- Winchester Center for Lung DiseaseFitkin Memorial Pavilion789 Howard AvenueNew Haven, CT 06519
Inderjit Singh, MBChB, BMedSci, FRCP, FCCP
Biography
Inderjit Singh, MBChB, (a medical degree awarded in the United Kingdom) is director of the Pulmonary Vascular Disease Program and specializes in treating pulmonary hypertension (high blood pressure in the heart-to-lung system).
Dr. Singh was steered toward medicine at an early age while growing up in Malaysia, where his father was a pediatrician. He often accompanied his father to work and says he enjoyed watching him help others feel better.
During medical school, he was drawn to pulmonary medicine, within which he discovered pulmonary vascular medicine—and pulmonary hypertension in particular.
“I have a strong interest in understanding the right heart and how it interacts with the pulmonary circulation,” Dr. Singh says. “And I like how pulmonary hypertension overlaps with so many specialties from cardiology to rheumatology to hepatology. You need to know all the different organs and disease processes to understand pulmonary hypertension.”
Pulmonary hypertension is also an exciting field because of many advancements in treatment, he says. “For a long time, we didn’t have much to offer in terms of therapy. But now there is more understanding of the disease, so much so that now you have dedicated training programs for pulmonary hypertension,” he says.
For research, Dr. Singh explores how the right ventricle of the heart and the pulmonary circulation interact, particularly during exercise.
“Our research is mainly focused on how the right heart interacts with the lungs’ blood vessels at rest and during exercise,” he explains. “We are one of the few centers in the world that performs invasive cardiopulmonary exercise test (iCPET). We primarily perform iCPET for patients who have unexplained shortness of breath or fatigue. So, these are patients who've had all the routine investigative testing, all of which do not explain their symptoms.”
Titles
- Associate Professor Term
- Director Pulmonary Vascular Program, Pulmonary, Critical Care & Sleep Medicine
- Associate Program Director, Advanced Fellowship in Pulmonary Vascular Disease , Pulmonary, Critical Care, and Sleep Medicine
Education & Training
- Fellow, Pulmonary VascularBrigham and Women's Hospital (2018)
- Fellow, Pulmonary & Critical CareNew York Presbyterian - Weill Cornell Medical Center (2016)
- Resident, Internal MedicineUniversity of Pennsylvania (2013)
- Intern, Internal MedicineUniversity of Pennsylvania (2011)
- Resident, Internal MedicineBeaumont Hospital, Dublin, Ireland (2010)
- Intern, Internal MedicineBeaumont Hospital, Dublin, Ireland (2008)
- BMedSciRoyal College of Surgeons in Ireland (2007)
- MBChBRoyal College of Surgeons in Ireland (2007)
Languages Spoken
- English
- Bahasa Malaysia (Malaysian)
- ਪੰਜਾਬੀ (Punjabi)
Additional Information
- Bronze award: Society of Critical Care Medicine (2024)
- Best abstract award: Society of Cardiovascular Anesthesiologists (2023)
- Best poster award: National Older Americans Independence Center (2023)
- Nominated for the Charles W. Bohmfalk Prize for teaching in clinical sciences: Yale Internal Medicine Residency Program (2022)
- Best abstract award: Society of Cardiovascular Anesthesiologists (2022)
- Best abstract award: Society of Cardiovascular Anesthesiologists (2022)
- Best abstract award: Pulmonary Circulation Assembly, American Thoracic Society (2021)
- Richard Matthay Award for Teacher of the Year: Division of Pulmonary, Critical Critical Care, and Sleep Medicine (2019)
- Malaysia National Scholarship: Malaysian Public Service Department (2002)
- AB of Internal Medicine, Internal Medicine (2013, recertified: 2015)
- CHEST (2023 - Present): Member
- American College of Chest Physcians (2023 - Present): Fellow
- Search Committee for Director of Echocardiography (2022): Member
- Clinical Immersion Program for Masters in Personalized Medicine and Applied Engineering Program (2022 - Present): Instructor
- Pulmonary Embolism Response Team (PERT) (2021 - Present): Member
- Advanced Mechanical Support / Lung Rescue Team (2020 - 2022): Member
- Royal College of Physicians in Ireland (2020 - Present): Fellow
- Hereditary Hemorrhagic Telangiectasia Committee (2018 - Present): Member
- The Annual Yale-Brigham and Women’s Hospital Combined Symposium on Pulmonary Heart Disease (2018 - Present): Director
- Division of Applied Hemodynamics, Department of Anesthesiology (2018 - Present): Member
- Singh I, Waxman A. The casting of invasive cardiopulmonary exercise testing: towards a common goal. European Respiratory Journal 2024, 64: 2400783. PMID: 38991723, DOI: 10.1183/13993003.00783-2024.
- Heerdt P, Kheyfets V, Oakland H, Joseph P, Singh I. Right Ventricular Pressure Waveform Analysis—Clinical Relevance and Future Directions. Journal Of Cardiothoracic And Vascular Anesthesia 2024, 38: 2433-2445. PMID: 39025682, DOI: 10.1053/j.jvca.2024.06.022.
- Manning E, Mishall P, Ramachandra A, Hassab A, Lamy J, Peters D, Murphy T, Heerdt P, Singh I, Downie S, Choudhary G, Tellides G, Humphrey J. Stiffening of the human proximal pulmonary artery with increasing age. Physiological Reports 2024, 12: e16090. PMID: 38884325, PMCID: PMC11181131, DOI: 10.14814/phy2.16090.
- Oakland H, Bellumkonda L, Sugeng L, Joseph P, Izzi D, Zalik F, McCabe S, Raza A, Amendola R, Heerdt P, Singh I, Hunter K. Three-dimensional (3D) Right Ventricular Surface Strain Computed From 3D Echocardiography Correlates With RVEF and Reveals Differences in Deformation Based on Severity of Pulmonary Arterial Hypertension Symptoms. 2024, a7381-a7381. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a7381.
- Kahn P, Joseph P, Heerdt P, Singh I. Differential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intolerance. ERJ Open Research 2023, 10: 00714-2023. PMID: 38348243, PMCID: PMC10860209, DOI: 10.1183/23120541.00714-2023.
- Tarras E, Khosla A, Heerdt P, Singh I. Right Heart Failure in the Intensive Care Unit: Etiology, Pathogenesis, Diagnosis, and Treatment. Journal Of Intensive Care Medicine 2023, 8850666231216889. PMID: 38031338, DOI: 10.1177/08850666231216889.
- Joseph P, Singh I. Post-Acute Sequelae of SARS-CoV-2 More Than Deconditioning. CHEST Journal 2023, 164: 583-584. PMID: 37689472, DOI: 10.1016/j.chest.2023.03.014.
