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Winchester Center for Lung Disease
Fitkin Memorial Pavilion
789 Howard Avenue, Ste 2nd floor
New Haven, CT 06519
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- Winchester Center for Lung DiseaseFitkin Memorial Pavilion789 Howard Avenue, Ste 2nd floorNew Haven, CT 06519
- Winchester Center for Lung Disease6 Devine StreetNorth Haven, CT 06473
Geoffrey Chupp, MD
Pulmonology & Sleep Medicine, Asthma , Pulmonary Critical Care
Telehealth is available
Patient type treated
Adult
Accepting new patients
Yes
Referral required
From patients or physicians
Board Certified in
Critical Care Medicine (Internal Medicine), Internal Medicine
, and Pulmonary Disease
Biography
Geoffrey Chupp, MD, is a pulmonologist who specializes in lung diseases that affect the airway, including severe asthma, Chronic Obstructive Pulmonary Disease (COPD), bronchiolitis, autoimmune airway diseases, and airway diseases that have not been classified. He also specializes in eosinophilic lung diseases such as eosinophilic pneumonia, eosinophilic granulomatosis with polyangiitis (EGPA), and Allergic Bronchopulmonary Aspergillosis (ABPA).
He often helps patients who have complex disease that has been difficult to treat.
“I wanted to pursue a career in medicine to comfort people who are sick and discover the cause or causes of their disease,” says Dr. Chupp. Working with pulmonary patients is especially rewarding for a doctor, he adds. “It crosses all segments of society, so I get to meet lots of interesting people.”
Dr. Chupp came to Yale in 1997 and developed the Yale Center for Asthma & Airways Disease (YCAAD), a multidisciplinary clinical program that he still directs. The center cares for a broad spectrum of conditions and has helped patients with conditions that are difficult to diagnose, sometimes because of a co-occurring illness such as gastroesophageal reflux or sinusitis, and provides treatments that may not be available elsewhere. “We have novel biologic treatments and access to clinical trials for these patients,” he says.
Up to 20 clinical trials are active at any given time at YCAAD. This research has helped put Yale Medicine on the cutting edge of individualized asthma therapy and precision medicine for patients with asthma. “We see a future where we will be identifying a patient’s particular genetic risk factors and the molecular signals that are driving their particular disease,” says Dr. Chupp. “We will develop a combination of treatments that is personalized for every patient; it will include lifestyle recommendations, inhaled therapies, and biologic therapies that will maximally manage their disease without guesswork.”
Titles
- Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine )
- Director, Yale Center for Asthma and Airways Disease (YCAAD), Pulmonary, Critical Care & Sleep Medicine
- Director, Pulmonary Function Laboratory, Yale-New Haven Hospital, Pulmonary, Critical Care & Sleep Medicine
Education & Training
- MAYale University, Privatim (2017)
- FellowBoston University School of Medicine (1997)
- ResidentTufts University/New England Medical Center (1993)
- InternTufts-New England Medical Center (1991)
- MDGeorge Washington University (1990)
- BSTufts University (1986)
Additional Information
Honors & Recognitions
- Yale Technology Summit: Technology Innovations Pitch Competition Award Second Place: (2017)
- Connecticut Magazine Top Docs 2016: Connecticut Magazine (2016)
- Connecticut Magazine Top Docs 2015: Connecticut Magazine (2015)
- Hero of Yale New Haven Hospital Award: (2009)
- Distinguished Service Award: Yale New Haven Hospital (2008)
- Distinguished Service Award: Yale New Haven Hospital (2007)
- Excellence in Teaching Award: Pulmonary and Critical Care Fellows), Division of Pulmonary and Critical Care Medicine (2006)
- Distinguished Service Award: Yale New Haven Hospital (2006)
- Excellence in Teaching Award: Pulmonary and Critical Care Fellows (2002)
- Loan Repayment Award: National Institutes of Health (2002)
Publications
- Carr T, Moore W, Kraft M, Brusselle G, Castro M, Chupp G, Wechsler M, Hunter G, Lindsley A, Llanos J, Burke L, Chandarana S, Ambrose C. Efficacy of Tezepelumab in Patients with Severe, Uncontrolled Asthma Across Multiple Clinically Relevant Subgroups in the NAVIGATOR Study. Advances In Therapy 2024, 41: 2978-2990. PMID: 38802635, PMCID: PMC11213736, DOI: 10.1007/s12325-024-02889-8.
- Chupp G, Murphy K, Gandhi H, Gilbert I, Bleecker E. Asthma control in the United States Relationships between short-acting β2-agonist and systemic corticosteroid use. Annals Of Allergy Asthma & Immunology 2024, 133: 302-309. PMID: 38740134, DOI: 10.1016/j.anai.2024.05.003.
- Lugogo N, Peters A, Chupp G, Wechsler M, Caveney S, Martin N, Parikh B, Ambrose C. Clinical Responses to Tezepelumab in Patients With Severe, Uncontrolled Asthma, and a History of Nasal Polyps From the NAVIGATOR Study. 2024, a5251-a5251. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5251.
- Liu M, Chaudhuri R, Chupp G, Heaney L, Lee J, Pilette C, Brusselle G, Alfonso Cristancho R, Zhang L, Howarth P. Impact of Atopic Status, Prior Omalizumab Use and Baseline Blood Eosinophil Count Alone and in Combination With Total Serum IgE on Maintenance OCS Reduction Outcomes in Patients With Severe Asthma Treated With Mepolizumab in the REALITI-A Study. 2024, a5376-a5376. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5376.
- Israel E, Chupp G, Lugogo N, Llanos J, Martin N, Martin N, Ambrose C, Jackson D. Asthma Exacerbation Rates as a Function of Biomarker Levels 4 Weeks After Initiation of Tezepelumab Treatment: An Analysis of the NAVIGATOR Study. 2024, a6704-a6704. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6704.
- Wilson G, Liu Q, Gautam S, Knight J, Shelar A, Stewart E, Visness C, Sanders J, Gill M, Gruchalla R, Liu A, Kattan M, Khurana Hershey G, Togias A, Becker P, Altman M, Busse W, Jackson D, Montgomery R, Chupp G. Innate Immune Mechanisms Associated With Exacerbations on Mepolizumab. 2024, a6984-a6984. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6984.
- Wilson G, Knight J, Liu Q, Shelar A, Stewart E, Wang X, Yan X, Sanders J, Visness C, Gill M, Gruchalla R, Liu A, Kattan M, Khurana Hershey G, Togias A, Becker P, Altman M, Busse W, Jackson D, Montgomery R, Chupp G. Activated sputum eosinophils associated with exacerbations in children on mepolizumab. Journal Of Allergy And Clinical Immunology 2024, 154: 297-307.e13. PMID: 38485057, PMCID: PMC11305967, DOI: 10.1016/j.jaci.2024.01.031.
- Chupp G, Alobid I, Lugogo N, Kariyawasam H, Bourdin A, Chaker A, Smith S, Sousa A, Mayer B, Chan R, Matucci A, Chachuat L. Mépolizumab est associé à des bénéfices cliniques chez les patients atteints de polypose nasosinusienne, indépendamment de l’utilisation antérieure de corticostéroïdes systémiques. Revue Des Maladies Respiratoires Actualités 2024, 16: 188-189. DOI: 10.1016/j.rmra.2023.11.387.
- Brusselle G, Lougheed D, Canonica G, Munoz-Esquerre M, Heaney L, Price R, Howarth P, Raimondi A, Gardiner F, Chupp G, Welte T, Picaud C. Obtention d’une rémission clinique dans l’asthme sévère après un traitement par mépolizumab : résultats de l’étude REALITI-A à 2 ans. Revue Des Maladies Respiratoires Actualités 2024, 16: 192-193. DOI: 10.1016/j.rmra.2023.11.393.
- Gautam S, Chu J, Cohen A, Kaur R, Lee S, Wilson G, Liu Q, Gomez J, Rajaveen H, Yan X, Cohn L, Clark B, Chupp G. Sputum alarmins delineate distinct T2 cytokine pathways and unique subtypes of patients with asthma. Allergy 2023, 78: 3274-3277. PMID: 37874609, PMCID: PMC10842366, DOI: 10.1111/all.15915.
- MOORE W, LUGOGO N, CHUPP G, MARTIN N, AMBROSE C, COOK W, ACKERT J. EFFICACY OF TEZEPELUMAB IN PATIENTS WITH SEVERE, UNCONTROLLED ASTHMA WITH COMORBID GASTROESOPHAGEAL REFLUX DISEASE: A POOLED ANALYSIS OF THE PATHWAY AND NAVIGATOR STUDIES. CHEST Journal 2023, 164: a4-a7. DOI: 10.1016/j.chest.2023.07.073.
- CHUPP G, LUGOGO N, WECHSLER M, LAWSON K, LINDSLEY A, SPAHN J, AMBROSE C. LONG-TERM EFFICACY OF TEZEPELUMAB IN PATIENTS WITH SEVERE, UNCONTROLLED ASTHMA BY BASELINE BODY MASS INDEX. CHEST Journal 2023, 164: a9-a14. DOI: 10.1016/j.chest.2023.07.075.
- iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjectsLiu Y, Zhao J, Adams T, Wang N, Schupp J, Wu W, McDonough J, Chupp G, Kaminski N, Wang Z, Yan X. iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjects. BMC Bioinformatics 2023, 24: 318. PMID: 37608264, PMCID: PMC10463720, DOI: 10.1186/s12859-023-05432-8.
- Chupp G, Alobid I, Lugogo N, Kariyawasam H, Bourdin A, Chaker A, Smith S, Sousa A, Mayer B, Chan R, Matucci A. Mepolizumab Reduces Systemic Corticosteroid Use in Chronic Rhinosinusitis With Nasal Polyps. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 3504-3512.e2. PMID: 37586475, DOI: 10.1016/j.jaip.2023.08.015.
- Liu Y, Rajeevan H, Simonov M, Lee S, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Ortega H, Zaeh S, Gomez J, Cohn L, Gautam S, Chupp G. Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 3383-3390.e3. PMID: 37454926, PMCID: PMC10787810, DOI: 10.1016/j.jaip.2023.07.006.
- Zaeh S, Chupp G, Eakin M. Is there a best strategy to prevent asthma exacerbations in inner-city patients with asthma? Annals Of Allergy Asthma & Immunology 2023, 132: 11-12. PMID: 37433383, PMCID: PMC10774450, DOI: 10.1016/j.anai.2023.07.003.
- Corren J, Menzies-Gow A, Chupp G, Israel E, Korn S, Cook B, Ambrose C, Hellqvist Å, Roseti S, Molfino N, Llanos J, Martin N, Bowen K, Griffiths J, Parnes J, Colice G. Efficacy of Tezepelumab in Severe, Uncontrolled Asthma: Pooled Analysis of the PATHWAY and NAVIGATOR Clinical Trials. American Journal Of Respiratory And Critical Care Medicine 2023, 208: 13-24. PMID: 37015033, PMCID: PMC10870853, DOI: 10.1164/rccm.202210-2005oc.
- Menzies-Gow A, Bourdin A, Chupp G, Israel E, Hellqvist Å, Hunter G, Roseti S, Ambrose C, Llanos J, Cook B, Corren J, Colice G. Effect of tezepelumab on healthcare utilization in patients with severe, uncontrolled asthma The NAVIGATOR study. Annals Of Allergy Asthma & Immunology 2023, 131: 343-348.e2. PMID: 37263380, DOI: 10.1016/j.anai.2023.05.028.
- Rabe K, Pavord I, Busse W, Chupp G, Izuhara K, Altincatal A, Gall R, Pandit‐Abid N, Deniz Y, Rowe P, Jacob‐Nara J, Radwan A. Dupilumab improves long‐term outcomes in patients with uncontrolled, moderate‐to‐severe GINA‐based type 2 asthma, irrespective of allergic status. Allergy 2023, 78: 2148-2156. PMID: 37073882, DOI: 10.1111/all.15747.
- Liu Y, Rajeevan H, Simonov M, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Gomez J, Cohn L, Gautam S, Chupp G. Mortality Differences Among Patients With Airway Disease Hospitalized With COVID-19. 2023, a6297-a6297. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6297.
