- Yale Pediatric Infectious DiseaseYale New Haven Hospital - West Pavilion1 Park Street, Fl 2New Haven, CT 06510
- Yale Pediatric Infectious DiseaseYale New Haven Hospital20 York StreetNew Haven, CT 06510
Eugene Shapiro, MD
Biography
Dr. Shapiro received a B.A. with a major in English Literature from Yale College in 1970 and an M.D. from the University of California, San Francisco School of Medicine, in 1976. He completed a residency in pediatrics at Children’s Hospital of Pittsburgh in 1979 and a two-year fellowship in pediatric infectious diseases at Children’s Hospital of Pittsburgh in 1981. He completed another two-year fellowship in clinical epidemiology (Robert Wood Johnson Clinical Scholars Program) at Yale in 1983.
He has been on the faculty at Yale since 1983, where he sees patients, teaches, and conducts research. He is currently Professor of Pediatrics, of Epidemiology and of Investigative Medicine and is Vice Chair for Research of Yale’s Department of Pediatrics. He is also Deputy Director of Yale’s PhD Program in Investigative Medicine and is Co-Director of Education and Director of Child Health Research for Yale’s Center for Clinical Investigation.
Dr. Shapiro is board certified in both Pediatrics (1980, unlimited) and Pediatric Infectious Diseases (1994, 2000, 2008). He served a 6-year term (2 years as Chair) as a member of the Infectious Diseases sub-board of the American Board of Pediatrics. This is the group that writes the questions for the certifying examination. Dr. Shapiro has more than 250 publications (more than 150 in peer-reviewed journals), most of which are studies related to vaccines. He has been the principal investigator of many clinical studies, a number of which have been funded by highly competitive R01 grants from the National Institutes of Health (NIH). He has also received funding from private foundations and from industry, including from Connaught, from Pasteur Merieux and from Merck Laboratories.
Dr. Shapiro has been a consultant to the World Health Organization (for both the Department of Vaccines and Biologicals and for the Acute Respiratory Infections Control Programme) and was Chair of the Advisory Group for the Epidemiology Branch of the National Institute of Health and Human Development. He also served as a Special Advisor to the Food and Drug Administration’s Vaccine Advisory Committee. He has been either Chair or a member of the Data Safety and Monitoring Boards for numerous clinical trials, including clinical trials of the efficacy of vaccines, many of which were (or are currently) funded by the National Institutes of Health. He has served as a member of a permanent NIH study section for a 4-year term and has been an ad hoc reviewer for the NIH many times. He has also served as a reviewer for grant proposals and/or awards for the Netherlands Organisation for Health Research and Development, the Department of Health of the United Kingdom, the University of Amsterdam, the Czech Health Research Council and the Karolinska Institute.
In 2014, Dr. Shapiro received the Stanley A. Plotkin Lectureship in Vaccinology Award for career achievement for research in vaccinology. In 2017, he received the Pediatric Diseases Society Distinguished Physician Award for “an extensive and distinguished career in pediatric infectious diseases.”
Titles
- Professor of Pediatrics (Infectious Diseases) and of Epidemiology (Microbial Diseases)
- Vice Chair for Research, Department of Pediatrics, Pediatrics
- Deputy Director, Investigative Medicine PhD Program, Investigative Medicine Program
- Co-Director of Education, Yale Center for Clinical Investigation, YCCI Senior Leadership
- Affiliated Faculty, Yale Institute for Global Health
Education & Training
- Clinical ScholarRobert Wood Johnson, Yale School of Medicine (1983)
- FellowChildren's Hospital of Pittsburgh, PA (1981)
- ResidentChildren's Hospital of Pittsburgh, PA (1979)
- MDUniversity of California/San Francisco (1976)
Additional Information
- Master of Arts Privatum (honorary degree): Yale University (1993)
- Fellow, Branford College, Yale University: (1991)
- AB of Pediatrics, Pediatrics (1980)
- American Board of PediatricsInfectious Diseases Subboard, (2005 - 2011): SubBoard of Pediatric Infectious Diseases
- NIH (1998 - Present): NIH Study Section member orchair standing committee plus many ad hoc committees College of CSR Reviewers
- Makhani N, Lebrun-Frenay C, Siva A, Shabanova V, Wassmer E, Santoro J, Narula S, Brenton J, Mar S, Durand-Dubief F, Zephir H, Mathey G, Rojas J, de Seze J, Tenembaum S, Stone R, Casez O, Carra-Dallière C, Neuteboom R, Ahsan N, Arroyo H, Cabre P, Gombolay G, Inglese M, Louapre C, Margoni M, Palavra F, Pohl D, Reich D, Ruet A, Thouvenot E, Timby N, Tintore M, Uygunoglu U, Vargas W, Venkateswaran S, Verhelst H, Wickstrom R, Azevedo C, Kantarci O, Shapiro E, Okuda D, Pelletier D. The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex. Journal Of Neurology 2024, 271: 4019-4027. PMID: 38564056, PMCID: PMC11323224, DOI: 10.1007/s00415-024-12289-1.