- Heller S, See C, Singh I, Fredericks C. Cognitive impairment in pulmonary arterial hypertension. Annals Of Clinical And Translational Neurology 2023, 10: 1899-1903. PMID: 37550957, PMCID: PMC10578884, DOI: 10.1002/acn3.51867.
- Khosla A, Zhao Y, Mojibian H, Pollak J, Singh I. High-Risk Pulmonary Embolism: Management for the Intensivist. Journal Of Intensive Care Medicine 2023, 38: 1087-1098. PMID: 37455352, DOI: 10.1177/08850666231188290.
- Heerdt P, Martin-Flores M, Oakland H, Joseph P, Singh I. Integrating Right Ventricular Pressure Waveform Analysis With Two-Point Volume Measurement for Quantification of Systolic and Diastolic Function: Experimental Validation and Clinical Application. Journal Of Cardiothoracic And Vascular Anesthesia 2023, 37: 1929-1937. PMID: 37422337, PMCID: PMC10529383, DOI: 10.1053/j.jvca.2023.06.011.
- Manning E, Ramachandra A, Cavinato C, Lee P, Heerdt P, Singh I, Tellides G, Kaminski N, Humphrey J. Pulmonary Hypertension-related Changes in Structure and Function of the Human Proximal Pulmonary Artery. 2023, a6133-a6133. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6133.
- Manning E, Ramachandra A, Cavinato C, Schupp J, Justet A, Lee P, Heerdt P, Singh I, Murphy T, Gill T, Tellides G, Kaminski N, Humphrey J. Age-related Changes in Structure, Function, and Transcriptomics of the Human Proximal Pulmonary Artery. 2023, a4656-a4656. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4656.
- Yuan Y, Khoury J, Ramachandra A, Singh I, Tellides G, Humphrey J, Kaminski N, Manning E. The Extracellular Matrix of the Human Proximal Pulmonary Artery Regulates Gene Expression of Resident Cells Responsible for Remodeling During Aging. 2023, a2680-a2680. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2680.
- Singh I, Leitner B, Wang Y, Zhang H, Joseph P, Lutchmansingh D, Gulati M, Possick J, Damsky W, Hwa J, Heerdt P, Chun H. Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome. Pulmonary Circulation 2023, 13: e12220. PMID: 37091121, PMCID: PMC10113513, DOI: 10.1002/pul2.12220.
- Joseph P, Singh I, Oliveira R, Capone C, Mullen M, Cook D, Stovall M, Squires J, Madsen K, Waxman A, Systrom D. Exercise Pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Postacute Sequelae of SARS-CoV-2 More in Common Than Not? CHEST Journal 2023, 164: 717-726. PMID: 37054777, PMCID: PMC10088277, DOI: 10.1016/j.chest.2023.03.049.
- Joseph P, Savarimuthu S, Oakland H, Cullinan M, Heerdt P, Singh I. Response to letter to the editor “noninvasive determinants of pulmonary hypertension in interstitial lung disease”. Pulmonary Circulation 2023, 13: e12238. PMID: 37180828, PMCID: PMC10166920, DOI: 10.1002/pul2.12238.
- Savarimuthu S, Singh I, Khosla A. Systemic Thrombolysis in Acute Pulmonary Embolism: Dose Considerations in Administration of Thrombolytics. 2023, 59-69. DOI: 10.1142/9781800612778_0005.
- Heller S, See C, Singh I, Fredericks CA. (2023), Cognitive impairment in pulmonary arterial hypertension. Ann Clin Transl Neurol. https://doi.org/10.1002/acn3.51867
- Joseph P, Savarimuthu S, Zhao J, Yan X, Oakland H, Cullinan M, Heerdt P, Singh I. Noninvasive determinants of pulmonary hypertension in interstitial lung disease. Pulmonary Circulation 2023, 13: e12197. PMID: 36814586, PMCID: PMC9939578, DOI: 10.1002/pul2.12197.
- Singh I, Joseph P. Short- and long-term noninvasive cardiopulmonary exercise assessment in previously hospitalised COVID-19 patients. European Respiratory Journal 2022, 61: 2201739. PMID: 36137592, PMCID: PMC9515479, DOI: 10.1183/13993003.01739-2022.
- Khosla A, Mojibian H, Assi R, Tantawy H, Singh I, Pollak J. Right heart thrombi (RHT) and clot in transit with concomitant PE management: Approach and considerations. Pulmonary Circulation 2022, 12: e12080. PMID: 35514771, PMCID: PMC9063956, DOI: 10.1002/pul2.12080.
- Heerdt PM, Singh I, Elassal A, Kheyfets V, Richter MJ, Tello K. Pressure‐based estimation of right ventricular ejection fraction. ESC Heart Failure 2022, 9: 1436-1443. PMID: 35150211, PMCID: PMC8934966, DOI: 10.1002/ehf2.13839.
- Oakland HT, Joseph P, Naeije R, Elassal A, Cullinan M, Heerdt PM, Singh I. Reply to Grignola and Trujillo. Journal Of Applied Physiology 2022, 132: 219-219. PMID: 35030044, PMCID: PMC8759952, DOI: 10.1152/japplphysiol.00810.2021.
- Heerdt PM, Shelley B, Singh I. Impaired systemic oxygen extraction long after mild COVID-19: potential perioperative implications. British Journal Of Anaesthesia 2021, 128: e246-e249. PMID: 35067364, PMCID: PMC8710396, DOI: 10.1016/j.bja.2021.12.036.
- Manning EP, Ramachandra AB, Schupp JC, Cavinato C, Raredon MSB, Bärnthaler T, Cosme C, Singh I, Tellides G, Kaminski N, Humphrey JD. Mechanisms of Hypoxia-Induced Pulmonary Arterial Stiffening in Mice Revealed by a Functional Genetics Assay of Structural, Functional, and Transcriptomic Data. Frontiers In Physiology 2021, 12: 726253. PMID: 34594238, PMCID: PMC8478173, DOI: 10.3389/fphys.2021.726253.
- Matusov Y, Singh I, Yu YR, Chun HJ, Maron BA, Tapson VF, Lewis MI, Rajagopal S. Chronic Thromboembolic Pulmonary Hypertension: the Bedside. Current Cardiology Reports 2021, 23: 147. PMID: 34410530, PMCID: PMC8375459, DOI: 10.1007/s11886-021-01573-5.
- Alba GA, Atri D, Darbha S, Singh I, Tapson VF, Lewis MI, Chun HJ, Yu YR, Maron BA, Rajagopal S. Chronic Thromboembolic Pulmonary Hypertension: the Bench. Current Cardiology Reports 2021, 23: 141. PMID: 34410515, DOI: 10.1007/s11886-021-01572-6.
- Singh I, Joseph P, Heerdt PM, Cullinan M, Lutchmansingh DD, Gulati M, Possick JD, Systrom DM, Waxman AB. Persistent Exertional Intolerance After COVID-19 Insights From Invasive Cardiopulmonary Exercise Testing. CHEST Journal 2021, 161: 54-63. PMID: 34389297, PMCID: PMC8354807, DOI: 10.1016/j.chest.2021.08.010.
