino J, Fairgrieve C, Klaire S, Garcia-Vassallo G. Rapid Transition From Methadone to Buprenorphine Utilizing a Micro-dosing Protocol in the Outpatient Veteran Affairs Setting. Journal Of Addiction Medicine 2020, 14: e271-e273. PMID: 32011408, PMCID: PMC7392785, DOI: 10.1097/adm.0000000000000618.
- Bommersbach T, Ross DA, De Aquino JP. Perpetual Hunger: The Neurobiological Consequences of Long-Term Opioid Use. Biological Psychiatry 2020, 87: e1-e3. PMID: 31806086, PMCID: PMC7830805, DOI: 10.1016/j.biopsych.2019.10.007.
- Parida S, De Aquino JP, Sofuoglu M. High potency synthetic opioids: Curbing the third wave of the opioid crisis. Neuroscience & Biobehavioral Reviews 2019, 106: 9-10. PMID: 31251966, DOI: 10.1016/j.neubiorev.2019.06.019.
- De Aquino JP, Sofuoglu M, Stefanovics E, Rosenheck R. Adverse Consequences of Co-Occurring Opioid Use Disorder and Cannabis Use Disorder Compared to Opioid Use Disorder Only. The American Journal Of Drug And Alcohol Abuse 2019, 45: 527-537. PMID: 31112429, DOI: 10.1080/00952990.2019.1607363.
- Gupta S, De Aquino JP, D’Souza D, Ranganathan M. Effects of haloperidol on the delta-9-tetrahydrocannabinol response in humans: a responder analysis. Psychopharmacology 2019, 236: 2635-2640. PMID: 30919005, PMCID: PMC6697616, DOI: 10.1007/s00213-019-05235-x.
- De Aquino JP, Moore DT, Wilkins K, Fuehrlein B. Enhancement of Medical Student Attitudes in the Treatment of Patients with Substance Use Disorders: a Follow-up Study. Academic Psychiatry 2019, 43: 350-351. PMID: 30756269, DOI: 10.1007/s40596-019-01038-6.
- De Aquino JP, Ross DA. Cannabinoids and Pain: Weeding Out Undesired Effects With a Novel Approach to Analgesia. Biological Psychiatry 2018, 84: e67-e69. PMID: 30360776, PMCID: PMC6697049, DOI: 10.1016/j.biopsych.2018.09.003.
- De Aquino JP, Sherif M, Radhakrishnan R, Cahill JD, Ranganathan M, D'Souza D. The Psychiatric Consequences of Cannabinoids. Clinical Therapeutics 2018, 40: 1448-1456. PMID: 29678279, DOI: 10.1016/j.clinthera.2018.03.013.
- De Aquino JP, Ross DA. Kraepelin’s Crumbling Twin Pillars: Using Biology to Reconstruct Psychiatric Nosology From the Bottom Up. Biological Psychiatry 2017, 82: e71-e74. PMID: 29031920, PMCID: PMC5714270, DOI: 10.1016/j.biopsych.2017.09.008.
- De Aquino J, Londono A, Carvalho A. An Update on the Epidemiology of Major Depressive Disorder Across Cultures. 2017, 309-315. DOI: 10.1007/978-981-10-6580-4_25.
- Lima JP, Brophy JM. The potential interaction between clopidogrel and proton pump inhibitors: a systematic review. BMC Medicine 2010, 8: 81. PMID: 21134261, PMCID: PMC3016262, DOI: 10.1186/1741-7015-8-81.
- de Aquino Lima JP, Brophy JM. Conflicting evidence: what's a clinician to do? Annals Of Internal Medicine 2010, 153: 413-5. PMID: 20855806, DOI: 10.7326/0003-4819-153-6-201009210-00011.