- Zaeh S, Eakin M, Chupp G. Clinical Practices and Barriers to the Use of Single Maintenance and Reliever Therapy for Asthma. 2023, a6006-a6006. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6006.
- Wilson G, Liu Q, Knight J, Shelar A, Stewart E, Visness C, Sanders J, Gill M, Gruchalla R, Liu A, Kattan M, Hershey G, Togias A, Becker P, Altman M, Busse W, Jackson D, Montgomery R, Chupp G. Functional Analysis of Sputum Eosinophil Subpopulations in Children With Asthma. 2023, a3016-a3016. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a3016.
- Chupp G, Liu Q, Adams T, Schupp J, Wilson G, Grant N, Gomez J, Cohn L, Kaminski N, Akuthota P, Weiss S, Glass K, Bleecker E, Meyers D, Tantisira K, Yan X. Activation of Adam12-SDC4 and CCL22-CCR4 Pathways in the Airway in Asthma. 2023, a5689-a5689. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a5689.
- Brusselle G, Lougheed M, Canonica G, Munoz-Esquerre M, Heaney L, Price R, Howarth P, Raimondi A, Gardiner F, Chupp G, Welte T. Clinical Remission Achievement in Severe Asthma Following Mepolizumab Treatment: Results From the REALITI-A Study at 2 Years. 2023, a5985-a5985. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a5985.
- Kraft M, Chupp G, Reeh K, Lindsley A, Cook B, Hunter G, Ambrose C. Efficacy of Tezepelumab in Patients With Severe, Uncontrolled Asthma by Sex: Results From the Phase 3 Navigator Study. 2023, a4751-a4751. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4751.
- Pavord I, Gardiner F, Heaney L, Domingo C, Price R, Pullan A, Oppenheimer J, Brusselle G, Nagase H, Chupp G, Pizzichini E, Bañas-Conejero D, Howarth P. Remission outcomes in severe eosinophilic asthma with mepolizumab therapy: Analysis of the REDES study. Frontiers In Immunology 2023, 14: 1150162. PMID: 37122713, PMCID: PMC10131245, DOI: 10.3389/fimmu.2023.1150162.
- Chupp G, Heaney L, Price R, Brusselle G, Gardiner F, Raimondi A, Chaudhuri R, Howarth P. Real-World Impact of Mepolizumab on the Oral Corticosteroid Freedom Component of Clinical Remission in Severe Eosinophilic Asthma: International, Prospective REALITI-A Study. Journal Of Allergy And Clinical Immunology 2023, 151: ab20. DOI: 10.1016/j.jaci.2022.12.066.
- Corren J, Wechsler M, Chupp G, Roseti S, Hellqvist Å, Martin N, Llanos J, Ambrose C, Colice G. Efficacy and safety of tezepelumab in patients with uncontrolled disease while receiving maintenance therapy for moderate or severe asthma. The Journal Of Allergy And Clinical Immunology In Practice 2022, 11: 943-945.e2. PMID: 36375743, DOI: 10.1016/j.jaip.2022.10.042.
- Ortega H, Katz L, Chupp G. Asthma exacerbations during the pandemic: Time to rethink clinical markers. Journal Of Allergy And Clinical Immunology Global 2022, 2: 97-100. PMID: 36281240, PMCID: PMC9581642, DOI: 10.1016/j.jacig.2022.09.003.
- Ayala A, Yin H, Khanal S, Niu N, Nunez M, Chupp G, Laguna T, Britto C. 117 Interleukin-6 and short-palate lung and nasal epithelium clone 1 fluctuations as sex-specific markers of acute cystic fibrosis exacerbation. Journal Of Cystic Fibrosis 2022, 21: s69. DOI: 10.1016/s1569-1993(22)00808-6.
- CORREN J, WECHSLER M, CHUPP G, AMBROSE C, ROSETI S, HELLQVIST Å, ACKERT J, MARTIN N, COLICE G. EFFICACY OF TEZEPELUMAB IN PATIENTS WITH UNCONTROLLED ASTHMA DESPITE RECEIVING TREATMENT FOR MODERATE OR SEVERE DISEASE: POOLED ANALYSIS OF PATHWAY AND NAVIGATOR STUDIES. CHEST Journal 2022, 162: a21-a22. DOI: 10.1016/j.chest.2022.08.018.
- Korde A, Haslip M, Ahangari F, Pober J, Chupp G, Manes P, Gonzalez A, Takyar S. Endothelial Thrombopoietin Receptor Controls Eosinophil Trafficking in Asthma and Chronic Rhinosinusitis. 2022, a5684-a5684. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5684.
- Menzies-Gow A, Bourdin A, Cook W, Ambrose C, Chupp G, Kmita K, Lanos-Ackert J, Colice G. Effect of tezepelumab on exacerbation-related oral corticosteroid use in NAVIGATOR. Pneumologie 2022, 76: s12-s13. DOI: 10.1055/s-0042-1747713.
- Cao G, Lam H, Jude J, Karmacharya N, Kan M, Jester W, Koziol-White C, Himes B, Chupp G, An S, Panettieri R. Inhibition of ABCC1 Decreases cAMP Egress and Promotes Human Airway Smooth Muscle Cell Relaxation. 2022, a3280-a3280. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3280.
- Wilson G, Liu Q, Knight J, Visness C, Villarreal M, Gill M, Gruchalla R, Liu A, Kattan M, Hershey G, Togias A, Becker P, Altman M, Busse W, Jackson D, Montgomery R, Chupp G. Exploring the Effect of Anti-IL5 Therapy on Sputum Eosinophils in Children with Asthma. 2022, a4833-a4833. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4833.
- Jung E, Howell R, Cohen A, Tsang D, Chupp G, Dela Cruz C, Gautam S, Brewster R, Flint J, Yin H, Ristic N, Cosme Jr C. Chemoattractant-Receptor Homologous Molecule on Th2 Cells (CRTH2) Regulates Neutrophilic Inflammation in the Lung. 2022, a2534-a2534. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2534.
- Chupp G, Lee J, Liu M, Schleich F, Heaney L, Ribas C, Carrillo-Díaz T, Aparicio M, Moragón E, Sanchez-Herrero M, Gardiner F, Alfonso-Cristancho R, Jakes R, Price R, Howarth P. Mepolizumab Demonstrates Real-world Clinical Effectiveness in both Type 2 Biomarker High and Type 2 Biomarker Low Patients with Severe Asthma. Journal Of Allergy And Clinical Immunology 2022, 149: ab318. DOI: 10.1016/j.jaci.2021.12.019.
- Chupp G, Alobid I, Lugogo N, Kariyawasam H, Bourdin A, Chaker A, Sousa A, Martin N, Yang S, Mayer B, Chan R, Matucci A, Chachuat L. Le mépolizumab réduit l’utilisation de corticostéroïdes systémiques chez les patients atteints de rhinosinusite chronique avec polypes nasaux. Revue Des Maladies Respiratoires Actualités 2022, 14: 34-35. DOI: 10.1016/j.rmra.2021.11.508.
- Israel E, Chupp G, Colice G, Cook B, Ambrose C, Roseti S, Hellqvist Å, Llanos-Ackert J. D011 TEZEPELUMAB EFFICACY ACCORDING TO US OMALIZUMAB ELIGIBILITY: RESULTS FROM THE NAVIGATOR PHASE 3 STUDY. Annals Of Allergy Asthma & Immunology 2021, 127: s14-s15. DOI: 10.1016/j.anai.2021.08.049.
- Oppenheimer J, Abott C, Chang S, Chupp G, Crawford J, Mannino D, Win P. D010 CAPTAIN STUDY: EFFECTS OF BASELINE IGE LEVELS ON TRIPLE THERAPY RESPONSE IN INADEQUATELY CONTROLLED ASTHMA. Annals Of Allergy Asthma & Immunology 2021, 127: s14. DOI: 10.1016/j.anai.2021.08.048.
- Chupp G, Feigler N, Gandhi H. VARIATIONS HIGHLIGHTED IN HYPERLOCAL HEATMAPS CAN ADDRESS UNMET NEED AND ALLOCATION OF RESOURCES IN COPD. CHEST Journal 2021, 160: a1796-a1797. DOI: 10.1016/j.chest.2021.07.1630.
- Chupp G, Menzies-Gow A, Ambrose C, Cook W, Kmita K, Lindsley A, Llanos-Ackert J, Colice G, Lugogo N. EFFICACY OF TEZEPELUMAB IN PATIENTS WITH SEVERE, UNCONTROLLED ASTHMA GROUPED BY BASELINE BMI IN THE NAVIGATOR STUDY. CHEST Journal 2021, 160: a37-a40. DOI: 10.1016/j.chest.2021.07.078.
- Korn S, Bourdin A, Chupp G, Colice G, Ambrose C, Kmita K, Llanos-Ackert J, Molfino N, Cook B. Effect of tezepelumab on the proportion of exacerbation-free patients with severe, uncontrolled asthma in NAVIGATOR. 2021, oa1198. DOI: 10.1183/13993003.congress-2021.oa1198.
- Bourdin A, Menzies-Gow A, Chupp G, Ambrose C, Kmita K, Llanos-Ackert J, Colice G, Cook B. Effect of tezepelumab on exacerbation-related oral corticosteroid use in NAVIGATOR. 2021, oa1484. DOI: 10.1183/13993003.congress-2021.oa1484.
- Israel E, Menzies-Gow A, Chupp G, Ambrose C, Cook B, Hunter G, Llanos-Ackert J, Downie J, Colice G. Efficacy of tezepelumab in adolescents with severe, uncontrolled asthma. 2021, oa1490. DOI: 10.1183/13993003.congress-2021.oa1490.
- Kerstjens H, Abbott C, Boulet L, Chang S, Chupp G, Crawford J, Hanania N, Nathan R, Oppenheimer J, Pizzichini E, Sagara H, Busse W. CAPTAIN: Effects of triple therapy on FEV1 response in patients with inadequately controlled asthma on ICS/LABA. 2021, pa3386. DOI: 10.1183/13993003.congress-2021.pa3386.
- Steinfeld J, Gleich G, Roufosse F, Chupp G, Faguer S, Reiter A, Walz B, Bentley J, Bradford E, Yancey S. Safety and Efficacy of Mepolizumab in Hypereosinophilic Syndrome: An Open-Label Extension Study. 2021, a1351-a1351. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1351.
- Chaudhuri R, Caruso C, Chupp G, Fera T, Koehler T, Schleich F, Valero A, Yang S, Howarth P, Jakes R, Maxwell A, Price R, Alfonso Cristancho R. International Differences in the Use of Mepolizumab to Treat Severe Asthma - Impact of Reimbursement Policies. 2021, a1595-a1595. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1595.
- Corren J, Bourdin A, Chupp G, Israel E, Ambrose C, Llanos Ackert J, Kmita K, Cook B, Colice G, Menzies-Gow A. Efficacy of Tezepelumab in Patients with Severe, Uncontrolled Asthma Grouped by Baseline Blood Eosinophil Count and Fractional Exhaled Nitric Oxide Level: Results from the NAVIGATOR Phase 3 Study. 2021, a1198-a1198. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1198.
- Chupp G, Beeh K, Jauhiainen A, Necander S, Brown M, Wählby Hamrén U, Forsman H, Kurdyukova Y, Steele J, Astbury C, Psallidas I. Results of a Phase 2b Dose Finding Study of Velsecorat, an Inhaled Non-Steroidal, Selective Glucocorticoid Receptor Modulator in Asthma (GRANIT). 2021, a1202-a1202. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1202.
- Bourdin A, Menzies-Gow A, Chupp G, Israel E, Hellqvist, Hunter G, Ambrose C, Llanos Ackert J, Colice G, Cook B, Corren J. Reductions in Asthma Exacerbation-Related Hospitalizations and Emergency Department Visits in Patients with Severe, Uncontrolled Asthma Treated with Tezepelumab: Results from the Phase 3 NAVIGATOR Study. 2021, a1203-a1203. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1203.
- Bourdin A, Korn S, Chupp G, Cosio B, Arbetter D, Shah M, Garcia Gil E. Integrated Safety and Efficacy Among Patients with Severe Asthma Receiving Benralizumab for Up to Five Years. 2021, a1205-a1205. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1205.