- Taylor-Salmon E, Shapiro E. Tick-borne infections in children in North America. Current Opinion In Pediatrics 2024, 36: 156-163. PMID: 38167816, PMCID: PMC10932821, DOI: 10.1097/mop.0000000000001326.
- Makhani N, Lebrun C, Siva A, Narula S, Wassmer E, Brenton J, Dalliere C, De Seze J, Dubief F, Langille M, Neuteboom R, Pelletier J, Pohl D, Rojas J, Shapiro E, Stone R, Tenembaum S, Tintore M, Uygunoglu U, Vargas W, Kantarci O, Okuda D, Pelletier D. Comparison of MRI Dissemination in Space Criteria for Predicting a First Clinical Event in Children with the Radiologically Isolated Syndrome (S2.001). Neurology 2017, 88 DOI: 10.1212/wnl.88.16_supplement.s2.001.
- Ali A, Weiss T, Dutton A, Hua A, Jones K, Kashikar-Zuck S, Silverman W, Shapiro E. (505) Mindfulness-Based Stress Reduction (MBSR) for adolescents with chronic pain: a pilot study. Journal Of Pain 2016, 17: s101. DOI: 10.1016/j.jpain.2016.01.312.
- Shapiro E. Borrelia burgdorferi (Lyme Disease). Pediatrics In Review 2014, 35: 500-509. DOI: 10.1542/pir.35.12.500.
- Solomon C, Shapiro E. Lyme Disease. New England Journal Of Medicine 2014, 370: 1724-1731. PMID: 24785207, PMCID: PMC4487875, DOI: 10.1056/nejmcp1314325.
- Faustino E, Li S, Pinto M, Polikoff L, Tala J, Silva C, Shapiro E. ABSTRACT 114. Pediatric Critical Care Medicine 2014, 15: 31. DOI: 10.1097/01.pcc.0000448840.20300.dd.
- Auwaerter P, Bakken J, Dattwyler R, Halperin J, Nadelman R, O'Connell S, Shapiro E, Weinstein A, Wormser G. Lyme disease antiscience – Authors' reply. The Lancet Infectious Diseases 2012, 12: 362-363. DOI: 10.1016/s1473-3099(12)70056-7.
- Shapiro E, Sood S. Prognosis of Persons with Lyme Borreliosis. 2011, 213-223. DOI: 10.1002/9780470933961.ch11.
- Wormser G, Shapiro E. Authors' Reply. Journal Of Women's Health 2009, 18: 1719-1720. PMCID: PMC2825721, DOI: 10.1089/jwh.2009.1683.
- Marques A, Shaw P, Schmid C, Steere A, Kaplan R, Hassett A, Shapiro E, Wormser G. A RANDOMIZED, PLACEBO-CONTROLLED TRIAL OF REPEATED IV ANTIBIOTIC THERAPY FOR LYME ENCEPHALOPATHY PROLONGED LYME DISEASE TREATMENT: ENOUGH IS ENOUGH. Neurology 2009, 72: 383-386. PMID: 19171842, DOI: 10.1212/01.wnl.0000343855.45704.7c.
- Baltimore R, Shapiro E. CHAPTER 7 EPIDEMIOLOGY OF INFECTIOUS DISEASES. 2009, 118-135. DOI: 10.1016/b978-1-4160-4044-6.50012-1.
- Wormser G, Dattwyler R, Shapiro E, Dumler J, O'Connell S, Radolf J, Nadelman R. Chemoprophylaxis against Lyme disease. The Lancet Infectious Diseases 2008, 8: 146-147. DOI: 10.1016/s1473-3099(08)70024-0.
- Feder HM, Johnson BJ, O'Connell S, Shapiro ED, Steere AC, Wormser GP, Agger W, Artsob H, Auwaerter P, Dumler J, Bakken J, Bockenstedt L, Green J, Dattwyler R, Munoz J, Nadelman R, Schwartz I, Draper T, McSweegan E, Halperin J, Klempner M, Krause P, Mead P, Morshed M, Porwancher R, Radolf J, Smith R, Sood S, Weinstein A, Wong S, Zemel L. A Critical Appraisal of “Chronic Lyme Disease”. New England Journal Of Medicine 2007, 357: 1422-1430. PMID: 17914043, DOI: 10.1056/nejmra072023.
- Wormser G, Dattwyler R, Shapiro E, Halperin J, Steere A, Klempner M, Krause P, Bakken J, Strle F, Stanek G, Bockenstedt L, Fish D, Dumler J, Nadelman R. Reply to Pollock, Donta, Wilson, and Arne. Clinical Infectious Diseases 2007, 44: 1137-1139. DOI: 10.1086/513029.