Titles
- Assistant Professor of Psychiatry
- Assistant Chief of the Clinical Neuroscience Research Unit (CNRU), Psychiatry
Education & Training
- Advanced Research FellowshipYale University & VA VISN-1 Mental Illness Research, Education, and Clinical Center (MIRECC) (2021)
- Addiction Psychiatry FellowshipYale University (2019)
- Psychiatry ResidencyYale University (2018)
- MDFederal University of Ceara, School of Medicine (2012)
Languages Spoken
- English
- Français (French)
- Português (Portuguese)
- Español (Spanish)
Additional Information
Honors & Recognitions
- Associate Member: American College of Neuropsychopharmacology (ACNP) (2024)
- Leadership Academy: United States Association for the Study of Pain (USASP) (2024)
- MIT/NIDA Substance Use Disorder Ventures Program: Massachusetts Institute of Technology (MIT) and National Institute on Drug Abuse (NIDA) (2024)
- NIH R01 Research Project Grant Program : National Institute on Drug Abuse (NIDA) (2024)
- NIH Early Career Reviewer: National Institute of Health (NIH) Center for Scientific Review (2023)
- ASCP New Investigator Award: American Society of Clinical Psychopharmacology (ASCP) (2023)
- ISCTM New Investigator Award: International Society of CNS Clinical Trials and Methodology (ISCTM) (2023)
- COVID-19 Fund to Retain Clinical Scientists : Doris Duke Foundation and Yale Center for Clinical Investigation (YCCI) (2023)
- IMPOWR-YOU Pilot Award: Integrative Management of Chronic Pain and Opioid Use Disorder for Whole Recovery-Yale Organizations United (IMPOWR-YOU) Research Center (2022)
- ACNP Past Travel Awardee Progress Funding: American College of Neuropsychopharmacology (ACNP) (2022)
Board Certifications
- AB of Psychiatry & Neurology, Addiction Psychiatry (2020)
- AB of Psychiatry & Neurology, Psychiatry (2018)
Professional Service
- United States Association for the Study of Pain (2024 - Present): Membership Committee
- American Academy of Addiction Psychiatry (AAAP) (2024 - Present): Research Committee Co-Chair
- American Society of Clinical Psychopharmacology (ASCP) (2023 - Present): ASCP Early Career Committee
- National Institute of Health (NIH) (2023 - 2024): Neurobiology of Pain and Itch (NPI) Study Section
- British Journal of Clinical Psychopharmacology (2023 - Present): Guest Editor
- Experimental and Clinical Psychopharmacology (2022 - Present): Editorial Board Member
- Janeway Society (2022 - Present): Council Member
- College on Problems of Drug Dependence (CPDD) (2022 - Present): Human Research Committee
- Frontiers Psychiatry Addictive Disorders (2021 - Present): Editorial Board Member
Publications
- De Aquino JP, Parida S, Avila-Quintero VJ, Flores J, Compton P, Hickey T, Gómez O, Sofuoglu M. Opioid-induced analgesia among persons with opioid use disorder receiving methadone or buprenorphine: A systematic review of experimental pain studies. Drug And Alcohol Dependence 2021, 228: 109097. PMID: 34601272, PMCID: PMC8595687, DOI: 10.1016/j.drugalcdep.2021.109097.
- Ranganathan M, De Aquino JP, Cortes-Briones JA, Radhakrishnan R, Pittman B, Bhakta S, D’Souza D. Highs and lows of cannabinoid-dopamine interactions: effects of genetic variability and pharmacological modulation of catechol-O-methyl transferase on the acute response to delta-9-tetrahydrocannabinol in humans. Psychopharmacology 2019, 236: 3209-3219. PMID: 31187152, DOI: 10.1007/s00213-019-05273-5.
- De Aquino JP, Flores JM, Avila‐Quintero V, Compton P, Sofuoglu M. Pharmacological treatment of pain among persons with opioid addiction: A systematic review and meta‐analysis with implications for drug development. Addiction Biology 2020, 26: e12964. PMID: 32974993, DOI: 10.1111/adb.12964.
- Sugarman DE, De Aquino JP, Poling J, Sofuoglu M. Feasibility and effects of galantamine on cognition in humans with cannabis use disorder. Pharmacology Biochemistry And Behavior 2019, 181: 86-92. PMID: 31082417, PMCID: PMC6545124, DOI: 10.1016/j.pbb.2019.05.004.
- De Aquino J, Sloan M, Nunes J, Costa G, Katz J, de Oliveira D, Ra J, Tang V, Petrakis I. Alcohol Use Disorder and Chronic Pain: An Overlooked Epidemic. American Journal Of Psychiatry 2024, 181: 391-402. PMID: 38706339, PMCID: PMC11521207, DOI: 10.1176/appi.ajp.20230886.
- Weleff J, Nunes J, Costa G, Sofuoglu M, MacLean R, De Aquino J. From taboo to treatment: The emergence of psychedelics in the management of pain and opioid use disorder. British Journal Of Clinical Pharmacology 2024, 90: 3036-3053. PMID: 38627909, PMCID: PMC11480258, DOI: 10.1111/bcp.16045.
- Nunes J, Costa G, Weleff J, Rogan M, Compton P, De Aquino J. Assessing pain in persons with opioid use disorder: Approaches, techniques and special considerations. British Journal Of Clinical Pharmacology 2024, 90: 2985-3002. PMID: 38556851, DOI: 10.1111/bcp.16055.