- Singh I, Oakland H, Elassal A, Heerdt PM. Defining end-systolic pressure for single-beat estimation of right ventricle–pulmonary artery coupling: simple… but not really. ERJ Open Research 2021, 7: 00219-2021. PMID: 34435035, PMCID: PMC8381254, DOI: 10.1183/23120541.00219-2021.
- Rahaghi FN, Nardelli P, Harder E, Singh I, Sánchez-Ferrero GV, Ross JC, San José Estépar R, Ash SY, Hunsaker AR, Maron BA, Leopold JA, Waxman AB, San José Estépar R, Washko GR. Quantification of Arterial and Venous Morphologic Markers in Pulmonary Arterial Hypertension Using CT Imaging. CHEST Journal 2021, 160: 2220-2231. PMID: 34270966, PMCID: PMC8692106, DOI: 10.1016/j.chest.2021.06.069.
- Elassal A, Steppan J, Charania S, Santhanam L, Singh I, Heerdt PM. Pressure-based estimation of right ventricular ejection fraction: Validation as a clinically relevant target for drug development in a rodent model of pulmonary hypertension. Journal Of Pharmacological And Toxicological Methods 2021, 112: 107102. PMID: 34245885, PMCID: PMC8616781, DOI: 10.1016/j.vascn.2021.107102.
- Oakland H, Joseph P, Naeije R, Elassal A, Cullinan M, Heerdt PM, Singh I. Arterial load and right ventricular-vascular coupling in pulmonary hypertension. Journal Of Applied Physiology 2021, 131: 424-433. PMID: 34043473, PMCID: PMC8325619, DOI: 10.1152/japplphysiol.00204.2021.
- Ntokou A, Dave JM, Kauffman AC, Sauler M, Ryu C, Hwa J, Herzog EL, Singh I, Saltzman WM, Greif DM. Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension. JCI Insight 2021, 6: e139067. PMID: 33591958, PMCID: PMC8026182, DOI: 10.1172/jci.insight.139067.
- Messina CMS, Ferreira EVM, Singh I, Fonseca AXC, Ramos RP, Nery LE, Systrom DM, Oliveira RKF, Ota-Arakaki JS. Impact of right ventricular work and pulmonary arterial compliance on peak exercise oxygen uptake in idiopathic pulmonary arterial hypertension. International Journal Of Cardiology 2021, 331: 230-235. PMID: 33545265, DOI: 10.1016/j.ijcard.2021.01.027.
- Singh I, Horn E, Haythe J. Pulmonary Hypertension in Pregnancy. Clinics In Chest Medicine 2021, 42: 91-99. PMID: 33541621, DOI: 10.1016/j.ccm.2020.10.006.
- Singh I, Oliveira RKF, Heerdt PM, Pari R, Systrom DM, Waxman AB. Sex-Related Differences in Dynamic Right Ventricular-Pulmonary Vascular Coupling in Heart Failure With Preserved Ejection Fraction. CHEST Journal 2021, 159: 2402-2416. PMID: 33388286, DOI: 10.1016/j.chest.2020.12.028.
- Tsao A, Nardelli P, Harder E, Vegas Sanchez-Ferrero G, Ross J, Ash S, Singh I, Hunsaker A, Waxman A, Washko G, San Jose Estepar R, Rahaghi F. Abstract 17136: Pulmonary Arterial and Venous Fractal Dimension as a Marker of Pulmonary Arterial Hypertension. Circulation 2020, 142 DOI: 10.1161/circ.142.suppl_3.17136.
- Harder E, Nardelli P, Sanchez-Ferrero G, Ross J, Ash S, Singh I, Hunsaker A, Waxman A, San Jose Estepar R, Washko G, Rahaghi F. Abstract 16667: Computed Tomography-Based Pulmonary Vascular Tortuosity as a Marker in Resting and Exercise Pulmonary Arterial Hypertension. Circulation 2020, 142 DOI: 10.1161/circ.142.suppl_3.16667.
- Lutchmansingh DD, Knauert MP, Antin-Ozerkis DE, Chupp G, Cohn L, Dela Cruz CS, Ferrante LE, Herzog EL, Koff J, Rochester CL, Ryu C, Singh I, Tickoo M, Winks V, Gulati M, Possick JD. A Clinic Blueprint for Post-Coronavirus Disease 2019 RECOVERY Learning From the Past, Looking to the Future. CHEST Journal 2020, 159: 949-958. PMID: 33159907, PMCID: PMC7641526, DOI: 10.1016/j.chest.2020.10.067.
- Fouad J, Singh I, Khosla A, Szabo C, Tantawy H, Razo-Vazquez A, Geirsson A, Bonde P, Fajardo E, Joseph P, Siner J, Chichra A. CHARACTERISTICS AND OUTCOMES OF PATIENTS WITH COVID-19 WITH RESPIRATORY FAILURE REQUIRING EXTRACORPOREAL MEMBRANE OXYGENATION. CHEST Journal 2020, 158: a703-a704. PMCID: PMC7548617, DOI: 10.1016/j.chest.2020.08.660.
- Oakland HT, Joseph P, Elassal A, Cullinan M, Heerdt PM, Singh I. Diagnostic utility of sub‐maximum cardiopulmonary exercise testing in the ambulatory setting for heart failure with preserved ejection fraction. Pulmonary Circulation 2020, 10: 1-10. PMID: 33282205, PMCID: PMC7691918, DOI: 10.1177/2045894020972273.
- Singh I, Oliveira RKF, Naeije R, Oldham WM, Faria-Urbina M, Waxman AB, Systrom DM. Systemic vascular distensibility relates to exercise capacity in connective tissue disease. Rheumatology 2020, 60: 1429-1434. PMID: 33001175, DOI: 10.1093/rheumatology/keaa510.
- Walia A, Singh I, Ryu C, Lutchmansingh DD. A 50-Year-Old Woman With Limited Scleroderma Presenting With Shortness of Breath. CHEST Journal 2020, 158: e37-e40. PMID: 32654737, PMCID: PMC8097629, DOI: 10.1016/j.chest.2020.02.041.
- Singh I, Oliveira RKF, Heerdt P, Brown MB, Faria‐Urbina M, Waxman AB, Systrom DM. Dynamic right ventricular function response to incremental exercise in pulmonary hypertension. Pulmonary Circulation 2020, 10: 1-8. PMID: 33062259, PMCID: PMC7534091, DOI: 10.1177/2045894020950187.
- Singh I, Oliveira R, Naeije R, Faria Urbina M, Waxman A, Systrom D. Systemic Vascular Distensibility Predicts Exercise Capacity in Connective Tissue Disease. 2020, a3240-a3240. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a3240.