- Spiro D, Shapiro E. Wait-and-See Prescription for Acute Otitis Media—Reply. JAMA 2007, 297: 152-153. DOI: 10.1001/jama.297.2.152-c.
- Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC, Klempner MS, Krause PJ, Bakken JS, Strle F, Stanek G, Bockenstedt L, Fish D, Dumler JS, Nadelman RB. The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America. Clinical Infectious Diseases 2006, 43: 1089-1134. PMID: 17029130, DOI: 10.1086/508667.
- Esper F, Shapiro E, Landry M, Kahn J. Reply to van der Hoek and Berkhout, Ebihara et al., and Belay et al. The Journal Of Infectious Diseases 2005, 192: 353-353. PMCID: PMC7110126, DOI: 10.1086/430796.
- Vázquez M, LaRussa PS, Gershon AA, Niccolai LM, Muehlenbein CE, Steinberg SP, Shapiro ED. Effectiveness Over Time of Varicella Vaccine. JAMA 2004, 291: 851-855. PMID: 14970064, DOI: 10.1001/jama.291.7.851.
- Shapiro ED. Case-control studies of the effectiveness of vaccines: validity and assessment of potential bias. The Pediatric Infectious Disease Journal 2004, 23: 127-131. PMID: 14872178, DOI: 10.1097/01.inf.0000109248.32907.1d.
- Wormser G, Shapiro E. Principles and Practice of Clinical Research Edited by John I. Gallin San Diego, CA: Academic Press, 2002. 490 pp., illustrated. $99.95 (cloth). Clinical Infectious Diseases 2003, 36: 677-677. DOI: 10.1086/367672.
- Colson E, Bergman D, Shapiro E, Leventhal J. Position for Newborn Sleep: Associations with Parents' Perceptions of Their Nursery Experience. Birth 2001, 28: 249-253. PMID: 11903213, DOI: 10.1046/j.1523-536x.2001.00249.x.
- Juhn Y, St. Sauver J, Shapiro E, McCarthy P. How do child care center personnel define fever? Child Care Health And Development 2001, 7: 143-148. DOI: 10.1046/j.1467-0658.2001.00137.x.
- Vázquez M, LaRussa P, Gershon A, Steinberg S, Freudigman K, Shapiro E. The Effectiveness of the Varicella Vaccine in Clinical Practice. New England Journal Of Medicine 2001, 344: 955-960. PMID: 11274621, DOI: 10.1056/nejm200103293441302.
- Juhn Y, Shapiro E, McCarthy P, Freudigman K. WILLINGNESS OF DIRECTORS OF CHILD CARE CENTERS TO CARE FOR CHILDREN WITH CHRONIC INFECTIONS. The Pediatric Infectious Disease Journal 2001, 20: 77-79. PMID: 11176573, DOI: 10.1097/00006454-200101000-00016.
- LaRussa P, Steinberg S, Shapiro E, Vazquez M, Gershon A. Varicella vaccine revisited. Nature Medicine 2000, 6: 1299-1299. PMID: 11100089, DOI: 10.1038/82070.
- LARUSSA P, STEINBERG S, SHAPIRO E, VAZQUEZ M, GERSHON A. Viral strain identification in varicella vaccinees with disseminated rashes. The Pediatric Infectious Disease Journal 2000, 19: 1037-1039. PMID: 11099082, DOI: 10.1097/00006454-200011000-00002.
- Shapiro E, Coleman D. The Scholarship of Application. Academic Medicine 2000, 75: 895-898. PMID: 10995610, DOI: 10.1097/00001888-200009000-00010.
- Shapiro E, Gerber M. Lyme Disease. Clinical Infectious Diseases 2000, 31: 533-542. PMID: 10987718, DOI: 10.1086/313982.
- Wormser G, Nadelman R, Dattwyler R, Dennis D, Shapiro E, Steere A, Rush T, Rahn D, Coyle P, Persing D, Fish D, Luft B. Practice Guidelines for the Treatment of Lyme Disease. Clinical Infectious Diseases 2000, 31: s1-s14. PMID: 10982743, DOI: 10.1086/314053.
- SIMPSON J, SHAPIRO E, ANDIMAN W. Prospective cohort study of children born to human immunodeficiency virus-infected mothers, 1985 through 1997: trends in the risk of vertical transmission, mortality and acquired immunodeficiency syndrome indicator diseases in the era before highly active antiretroviral therapy. The Pediatric Infectious Disease Journal 2000, 19: 618-624. PMID: 10917219, DOI: 10.1097/00006454-200007000-00007.
- Wormser G, Nadelman R, Dattwyler R, Dennis D, Shapiro E, Steere A, Rush T, Rahn D, Coyle P, Persing D, Fish D, Luft B. Practice Guidelines for the Treatment of Lyme Disease. Clinical Infectious Diseases 2000, 31: i-i. DOI: 10.1086/512462.