- Chupp G, Alobid I, Lugogo N, Kariyawasam H, Bourdin A, Chaker A, Sousa A, Martin N, Yang S, Mayer B, Chan R, Matucci A. Mepolizumab Reduces Systemic Corticosteroid Use in Patients with Chronic Rhinosinusitis with Nasal Polyps. 2021, a1344-a1344. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1344.
- Menzies-Gow A, Corren J, Bourdin A, Chupp G, Israel E, Griffiths J, Hellqvist Å, Bowen K, Kaur P, Almqvist G, Ponnarambil S, Colice G. Efficacy and Safety of Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma: Results from the Phase 3 NAVIGATOR Study. Journal Of Allergy And Clinical Immunology 2021, 147: ab249. DOI: 10.1016/j.jaci.2020.12.050.
- Bleecker E, Murphy K, Gandhi H, Gilbert I, Zein J, Reibman J, Chupp G. Natural history of disease burden for US patients with asthma vs asthma and COPD. 2020, 1397. DOI: 10.1183/13993003.congress-2020.1397.
- Murphy K, Chipps B, Beuther D, Wise R, McCann W, Gilbert I, Eudicone J, Gandhi H, Harding G, Coyne K, Zeiger R, Board P, Kobernick A, Mohammad A, Cherry A, Fein A, Gaines A, Ramsey A, Michaud A, Palmer A, Kim A, Smith A, White A, Ricci A, Kettelhut B, Modena B, Stone B, Rolston B, Schnapf B, Krajicek B, Kraft C, Hopkins C, Natalie C, Anderson C, Czajkowski C, Arce D, Hamlin D, Hill D, Mares D, Pham D, Liao D, Simmons D, Johnson D, Jhaveri D, Maselli D, Kerwin E, Schuman E, Sher E, Bleecker E, Rakowski E, Hsu F, Averill F, Barsanti F, Gross G, Chupp G, Head G, Nasir H, Lee H, Barjaktarevic I, Cook J, Krainson J, Pearl J, Bellak J, Perez-Fernandez J, Rehm J, Trevor J, Most J, Hanson J, Blessing-Moore J, Biller J, Gedell J, Southard J, Chancellor J, Ilowite J, Romeo J, Mercado J, Fisher J, Greiwe J, Gregory K, Nadeau K, Shenoy K, Tan L, Stefanowicz L, Humes L, Bowers L, O’Connor M, Perez M, White M, Hegewald M, Wilson M, Sikora M, Morganroth M, Smith M, Farooqui N, Lesch N, Jain N, Parikh N, Hartog N, Luthin P, Stewart P, O’Connor P, Schochet P, Goldberg P, Patel P, Chinthrajah R, Sidhu R, Ayinla R, Brown R, Stadtler R, Wachs R, Balkissoon R, Duplantier R, Puente R, Settipane R, Mustafa S, Surani S, Jawad S, Adams S, Villegas S, Al-Farra S, Subramanian S, Bains S, Kelsen S, Wise S, Estrella-Eades S, Smith S, Qureshi T, Chen T, Kelbel T, Miller T, Jain V, Soong W, Soler X, Mattar Z. Development of the Asthma Impairment and Risk Questionnaire (AIRQ): A Composite Control Measure. The Journal Of Allergy And Clinical Immunology In Practice 2020, 8: 2263-2274.e5. PMID: 32387166, DOI: 10.1016/j.jaip.2020.02.042.
- Wang Z, Shan N, Yan X, Mane S, Gomez J, Chupp G. Whole Exome Sequencing of Severe Asthma Identifies Novel Gene Association Candidates. 2020, a1336-a1336. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a1336.
- Koziol-White C, Parikh V, Chupp G, Panettieri R. Blocking YKL-40 (Chitinase-Like Protein Chitinase 3) Reverses IL-13/IL-4-Induced Hyporesponsiveness to Bronchodilators in Human Small Airways and in Human Airway Smooth Muscle Cells. 2020, a1252-a1252. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a1252.
- Bleecker E, Murphy K, Gandhi H, Gilbert I, Chupp G. Assessing Asthma Control in the United States by Examining the Relationships Between Short-Acting Beta 2 -Agonist and Systemic Corticosteroid Use. 2020, a1818-a1818. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a1818.
- Glynn N, Gmelin T, Santanasto A, Lovato L, Lange‐Maia B, Nicklas B, Fielding R, Manini T, Myers V, Rekeneire N, Spring B, Pahor M, King A, Rejeski W, Newman A, Pahor M, Guralnik J, Anton S, Buford T, Leeuwenburgh C, Nayfield S, Manini T, Caudle C, Crump L, Holmes L, Lee J, Lu C, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Joyce K, Lovato L, Pierce J, Roberson W, Robertson J, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Chen S, Pierce J, Chen H, Hadley E, Romashkan S, Patel K, Bethesda, Bonds D, McDermott M, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor‐Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Yank V, Berra K, Bell C, Thiessen R, Youngman K, Virgen S, Maldonado E, Tarin K, Klaftenegger H, Prosak C, Campero I, Garcia D, Soto J, Chio L, Hoskins D, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kirn D, Pasha E, Kim W, Krol J, Beard V, Tsiroyannis E, Hau C, Manini T, Pahor M, Anton S, Buford T, Marsiske M, Nayfield S, Sandesara B, Black M, Burk W, Hoover B, Knaggs J, Marena W, Korytov I, Curtis S, Lorow M, Goswami C, Lewis M, Kamen M, Bitz J, Stanton B, Hicks T, Gay C, Xie C, Morris H, Singletary F, Causer J, Yonce S, Radcliff K, Smith M, Scott J, Rodriguez M, Fitch M, Dunn M, Schllesinger J, Newman A, Studenski S, Goodpaster B, Lopez O, Glynn N, Nadkarni N, Ives D, Newman M, Grove G, Williams K, Bonk J, Rush J, Kost P, Vincent P, Gerger A, Romeo J, Monheim L, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer‐Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, Rekeneire N, McGloin J, Mautner R, Huie‐White S, Bianco L, Zocher J, Wu K, Shepard D, Fennelly B, Castro R, Halpin S, Brennan M, Barnett T, Iannone L, Zenoni M, Bugaj J, Bailey C, Charpentier P, Hawthorne‐Jones G, Mignosa B, Lewis L, Williamson J, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Wilson V, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Gill T, Hankinson J, Vaz Fragoso C, Groessl E, Kaplan R. Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability. Journal Of The American Geriatrics Society 2019, 68: 619-624. PMID: 31867713, PMCID: PMC8061638, DOI: 10.1111/jgs.16274.
- Mohan A, Grace J, Mainardi A, Chupp G, Lugogo N. Biomarkers, Targeted Therapies, Biologics, and Bronchial Thermoplasty. Respiratory Medicine 2019, 123-153. DOI: 10.1007/978-3-030-20812-7_8.
- Stewart E, Chupp G, Montgomery R, Liu Q, Estrom J. Analysis of Sputum Immune Cell Populations and Their Functional Status in Asthmatics. 2019, a2916-a2916. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2916.
- Gomez J, Chen A, Yan X, Cohn L, Chupp G. MicroRNA miR-223 Is Associated with Lung Function Impairment and TH17 Inflammation in Asthma. 2019, a2929-a2929. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2929.
- Yan X, Liu Q, Mihaljinec A, Gomez J, Cohn L, Chupp G. Cell Lineage Defined by Single Cell Transcriptomics of the Sputum in Asthma. 2019, a6085-a6085. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6085.
- Chu J, Yan X, Liang A, Hu B, Gomez J, Chupp G. Integration of Sputum eQTL and GWAS Indicates IL-27/EBI3 Pathway Is Associated with Severe Asthma. 2019, a6088-a6088. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6088.
- Chupp G, Brown M, Beeh K, Wahlby-Hamren U, Ekelund A, Barkstedt E, Forsman H, Björnsson E, Jauhiainen A, Steele J, Psallidas I. Design of a Phase 2b Dose Finding Study of AZD7594, an Inhaled Non-Steroidal, Selective Glucocorticoid Receptor Modulator, for the Treatment of Asthma. 2019, a1315-a1315. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a1315.
- Chupp G, Kline J, Khatri S, McEvoy C, Silvestri G, Shifren A, Castro M, Bansal S, McClelland M, Dransfield M, Olivenstein R, Kahlstrom R, Ryan S, Lawson E, Simoff M, Wahidi M, Lamb C, Ferguson J, Haas A, Hogarth D, Tejedor R, Toth J, Majid A, Fitzgerald J, Enfield K, Grubb G, Laviolette M. Long-Term Efficacy and Safety of Bronchial Thermoplasty (BT): 4 Year Follow-Up Results from a Large Scale Prospective Study. 2019, a2683-a2683. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2683.
- Bleecker E, Murphy K, Gandhi H, Gilbert I, Chupp G. The Natural History of the Burden of Asthma in the United States by Age and Sex. 2019, a7397-a7397. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7397.
- Corbett DB, Rejeski WJ, Tudor-Locke C, Glynn NW, Kritchevsky SB, McDermott MM, Church TS, Fielding RA, Gill TM, King AC, Miller ME, Chen H, Pahor M, Manini TM, Pahor M, Guralnik J, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Lee J, Lu C, Salem W, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Hadley E, Romashkan S, Patel K, Bonds D, McDermott M, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor-Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kim W, Beard V, Manini T, Pahor M, Anton S, Buford T, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Newman A, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rush J, Kost P, Ives D, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer-Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Williamson J, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Gill T, Hankinson J, Fragoso C, Groessl E, Kaplan R. Social Participation Modifies the Effect of a Structured Physical Activity Program on Major Mobility Disability Among Older Adults: Results From the LIFE Study. The Journals Of Gerontology Series B 2017, 73: 1501-1513. PMID: 28482106, PMCID: PMC6178963, DOI: 10.1093/geronb/gbx051.
- Trevor J, Bradford E, Albers F, Bratton D, Wang-Jairaj J, Nelsen L, Chupp G, Magnan A, Brinke A. Mepolizumab Improves Lung Function and Exacerbation Rates in Severe Eosinophilic Asthma: The Musca Study - a Phase IIIb Randomized, Placebo-Controlled Tria. Journal Of Allergy And Clinical Immunology 2017, 139: ab380. DOI: 10.1016/j.jaci.2016.12.912.
- Chupp G, Bradford E, Albers F, Bratton D, Wang-Jairaj J, Nelsen L, Trevor J, Magnan A, Brinke A. Mepolizumab Significantly Improves Health Status and Asthma Control in Severe Eosinophilic Asthma: The Musca Study - a Phase IIIb Randomized, Placebo-Controlled Trial. Journal Of Allergy And Clinical Immunology 2017, 139: ab380. DOI: 10.1016/j.jaci.2016.12.911.
- Yao Y, Welp T, Liu Q, Niu N, Wang X, Britto CJ, Krishnaswamy S, Chupp G, Montgomery RR. Multiparameter Single Cell Profiling of Airway Inflammatory Cells. Cytometry Part B Clinical Cytometry 2017, 92: 12-20. PMID: 27807928, PMCID: PMC5250532, DOI: 10.1002/cyto.b.21491.
- Aubertin-Leheudre M, Anton S, Beavers D, Manini T, Fielding R, Newman A, Church T, Kritchevsky S, Conroy D, McDermott M, Botoseneanu A, Hauser M, Pahor M, Gill T, Fragoso C, Fielding R, Hauser M, Pahor M, Guralnik J, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Lee J, Lu C, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler M, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Hadley E, Romashkan S, Patel K, Bonds D, McDermott M, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor-Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kirn D, Pasha E, Kim W, Beard V, Tsiroyannis E, Hau C, Manini T, Pahor M, Anton S, Nayfield S, Buford T, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Newman A, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rush J, Kost P, Ives D, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer-Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Williamson J, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Wilson V, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Gill T, Hankinson J, Fragoso C, Groessl E, Kaplan R. Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study. Journal Of The American Medical Directors Association 2016, 18: 312-319. PMID: 27914851, PMCID: PMC5366275, DOI: 10.1016/j.jamda.2016.10.001.