- Schwartz E, De Aquino J, Sofuoglu M. Glial modulators as novel therapeutics for comorbid pain and opioid use disorder. British Journal Of Clinical Pharmacology 2024, 90: 3054-3066. PMID: 38752593, DOI: 10.1111/bcp.16094.
- Costa G, Nunes J, Heringer D, Anand A, De Aquino J. The impact of cannabis on non-medical opioid use among individuals receiving pharmacotherapies for opioid use disorder: a systematic review and meta-analysis of longitudinal studies. The American Journal Of Drug And Alcohol Abuse 2024, 50: 12-26. PMID: 38225727, DOI: 10.1080/00952990.2023.2287406.
- De Aquino J. Fatty Acid Amide Hydrolase, Neurodevelopment, and Alcohol: Illuminating the Intricacies of the Endocannabinoid System in Addiction Susceptibility. Biological Psychiatry 2023, 94: e19-e21. PMID: 37558315, DOI: 10.1016/j.biopsych.2023.06.027.
- Weleff J, Christian N, Wang J, Singh M, De Aquino J, Saxon A, Vassallo G. Navigating new norms: Addiction specialists' perspectives on opioid use disorder treatments and policy challenges in the fentanyl era. American Journal On Addictions 2024 PMID: 39364597, DOI: 10.1111/ajad.13653.
- Sofuoglu M, MacLean R, De Aquino J. Editorial for the themed issue: Addressing the dual challenges of opioid use disorder and chronic pain in the context of the opioid crisis. British Journal Of Clinical Pharmacology 2024, 90: 2960-2961. PMID: 39340184, PMCID: PMC11604519, DOI: 10.1111/bcp.16273.
- Jegede O, De Aquino J, Hsaio C, Caldwell E, Funaro M, Petrakis I, Muvvala S. The Impact of High-Potency Synthetic Opioids on Pharmacotherapies for Opioid Use Disorder: A Scoping Review. Journal Of Addiction Medicine 2024, 18: 499-510. PMID: 39356620, PMCID: PMC11449257, DOI: 10.1097/adm.0000000000001356.
- Nunes J, Jegede O, De Aquino J. Disentangling the effects of racism-related stress on opioid use disorder and chronic pain outcomes. The American Journal Of Drug And Alcohol Abuse 2024, 50: 455-461. PMID: 39018662, DOI: 10.1080/00952990.2024.2369866.
- Wolkowicz N, Sofuoglu M, De Aquino J, MacLean R. W82 Variation in Psychosocial Symptom Change: A Preliminary Examination of Veterans in Early Medication Treatment for Opioid Use Disorder. Drug And Alcohol Dependence 2024, 260: 110700. DOI: 10.1016/j.drugalcdep.2023.110700.
- Wolkowicz N, Sofuoglu M, Pittman B, Meyerovich J, MacLean R, De Aquino J. A preliminary investigation of the acute effects of delta-9-tetrahydrocannabinol on pain and opioid attentional bias among persons with opioid use disorder. Journal Of Psychiatric Research 2024, 177: 90-95. PMID: 38991269, PMCID: PMC11371499, DOI: 10.1016/j.jpsychires.2024.06.047.
- Mohammad Aghaei A, Urban Spillane L, Pittman B, Flynn L, De Aquino J, Bassir Nia A, Ranganathan M. Sex differences in the acute effects of oral THC: a randomized, placebo-controlled, crossover human laboratory study. Psychopharmacology 2024, 241: 2145-2155. PMID: 38832949, DOI: 10.1007/s00213-024-06625-6.
- Rogan M, Nunes J, Xie C, Sofuoglu M, Pittman B, De Aquino J. Brief report: The influence of childhood trauma on the effects of delta‐9‐tetrahydrocannabinol in persons with opioid use disorder. American Journal On Addictions 2023, 33: 343-346. PMID: 38059660, PMCID: PMC11032222, DOI: 10.1111/ajad.13504.
- De Aquino J, Meyerovich J, Xie C, Ranganathan M, Compton P, Pittman B, Rogan M, Sofuoglu M. Delta‐9‐tetrahydrocannabinol modulates pain sensitivity among persons receiving opioid agonist therapy for opioid use disorder: A within‐subject, randomized, placebo‐controlled laboratory study. Addiction Biology 2023, 28: e13317. PMID: 37644897, PMCID: PMC10468603, DOI: 10.1111/adb.13317.