- Seltzer E, Shapiro E, Gerber M. Long-term Outcomes of Lyme Disease—Reply. JAMA 2000, 283: 3069-3069. PMID: 10865292, DOI: 10.1001/jama.283.23.3068b.
- King J, Borkowsky W, Mahidhara N, Madore D, Shapiro E, Rutstein R, Tan T, Farley J, Dankner W, Nachman S, Simoes E, Flynn P, Clemens J, Hamilton R. Group-Specific Antibody Levels Surrounding Invasive Pneumococcal Illness in Children Infected with Human Immunodeficiency Virus. The Journal Of Infectious Diseases 2000, 181: 1817-1821. PMID: 10823792, DOI: 10.1086/315441.
- Butler J, Shapiro E, Carlone G. Pneumococcal vaccines: history, current status, and future directions. The American Journal Of Medicine 1999, 107: 69-76. PMID: 10451012, DOI: 10.1016/s0002-9343(99)00105-9.
- Simpson B, Shapiro E, Andiman W. Trends in the Risk of Vertical Transmission, Survival and AIDS Indicator Diseases among HIV-Infected Children in Southern Connecticut, 1985-1997. Pediatric Research 1999, 45: 106-106. DOI: 10.1203/00006450-199904020-00634.
- Vazquez M, Sparrow S, Goudreau D, Catalano A, Klunk J, Davis S, Shapiro E. Long-Term Outcomes of Children with Facial Nerve Palsy Due To Lyme Disease. Pediatric Research 1999, 45: 177-177. DOI: 10.1203/00006450-199904020-01050.
- Gerber M, Zemel L, Shapiro E. Lyme Arthritis in Children: Clinical Epidemiology and Long-term Outcomes. Pediatrics 1998, 102: 905-908. PMID: 9755263, DOI: 10.1542/peds.102.4.905.
- Butler J, Spika J, Nichol K, Shapiro E, Breinan R. Effectiveness of pneumococcal vaccine. The Lancet 1998, 351: 1961. PMID: 9654289, DOI: 10.1016/s0140-6736(05)78647-5.
- Shapiro E. Lyme Disease. Pediatrics In Review 1998, 19: 147-154. PMID: 9584524, DOI: 10.1542/pir.19-5-147.
- Shapiro E. Lyme Disease. Pediatrics In Review 1998, 19: 147-154. DOI: 10.1542/pir.19.5.147.
- McCarthy P, Kahn J, Shapiro E, Klig J. Fever without apparent source on clinical examination, Infectious diseases, and Lower respiratory infections in children. Current Opinion In Pediatrics 1998, 10: 101-116. PMID: 9529649, DOI: 10.1097/00008480-199802000-00021.
- Shapiro E. Epidemiology of acute respiratory infections. Seminars In Pediatric Infectious Diseases 1998, 9: 31-36. DOI: 10.1016/s1045-1870(98)80048-4.
- Baltimore R, Shapiro E. Pneumococcal Infections. 1998, 559-582. DOI: 10.1007/978-1-4615-5327-4_29.
- Shapiro E, LaRussa P. Vaccination for Varicella—Just Do It! JAMA 1997, 278: 1529-1530. DOI: 10.1001/jama.1997.03550180079042.
- Shapiro E, LaRussa P. Vaccination for varicella--just do it! JAMA 1997, 278: 1529-30. PMID: 9363975, DOI: 10.1001/jama.278.18.1529.
- Shapiro E, Seltzer E. Lyme Disease in Children. Seminars In Neurology 1997, 17: 39-44. PMID: 9166958, DOI: 10.1055/s-2008-1040911.
- McCarthy P, Klig J, Kahn J, Shapiro E, Baron M. Fever without apparent source on clinical examination, Lower respiratory infections in children, Other infectious diseases, and Acute gastroenteritis and diarrhea of infancy and early childhood. Current Opinion In Pediatrics 1997, 9: 105-126. PMID: 9088764, DOI: 10.1097/00008480-199702000-00021.
- Simpson B, Shapiro E, Andiman W. Reduction in the Risk of Vertical Transmission of HIV-1 Associated with Treatment of Pregnant Women with Orally Administered Zidovudine Alone. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1997, 14: 145-152. PMID: 9052723, DOI: 10.1097/00042560-199702010-00007.
- Gerber M, Shapiro E, Burke G, Parcells V, Bell G. Lyme Disease in Children in Southeastern Connecticut. New England Journal Of Medicine 1996, 335: 1270-1274. PMID: 8857006, DOI: 10.1056/nejm199610243351703.
- Seltzer EG, Shapiro ED. Misdiagnosis of Lyme disease: when not to order serologic tests. The Pediatric Infectious Disease Journal 1996, 15: 762-3. PMID: 8878216, DOI: 10.1097/00006454-199609000-00003.