- Heerdt P, Charania S, Elassal A, Singh I, Steppan J. A Pressure-Based Method for Estimation of Right Ventricular Ejection Fraction in a Rodent Model of Pulmonary Arterial Hypertension. 2020, a2086-a2086. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2086.
- Singh I, Oliveira R, Brown M, Faria Urbina M, Waxman A, Systrom D. Right Ventricular-Pulmonary Vascular Uncoupling Threshold During Incremental Exercise. 2020, a2069-a2069. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2069.
- Singh I, Oldham W, Rahaghi F. Precision Medicine in Pulmonary Hypertension. Respiratory Medicine 2020, 241-255. DOI: 10.1007/978-3-030-31507-8_16.
- Heerdt PM, Kheyfets V, Charania S, Elassal A, Singh I. A pressure-based single beat method for estimation of right ventricular ejection fraction: proof of concept. European Respiratory Journal 2019, 55: 1901635. PMID: 31771999, PMCID: PMC7885179, DOI: 10.1183/13993003.01635-2019.
- Singh I, Rahaghi F, Naeije R, Oliveira R, Vanderpool RR, Waxman A, Systrom D. Dynamic right ventricular–pulmonary arterial uncoupling during maximum incremental exercise in exercise pulmonary hypertension and pulmonary arterial hypertension. Pulmonary Circulation 2019, 9: 1-10. PMID: 31218910, PMCID: PMC6643191, DOI: 10.1177/2045894019862435.
- Singh I, Oliveira RKF, Naeije R, Rahaghi FN, Oldham WM, Systrom DM, Waxman AB. Pulmonary Vascular Distensibility and Early Pulmonary Vascular Remodeling in Pulmonary Hypertension. CHEST Journal 2019, 156: 724-732. PMID: 31121149, DOI: 10.1016/j.chest.2019.04.111.
- Singh I, Rahaghi FN, Naeije R, Oliveira RKF, Systrom DM, Waxman AB. Right Ventricular-Arterial Uncoupling During Exercise in Heart Failure With Preserved Ejection Fraction Role of Pulmonary Vascular Dysfunction. CHEST Journal 2019, 156: 933-943. PMID: 31103695, DOI: 10.1016/j.chest.2019.04.109.
- Pulmonary Vascular Distensibility and Early Pulmonary Vascular Remodelling in Pulmonary HypertensionSingh I, Oliveira R, Naeije R, Rahaghi F, Oldham W, Systrom D, Waxman A. Pulmonary Vascular Distensibility and Early Pulmonary Vascular Remodelling in Pulmonary Hypertension. 2019, a3668-a3668. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a3668.
- Rahaghi F, de La Bruere I, Singh I, Nardelli P, Come C, Faria Urbina M, Leopold J, Hunsaker A, San José Estépar R, San José Estépar R, Systrom D, Waxman A, Washko G. Decrease in Intraparenchymal Small Vessel Fraction in Exercise Pulmonary Arterial Hypertension. 2019, a5590-a5590. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5590.
- Ruopp N, De La Bruere I, Singh I, Come C, Faria Urbina M, Leopold J, Washko G, San Jose Estepar R, Systrom D, Waxman A, Rahaghi F. Main Pulmonary Artery Dilation in Early/Exercise Pulmonary Hypertension. 2019, a3664-a3664. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a3664.
- Ansari S, de La Bruere I, Singh I, Come C, Faria Urbina M, Leopold J, Hunsaker A, San Jose Estepar R, Washko G, Systrom D, Waxman A, Rahaghi F. Right and Left Pulmonary Artery Dilation in Pulmonary Hypertension. 2019, a3643-a3643. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a3643.
- Clapham KR, Singh I, Capuano IS, Rajagopal S, Chun HJ. MEF2 and the Right Ventricle: From Development to Disease. Frontiers In Cardiovascular Medicine 2019, 6: 29. PMID: 30984767, PMCID: PMC6448530, DOI: 10.3389/fcvm.2019.00029.
- Shojaee S, Singh I, Solsky I, Nana-Sinkam P. Malignant Pleural Effusion at Presentation in Patients with Small-Cell Lung Cancer. Respiration; International Review Of Thoracic Diseases 2019, 98: 198-202. PMID: 31121583, DOI: 10.1159/000499372.
- Dynamic right ventricular-pulmonary arterial (RV-PA) uncoupling during incremental exercise in HFpEFSingh I, Rahaghi F, Oliveira R, Systrom D, Waxman A. Dynamic right ventricular-pulmonary arterial (RV-PA) uncoupling during incremental exercise in HFpEF. 2018, pa3313. DOI: 10.1183/13993003.congress-2018.pa3313.
- Singh I, Mikita G, Green D, Risquez C, Sanders A. Pulmonary extra‐medullary hematopoiesis and pulmonary hypertension from underlying polycythemia vera: a case series. Pulmonary Circulation 2017, 7: 261-267. PMID: 28680586, PMCID: PMC5448544, DOI: 10.1177/2045893217702064.
- Singh I, Kaner R. A Woman with Asthma and Ground-Glass Opacities. Annals Of The American Thoracic Society 2017, 14: 140-144. PMID: 28035877, DOI: 10.1513/annalsats.201606-473cc.
- Singh I, Mikita G, Green D, Risquez C, Sanders A. Pulmonary Extra-medullary Hematopoiesis and Pulmonary Hypertension From Underlying Polycythemia Vera: A Case Series. Pulmonary Circulation 2016 DOI: 10.1086/690730.
- Singh I, Risquez C, Sanders A. When the JAK Fails the Pump. CHEST Journal 2016, 150: 687a. DOI: 10.1016/j.chest.2016.08.782.
- Singh I, Cong K, Berlin DA. Pathophysiology of Pulmonary Hypertension in Chronic Parenchymal Lung Disease. The American Journal Of Medicine 2015, 129: 366-371. PMID: 26706386, DOI: 10.1016/j.amjmed.2015.11.026.
- Singh I, West F, Sanders A, Hartman B, Zappetti D. Pulmonary Nocardiosis in the Immunocompetent Host: Case Series. Case Reports In Pulmonology 2015, 2015: 314831. PMID: 26491594, PMCID: PMC4605260, DOI: 10.1155/2015/314831.
- Singh I, Zappetti D. Exercise Intolerance in Pulmonary Hypertension. Clinical Pulmonary Medicine 2015, 22: 258-259. DOI: 10.1097/cpm.0000000000000122.
- Berlin D, Singh I, Barjaktarevic I, Friedman O. A Technique for Bronchoscopic Intubation During High-Flow Nasal Cannula Oxygen Therapy. Journal Of Intensive Care Medicine 2015, 31: 213-215. PMID: 25911299, DOI: 10.1177/0885066615582020.