- Oliveira D, Fontenele R, Weleff J, Sofuoglu M, De Aquino J. Developing non-opioid therapeutics to alleviate pain among persons with opioid use disorder: a review of the human evidence. International Review Of Psychiatry 2023, 35: 377-396. PMID: 38299655, PMCID: PMC10835074, DOI: 10.1080/09540261.2023.2229430.
- De Aquino J, Bahji A, Gómez O, Sofuoglu M. Alleviation of opioid withdrawal by cannabis and delta-9-tetrahydrocannabinol: A systematic review of observational and experimental human studies. Drug And Alcohol Dependence 2022, 241: 109702. PMID: 36434879, PMCID: PMC9772106, DOI: 10.1016/j.drugalcdep.2022.109702.
- Lassi D, Malbergier A, Negrão A, Florio L, De Aquino J, Castaldelli-Maia J. Pharmacological Treatments for Cocaine Craving: What Is the Way Forward? A Systematic Review. Brain Sciences 2022, 12: 1546. PMID: 36421870, PMCID: PMC9688748, DOI: 10.3390/brainsci12111546.
- Schwartz EKC, Wolkowicz NR, De Aquino JP, MacLean RR, Sofuoglu M. Cocaine Use Disorder (CUD): Current Clinical Perspectives. Substance Abuse And Rehabilitation 2022, 13: 25-46. PMID: 36093428, PMCID: PMC9451050, DOI: 10.2147/sar.s337338.
- Martins B, Rutland W, De Aquino JP, Kazer BL, Funaro M, Potenza MN, Angarita GA. Helpful or Harmful? The Therapeutic Potential of Medications with Varying Degrees of Abuse Liability in the Treatment of Substance Use Disorders. Current Addiction Reports 2022, 9: 647-659. PMID: 35990796, PMCID: PMC9376579, DOI: 10.1007/s40429-022-00432-9.
- De Aquino JP, DeVito EE, Xie C, Meyerovich J, Parida S, Gueorguieva R, Sofuoglu M. Development of pulsed intravenous nicotine infusions as a model for inhaled nicotine in humans. Psychopharmacology 2022, 239: 2809-2818. PMID: 35554617, DOI: 10.1007/s00213-022-06162-0.
- Jegede O, Parida S, De Aquino JP. Buprenorphine Treatment of Fentanyl-Related Opioid Use Disorder. The Primary Care Companion For CNS Disorders 2022, 24 PMID: 35486939, DOI: 10.4088/pcc.21cr03163.
- Selloni A, Bhatia G, Ranganathan M, De Aquino JP. Multimodal Correlates of Cannabis Use among U.S. Veterans with Bipolar Disorder: An Integrated Study of Clinical, Cognitive, and Functional Outcomes. Journal Of Dual Diagnosis 2022, 18: 81-91. PMID: 35430960, PMCID: PMC9794455, DOI: 10.1080/15504263.2022.2053264.
- Florence L, Lassi D, Kortas G, Lima D, de Azevedo-Marques Périco C, Andrade A, Torales J, Ventriglio A, De Berardis D, De Aquino J, Castaldelli-Maia J. Brain Correlates of the Alcohol Use Disorder Pharmacotherapy Response: A Systematic Review of Neuroimaging Studies. Brain Sciences 2022, 12: 386. PMID: 35326342, PMCID: PMC8946664, DOI: 10.3390/brainsci12030386.
- De Aquino JP, MacLean RR, Gueorguieva R, DeVito EE, Eid T, Sofuoglu M. Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science. Addiction Biology 2022, 27: e13161. PMID: 35229960, PMCID: PMC8903077, DOI: 10.1111/adb.13161.
- De Aquino JP, Bahji A, D'Souza DC. Letter to the Editor: Cannabis as a Solution to the Opioid Crisis: Is the Cart Before the Horse Again? Cannabis And Cannabinoid Research 2021, 7: 898-900. PMID: 34714101, PMCID: PMC9784580, DOI: 10.1089/can.2021.0155.
- Wright M, De Aquino J, Bystrak T. Case Report: Increasing the Frequency of Intramuscular Naltrexone Administration in a High Risk Patient with Opioid use Disorder. Substance Use & Addiction Journal 2021, 42: 493-496. PMID: 33689592, DOI: 10.1080/08897077.2021.1876811.
- De Aquino JP, Parida S, Sofuoglu M. Buprenorphine Microinduction: Logistical Barriers and the Need for Convergent Evidence. Clinical Drug Investigation 2021, 41: 665-665. PMID: 34106434, DOI: 10.1007/s40261-021-01049-y.