- Simpson B, Shapiro E, Andiman W. TRENDS IN THE RISK OF VERTICAL TRANSMISSION, MORTALITY, AND AIDS-DEFINING ILLNESSES AMONG CHILDREN OF HIV+ MOTHERS ENROLLED IN A COHORT STUDY, 1985-1995. • 663. Pediatric Research 1996, 39: 113-113. DOI: 10.1203/00006450-199604001-00685.
- Shapiro E, Seltzer E, Gerber M, Cartter M. LONG-TERM OUTCOMES OF CHILDREN WITH LYME DISEASE. † 1094. Pediatric Research 1996, 39: 185-185. DOI: 10.1203/00006450-199604001-01116.
- McCarthy P, Klig J, Shapiro E, Baron M. Fever without apparent source on clinical examination, Lower respiratory infections in children, Other infectious diseases, and Acute gastroenteritis and diarrhea of infancy and early childhood. Current Opinion In Pediatrics 1996, 8: 75-93. PMID: 8680522, DOI: 10.1097/00008480-199602000-00017.
- Berg A, Shinnar S, Shapiro E, Salomon M, Crain E, Hauser W. Risk Factors for a First Febrile Seizure: A Matched Case‐Control Study. Epilepsia 1995, 36: 334-341. PMID: 7541745, DOI: 10.1111/j.1528-1157.1995.tb01006.x.
- McCarthy P, Bachman D, Shapiro E, Baron M. Office pediatrics. Current Opinion In Pediatrics 1995, 7: 107-125. PMID: 7728195, DOI: 10.1097/00008480-199502000-00020.
- Fedson D, Shapiro E, LaForce F, Mufson M, Musher D, Spika J, Breiman R, Broome C. Pneumococcal Vaccine After 15 Years of Use: Another View. JAMA Internal Medicine 1994, 154: 2531-2535. DOI: 10.1001/archinte.1994.00420220021003.
- Andiman W, Mezger J, Shapiro E. Invasive bacterial infections in children born to women infected with human immunodeficiency virus type 1. The Journal Of Pediatrics 1994, 124: 846-852. PMID: 8201465, DOI: 10.1016/s0022-3476(05)83169-5.
- Baltimore R, Shapiro E. Lyme Disease. Pediatrics In Review 1994, 15: 167-173. PMID: 8036192, DOI: 10.1542/pir.15-5-167.
- Baltimore R, Shapiro E. Lyme Disease. Pediatrics In Review 1994, 15: 167-173. DOI: 10.1542/pir.15.5.167.
- McCarthy P, Bachman D, Shapiro E, Baron M. Fever without apparent source on clinical examination, Lower respiratory infections in children, Bacterial infections, and Acute gastroenteritis and diarrhea of infancy and early childhood. Current Opinion In Pediatrics 1994, 6: 105. PMID: 8205167, DOI: 10.1097/00008480-199402000-00019.
- Ikeda M, Andiman W, Mezger J, Shapiro E, Miller G. Quantitative leukoviremia and immune complex-dissociated antigenemia as predictors of infection status in children born to mothers infected with human immunodeficiency virus type 1. The Journal Of Pediatrics 1993, 122: 524-531. PMID: 8463895, DOI: 10.1016/s0022-3476(05)83530-9.
- Shapiro E, Gerber M, Holabird N, Berg A, Feder H, Bell G, Rys P, Persing D. A Controlled Trial of Antimicrobial Prophylaxis for Lyme Disease after Deer-Tick Bites. New England Journal Of Medicine 1992, 327: 1769-1773. PMID: 1435930, DOI: 10.1056/nejm199212173272501.
- Berg A, Shinnar S, Hauser W, Alemany M, Shapiro E, Salomon M, Crain E. A Prospective Study of Recurrent Febrile Seizures. New England Journal Of Medicine 1992, 327: 1122-1127. PMID: 1528207, DOI: 10.1056/nejm199210153271603.
- KORONES D, MARSHALL G, SHAPIRO E. Outcome of children with occult bacteremia caused by Haemophilus influenzae type b. The Pediatric Infectious Disease Journal 1992, 11: 516-520. PMID: 1528640, DOI: 10.1097/00006454-199207000-00002.
- Gerber M, Shapiro E. Diagnosis of Lyme disease in children. The Journal Of Pediatrics 1992, 121: 157-162. PMID: 1625075, DOI: 10.1016/s0022-3476(05)82569-7.
- ANDIMAN W, SILVA T, SHAPIRO E, O'CONNOR T, OLSON B. Predictive value of the human immunodeficiency virus 1 antigen test in children born to infected mothers. The Pediatric Infectious Disease Journal 1992, 11: 436-440. PMID: 1608678, DOI: 10.1097/00006454-199206000-00003.
- Katz B, Berkman A, Shapiro E. Serologic evidence of active Epstein-barr virus infection in epstein-barr virus-associated lymphoproliferative disorders of children with acquired immunodeficiency syndrome. The Journal Of Pediatrics 1992, 120: 228-232. PMID: 1310507, DOI: 10.1016/s0022-3476(05)80432-9.