- Winchester Center for Lung DiseaseFitkin Memorial Pavilion789 Howard AvenueNew Haven, CT 06519
Biography
Inderjit Singh, MBChB, (a medical degree awarded in the United Kingdom) is director of the Pulmonary Vascular Disease Program and specializes in treating pulmonary hypertension (high blood pressure in the heart-to-lung system).
Dr. Singh was steered toward medicine at an early age while growing up in Malaysia, where his father was a pediatrician. He often accompanied his father to work and says he enjoyed watching him help others feel better.
During medical school, he was drawn to pulmonary medicine, within which he discovered pulmonary vascular medicine—and pulmonary hypertension in particular.
“I have a strong interest in understanding the right heart and how it interacts with the pulmonary circulation,” Dr. Singh says. “And I like how pulmonary hypertension overlaps with so many specialties from cardiology to rheumatology to hepatology. You need to know all the different organs and disease processes to understand pulmonary hypertension.”
Pulmonary hypertension is also an exciting field because of many advancements in treatment, he says. “For a long time, we didn’t have much to offer in terms of therapy. But now there is more understanding of the disease, so much so that now you have dedicated training programs for pulmonary hypertension,” he says.
For research, Dr. Singh explores how the right ventricle of the heart and the pulmonary circulation interact, particularly during exercise.
“Our research is mainly focused on how the right heart interacts with the lungs’ blood vessels at rest and during exercise,” he explains. “We are one of the few centers in the world that performs invasive cardiopulmonary exercise test (iCPET). We primarily perform iCPET for patients who have unexplained shortness of breath or fatigue. So, these are patients who've had all the routine investigative testing, all of which do not explain their symptoms.”
Titles
- Associate Professor Term
- Director Pulmonary Vascular Program, Pulmonary, Critical Care & Sleep Medicine
- Associate Program Director, Advanced Fellowship in Pulmonary Vascular Disease , Pulmonary, Critical Care, and Sleep Medicine
Education & Training
- Fellow, Pulmonary VascularBrigham and Women's Hospital (2018)
- Fellow, Pulmonary & Critical CareNew York Presbyterian - Weill Cornell Medical Center (2016)
- Resident, Internal MedicineUniversity of Pennsylvania (2013)
- Intern, Internal MedicineUniversity of Pennsylvania (2011)
- Resident, Internal MedicineBeaumont Hospital, Dublin, Ireland (2010)
- Intern, Internal MedicineBeaumont Hospital, Dublin, Ireland (2008)
- BMedSciRoyal College of Surgeons in Ireland (2007)
- MBChBRoyal College of Surgeons in Ireland (2007)
Languages Spoken
- English
- Bahasa Malaysia (Malaysian)
- ਪੰਜਾਬੀ (Punjabi)
Additional Information
- Bronze award: Society of Critical Care Medicine (2024)
- Best abstract award: Society of Cardiovascular Anesthesiologists (2023)
- Best poster award: National Older Americans Independence Center (2023)
- Nominated for the Charles W. Bohmfalk Prize for teaching in clinical sciences: Yale Internal Medicine Residency Program (2022)
- Best abstract award: Society of Cardiovascular Anesthesiologists (2022)
- Best abstract award: Society of Cardiovascular Anesthesiologists (2022)
- Best abstract award: Pulmonary Circulation Assembly, American Thoracic Society (2021)
- Richard Matthay Award for Teacher of the Year: Division of Pulmonary, Critical Critical Care, and Sleep Medicine (2019)
- Malaysia National Scholarship: Malaysian Public Service Department (2002)
- AB of Internal Medicine, Internal Medicine (2013, recertified: 2015)
- CHEST (2023 - Present): Member
- American College of Chest Physcians (2023 - Present): Fellow
- Search Committee for Director of Echocardiography (2022): Member
- Clinical Immersion Program for Masters in Personalized Medicine and Applied Engineering Program (2022 - Present): Instructor
- Pulmonary Embolism Response Team (PERT) (2021 - Present): Member
- Advanced Mechanical Support / Lung Rescue Team (2020 - 2022): Member
- Royal College of Physicians in Ireland (2020 - Present): Fellow
- Hereditary Hemorrhagic Telangiectasia Committee (2018 - Present): Member
- The Annual Yale-Brigham and Women’s Hospital Combined Symposium on Pulmonary Heart Disease (2018 - Present): Director
- Division of Applied Hemodynamics, Department of Anesthesiology (2018 - Present): Member
- Singh I, Waxman A. The casting of invasive cardiopulmonary exercise testing: towards a common goal. European Respiratory Journal 2024, 64: 2400783. PMID: 38991723, DOI: 10.1183/13993003.00783-2024.
- Heerdt P, Kheyfets V, Oakland H, Joseph P, Singh I. Right Ventricular Pressure Waveform Analysis—Clinical Relevance and Future Directions. Journal Of Cardiothoracic And Vascular Anesthesia 2024, 38: 2433-2445. PMID: 39025682, DOI: 10.1053/j.jvca.2024.06.022.
- Manning E, Mishall P, Ramachandra A, Hassab A, Lamy J, Peters D, Murphy T, Heerdt P, Singh I, Downie S, Choudhary G, Tellides G, Humphrey J. Stiffening of the human proximal pulmonary artery with increasing age. Physiological Reports 2024, 12: e16090. PMID: 38884325, PMCID: PMC11181131, DOI: 10.14814/phy2.16090.
- Oakland H, Bellumkonda L, Sugeng L, Joseph P, Izzi D, Zalik F, McCabe S, Raza A, Amendola R, Heerdt P, Singh I, Hunter K. Three-dimensional (3D) Right Ventricular Surface Strain Computed From 3D Echocardiography Correlates With RVEF and Reveals Differences in Deformation Based on Severity of Pulmonary Arterial Hypertension Symptoms. 2024, a7381-a7381. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a7381.
- Kahn P, Joseph P, Heerdt P, Singh I. Differential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intolerance. ERJ Open Research 2023, 10: 00714-2023. PMID: 38348243, PMCID: PMC10860209, DOI: 10.1183/23120541.00714-2023.
- Tarras E, Khosla A, Heerdt P, Singh I. Right Heart Failure in the Intensive Care Unit: Etiology, Pathogenesis, Diagnosis, and Treatment. Journal Of Intensive Care Medicine 2023, 8850666231216889. PMID: 38031338, DOI: 10.1177/08850666231216889.
- Joseph P, Singh I. Post-Acute Sequelae of SARS-CoV-2 More Than Deconditioning. CHEST Journal 2023, 164: 583-584. PMID: 37689472, DOI: 10.1016/j.chest.2023.03.014.
- Heller S, See C, Singh I, Fredericks C. Cognitive impairment in pulmonary arterial hypertension. Annals Of Clinical And Translational Neurology 2023, 10: 1899-1903. PMID: 37550957, PMCID: PMC10578884, DOI: 10.1002/acn3.51867.