- De Aquino JP, Parida S, Sofuoglu M. The Pharmacology of Buprenorphine Microinduction for Opioid Use Disorder. Clinical Drug Investigation 2021, 41: 425-436. PMID: 33818748, PMCID: PMC8020374, DOI: 10.1007/s40261-021-01032-7.
- De Aquino JP, Sofuoglu M, Stefanovics EA, Rosenheck RA. Impact of cannabis on non-medical opioid use and symptoms of posttraumatic stress disorder: a nationwide longitudinal VA study. The American Journal Of Drug And Alcohol Abuse 2020, 46: 812-822. PMID: 33035104, DOI: 10.1080/00952990.2020.1818248.
- De Aquino J, Arnaout B. Cannabinoids. 2020, 153-167. DOI: 10.1007/978-3-030-33404-8_10.
- De Aquino J, Fairgrieve C, Klaire S, Garcia-Vassallo G. Rapid Transition From Methadone to Buprenorphine Utilizing a Micro-dosing Protocol in the Outpatient Veteran Affairs Setting. Journal Of Addiction Medicine 2020, 14: e271-e273. PMID: 32011408, PMCID: PMC7392785, DOI: 10.1097/adm.0000000000000618.
- Bommersbach T, Ross DA, De Aquino JP. Perpetual Hunger: The Neurobiological Consequences of Long-Term Opioid Use. Biological Psychiatry 2020, 87: e1-e3. PMID: 31806086, PMCID: PMC7830805, DOI: 10.1016/j.biopsych.2019.10.007.
- Parida S, De Aquino JP, Sofuoglu M. High potency synthetic opioids: Curbing the third wave of the opioid crisis. Neuroscience & Biobehavioral Reviews 2019, 106: 9-10. PMID: 31251966, DOI: 10.1016/j.neubiorev.2019.06.019.
- De Aquino JP, Sofuoglu M, Stefanovics E, Rosenheck R. Adverse Consequences of Co-Occurring Opioid Use Disorder and Cannabis Use Disorder Compared to Opioid Use Disorder Only. The American Journal Of Drug And Alcohol Abuse 2019, 45: 527-537. PMID: 31112429, DOI: 10.1080/00952990.2019.1607363.
- Gupta S, De Aquino JP, D’Souza D, Ranganathan M. Effects of haloperidol on the delta-9-tetrahydrocannabinol response in humans: a responder analysis. Psychopharmacology 2019, 236: 2635-2640. PMID: 30919005, PMCID: PMC6697616, DOI: 10.1007/s00213-019-05235-x.
- De Aquino JP, Moore DT, Wilkins K, Fuehrlein B. Enhancement of Medical Student Attitudes in the Treatment of Patients with Substance Use Disorders: a Follow-up Study. Academic Psychiatry 2019, 43: 350-351. PMID: 30756269, DOI: 10.1007/s40596-019-01038-6.
- De Aquino JP, Ross DA. Cannabinoids and Pain: Weeding Out Undesired Effects With a Novel Approach to Analgesia. Biological Psychiatry 2018, 84: e67-e69. PMID: 30360776, PMCID: PMC6697049, DOI: 10.1016/j.biopsych.2018.09.003.
- De Aquino JP, Sherif M, Radhakrishnan R, Cahill JD, Ranganathan M, D'Souza D. The Psychiatric Consequences of Cannabinoids. Clinical Therapeutics 2018, 40: 1448-1456. PMID: 29678279, DOI: 10.1016/j.clinthera.2018.03.013.
- De Aquino JP, Ross DA. Kraepelin’s Crumbling Twin Pillars: Using Biology to Reconstruct Psychiatric Nosology From the Bottom Up. Biological Psychiatry 2017, 82: e71-e74. PMID: 29031920, PMCID: PMC5714270, DOI: 10.1016/j.biopsych.2017.09.008.
- De Aquino J, Londono A, Carvalho A. An Update on the Epidemiology of Major Depressive Disorder Across Cultures. 2017, 309-315. DOI: 10.1007/978-981-10-6580-4_25.
- Lima JP, Brophy JM. The potential interaction between clopidogrel and proton pump inhibitors: a systematic review. BMC Medicine 2010, 8: 81. PMID: 21134261, PMCID: PMC3016262, DOI: 10.1186/1741-7015-8-81.
- de Aquino Lima JP, Brophy JM. Conflicting evidence: what's a clinician to do? Annals Of Internal Medicine 2010, 153: 413-5. PMID: 20855806, DOI: 10.7326/0003-4819-153-6-201009210-00011.