- Baldassarri S, Chupp G, Leone F, Warren G, Toll B. Chest Health-care Provider Perceptions of Electronic Cigarettes. CHEST Journal 2016, 150: 1302a. DOI: 10.1016/j.chest.2016.08.1417.
- Chupp G, Yan X, Nezgovorova V, Grant N, Bradford W, Brophy C, Cohn L. MAPKAP kinase 2(MK2) expression is associated with severe asthma. 2016, pa4649. DOI: 10.1183/13993003.congress-2016.pa4649.
- Gueble M, Holm C, Grant N, Ravage-Mass L, Levesh T, Estrom J, Kapagiannidou E, Liu Q, O'Connor P, Gomez-Villalobos J, Cohn L, Chupp G. Proinflammatory cytokines and IP-10 differentiate neutrophilic and eosinophilic asthma subgroups. 2016, pa908. DOI: 10.1183/13993003.congress-2016.pa908.
- Layne AS, Hsu FC, Blair SN, Chen SH, Dungan J, Fielding RA, Glynn NW, Hajduk AM, King AC, Manini TM, Marsh AP, Pahor M, Pellegrini CA, Buford TW, Investigators L, Pahor M, Guralnik J, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Lee J, Lu C, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Hadley E, Romashkan S, Patel K, Bonds D, McDermott M, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor-Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kim W, Beard V, Manini T, Pahor M, Anton S, Nayfield S, Buford T, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Newman A, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rush J, Kost P, Ives D, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer-Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Williamson J, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Gill T, Hankinson J, Fragoso C, Groessl E, Kaplan R. Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study. Archives Of Physical Medicine And Rehabilitation 2016, 98: 11-24.e3. PMID: 27568165, PMCID: PMC5183463, DOI: 10.1016/j.apmr.2016.07.019.
- Baker M, Steinke J, Borish L, Chupp G. Leukotriene C4 Synthase Expression in Sputum Correlates with Disease Severity Amongst Patients with Different Clinical Phenotypes of Asthma. Journal Of Allergy And Clinical Immunology 2016, 137: ab207. DOI: 10.1016/j.jaci.2015.12.1118.
- Baldassarri S, Chupp G. A 43-Year-Old Man With Intravenous Drug Abuse and Recurrent Endocarditis. CHEST Journal 2013, 144: 296a-296b. DOI: 10.1378/chest.1676394.
- Scatena R, Holm C, He S, Wright P, Sessa W, Cohn L, Gomez-Villalobos J, Mitchell A, Chupp G. Characterization Of The Poor Emotional Function Phenotype In Asthma. 2012, a3967-a3967. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3967.
- Fielding RA, Rejeski WJ, Blair S, Church T, Espeland MA, Gill TM, Guralnik JM, Hsu FC, Katula J, King AC, Kritchevsky SB, McDermott MM, Miller ME, Nayfield S, Newman AB, Williamson JD, Bonds D, Romashkan S, Hadley E, Pahor M. The Lifestyle Interventions and Independence for Elders Study: Design and Methods. The Journals Of Gerontology Series A 2011, 66A: 1226-1237. PMID: 21825283, PMCID: PMC3193523, DOI: 10.1093/gerona/glr123.
- Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in BloodBjornsdottir US, Holgate ST, Reddy PS, Hill AA, McKee CM, Csimma CI, Weaver AA, Legault HM, Small CG, Ramsey RC, Ellis DK, Burke CM, Thompson PJ, Howarth PH, Wardlaw AJ, Bardin PG, Bernstein DI, Irving LB, Chupp GL, Bensch GW, Bensch GW, Stahlman JE, Karetzky M, Baker JW, Miller RL, Goodman BH, Raible DG, Goldman SJ, Miller DK, Ryan JL, Dorner AJ, Immermann FW, O'Toole M. Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood. PLOS ONE 2011, 6: e21902. PMID: 21779351, PMCID: PMC3136489, DOI: 10.1371/journal.pone.0021902.
- Ramaprakash H, Shibata T, Duffy KE, Ismailoglu UB, Bredernitz RM, Moreira AP, Coelho AL, Das AM, Fursov N, Chupp GL, Hogaboam CM. Targeting ST2L Potentiates CpG-Mediated Therapeutic Effects in a Chronic Fungal Asthma Model. American Journal Of Pathology 2011, 179: 104-115. PMID: 21640974, PMCID: PMC3123853, DOI: 10.1016/j.ajpath.2011.03.032.
- Gomez J, Perez M, Mitchell A, Holm C, He S, Chupp G. Airway Macrophage Expression Signatures Associated With Severe Airflow Obstruction In Asthma. 2011, a4540-a4540. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4540.
- Scatena R, Chupp G, Perez M, Gomez J, Wright P, Sessa W, Holm C. The Role Of Neurite Outgrowth Inhibitory Protein-B In Poorly Controlled Asthma. 2011, a1349-a1349. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a1349.
- Perez M, Gomez J, He S, Holm C, Chupp G. Characterization Of Chitinase Activity In Patients With Stable Asthma. 2011, a4334-a4334. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4334.
- Ong P, Wisnewski A, Stowe M, Holm C, He X, Zheng W, Zhang C, Zhao H, Redlich C, Chupp G. The 24-bp CHIT1 Exon 10 Polymorphism Is Associated With Airway Hyperresponsiveness In A Population Of Autobody Shop Workers. 2010, a4002-a4002. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4002.
- Gomez J, Perez M, He X, Mitchell A, Holm C, Chupp G. Characterization Of Chitinase Activity And YKL-40 Expression In Induced Sputum From Asthmatics: Correlations With Inflammation And Cell Viability And Gene Expression. 2010, a4279-a4279. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4279.
- Perez M, Gomez J, He X, Mitchell A, Kelly E, Jarjour N, Chupp G. Correlations Between The Chitinase-Like Protein YKL-40 And IL-18 After Segmental Antigen Challenge. 2010, a5605-a5605. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5605.
- Marshall P, Possick J, Chupp G. Intensive Care Unit Management of Status Asthmaticus. Clinical Pulmonary Medicine 2009, 16: 293-301. DOI: 10.1097/cpm.0b013e3181bdff38.
- Ober C, Chupp GL. The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases. Current Opinion In Allergy And Clinical Immunology 2009, 9: 401-408. PMID: 19644363, PMCID: PMC3018778, DOI: 10.1097/aci.0b013e3283306533.
- Crisafi G, Chupp G, Evans M, Sorkness R, Swenson C, Busse W, Jarjour N. Chitotriosidase Activity and YKL-40 Protein Are Increased in Severe Asthma. 2009, a5440. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5440.
- Vicencio A, Tsirilakis K, Du Z, Zeng W, Kipperman S, Veler H, Chupp G, Goldman D. Chitinase Activity and YKL-40 Expression in Lungs of Children with Persistent Asthma. 2009, a4811. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a4811.
- O'Toole M, Bjornsdottir U, Holgate S, Reddy P, Hill A, McKee C, Csimma C, Legault H, Weaver A, Small C, Ramsey R, Ellis D, Burke C, Thompson P, Irving L, Enden J, Chupp G, Wardlaw A, Stahlman J, Raible D, Miller D, Goldman S, Ryan J, Dorner A, Immermann F. Biological Mechanism Associated with Asthma Exacerbation Attack as Revealed By Gene Expression Patterns of Peripheral Blood Mononuclear Cells. Journal Of Allergy And Clinical Immunology 2009, 123: s154. DOI: 10.1016/j.jaci.2008.12.576.
- Ober C, Tan Z, Sun Y, Possick JD, Pan L, Nicolae R, Radford S, Parry RR, Heinzmann A, Deichmann KA, Lester LA, Gern JE, Lemanske RF, Nicolae DL, Elias JA, Chupp GL. Effect of Variation in CHI3L1 on Serum YKL-40 Level, Risk of Asthma, and Lung Function. New England Journal Of Medicine 2008, 358: 1682-1691. PMID: 18403759, PMCID: PMC2629486, DOI: 10.1056/nejmoa0708801.
- Chupp GL, Lee CG, Jarjour N, Shim YM, Holm CT, He S, Dziura JD, Reed J, Coyle AJ, Kiener P, Cullen M, Grandsaigne M, Dombret MC, Aubier M, Pretolani M, Elias JA. A Chitinase-like Protein in the Lung and Circulation of Patients with Severe Asthma. New England Journal Of Medicine 2007, 357: 2016-2027. PMID: 18003958, DOI: 10.1056/nejmoa073600.
- Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA. Hyperoxia causes angiopoietin 2–mediated acute lung injury and necrotic cell death. Nature Medicine 2006, 12: 1286-1293. PMID: 17086189, PMCID: PMC2768268, DOI: 10.1038/nm1494.
- Khazeni N, Homer RJ, Rubinowitz AN, Chupp GL. Massive cavitary pulmonary rheumatoid nodules in a patient with HIV. European Respiratory Journal 2006, 28: 872-874. PMID: 17012633, DOI: 10.1183/09031936.06.00144105.
- Lee CG, Kang HR, Homer RJ, Chupp G, Elias JA. Transgenic Modeling of Transforming Growth Factor-β1. Annals Of The American Thoracic Society 2006, 3: 418-423. PMID: 16799085, PMCID: PMC2658706, DOI: 10.1513/pats.200602-017aw.
- Sabina AB, Williams A, Wall HK, Bansal S, Chupp G, Katz DL. Yoga intervention for adults with mild-to-moderate asthma: a pilot study. Annals Of Allergy Asthma & Immunology 2005, 94: 543-548. PMID: 15945557, DOI: 10.1016/s1081-1206(10)61131-3.
- Cohn L, Elias JA, Chupp GL. Asthma: Mechanisms of Disease Persistence and Progression. Annual Review Of Immunology 2004, 22: 789-815. PMID: 15032597, DOI: 10.1146/annurev.immunol.22.012703.104716.
- CHUPP G. PREFACE. Clinics In Chest Medicine 2001, 22: xi. DOI: 10.1016/s0272-5231(05)70054-x.
- O'Regan A, Nau G, Chupp G, Berman J. Osteopontin (Eta-1) in cell-mediated immunity: teaching an old dog new tricks. Trends In Immunology 2000, 21: 475-478. PMID: 11071524, DOI: 10.1016/s0167-5699(00)01715-1.
- Corne J, Chupp G, Lee C, Homer R, Zhu Z, Chen Q, Ma B, Du Y, Roux F, McArdle J, Waxman A, Elias J. IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury. Journal Of Clinical Investigation 2000, 106: 783-791. PMID: 10995789, PMCID: PMC381393, DOI: 10.1172/jci9674.
- Nau G, Chupp G, Emile J, Jouanguy E, Berman J, Casanova J, Young R. Osteopontin Expression Correlates with Clinical Outcome in Patients with Mycobacterial Infection. American Journal Of Pathology 2000, 157: 37-42. PMID: 10880373, PMCID: PMC1850209, DOI: 10.1016/s0002-9440(10)64514-2.
- Elias J, Zhu Z, Chupp G, Homer R. Airway remodeling in asthma. Journal Of Clinical Investigation 1999, 104: 1001-1006. PMID: 10525034, PMCID: PMC408860, DOI: 10.1172/jci8124.
- Nau G, Liaw L, Chupp G, Berman J, Hogan B, Young R. Attenuated Host Resistance againstMycobacterium bovis BCG Infection in Mice Lacking Osteopontin. Infection And Immunity 1999, 67: 4223-4230. PMID: 10417195, PMCID: PMC96728, DOI: 10.1128/iai.67.8.4223-4230.1999.
- Nau G, Guilfoile P, Chupp G, Berman J, Kim S, Kornfeld H, Young R. A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 6414-6419. PMID: 9177232, PMCID: PMC21064, DOI: 10.1073/pnas.94.12.6414.
- Cruikshank W, Kornfeld H, Berman J, Chupp G, Keane J, Center D. Biological activity of interleukin-16. Nature 1996, 382: 501-502. PMID: 8700223, DOI: 10.1038/382501b0.