- Shapiro E, Berg A, Austrian R, Schroeder D, Parcells V, Margolis A, Adair R, Clemens J. The Protective Efficacy of Polyvalent Pneumococcal Polysaccharide Vaccine. New England Journal Of Medicine 1991, 325: 1453-1460. PMID: 1944423, DOI: 10.1056/nejm199111213252101.
- FORSYTH B, SHAPIRO E, HORWITZ R, VISCOLI C, ACAMPORA D. Misdiagnosis of Reye's-like Illness. JAMA Pediatrics 1991, 145: 964-966. PMID: 1877570, DOI: 10.1001/archpedi.1991.02160090014005.
- Baltimore R, Shapiro E. Pneumococcal Infections. 1991, 525-546. DOI: 10.1007/978-1-4757-1211-7_25.
- Shapiro E. New Vaccines Against Haemophilus Influenzae Type b. Pediatric Clinics Of North America 1990, 37: 567-583. PMID: 2190140, DOI: 10.1016/s0031-3955(16)36905-x.
- Shapiro E, Berg A. Protective efficacy of Haemophilus influenzae type b polysaccharide vaccine. Pediatrics 1990, 85: 643-7. PMID: 2179854, DOI: 10.1542/peds.85.4.643.
- Shapiro E. Lyme disease. Current Opinion In Pediatrics 1990, 2: 81-86. DOI: 10.1097/00008480-199002000-00015.
- D'Cruz O, Shapiro E, Spiegelman K, Leicher C, Breningstall G, Khatri B, Dobyns W. Acute inflammatory demyelinating polyradiculoneuropathy (Guillain-Barré syndrome) after immunization with Haemophilus influenzae type b conjugate vaccine. The Journal Of Pediatrics 1989, 115: 743-746. PMID: 2809907, DOI: 10.1016/s0022-3476(89)80653-5.
- Leventhal J, Shapiro E, Bauchner H. Science versus Opinion: A Response to Cunningham's Critique. Journal Of Human Lactation 1989, 5: 126-128. PMID: 2775462, DOI: 10.1177/089033448900500308.
- Alario A, Nelson E, Shapiro E. Blood cultures in the management of febrile outpatients later found to have bacteremia. The Journal Of Pediatrics 1989, 115: 195-199. PMID: 2787855, DOI: 10.1016/s0022-3476(89)80064-2.
- Forsyth B, Horwitz R, Acampora D, Shapiro E, Viscoli C, Feinstein A, Henner R, Holabird N, Jones B, Karabelas A, Kramer M, Miclette M, Wells J. New Epidemiologic Evidence Confirming That Bias Does Not Explain the Aspirin/Reye's Syndrome Association. JAMA 1989, 261: 2517-2524. PMID: 2704111, DOI: 10.1001/jama.1989.03420170061031.
- Shapiro E. Analytic Strategies in Hospital Epidemiology: Case-Control Studies. Infection Control And Hospital Epidemiology 1989, 10: 167-169. DOI: 10.2307/30144323.
- WOOD C, MCNAMARA J, SCHWARZ D, MERRILL W, SHAPIRO E. Prevention of pneumococcal bacteremia in a child with acquired immunodeficiency syndrome-related complex. The Pediatric Infectious Disease Journal 1987, 6: 564-566. PMID: 3112723, DOI: 10.1097/00006454-198706000-00015.
- Shapiro E, Lichtman J, Petersen L, Hadler J, Leventhal J. USE OF HAEMOPHILUS VACCINE IN CONNECTICUT. Pediatric Research 1987, 21: 287-287. DOI: 10.1203/00006450-198704010-00719.
- Shapiro E. A COMMUNITY-BASED CASE-CONTROL STUDY OF THE ASSOCIATION BETWEEN THE ATTENDANDCE OF GROUP DAY CARE AND DISEASE DUE TO HAEMOPHILUS INFLUNZAE TYPE B (Hib). Pediatric Research 1987, 21: 262-262. DOI: 10.1203/00006450-198704010-00569.
- Shapiro E. Lack of transmission of hepatitis B in a day care center. The Journal Of Pediatrics 1987, 110: 90-92. PMID: 3794892, DOI: 10.1016/s0022-3476(87)80296-2.
- Leventhal J, Shapiro E, Aten C, Berg A, Egerter S. Does breast-feeding protect against infections in infants less than 3 months of age? Pediatrics 1986, 78: 896-903. PMID: 3093969, DOI: 10.1542/peds.78.5.896.
- Katz B, Shapiro E. PREDICTORS OF PERSISTENTLY POSITIVE BLOOD CULTURES IN CHILDREN WITH “OCCULT” SALMONELLA BACTEREMIA. The Pediatric Infectious Disease Journal 1986, 5: 713. PMID: 3797307, DOI: 10.1097/00006454-198611000-00029.