- Khosla A, Zhao Y, Mojibian H, Pollak J, Singh I. High-Risk Pulmonary Embolism: Management for the Intensivist. Journal Of Intensive Care Medicine 2023, 38: 1087-1098. PMID: 37455352, DOI: 10.1177/08850666231188290.
- Heerdt P, Martin-Flores M, Oakland H, Joseph P, Singh I. Integrating Right Ventricular Pressure Waveform Analysis With Two-Point Volume Measurement for Quantification of Systolic and Diastolic Function: Experimental Validation and Clinical Application. Journal Of Cardiothoracic And Vascular Anesthesia 2023, 37: 1929-1937. PMID: 37422337, PMCID: PMC10529383, DOI: 10.1053/j.jvca.2023.06.011.
- Manning E, Ramachandra A, Cavinato C, Lee P, Heerdt P, Singh I, Tellides G, Kaminski N, Humphrey J. Pulmonary Hypertension-related Changes in Structure and Function of the Human Proximal Pulmonary Artery. 2023, a6133-a6133. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6133.
- Manning E, Ramachandra A, Cavinato C, Schupp J, Justet A, Lee P, Heerdt P, Singh I, Murphy T, Gill T, Tellides G, Kaminski N, Humphrey J. Age-related Changes in Structure, Function, and Transcriptomics of the Human Proximal Pulmonary Artery. 2023, a4656-a4656. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4656.
- Yuan Y, Khoury J, Ramachandra A, Singh I, Tellides G, Humphrey J, Kaminski N, Manning E. The Extracellular Matrix of the Human Proximal Pulmonary Artery Regulates Gene Expression of Resident Cells Responsible for Remodeling During Aging. 2023, a2680-a2680. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2680.
- Singh I, Leitner B, Wang Y, Zhang H, Joseph P, Lutchmansingh D, Gulati M, Possick J, Damsky W, Hwa J, Heerdt P, Chun H. Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome. Pulmonary Circulation 2023, 13: e12220. PMID: 37091121, PMCID: PMC10113513, DOI: 10.1002/pul2.12220.
- Joseph P, Singh I, Oliveira R, Capone C, Mullen M, Cook D, Stovall M, Squires J, Madsen K, Waxman A, Systrom D. Exercise Pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Postacute Sequelae of SARS-CoV-2 More in Common Than Not? CHEST Journal 2023, 164: 717-726. PMID: 37054777, PMCID: PMC10088277, DOI: 10.1016/j.chest.2023.03.049.
- Joseph P, Savarimuthu S, Oakland H, Cullinan M, Heerdt P, Singh I. Response to letter to the editor “noninvasive determinants of pulmonary hypertension in interstitial lung disease”. Pulmonary Circulation 2023, 13: e12238. PMID: 37180828, PMCID: PMC10166920, DOI: 10.1002/pul2.12238.
- Savarimuthu S, Singh I, Khosla A. Systemic Thrombolysis in Acute Pulmonary Embolism: Dose Considerations in Administration of Thrombolytics. 2023, 59-69. DOI: 10.1142/9781800612778_0005.
- Heller S, See C, Singh I, Fredericks CA. (2023), Cognitive impairment in pulmonary arterial hypertension. Ann Clin Transl Neurol. https://doi.org/10.1002/acn3.51867
- Joseph P, Savarimuthu S, Zhao J, Yan X, Oakland H, Cullinan M, Heerdt P, Singh I. Noninvasive determinants of pulmonary hypertension in interstitial lung disease. Pulmonary Circulation 2023, 13: e12197. PMID: 36814586, PMCID: PMC9939578, DOI: 10.1002/pul2.12197.
- Singh I, Joseph P. Short- and long-term noninvasive cardiopulmonary exercise assessment in previously hospitalised COVID-19 patients. European Respiratory Journal 2022, 61: 2201739. PMID: 36137592, PMCID: PMC9515479, DOI: 10.1183/13993003.01739-2022.
- Khosla A, Mojibian H, Assi R, Tantawy H, Singh I, Pollak J. Right heart thrombi (RHT) and clot in transit with concomitant PE management: Approach and considerations. Pulmonary Circulation 2022, 12: e12080. PMID: 35514771, PMCID: PMC9063956, DOI: 10.1002/pul2.12080.
- Heerdt PM, Singh I, Elassal A, Kheyfets V, Richter MJ, Tello K. Pressure‐based estimation of right ventricular ejection fraction. ESC Heart Failure 2022, 9: 1436-1443. PMID: 35150211, PMCID: PMC8934966, DOI: 10.1002/ehf2.13839.
- Oakland HT, Joseph P, Naeije R, Elassal A, Cullinan M, Heerdt PM, Singh I. Reply to Grignola and Trujillo. Journal Of Applied Physiology 2022, 132: 219-219. PMID: 35030044, PMCID: PMC8759952, DOI: 10.1152/japplphysiol.00810.2021.
- Heerdt PM, Shelley B, Singh I. Impaired systemic oxygen extraction long after mild COVID-19: potential perioperative implications. British Journal Of Anaesthesia 2021, 128: e246-e249. PMID: 35067364, PMCID: PMC8710396, DOI: 10.1016/j.bja.2021.12.036.
- Manning EP, Ramachandra AB, Schupp JC, Cavinato C, Raredon MSB, Bärnthaler T, Cosme C, Singh I, Tellides G, Kaminski N, Humphrey JD. Mechanisms of Hypoxia-Induced Pulmonary Arterial Stiffening in Mice Revealed by a Functional Genetics Assay of Structural, Functional, and Transcriptomic Data. Frontiers In Physiology 2021, 12: 726253. PMID: 34594238, PMCID: PMC8478173, DOI: 10.3389/fphys.2021.726253.
- Matusov Y, Singh I, Yu YR, Chun HJ, Maron BA, Tapson VF, Lewis MI, Rajagopal S. Chronic Thromboembolic Pulmonary Hypertension: the Bedside. Current Cardiology Reports 2021, 23: 147. PMID: 34410530, PMCID: PMC8375459, DOI: 10.1007/s11886-021-01573-5.
- Alba GA, Atri D, Darbha S, Singh I, Tapson VF, Lewis MI, Chun HJ, Yu YR, Maron BA, Rajagopal S. Chronic Thromboembolic Pulmonary Hypertension: the Bench. Current Cardiology Reports 2021, 23: 141. PMID: 34410515, DOI: 10.1007/s11886-021-01572-6.
- Singh I, Joseph P, Heerdt PM, Cullinan M, Lutchmansingh DD, Gulati M, Possick JD, Systrom DM, Waxman AB. Persistent Exertional Intolerance After COVID-19 Insights From Invasive Cardiopulmonary Exercise Testing. CHEST Journal 2021, 161: 54-63. PMID: 34389297, PMCID: PMC8354807, DOI: 10.1016/j.chest.2021.08.010.