Locations
1
Winchester Center for Lung Disease
Fitkin Memorial Pavilion
789 Howard Avenue, Ste 2nd floor
New Haven, CT 06519
1 of 2
- Winchester Center for Lung DiseaseFitkin Memorial Pavilion789 Howard Avenue, Ste 2nd floorNew Haven, CT 06519
- Winchester Center for Lung Disease6 Devine StreetNorth Haven, CT 06473
Biography
Geoffrey Chupp, MD, is a pulmonologist who specializes in lung diseases that affect the airway, including severe asthma, Chronic Obstructive Pulmonary Disease (COPD), bronchiolitis, autoimmune airway diseases, and airway diseases that have not been classified. He also specializes in eosinophilic lung diseases such as eosinophilic pneumonia, eosinophilic granulomatosis with polyangiitis (EGPA), and Allergic Bronchopulmonary Aspergillosis (ABPA).
He often helps patients who have complex disease that has been difficult to treat.
“I wanted to pursue a career in medicine to comfort people who are sick and discover the cause or causes of their disease,” says Dr. Chupp. Working with pulmonary patients is especially rewarding for a doctor, he adds. “It crosses all segments of society, so I get to meet lots of interesting people.”
Dr. Chupp came to Yale in 1997 and developed the Yale Center for Asthma & Airways Disease (YCAAD), a multidisciplinary clinical program that he still directs. The center cares for a broad spectrum of conditions and has helped patients with conditions that are difficult to diagnose, sometimes because of a co-occurring illness such as gastroesophageal reflux or sinusitis, and provides treatments that may not be available elsewhere. “We have novel biologic treatments and access to clinical trials for these patients,” he says.
Up to 20 clinical trials are active at any given time at YCAAD. This research has helped put Yale Medicine on the cutting edge of individualized asthma therapy and precision medicine for patients with asthma. “We see a future where we will be identifying a patient’s particular genetic risk factors and the molecular signals that are driving their particular disease,” says Dr. Chupp. “We will develop a combination of treatments that is personalized for every patient; it will include lifestyle recommendations, inhaled therapies, and biologic therapies that will maximally manage their disease without guesswork.”
Titles
- Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine )
- Director, Yale Center for Asthma and Airways Disease (YCAAD), Pulmonary, Critical Care & Sleep Medicine
- Director, Pulmonary Function Laboratory, Yale-New Haven Hospital, Pulmonary, Critical Care & Sleep Medicine
Education & Training
- MAYale University, Privatim (2017)
- FellowBoston University School of Medicine (1997)
- ResidentTufts University/New England Medical Center (1993)
- InternTufts-New England Medical Center (1991)
- MDGeorge Washington University (1990)
- BSTufts University (1986)
Additional Information
Honors & Recognitions
- Yale Technology Summit: Technology Innovations Pitch Competition Award Second Place: (2017)
- Connecticut Magazine Top Docs 2016: Connecticut Magazine (2016)
- Connecticut Magazine Top Docs 2015: Connecticut Magazine (2015)
- Hero of Yale New Haven Hospital Award: (2009)
- Distinguished Service Award: Yale New Haven Hospital (2008)
- Distinguished Service Award: Yale New Haven Hospital (2007)
- Excellence in Teaching Award: Pulmonary and Critical Care Fellows), Division of Pulmonary and Critical Care Medicine (2006)
- Distinguished Service Award: Yale New Haven Hospital (2006)
- Excellence in Teaching Award: Pulmonary and Critical Care Fellows (2002)
- Loan Repayment Award: National Institutes of Health (2002)
Publications
- Carr T, Moore W, Kraft M, Brusselle G, Castro M, Chupp G, Wechsler M, Hunter G, Lindsley A, Llanos J, Burke L, Chandarana S, Ambrose C. Efficacy of Tezepelumab in Patients with Severe, Uncontrolled Asthma Across Multiple Clinically Relevant Subgroups in the NAVIGATOR Study. Advances In Therapy 2024, 41: 2978-2990. PMID: 38802635, PMCID: PMC11213736, DOI: 10.1007/s12325-024-02889-8.
- Chupp G, Murphy K, Gandhi H, Gilbert I, Bleecker E. Asthma control in the United States Relationships between short-acting β2-agonist and systemic corticosteroid use. Annals Of Allergy Asthma & Immunology 2024, 133: 302-309. PMID: 38740134, DOI: 10.1016/j.anai.2024.05.003.
- Lugogo N, Peters A, Chupp G, Wechsler M, Caveney S, Martin N, Parikh B, Ambrose C. Clinical Responses to Tezepelumab in Patients With Severe, Uncontrolled Asthma, and a History of Nasal Polyps From the NAVIGATOR Study. 2024, a5251-a5251. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5251.
- Liu M, Chaudhuri R, Chupp G, Heaney L, Lee J, Pilette C, Brusselle G, Alfonso Cristancho R, Zhang L, Howarth P. Impact of Atopic Status, Prior Omalizumab Use and Baseline Blood Eosinophil Count Alone and in Combination With Total Serum IgE on Maintenance OCS Reduction Outcomes in Patients With Severe Asthma Treated With Mepolizumab in the REALITI-A Study. 2024, a5376-a5376. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5376.
- Israel E, Chupp G, Lugogo N, Llanos J, Martin N, Martin N, Ambrose C, Jackson D. Asthma Exacerbation Rates as a Function of Biomarker Levels 4 Weeks After Initiation of Tezepelumab Treatment: An Analysis of the NAVIGATOR Study. 2024, a6704-a6704. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6704.
- Wilson G, Liu Q, Gautam S, Knight J, Shelar A, Stewart E, Visness C, Sanders J, Gill M, Gruchalla R, Liu A, Kattan M, Khurana Hershey G, Togias A, Becker P, Altman M, Busse W, Jackson D, Montgomery R, Chupp G. Innate Immune Mechanisms Associated With Exacerbations on Mepolizumab. 2024, a6984-a6984. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6984.
- Wilson G, Knight J, Liu Q, Shelar A, Stewart E, Wang X, Yan X, Sanders J, Visness C, Gill M, Gruchalla R, Liu A, Kattan M, Khurana Hershey G, Togias A, Becker P, Altman M, Busse W, Jackson D, Montgomery R, Chupp G. Activated sputum eosinophils associated with exacerbations in children on mepolizumab. Journal Of Allergy And Clinical Immunology 2024, 154: 297-307.e13. PMID: 38485057, PMCID: PMC11305967, DOI: 10.1016/j.jaci.2024.01.031.
- Chupp G, Alobid I, Lugogo N, Kariyawasam H, Bourdin A, Chaker A, Smith S, Sousa A, Mayer B, Chan R, Matucci A, Chachuat L. Mépolizumab est associé à des bénéfices cliniques chez les patients atteints de polypose nasosinusienne, indépendamment de l’utilisation antérieure de corticostéroïdes systémiques. Revue Des Maladies Respiratoires Actualités 2024, 16: 188-189. DOI: 10.1016/j.rmra.2023.11.387.
- Brusselle G, Lougheed D, Canonica G, Munoz-Esquerre M, Heaney L, Price R, Howarth P, Raimondi A, Gardiner F, Chupp G, Welte T, Picaud C. Obtention d’une rémission clinique dans l’asthme sévère après un traitement par mépolizumab : résultats de l’étude REALITI-A à 2 ans. Revue Des Maladies Respiratoires Actualités 2024, 16: 192-193. DOI: 10.1016/j.rmra.2023.11.393.
- Gautam S, Chu J, Cohen A, Kaur R, Lee S, Wilson G, Liu Q, Gomez J, Rajaveen H, Yan X, Cohn L, Clark B, Chupp G. Sputum alarmins delineate distinct T2 cytokine pathways and unique subtypes of patients with asthma. Allergy 2023, 78: 3274-3277. PMID: 37874609, PMCID: PMC10842366, DOI: 10.1111/all.15915.
- MOORE W, LUGOGO N, CHUPP G, MARTIN N, AMBROSE C, COOK W, ACKERT J. EFFICACY OF TEZEPELUMAB IN PATIENTS WITH SEVERE, UNCONTROLLED ASTHMA WITH COMORBID GASTROESOPHAGEAL REFLUX DISEASE: A POOLED ANALYSIS OF THE PATHWAY AND NAVIGATOR STUDIES. CHEST Journal 2023, 164: a4-a7. DOI: 10.1016/j.chest.2023.07.073.
- CHUPP G, LUGOGO N, WECHSLER M, LAWSON K, LINDSLEY A, SPAHN J, AMBROSE C. LONG-TERM EFFICACY OF TEZEPELUMAB IN PATIENTS WITH SEVERE, UNCONTROLLED ASTHMA BY BASELINE BODY MASS INDEX. CHEST Journal 2023, 164: a9-a14. DOI: 10.1016/j.chest.2023.07.075.
- iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjectsLiu Y, Zhao J, Adams T, Wang N, Schupp J, Wu W, McDonough J, Chupp G, Kaminski N, Wang Z, Yan X. iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjects. BMC Bioinformatics 2023, 24: 318. PMID: 37608264, PMCID: PMC10463720, DOI: 10.1186/s12859-023-05432-8.
- Chupp G, Alobid I, Lugogo N, Kariyawasam H, Bourdin A, Chaker A, Smith S, Sousa A, Mayer B, Chan R, Matucci A. Mepolizumab Reduces Systemic Corticosteroid Use in Chronic Rhinosinusitis With Nasal Polyps. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 3504-3512.e2. PMID: 37586475, DOI: 10.1016/j.jaip.2023.08.015.
- Liu Y, Rajeevan H, Simonov M, Lee S, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Ortega H, Zaeh S, Gomez J, Cohn L, Gautam S, Chupp G. Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 3383-3390.e3. PMID: 37454926, PMCID: PMC10787810, DOI: 10.1016/j.jaip.2023.07.006.
- Zaeh S, Chupp G, Eakin M. Is there a best strategy to prevent asthma exacerbations in inner-city patients with asthma? Annals Of Allergy Asthma & Immunology 2023, 132: 11-12. PMID: 37433383, PMCID: PMC10774450, DOI: 10.1016/j.anai.2023.07.003.
- Corren J, Menzies-Gow A, Chupp G, Israel E, Korn S, Cook B, Ambrose C, Hellqvist Å, Roseti S, Molfino N, Llanos J, Martin N, Bowen K, Griffiths J, Parnes J, Colice G. Efficacy of Tezepelumab in Severe, Uncontrolled Asthma: Pooled Analysis of the PATHWAY and NAVIGATOR Clinical Trials. American Journal Of Respiratory And Critical Care Medicine 2023, 208: 13-24. PMID: 37015033, PMCID: PMC10870853, DOI: 10.1164/rccm.202210-2005oc.
- Menzies-Gow A, Bourdin A, Chupp G, Israel E, Hellqvist Å, Hunter G, Roseti S, Ambrose C, Llanos J, Cook B, Corren J, Colice G. Effect of tezepelumab on healthcare utilization in patients with severe, uncontrolled asthma The NAVIGATOR study. Annals Of Allergy Asthma & Immunology 2023, 131: 343-348.e2. PMID: 37263380, DOI: 10.1016/j.anai.2023.05.028.
- Rabe K, Pavord I, Busse W, Chupp G, Izuhara K, Altincatal A, Gall R, Pandit‐Abid N, Deniz Y, Rowe P, Jacob‐Nara J, Radwan A. Dupilumab improves long‐term outcomes in patients with uncontrolled, moderate‐to‐severe GINA‐based type 2 asthma, irrespective of allergic status. Allergy 2023, 78: 2148-2156. PMID: 37073882, DOI: 10.1111/all.15747.
- Liu Y, Rajeevan H, Simonov M, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Gomez J, Cohn L, Gautam S, Chupp G. Mortality Differences Among Patients With Airway Disease Hospitalized With COVID-19. 2023, a6297-a6297. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6297.
- Zaeh S, Eakin M, Chupp G. Clinical Practices and Barriers to the Use of Single Maintenance and Reliever Therapy for Asthma. 2023, a6006-a6006. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6006.
- Wilson G, Liu Q, Knight J, Shelar A, Stewart E, Visness C, Sanders J, Gill M, Gruchalla R, Liu A, Kattan M, Hershey G, Togias A, Becker P, Altman M, Busse W, Jackson D, Montgomery R, Chupp G. Functional Analysis of Sputum Eosinophil Subpopulations in Children With Asthma. 2023, a3016-a3016. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a3016.