- Bauchner H, Leventhal J, Shapiro E. Studies of Breast-feeding and Infections: How Good Is the Evidence? JAMA 1986, 256: 887-892. DOI: 10.1001/jama.1986.03380070093026.
- Shapiro E, Aaron N, Wald E, Chiponis D. Risk factors for development of bacterial meningitis among children with occult bacteremia. The Journal Of Pediatrics 1986, 109: 15-19. PMID: 3088242, DOI: 10.1016/s0022-3476(86)80564-9.
- Katz J, Horwitz R, Dolan T, Shapiro E. Clinical features as predictors of functional status in children with cystic fibrosis. The Journal Of Pediatrics 1986, 108: 352-358. PMID: 3950815, DOI: 10.1016/s0022-3476(86)80872-1.
- Kovatch A, Wald E, Albo V, Prin W, Orlando S, Wollman M, Phebus C, Shapiro E. Oral trimethoprim/sulfamethoxazole for prevention of bacterial infection during the induction phase of cancer chemotherapy in children. Pediatrics 1985, 76: 754-60. PMID: 3903647, DOI: 10.1542/peds.76.5.754.
- Shapiro E. Prophylaxis for Bacterial Meningitis. Medical Clinics Of North America 1985, 69: 269-280. PMID: 3990434, DOI: 10.1016/s0025-7125(16)31042-2.
- Baron J, Shapiro E. UNSUSPECTED BACTEREMIA CAUSED BY BRANHAMELLA CATARRHALIS. The Pediatric Infectious Disease Journal 1985, 4: 100. PMID: 3969356, DOI: 10.1097/00006454-198501000-00025.
- Shapiro E. Exclusion of III Children from Day-care Centers. Clinical Pediatrics 1984, 23: 689-691. PMID: 6499349, DOI: 10.1177/000992288402301207.
- Clemens J, Shapiro E. Resolving the Pneumococcal Vaccine Controversy: Are There Alternatives to Randomized Clinical Trials? Clinical Infectious Diseases 1984, 6: 589-600. PMID: 6390636, DOI: 10.1093/clinids/6.5.589.
- Shapiro E, Clemens J. A controlled evaluation of the protective efficacy of pneumococcal vaccine for patients at high risk of serious pneumococcal infections. Annals Of Internal Medicine 1984, 101: 325-30. PMID: 6380367, DOI: 10.7326/0003-4819-101-3-325.
- Shapiro E, Wald E. LONG-TERM FOLLOW-UP OF THE RATE OF PHARYNGEAL COLONIZATION WITH HAEMOPHILUS INFLUENZAE TYPE B (Hib) AT A CHRONIC-CARE FACILITY FOLLOWING PROPHYLAXIS WITH RIFAMPIN. Pediatric Research 1984, 18: 187-187. DOI: 10.1203/00006450-198404001-00565.
- Bowers S, Shapiro E. Reply to Dr. Plauché. American Journal Of Obstetrics And Gynecology 1982, 144: 863. DOI: 10.1016/0002-9378(82)90374-x.
- SHAPIRO E. Short course antimicrobial treatment of urinary tract infections in children. The Pediatric Infectious Disease Journal 1982, 1: 294-297. PMID: 6760145, DOI: 10.1097/00006454-198209000-00002.
- Shapiro E, Wald E, Nelson K, Spiegelman K. Broviac Catheter-Related Bacteremia in Oncology Patients. JAMA Pediatrics 1982, 136: 679-681. PMID: 7102618, DOI: 10.1001/archpedi.1982.03970440023006.
- Shapiro E, Wald E. Replies. The Journal Of Pediatrics 1982, 101: 316. DOI: 10.1016/s0022-3476(82)80159-5.
- Bowers S, MacDonald H, Shapiro E. Prevention of iatrogenic neonatal respiratory distress syndrome: Elective repeat cesarean section and spontaneous labor. American Journal Of Obstetrics And Gynecology 1982, 143: 186-189. PMID: 7081331, DOI: 10.1016/0002-9378(82)90653-6.
- SHAPIRO E. Prophylaxis for contacts of patients with meningococcal or Haemophilus influenzae type b disease. The Pediatric Infectious Disease Journal 1982, 1: 132-138. PMID: 6757888, DOI: 10.1097/00006454-198203000-00015.
- SHAPIRO E, WALD E, BROZANSKI B. Periorbital cellulitis and paranasal sinusitis. The Pediatric Infectious Disease Journal 1982, 1: 91-94. PMID: 7177909, DOI: 10.1097/00006454-198203000-00005.
- Shapiro E, Doyle W, Wald E, Rohn D. Bacteriology of the Maxillary Sinus of Rhesus Monkeys. Annals Of Otology Rhinology & Laryngology 1982, 91: 150-151. PMID: 7081875, DOI: 10.1177/000348948209100205.