- Singh I, Oakland H, Elassal A, Heerdt PM. Defining end-systolic pressure for single-beat estimation of right ventricle–pulmonary artery coupling: simple… but not really. ERJ Open Research 2021, 7: 00219-2021. PMID: 34435035, PMCID: PMC8381254, DOI: 10.1183/23120541.00219-2021.
- Rahaghi FN, Nardelli P, Harder E, Singh I, Sánchez-Ferrero GV, Ross JC, San José Estépar R, Ash SY, Hunsaker AR, Maron BA, Leopold JA, Waxman AB, San José Estépar R, Washko GR. Quantification of Arterial and Venous Morphologic Markers in Pulmonary Arterial Hypertension Using CT Imaging. CHEST Journal 2021, 160: 2220-2231. PMID: 34270966, PMCID: PMC8692106, DOI: 10.1016/j.chest.2021.06.069.
- Elassal A, Steppan J, Charania S, Santhanam L, Singh I, Heerdt PM. Pressure-based estimation of right ventricular ejection fraction: Validation as a clinically relevant target for drug development in a rodent model of pulmonary hypertension. Journal Of Pharmacological And Toxicological Methods 2021, 112: 107102. PMID: 34245885, PMCID: PMC8616781, DOI: 10.1016/j.vascn.2021.107102.
- Oakland H, Joseph P, Naeije R, Elassal A, Cullinan M, Heerdt PM, Singh I. Arterial load and right ventricular-vascular coupling in pulmonary hypertension. Journal Of Applied Physiology 2021, 131: 424-433. PMID: 34043473, PMCID: PMC8325619, DOI: 10.1152/japplphysiol.00204.2021.
- Ntokou A, Dave JM, Kauffman AC, Sauler M, Ryu C, Hwa J, Herzog EL, Singh I, Saltzman WM, Greif DM. Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension. JCI Insight 2021, 6: e139067. PMID: 33591958, PMCID: PMC8026182, DOI: 10.1172/jci.insight.139067.
- Messina CMS, Ferreira EVM, Singh I, Fonseca AXC, Ramos RP, Nery LE, Systrom DM, Oliveira RKF, Ota-Arakaki JS. Impact of right ventricular work and pulmonary arterial compliance on peak exercise oxygen uptake in idiopathic pulmonary arterial hypertension. International Journal Of Cardiology 2021, 331: 230-235. PMID: 33545265, DOI: 10.1016/j.ijcard.2021.01.027.
- Singh I, Horn E, Haythe J. Pulmonary Hypertension in Pregnancy. Clinics In Chest Medicine 2021, 42: 91-99. PMID: 33541621, DOI: 10.1016/j.ccm.2020.10.006.
- Singh I, Oliveira RKF, Heerdt PM, Pari R, Systrom DM, Waxman AB. Sex-Related Differences in Dynamic Right Ventricular-Pulmonary Vascular Coupling in Heart Failure With Preserved Ejection Fraction. CHEST Journal 2021, 159: 2402-2416. PMID: 33388286, DOI: 10.1016/j.chest.2020.12.028.
- Tsao A, Nardelli P, Harder E, Vegas Sanchez-Ferrero G, Ross J, Ash S, Singh I, Hunsaker A, Waxman A, Washko G, San Jose Estepar R, Rahaghi F. Abstract 17136: Pulmonary Arterial and Venous Fractal Dimension as a Marker of Pulmonary Arterial Hypertension. Circulation 2020, 142 DOI: 10.1161/circ.142.suppl_3.17136.
- Harder E, Nardelli P, Sanchez-Ferrero G, Ross J, Ash S, Singh I, Hunsaker A, Waxman A, San Jose Estepar R, Washko G, Rahaghi F. Abstract 16667: Computed Tomography-Based Pulmonary Vascular Tortuosity as a Marker in Resting and Exercise Pulmonary Arterial Hypertension. Circulation 2020, 142 DOI: 10.1161/circ.142.suppl_3.16667.
- Lutchmansingh DD, Knauert MP, Antin-Ozerkis DE, Chupp G, Cohn L, Dela Cruz CS, Ferrante LE, Herzog EL, Koff J, Rochester CL, Ryu C, Singh I, Tickoo M, Winks V, Gulati M, Possick JD. A Clinic Blueprint for Post-Coronavirus Disease 2019 RECOVERY Learning From the Past, Looking to the Future. CHEST Journal 2020, 159: 949-958. PMID: 33159907, PMCID: PMC7641526, DOI: 10.1016/j.chest.2020.10.067.
- Fouad J, Singh I, Khosla A, Szabo C, Tantawy H, Razo-Vazquez A, Geirsson A, Bonde P, Fajardo E, Joseph P, Siner J, Chichra A. CHARACTERISTICS AND OUTCOMES OF PATIENTS WITH COVID-19 WITH RESPIRATORY FAILURE REQUIRING EXTRACORPOREAL MEMBRANE OXYGENATION. CHEST Journal 2020, 158: a703-a704. PMCID: PMC7548617, DOI: 10.1016/j.chest.2020.08.660.
- Oakland HT, Joseph P, Elassal A, Cullinan M, Heerdt PM, Singh I. Diagnostic utility of sub‐maximum cardiopulmonary exercise testing in the ambulatory setting for heart failure with preserved ejection fraction. Pulmonary Circulation 2020, 10: 1-10. PMID: 33282205, PMCID: PMC7691918, DOI: 10.1177/2045894020972273.
- Singh I, Oliveira RKF, Naeije R, Oldham WM, Faria-Urbina M, Waxman AB, Systrom DM. Systemic vascular distensibility relates to exercise capacity in connective tissue disease. Rheumatology 2020, 60: 1429-1434. PMID: 33001175, DOI: 10.1093/rheumatology/keaa510.
- Walia A, Singh I, Ryu C, Lutchmansingh DD. A 50-Year-Old Woman With Limited Scleroderma Presenting With Shortness of Breath. CHEST Journal 2020, 158: e37-e40. PMID: 32654737, PMCID: PMC8097629, DOI: 10.1016/j.chest.2020.02.041.
- Singh I, Oliveira RKF, Heerdt P, Brown MB, Faria‐Urbina M, Waxman AB, Systrom DM. Dynamic right ventricular function response to incremental exercise in pulmonary hypertension. Pulmonary Circulation 2020, 10: 1-8. PMID: 33062259, PMCID: PMC7534091, DOI: 10.1177/2045894020950187.
- Singh I, Oliveira R, Naeije R, Faria Urbina M, Waxman A, Systrom D. Systemic Vascular Distensibility Predicts Exercise Capacity in Connective Tissue Disease. 2020, a3240-a3240. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a3240.
- Heerdt P, Charania S, Elassal A, Singh I, Steppan J. A Pressure-Based Method for Estimation of Right Ventricular Ejection Fraction in a Rodent Model of Pulmonary Arterial Hypertension. 2020, a2086-a2086. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2086.