- Chupp G, Liu Q, Adams T, Schupp J, Wilson G, Grant N, Gomez J, Cohn L, Kaminski N, Akuthota P, Weiss S, Glass K, Bleecker E, Meyers D, Tantisira K, Yan X. Activation of Adam12-SDC4 and CCL22-CCR4 Pathways in the Airway in Asthma. 2023, a5689-a5689. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a5689.
- Brusselle G, Lougheed M, Canonica G, Munoz-Esquerre M, Heaney L, Price R, Howarth P, Raimondi A, Gardiner F, Chupp G, Welte T. Clinical Remission Achievement in Severe Asthma Following Mepolizumab Treatment: Results From the REALITI-A Study at 2 Years. 2023, a5985-a5985. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a5985.
- Kraft M, Chupp G, Reeh K, Lindsley A, Cook B, Hunter G, Ambrose C. Efficacy of Tezepelumab in Patients With Severe, Uncontrolled Asthma by Sex: Results From the Phase 3 Navigator Study. 2023, a4751-a4751. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4751.
- Pavord I, Gardiner F, Heaney L, Domingo C, Price R, Pullan A, Oppenheimer J, Brusselle G, Nagase H, Chupp G, Pizzichini E, Bañas-Conejero D, Howarth P. Remission outcomes in severe eosinophilic asthma with mepolizumab therapy: Analysis of the REDES study. Frontiers In Immunology 2023, 14: 1150162. PMID: 37122713, PMCID: PMC10131245, DOI: 10.3389/fimmu.2023.1150162.
- Chupp G, Heaney L, Price R, Brusselle G, Gardiner F, Raimondi A, Chaudhuri R, Howarth P. Real-World Impact of Mepolizumab on the Oral Corticosteroid Freedom Component of Clinical Remission in Severe Eosinophilic Asthma: International, Prospective REALITI-A Study. Journal Of Allergy And Clinical Immunology 2023, 151: ab20. DOI: 10.1016/j.jaci.2022.12.066.
- Corren J, Wechsler M, Chupp G, Roseti S, Hellqvist Å, Martin N, Llanos J, Ambrose C, Colice G. Efficacy and safety of tezepelumab in patients with uncontrolled disease while receiving maintenance therapy for moderate or severe asthma. The Journal Of Allergy And Clinical Immunology In Practice 2022, 11: 943-945.e2. PMID: 36375743, DOI: 10.1016/j.jaip.2022.10.042.
- Ortega H, Katz L, Chupp G. Asthma exacerbations during the pandemic: Time to rethink clinical markers. Journal Of Allergy And Clinical Immunology Global 2022, 2: 97-100. PMID: 36281240, PMCID: PMC9581642, DOI: 10.1016/j.jacig.2022.09.003.
- Ayala A, Yin H, Khanal S, Niu N, Nunez M, Chupp G, Laguna T, Britto C. 117 Interleukin-6 and short-palate lung and nasal epithelium clone 1 fluctuations as sex-specific markers of acute cystic fibrosis exacerbation. Journal Of Cystic Fibrosis 2022, 21: s69. DOI: 10.1016/s1569-1993(22)00808-6.
- CORREN J, WECHSLER M, CHUPP G, AMBROSE C, ROSETI S, HELLQVIST Å, ACKERT J, MARTIN N, COLICE G. EFFICACY OF TEZEPELUMAB IN PATIENTS WITH UNCONTROLLED ASTHMA DESPITE RECEIVING TREATMENT FOR MODERATE OR SEVERE DISEASE: POOLED ANALYSIS OF PATHWAY AND NAVIGATOR STUDIES. CHEST Journal 2022, 162: a21-a22. DOI: 10.1016/j.chest.2022.08.018.
- Korde A, Haslip M, Ahangari F, Pober J, Chupp G, Manes P, Gonzalez A, Takyar S. Endothelial Thrombopoietin Receptor Controls Eosinophil Trafficking in Asthma and Chronic Rhinosinusitis. 2022, a5684-a5684. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5684.
- Menzies-Gow A, Bourdin A, Cook W, Ambrose C, Chupp G, Kmita K, Lanos-Ackert J, Colice G. Effect of tezepelumab on exacerbation-related oral corticosteroid use in NAVIGATOR. Pneumologie 2022, 76: s12-s13. DOI: 10.1055/s-0042-1747713.
- Cao G, Lam H, Jude J, Karmacharya N, Kan M, Jester W, Koziol-White C, Himes B, Chupp G, An S, Panettieri R. Inhibition of ABCC1 Decreases cAMP Egress and Promotes Human Airway Smooth Muscle Cell Relaxation. 2022, a3280-a3280. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3280.
- Wilson G, Liu Q, Knight J, Visness C, Villarreal M, Gill M, Gruchalla R, Liu A, Kattan M, Hershey G, Togias A, Becker P, Altman M, Busse W, Jackson D, Montgomery R, Chupp G. Exploring the Effect of Anti-IL5 Therapy on Sputum Eosinophils in Children with Asthma. 2022, a4833-a4833. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4833.
- Jung E, Howell R, Cohen A, Tsang D, Chupp G, Dela Cruz C, Gautam S, Brewster R, Flint J, Yin H, Ristic N, Cosme Jr C. Chemoattractant-Receptor Homologous Molecule on Th2 Cells (CRTH2) Regulates Neutrophilic Inflammation in the Lung. 2022, a2534-a2534. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2534.
- Chupp G, Lee J, Liu M, Schleich F, Heaney L, Ribas C, Carrillo-Díaz T, Aparicio M, Moragón E, Sanchez-Herrero M, Gardiner F, Alfonso-Cristancho R, Jakes R, Price R, Howarth P. Mepolizumab Demonstrates Real-world Clinical Effectiveness in both Type 2 Biomarker High and Type 2 Biomarker Low Patients with Severe Asthma. Journal Of Allergy And Clinical Immunology 2022, 149: ab318. DOI: 10.1016/j.jaci.2021.12.019.
- Chupp G, Alobid I, Lugogo N, Kariyawasam H, Bourdin A, Chaker A, Sousa A, Martin N, Yang S, Mayer B, Chan R, Matucci A, Chachuat L. Le mépolizumab réduit l’utilisation de corticostéroïdes systémiques chez les patients atteints de rhinosinusite chronique avec polypes nasaux. Revue Des Maladies Respiratoires Actualités 2022, 14: 34-35. DOI: 10.1016/j.rmra.2021.11.508.
- Israel E, Chupp G, Colice G, Cook B, Ambrose C, Roseti S, Hellqvist Å, Llanos-Ackert J. D011 TEZEPELUMAB EFFICACY ACCORDING TO US OMALIZUMAB ELIGIBILITY: RESULTS FROM THE NAVIGATOR PHASE 3 STUDY. Annals Of Allergy Asthma & Immunology 2021, 127: s14-s15. DOI: 10.1016/j.anai.2021.08.049.
- Oppenheimer J, Abott C, Chang S, Chupp G, Crawford J, Mannino D, Win P. D010 CAPTAIN STUDY: EFFECTS OF BASELINE IGE LEVELS ON TRIPLE THERAPY RESPONSE IN INADEQUATELY CONTROLLED ASTHMA. Annals Of Allergy Asthma & Immunology 2021, 127: s14. DOI: 10.1016/j.anai.2021.08.048.
- Chupp G, Feigler N, Gandhi H. VARIATIONS HIGHLIGHTED IN HYPERLOCAL HEATMAPS CAN ADDRESS UNMET NEED AND ALLOCATION OF RESOURCES IN COPD. CHEST Journal 2021, 160: a1796-a1797. DOI: 10.1016/j.chest.2021.07.1630.
- Chupp G, Menzies-Gow A, Ambrose C, Cook W, Kmita K, Lindsley A, Llanos-Ackert J, Colice G, Lugogo N. EFFICACY OF TEZEPELUMAB IN PATIENTS WITH SEVERE, UNCONTROLLED ASTHMA GROUPED BY BASELINE BMI IN THE NAVIGATOR STUDY. CHEST Journal 2021, 160: a37-a40. DOI: 10.1016/j.chest.2021.07.078.
- Korn S, Bourdin A, Chupp G, Colice G, Ambrose C, Kmita K, Llanos-Ackert J, Molfino N, Cook B. Effect of tezepelumab on the proportion of exacerbation-free patients with severe, uncontrolled asthma in NAVIGATOR. 2021, oa1198. DOI: 10.1183/13993003.congress-2021.oa1198.
- Bourdin A, Menzies-Gow A, Chupp G, Ambrose C, Kmita K, Llanos-Ackert J, Colice G, Cook B. Effect of tezepelumab on exacerbation-related oral corticosteroid use in NAVIGATOR. 2021, oa1484. DOI: 10.1183/13993003.congress-2021.oa1484.
- Israel E, Menzies-Gow A, Chupp G, Ambrose C, Cook B, Hunter G, Llanos-Ackert J, Downie J, Colice G. Efficacy of tezepelumab in adolescents with severe, uncontrolled asthma. 2021, oa1490. DOI: 10.1183/13993003.congress-2021.oa1490.
- Kerstjens H, Abbott C, Boulet L, Chang S, Chupp G, Crawford J, Hanania N, Nathan R, Oppenheimer J, Pizzichini E, Sagara H, Busse W. CAPTAIN: Effects of triple therapy on FEV1 response in patients with inadequately controlled asthma on ICS/LABA. 2021, pa3386. DOI: 10.1183/13993003.congress-2021.pa3386.
- Steinfeld J, Gleich G, Roufosse F, Chupp G, Faguer S, Reiter A, Walz B, Bentley J, Bradford E, Yancey S. Safety and Efficacy of Mepolizumab in Hypereosinophilic Syndrome: An Open-Label Extension Study. 2021, a1351-a1351. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1351.
- Chaudhuri R, Caruso C, Chupp G, Fera T, Koehler T, Schleich F, Valero A, Yang S, Howarth P, Jakes R, Maxwell A, Price R, Alfonso Cristancho R. International Differences in the Use of Mepolizumab to Treat Severe Asthma - Impact of Reimbursement Policies. 2021, a1595-a1595. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1595.
- Corren J, Bourdin A, Chupp G, Israel E, Ambrose C, Llanos Ackert J, Kmita K, Cook B, Colice G, Menzies-Gow A. Efficacy of Tezepelumab in Patients with Severe, Uncontrolled Asthma Grouped by Baseline Blood Eosinophil Count and Fractional Exhaled Nitric Oxide Level: Results from the NAVIGATOR Phase 3 Study. 2021, a1198-a1198. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1198.
- Chupp G, Beeh K, Jauhiainen A, Necander S, Brown M, Wählby Hamrén U, Forsman H, Kurdyukova Y, Steele J, Astbury C, Psallidas I. Results of a Phase 2b Dose Finding Study of Velsecorat, an Inhaled Non-Steroidal, Selective Glucocorticoid Receptor Modulator in Asthma (GRANIT). 2021, a1202-a1202. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1202.
- Bourdin A, Menzies-Gow A, Chupp G, Israel E, Hellqvist, Hunter G, Ambrose C, Llanos Ackert J, Colice G, Cook B, Corren J. Reductions in Asthma Exacerbation-Related Hospitalizations and Emergency Department Visits in Patients with Severe, Uncontrolled Asthma Treated with Tezepelumab: Results from the Phase 3 NAVIGATOR Study. 2021, a1203-a1203. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1203.
- Bourdin A, Korn S, Chupp G, Cosio B, Arbetter D, Shah M, Garcia Gil E. Integrated Safety and Efficacy Among Patients with Severe Asthma Receiving Benralizumab for Up to Five Years. 2021, a1205-a1205. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1205.
- Chupp G, Alobid I, Lugogo N, Kariyawasam H, Bourdin A, Chaker A, Sousa A, Martin N, Yang S, Mayer B, Chan R, Matucci A. Mepolizumab Reduces Systemic Corticosteroid Use in Patients with Chronic Rhinosinusitis with Nasal Polyps. 2021, a1344-a1344. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1344.
- Menzies-Gow A, Corren J, Bourdin A, Chupp G, Israel E, Griffiths J, Hellqvist Å, Bowen K, Kaur P, Almqvist G, Ponnarambil S, Colice G. Efficacy and Safety of Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma: Results from the Phase 3 NAVIGATOR Study. Journal Of Allergy And Clinical Immunology 2021, 147: ab249. DOI: 10.1016/j.jaci.2020.12.050.
- Bleecker E, Murphy K, Gandhi H, Gilbert I, Zein J, Reibman J, Chupp G. Natural history of disease burden for US patients with asthma vs asthma and COPD. 2020, 1397. DOI: 10.1183/13993003.congress-2020.1397.
- Murphy K, Chipps B, Beuther D, Wise R, McCann W, Gilbert I, Eudicone J, Gandhi H, Harding G, Coyne K, Zeiger R, Board P, Kobernick A, Mohammad A, Cherry A, Fein A, Gaines A, Ramsey A, Michaud A, Palmer A, Kim A, Smith A, White A, Ricci A, Kettelhut B, Modena B, Stone B, Rolston B, Schnapf B, Krajicek B, Kraft C, Hopkins C, Natalie C, Anderson C, Czajkowski C, Arce D, Hamlin D, Hill D, Mares D, Pham D, Liao D, Simmons D, Johnson D, Jhaveri D, Maselli D, Kerwin E, Schuman E, Sher E, Bleecker E, Rakowski E, Hsu F, Averill F, Barsanti F, Gross G, Chupp G, Head G, Nasir H, Lee H, Barjaktarevic I, Cook J, Krainson J, Pearl J, Bellak J, Perez-Fernandez J, Rehm J, Trevor J, Most J, Hanson J, Blessing-Moore J, Biller J, Gedell J, Southard J, Chancellor J, Ilowite J, Romeo J, Mercado J, Fisher J, Greiwe J, Gregory K, Nadeau K, Shenoy K, Tan L, Stefanowicz L, Humes L, Bowers L, O’Connor M, Perez M, White M, Hegewald M, Wilson M, Sikora M, Morganroth M, Smith M, Farooqui N, Lesch N, Jain N, Parikh N, Hartog N, Luthin P, Stewart P, O’Connor P, Schochet P, Goldberg P, Patel P, Chinthrajah R, Sidhu R, Ayinla R, Brown R, Stadtler R, Wachs R, Balkissoon R, Duplantier R, Puente R, Settipane R, Mustafa S, Surani S, Jawad S, Adams S, Villegas S, Al-Farra S, Subramanian S, Bains S, Kelsen S, Wise S, Estrella-Eades S, Smith S, Qureshi T, Chen T, Kelbel T, Miller T, Jain V, Soong W, Soler X, Mattar Z. Development of the Asthma Impairment and Risk Questionnaire (AIRQ): A Composite Control Measure. The Journal Of Allergy And Clinical Immunology In Practice 2020, 8: 2263-2274.e5. PMID: 32387166, DOI: 10.1016/j.jaip.2020.02.042.
- Wang Z, Shan N, Yan X, Mane S, Gomez J, Chupp G. Whole Exome Sequencing of Severe Asthma Identifies Novel Gene Association Candidates. 2020, a1336-a1336. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a1336.
- Koziol-White C, Parikh V, Chupp G, Panettieri R. Blocking YKL-40 (Chitinase-Like Protein Chitinase 3) Reverses IL-13/IL-4-Induced Hyporesponsiveness to Bronchodilators in Human Small Airways and in Human Airway Smooth Muscle Cells. 2020, a1252-a1252. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a1252.
- Bleecker E, Murphy K, Gandhi H, Gilbert I, Chupp G. Assessing Asthma Control in the United States by Examining the Relationships Between Short-Acting Beta 2 -Agonist and Systemic Corticosteroid Use. 2020, a1818-a1818. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a1818.
- Glynn N, Gmelin T, Santanasto A, Lovato L, Lange‐Maia B, Nicklas B, Fielding R, Manini T, Myers V, Rekeneire N, Spring B, Pahor M, King A, Rejeski W, Newman A, Pahor M, Guralnik J, Anton S, Buford T, Leeuwenburgh C, Nayfield S, Manini T, Caudle C, Crump L, Holmes L, Lee J, Lu C, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Joyce K, Lovato L, Pierce J, Roberson W, Robertson J, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Chen S, Pierce J, Chen H, Hadley E, Romashkan S, Patel K, Bethesda, Bonds D, McDermott M, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor‐Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Yank V, Berra K, Bell C, Thiessen R, Youngman K, Virgen S, Maldonado E, Tarin K, Klaftenegger H, Prosak C, Campero I, Garcia D, Soto J, Chio L, Hoskins D, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kirn D, Pasha E, Kim W, Krol J, Beard V, Tsiroyannis E, Hau C, Manini T, Pahor M, Anton S, Buford T, Marsiske M, Nayfield S, Sandesara B, Black M, Burk W, Hoover B, Knaggs J, Marena W, Korytov I, Curtis S, Lorow M, Goswami C, Lewis M, Kamen M, Bitz J, Stanton B, Hicks T, Gay C, Xie C, Morris H, Singletary F, Causer J, Yonce S, Radcliff K, Smith M, Scott J, Rodriguez M, Fitch M, Dunn M, Schllesinger J, Newman A, Studenski S, Goodpaster B, Lopez O, Glynn N, Nadkarni N, Ives D, Newman M, Grove G, Williams K, Bonk J, Rush J, Kost P, Vincent P, Gerger A, Romeo J, Monheim L, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer‐Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, Rekeneire N, McGloin J, Mautner R, Huie‐White S, Bianco L, Zocher J, Wu K, Shepard D, Fennelly B, Castro R, Halpin S, Brennan M, Barnett T, Iannone L, Zenoni M, Bugaj J, Bailey C, Charpentier P, Hawthorne‐Jones G, Mignosa B, Lewis L, Williamson J, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Wilson V, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Gill T, Hankinson J, Vaz Fragoso C, Groessl E, Kaplan R. Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability. Journal Of The American Geriatrics Society 2019, 68: 619-624. PMID: 31867713, PMCID: PMC8061638, DOI: 10.1111/jgs.16274.
- Mohan A, Grace J, Mainardi A, Chupp G, Lugogo N. Biomarkers, Targeted Therapies, Biologics, and Bronchial Thermoplasty. Respiratory Medicine 2019, 123-153. DOI: 10.1007/978-3-030-20812-7_8.
- Stewart E, Chupp G, Montgomery R, Liu Q, Estrom J. Analysis of Sputum Immune Cell Populations and Their Functional Status in Asthmatics. 2019, a2916-a2916. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2916.
- Gomez J, Chen A, Yan X, Cohn L, Chupp G. MicroRNA miR-223 Is Associated with Lung Function Impairment and TH17 Inflammation in Asthma. 2019, a2929-a2929. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2929.
- Yan X, Liu Q, Mihaljinec A, Gomez J, Cohn L, Chupp G. Cell Lineage Defined by Single Cell Transcriptomics of the Sputum in Asthma. 2019, a6085-a6085. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6085.
- Chu J, Yan X, Liang A, Hu B, Gomez J, Chupp G. Integration of Sputum eQTL and GWAS Indicates IL-27/EBI3 Pathway Is Associated with Severe Asthma. 2019, a6088-a6088. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6088.
- Chupp G, Brown M, Beeh K, Wahlby-Hamren U, Ekelund A, Barkstedt E, Forsman H, Björnsson E, Jauhiainen A, Steele J, Psallidas I. Design of a Phase 2b Dose Finding Study of AZD7594, an Inhaled Non-Steroidal, Selective Glucocorticoid Receptor Modulator, for the Treatment of Asthma. 2019, a1315-a1315. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a1315.
- Chupp G, Kline J, Khatri S, McEvoy C, Silvestri G, Shifren A, Castro M, Bansal S, McClelland M, Dransfield M, Olivenstein R, Kahlstrom R, Ryan S, Lawson E, Simoff M, Wahidi M, Lamb C, Ferguson J, Haas A, Hogarth D, Tejedor R, Toth J, Majid A, Fitzgerald J, Enfield K, Grubb G, Laviolette M. Long-Term Efficacy and Safety of Bronchial Thermoplasty (BT): 4 Year Follow-Up Results from a Large Scale Prospective Study. 2019, a2683-a2683. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2683.
- Bleecker E, Murphy K, Gandhi H, Gilbert I, Chupp G. The Natural History of the Burden of Asthma in the United States by Age and Sex. 2019, a7397-a7397. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7397.
- Corbett DB, Rejeski WJ, Tudor-Locke C, Glynn NW, Kritchevsky SB, McDermott MM, Church TS, Fielding RA, Gill TM, King AC, Miller ME, Chen H, Pahor M, Manini TM, Pahor M, Guralnik J, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Lee J, Lu C, Salem W, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Hadley E, Romashkan S, Patel K, Bonds D, McDermott M, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor-Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kim W, Beard V, Manini T, Pahor M, Anton S, Buford T, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Newman A, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rush J, Kost P, Ives D, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer-Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Williamson J, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Gill T, Hankinson J, Fragoso C, Groessl E, Kaplan R. Social Participation Modifies the Effect of a Structured Physical Activity Program on Major Mobility Disability Among Older Adults: Results From the LIFE Study. The Journals Of Gerontology Series B 2017, 73: 1501-1513. PMID: 28482106, PMCID: PMC6178963, DOI: 10.1093/geronb/gbx051.
- Trevor J, Bradford E, Albers F, Bratton D, Wang-Jairaj J, Nelsen L, Chupp G, Magnan A, Brinke A. Mepolizumab Improves Lung Function and Exacerbation Rates in Severe Eosinophilic Asthma: The Musca Study - a Phase IIIb Randomized, Placebo-Controlled Tria. Journal Of Allergy And Clinical Immunology 2017, 139: ab380. DOI: 10.1016/j.jaci.2016.12.912.
- Chupp G, Bradford E, Albers F, Bratton D, Wang-Jairaj J, Nelsen L, Trevor J, Magnan A, Brinke A. Mepolizumab Significantly Improves Health Status and Asthma Control in Severe Eosinophilic Asthma: The Musca Study - a Phase IIIb Randomized, Placebo-Controlled Trial. Journal Of Allergy And Clinical Immunology 2017, 139: ab380. DOI: 10.1016/j.jaci.2016.12.911.
- Yao Y, Welp T, Liu Q, Niu N, Wang X, Britto CJ, Krishnaswamy S, Chupp G, Montgomery RR. Multiparameter Single Cell Profiling of Airway Inflammatory Cells. Cytometry Part B Clinical Cytometry 2017, 92: 12-20. PMID: 27807928, PMCID: PMC5250532, DOI: 10.1002/cyto.b.21491.
- Aubertin-Leheudre M, Anton S, Beavers D, Manini T, Fielding R, Newman A, Church T, Kritchevsky S, Conroy D, McDermott M, Botoseneanu A, Hauser M, Pahor M, Gill T, Fragoso C, Fielding R, Hauser M, Pahor M, Guralnik J, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Lee J, Lu C, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler M, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Hadley E, Romashkan S, Patel K, Bonds D, McDermott M, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor-Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kirn D, Pasha E, Kim W, Beard V, Tsiroyannis E, Hau C, Manini T, Pahor M, Anton S, Nayfield S, Buford T, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Newman A, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rush J, Kost P, Ives D, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer-Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Williamson J, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Wilson V, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Gill T, Hankinson J, Fragoso C, Groessl E, Kaplan R. Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study. Journal Of The American Medical Directors Association 2016, 18: 312-319. PMID: 27914851, PMCID: PMC5366275, DOI: 10.1016/j.jamda.2016.10.001.
- Baldassarri S, Chupp G, Leone F, Warren G, Toll B. Chest Health-care Provider Perceptions of Electronic Cigarettes. CHEST Journal 2016, 150: 1302a. DOI: 10.1016/j.chest.2016.08.1417.
- Chupp G, Yan X, Nezgovorova V, Grant N, Bradford W, Brophy C, Cohn L. MAPKAP kinase 2(MK2) expression is associated with severe asthma. 2016, pa4649. DOI: 10.1183/13993003.congress-2016.pa4649.