- Singh I, Oliveira R, Brown M, Faria Urbina M, Waxman A, Systrom D. Right Ventricular-Pulmonary Vascular Uncoupling Threshold During Incremental Exercise. 2020, a2069-a2069. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2069.
- Singh I, Oldham W, Rahaghi F. Precision Medicine in Pulmonary Hypertension. Respiratory Medicine 2020, 241-255. DOI: 10.1007/978-3-030-31507-8_16.
- Heerdt PM, Kheyfets V, Charania S, Elassal A, Singh I. A pressure-based single beat method for estimation of right ventricular ejection fraction: proof of concept. European Respiratory Journal 2019, 55: 1901635. PMID: 31771999, PMCID: PMC7885179, DOI: 10.1183/13993003.01635-2019.
- Singh I, Rahaghi F, Naeije R, Oliveira R, Vanderpool RR, Waxman A, Systrom D. Dynamic right ventricular–pulmonary arterial uncoupling during maximum incremental exercise in exercise pulmonary hypertension and pulmonary arterial hypertension. Pulmonary Circulation 2019, 9: 1-10. PMID: 31218910, PMCID: PMC6643191, DOI: 10.1177/2045894019862435.
- Singh I, Oliveira RKF, Naeije R, Rahaghi FN, Oldham WM, Systrom DM, Waxman AB. Pulmonary Vascular Distensibility and Early Pulmonary Vascular Remodeling in Pulmonary Hypertension. CHEST Journal 2019, 156: 724-732. PMID: 31121149, DOI: 10.1016/j.chest.2019.04.111.
- Singh I, Rahaghi FN, Naeije R, Oliveira RKF, Systrom DM, Waxman AB. Right Ventricular-Arterial Uncoupling During Exercise in Heart Failure With Preserved Ejection Fraction Role of Pulmonary Vascular Dysfunction. CHEST Journal 2019, 156: 933-943. PMID: 31103695, DOI: 10.1016/j.chest.2019.04.109.
- Pulmonary Vascular Distensibility and Early Pulmonary Vascular Remodelling in Pulmonary HypertensionSingh I, Oliveira R, Naeije R, Rahaghi F, Oldham W, Systrom D, Waxman A. Pulmonary Vascular Distensibility and Early Pulmonary Vascular Remodelling in Pulmonary Hypertension. 2019, a3668-a3668. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a3668.
- Rahaghi F, de La Bruere I, Singh I, Nardelli P, Come C, Faria Urbina M, Leopold J, Hunsaker A, San José Estépar R, San José Estépar R, Systrom D, Waxman A, Washko G. Decrease in Intraparenchymal Small Vessel Fraction in Exercise Pulmonary Arterial Hypertension. 2019, a5590-a5590. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5590.
- Ruopp N, De La Bruere I, Singh I, Come C, Faria Urbina M, Leopold J, Washko G, San Jose Estepar R, Systrom D, Waxman A, Rahaghi F. Main Pulmonary Artery Dilation in Early/Exercise Pulmonary Hypertension. 2019, a3664-a3664. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a3664.
- Ansari S, de La Bruere I, Singh I, Come C, Faria Urbina M, Leopold J, Hunsaker A, San Jose Estepar R, Washko G, Systrom D, Waxman A, Rahaghi F. Right and Left Pulmonary Artery Dilation in Pulmonary Hypertension. 2019, a3643-a3643. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a3643.
- Clapham KR, Singh I, Capuano IS, Rajagopal S, Chun HJ. MEF2 and the Right Ventricle: From Development to Disease. Frontiers In Cardiovascular Medicine 2019, 6: 29. PMID: 30984767, PMCID: PMC6448530, DOI: 10.3389/fcvm.2019.00029.
- Shojaee S, Singh I, Solsky I, Nana-Sinkam P. Malignant Pleural Effusion at Presentation in Patients with Small-Cell Lung Cancer. Respiration; International Review Of Thoracic Diseases 2019, 98: 198-202. PMID: 31121583, DOI: 10.1159/000499372.
- Dynamic right ventricular-pulmonary arterial (RV-PA) uncoupling during incremental exercise in HFpEFSingh I, Rahaghi F, Oliveira R, Systrom D, Waxman A. Dynamic right ventricular-pulmonary arterial (RV-PA) uncoupling during incremental exercise in HFpEF. 2018, pa3313. DOI: 10.1183/13993003.congress-2018.pa3313.
- Singh I, Mikita G, Green D, Risquez C, Sanders A. Pulmonary extra‐medullary hematopoiesis and pulmonary hypertension from underlying polycythemia vera: a case series. Pulmonary Circulation 2017, 7: 261-267. PMID: 28680586, PMCID: PMC5448544, DOI: 10.1177/2045893217702064.
- Singh I, Kaner R. A Woman with Asthma and Ground-Glass Opacities. Annals Of The American Thoracic Society 2017, 14: 140-144. PMID: 28035877, DOI: 10.1513/annalsats.201606-473cc.
- Singh I, Mikita G, Green D, Risquez C, Sanders A. Pulmonary Extra-medullary Hematopoiesis and Pulmonary Hypertension From Underlying Polycythemia Vera: A Case Series. Pulmonary Circulation 2016 DOI: 10.1086/690730.
- Singh I, Risquez C, Sanders A. When the JAK Fails the Pump. CHEST Journal 2016, 150: 687a. DOI: 10.1016/j.chest.2016.08.782.
- Singh I, Cong K, Berlin DA. Pathophysiology of Pulmonary Hypertension in Chronic Parenchymal Lung Disease. The American Journal Of Medicine 2015, 129: 366-371. PMID: 26706386, DOI: 10.1016/j.amjmed.2015.11.026.
- Singh I, West F, Sanders A, Hartman B, Zappetti D. Pulmonary Nocardiosis in the Immunocompetent Host: Case Series. Case Reports In Pulmonology 2015, 2015: 314831. PMID: 26491594, PMCID: PMC4605260, DOI: 10.1155/2015/314831.
- Singh I, Zappetti D. Exercise Intolerance in Pulmonary Hypertension. Clinical Pulmonary Medicine 2015, 22: 258-259. DOI: 10.1097/cpm.0000000000000122.
- Berlin D, Singh I, Barjaktarevic I, Friedman O. A Technique for Bronchoscopic Intubation During High-Flow Nasal Cannula Oxygen Therapy. Journal Of Intensive Care Medicine 2015, 31: 213-215. PMID: 25911299, DOI: 10.1177/0885066615582020.
- Winchester Center for Lung DiseaseFitkin Memorial Pavilion789 Howard AvenueNew Haven, CT 06519
- Winchester Center for Lung DiseaseFitkin Memorial Pavilion789 Howard AvenueNew Haven, CT 06519