- Gueble M, Holm C, Grant N, Ravage-Mass L, Levesh T, Estrom J, Kapagiannidou E, Liu Q, O'Connor P, Gomez-Villalobos J, Cohn L, Chupp G. Proinflammatory cytokines and IP-10 differentiate neutrophilic and eosinophilic asthma subgroups. 2016, pa908. DOI: 10.1183/13993003.congress-2016.pa908.
- Layne AS, Hsu FC, Blair SN, Chen SH, Dungan J, Fielding RA, Glynn NW, Hajduk AM, King AC, Manini TM, Marsh AP, Pahor M, Pellegrini CA, Buford TW, Investigators L, Pahor M, Guralnik J, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Lee J, Lu C, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Hadley E, Romashkan S, Patel K, Bonds D, McDermott M, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor-Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kim W, Beard V, Manini T, Pahor M, Anton S, Nayfield S, Buford T, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Newman A, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rush J, Kost P, Ives D, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer-Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Williamson J, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Gill T, Hankinson J, Fragoso C, Groessl E, Kaplan R. Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study. Archives Of Physical Medicine And Rehabilitation 2016, 98: 11-24.e3. PMID: 27568165, PMCID: PMC5183463, DOI: 10.1016/j.apmr.2016.07.019.
- Baker M, Steinke J, Borish L, Chupp G. Leukotriene C4 Synthase Expression in Sputum Correlates with Disease Severity Amongst Patients with Different Clinical Phenotypes of Asthma. Journal Of Allergy And Clinical Immunology 2016, 137: ab207. DOI: 10.1016/j.jaci.2015.12.1118.
- Baldassarri S, Chupp G. A 43-Year-Old Man With Intravenous Drug Abuse and Recurrent Endocarditis. CHEST Journal 2013, 144: 296a-296b. DOI: 10.1378/chest.1676394.
- Scatena R, Holm C, He S, Wright P, Sessa W, Cohn L, Gomez-Villalobos J, Mitchell A, Chupp G. Characterization Of The Poor Emotional Function Phenotype In Asthma. 2012, a3967-a3967. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3967.
- Fielding RA, Rejeski WJ, Blair S, Church T, Espeland MA, Gill TM, Guralnik JM, Hsu FC, Katula J, King AC, Kritchevsky SB, McDermott MM, Miller ME, Nayfield S, Newman AB, Williamson JD, Bonds D, Romashkan S, Hadley E, Pahor M. The Lifestyle Interventions and Independence for Elders Study: Design and Methods. The Journals Of Gerontology Series A 2011, 66A: 1226-1237. PMID: 21825283, PMCID: PMC3193523, DOI: 10.1093/gerona/glr123.
- Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in BloodBjornsdottir US, Holgate ST, Reddy PS, Hill AA, McKee CM, Csimma CI, Weaver AA, Legault HM, Small CG, Ramsey RC, Ellis DK, Burke CM, Thompson PJ, Howarth PH, Wardlaw AJ, Bardin PG, Bernstein DI, Irving LB, Chupp GL, Bensch GW, Bensch GW, Stahlman JE, Karetzky M, Baker JW, Miller RL, Goodman BH, Raible DG, Goldman SJ, Miller DK, Ryan JL, Dorner AJ, Immermann FW, O'Toole M. Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood. PLOS ONE 2011, 6: e21902. PMID: 21779351, PMCID: PMC3136489, DOI: 10.1371/journal.pone.0021902.
- Ramaprakash H, Shibata T, Duffy KE, Ismailoglu UB, Bredernitz RM, Moreira AP, Coelho AL, Das AM, Fursov N, Chupp GL, Hogaboam CM. Targeting ST2L Potentiates CpG-Mediated Therapeutic Effects in a Chronic Fungal Asthma Model. American Journal Of Pathology 2011, 179: 104-115. PMID: 21640974, PMCID: PMC3123853, DOI: 10.1016/j.ajpath.2011.03.032.
- Gomez J, Perez M, Mitchell A, Holm C, He S, Chupp G. Airway Macrophage Expression Signatures Associated With Severe Airflow Obstruction In Asthma. 2011, a4540-a4540. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4540.
- Scatena R, Chupp G, Perez M, Gomez J, Wright P, Sessa W, Holm C. The Role Of Neurite Outgrowth Inhibitory Protein-B In Poorly Controlled Asthma. 2011, a1349-a1349. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a1349.
- Perez M, Gomez J, He S, Holm C, Chupp G. Characterization Of Chitinase Activity In Patients With Stable Asthma. 2011, a4334-a4334. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4334.
- Ong P, Wisnewski A, Stowe M, Holm C, He X, Zheng W, Zhang C, Zhao H, Redlich C, Chupp G. The 24-bp CHIT1 Exon 10 Polymorphism Is Associated With Airway Hyperresponsiveness In A Population Of Autobody Shop Workers. 2010, a4002-a4002. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4002.
- Gomez J, Perez M, He X, Mitchell A, Holm C, Chupp G. Characterization Of Chitinase Activity And YKL-40 Expression In Induced Sputum From Asthmatics: Correlations With Inflammation And Cell Viability And Gene Expression. 2010, a4279-a4279. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4279.
- Perez M, Gomez J, He X, Mitchell A, Kelly E, Jarjour N, Chupp G. Correlations Between The Chitinase-Like Protein YKL-40 And IL-18 After Segmental Antigen Challenge. 2010, a5605-a5605. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5605.
- Marshall P, Possick J, Chupp G. Intensive Care Unit Management of Status Asthmaticus. Clinical Pulmonary Medicine 2009, 16: 293-301. DOI: 10.1097/cpm.0b013e3181bdff38.
- Ober C, Chupp GL. The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases. Current Opinion In Allergy And Clinical Immunology 2009, 9: 401-408. PMID: 19644363, PMCID: PMC3018778, DOI: 10.1097/aci.0b013e3283306533.
- Crisafi G, Chupp G, Evans M, Sorkness R, Swenson C, Busse W, Jarjour N. Chitotriosidase Activity and YKL-40 Protein Are Increased in Severe Asthma. 2009, a5440. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5440.
- Vicencio A, Tsirilakis K, Du Z, Zeng W, Kipperman S, Veler H, Chupp G, Goldman D. Chitinase Activity and YKL-40 Expression in Lungs of Children with Persistent Asthma. 2009, a4811. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a4811.
- O'Toole M, Bjornsdottir U, Holgate S, Reddy P, Hill A, McKee C, Csimma C, Legault H, Weaver A, Small C, Ramsey R, Ellis D, Burke C, Thompson P, Irving L, Enden J, Chupp G, Wardlaw A, Stahlman J, Raible D, Miller D, Goldman S, Ryan J, Dorner A, Immermann F. Biological Mechanism Associated with Asthma Exacerbation Attack as Revealed By Gene Expression Patterns of Peripheral Blood Mononuclear Cells. Journal Of Allergy And Clinical Immunology 2009, 123: s154. DOI: 10.1016/j.jaci.2008.12.576.
- Ober C, Tan Z, Sun Y, Possick JD, Pan L, Nicolae R, Radford S, Parry RR, Heinzmann A, Deichmann KA, Lester LA, Gern JE, Lemanske RF, Nicolae DL, Elias JA, Chupp GL. Effect of Variation in CHI3L1 on Serum YKL-40 Level, Risk of Asthma, and Lung Function. New England Journal Of Medicine 2008, 358: 1682-1691. PMID: 18403759, PMCID: PMC2629486, DOI: 10.1056/nejmoa0708801.
- Chupp GL, Lee CG, Jarjour N, Shim YM, Holm CT, He S, Dziura JD, Reed J, Coyle AJ, Kiener P, Cullen M, Grandsaigne M, Dombret MC, Aubier M, Pretolani M, Elias JA. A Chitinase-like Protein in the Lung and Circulation of Patients with Severe Asthma. New England Journal Of Medicine 2007, 357: 2016-2027. PMID: 18003958, DOI: 10.1056/nejmoa073600.
- Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA. Hyperoxia causes angiopoietin 2–mediated acute lung injury and necrotic cell death. Nature Medicine 2006, 12: 1286-1293. PMID: 17086189, PMCID: PMC2768268, DOI: 10.1038/nm1494.
- Khazeni N, Homer RJ, Rubinowitz AN, Chupp GL. Massive cavitary pulmonary rheumatoid nodules in a patient with HIV. European Respiratory Journal 2006, 28: 872-874. PMID: 17012633, DOI: 10.1183/09031936.06.00144105.
- Lee CG, Kang HR, Homer RJ, Chupp G, Elias JA. Transgenic Modeling of Transforming Growth Factor-β1. Annals Of The American Thoracic Society 2006, 3: 418-423. PMID: 16799085, PMCID: PMC2658706, DOI: 10.1513/pats.200602-017aw.
- Sabina AB, Williams A, Wall HK, Bansal S, Chupp G, Katz DL. Yoga intervention for adults with mild-to-moderate asthma: a pilot study. Annals Of Allergy Asthma & Immunology 2005, 94: 543-548. PMID: 15945557, DOI: 10.1016/s1081-1206(10)61131-3.
- Cohn L, Elias JA, Chupp GL. Asthma: Mechanisms of Disease Persistence and Progression. Annual Review Of Immunology 2004, 22: 789-815. PMID: 15032597, DOI: 10.1146/annurev.immunol.22.012703.104716.
- CHUPP G. PREFACE. Clinics In Chest Medicine 2001, 22: xi. DOI: 10.1016/s0272-5231(05)70054-x.
- O'Regan A, Nau G, Chupp G, Berman J. Osteopontin (Eta-1) in cell-mediated immunity: teaching an old dog new tricks. Trends In Immunology 2000, 21: 475-478. PMID: 11071524, DOI: 10.1016/s0167-5699(00)01715-1.
- Corne J, Chupp G, Lee C, Homer R, Zhu Z, Chen Q, Ma B, Du Y, Roux F, McArdle J, Waxman A, Elias J. IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury. Journal Of Clinical Investigation 2000, 106: 783-791. PMID: 10995789, PMCID: PMC381393, DOI: 10.1172/jci9674.
- Nau G, Chupp G, Emile J, Jouanguy E, Berman J, Casanova J, Young R. Osteopontin Expression Correlates with Clinical Outcome in Patients with Mycobacterial Infection. American Journal Of Pathology 2000, 157: 37-42. PMID: 10880373, PMCID: PMC1850209, DOI: 10.1016/s0002-9440(10)64514-2.
- Elias J, Zhu Z, Chupp G, Homer R. Airway remodeling in asthma. Journal Of Clinical Investigation 1999, 104: 1001-1006. PMID: 10525034, PMCID: PMC408860, DOI: 10.1172/jci8124.
- Nau G, Liaw L, Chupp G, Berman J, Hogan B, Young R. Attenuated Host Resistance againstMycobacterium bovis BCG Infection in Mice Lacking Osteopontin. Infection And Immunity 1999, 67: 4223-4230. PMID: 10417195, PMCID: PMC96728, DOI: 10.1128/iai.67.8.4223-4230.1999.
- Nau G, Guilfoile P, Chupp G, Berman J, Kim S, Kornfeld H, Young R. A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 6414-6419. PMID: 9177232, PMCID: PMC21064, DOI: 10.1073/pnas.94.12.6414.
- Cruikshank W, Kornfeld H, Berman J, Chupp G, Keane J, Center D. Biological activity of interleukin-16. Nature 1996, 382: 501-502. PMID: 8700223, DOI: 10.1038/382501b0.
Locations
1
Winchester Center for Lung Disease
Fitkin Memorial Pavilion
789 Howard Avenue, Ste 2nd floor
New Haven, CT 06519
1 of 2
- Winchester Center for Lung DiseaseFitkin Memorial Pavilion789 Howard Avenue, Ste 2nd floorNew Haven, CT 06519
- Winchester Center for Lung Disease6 Devine StreetNorth Haven, CT 06473
1
Winchester Center for Lung Disease
Fitkin Memorial Pavilion
789 Howard Avenue, Ste 2nd floor
New Haven, CT 06519
1 of 2
- Winchester Center for Lung DiseaseFitkin Memorial Pavilion789 Howard Avenue, Ste 2nd floorNew Haven, CT 06519
- Winchester Center for Lung Disease6 Devine StreetNorth Haven, CT 06473