- Shapiro E, Wald E. Single-dose amoxicillin treatment of urinary tract infections. The Journal Of Pediatrics 1981, 99: 989-992. PMID: 7031216, DOI: 10.1016/s0022-3476(81)80039-x.
- Shapiro E, Wald E, Bronzanski B, Michaels R. 688 PERIORBITAL AND ORBITAL CELLULITIS-A REAPPRAISAL. Pediatric Research 1981, 15: 557-557. DOI: 10.1203/00006450-198104001-00711.
- Shapiro E, Spiegelman K, Wald E, Nelson K, Michaels R. 870 CATHETER RELATED BACTEREMIA IN ONCOLOGY PATIENTS WITH INDWELLING BROVIAC CATHETERS. Pediatric Research 1981, 15: 587-587. DOI: 10.1203/00006450-198104001-00895.
- Shapiro E, Wald E, Doyle W, Rohn D. 1068 THE NORMAL BACTERIAL FLORA OF THE MAXILLARY SINUS OF RHESUS MONKEYS. Pediatric Research 1981, 15: 620-620. DOI: 10.1203/00006450-198104001-01094.
- Bowers S, Macdonald H, Shapiro E. 1255 PRECEDING SPONTANEOUS LABOR (PSL), ELECTIVE REPEAT CESAREAN SECTION(RCS), AND IATROGENIC RESPIRATORY DISTRESS SYNDROME(IaRDS). Pediatric Research 1981, 15: 652-652. DOI: 10.1203/00006450-198104001-01283.
- Yale Pediatric Infectious DiseaseYale New Haven Hospital - West Pavilion1 Park Street, Fl 2New Haven, CT 06510
- Yale Pediatric Infectious DiseaseYale New Haven Hospital20 York StreetNew Haven, CT 06510
Biography
Dr. Shapiro received a B.A. with a major in English Literature from Yale College in 1970 and an M.D. from the University of California, San Francisco School of Medicine, in 1976. He completed a residency in pediatrics at Children’s Hospital of Pittsburgh in 1979 and a two-year fellowship in pediatric infectious diseases at Children’s Hospital of Pittsburgh in 1981. He completed another two-year fellowship in clinical epidemiology (Robert Wood Johnson Clinical Scholars Program) at Yale in 1983.
He has been on the faculty at Yale since 1983, where he sees patients, teaches, and conducts research. He is currently Professor of Pediatrics, of Epidemiology and of Investigative Medicine and is Vice Chair for Research of Yale’s Department of Pediatrics. He is also Deputy Director of Yale’s PhD Program in Investigative Medicine and is Co-Director of Education and Director of Child Health Research for Yale’s Center for Clinical Investigation.
Dr. Shapiro is board certified in both Pediatrics (1980, unlimited) and Pediatric Infectious Diseases (1994, 2000, 2008). He served a 6-year term (2 years as Chair) as a member of the Infectious Diseases sub-board of the American Board of Pediatrics. This is the group that writes the questions for the certifying examination. Dr. Shapiro has more than 250 publications (more than 150 in peer-reviewed journals), most of which are studies related to vaccines. He has been the principal investigator of many clinical studies, a number of which have been funded by highly competitive R01 grants from the National Institutes of Health (NIH). He has also received funding from private foundations and from industry, including from Connaught, from Pasteur Merieux and from Merck Laboratories.
Dr. Shapiro has been a consultant to the World Health Organization (for both the Department of Vaccines and Biologicals and for the Acute Respiratory Infections Control Programme) and was Chair of the Advisory Group for the Epidemiology Branch of the National Institute of Health and Human Development. He also served as a Special Advisor to the Food and Drug Administration’s Vaccine Advisory Committee. He has been either Chair or a member of the Data Safety and Monitoring Boards for numerous clinical trials, including clinical trials of the efficacy of vaccines, many of which were (or are currently) funded by the National Institutes of Health. He has served as a member of a permanent NIH study section for a 4-year term and has been an ad hoc reviewer for the NIH many times. He has also served as a reviewer for grant proposals and/or awards for the Netherlands Organisation for Health Research and Development, the Department of Health of the United Kingdom, the University of Amsterdam, the Czech Health Research Council and the Karolinska Institute.
In 2014, Dr. Shapiro received the Stanley A. Plotkin Lectureship in Vaccinology Award for career achievement for research in vaccinology. In 2017, he received the Pediatric Diseases Society Distinguished Physician Award for “an extensive and distinguished career in pediatric infectious diseases.”
Titles
- Professor of Pediatrics (Infectious Diseases) and of Epidemiology (Microbial Diseases)
- Vice Chair for Research, Department of Pediatrics, Pediatrics
- Deputy Director, Investigative Medicine PhD Program, Investigative Medicine Program
- Co-Director of Education, Yale Center for Clinical Investigation, YCCI Senior Leadership
- Affiliated Faculty, Yale Institute for Global Health
Education & Training
- Clinical ScholarRobert Wood Johnson, Yale School of Medicine (1983)
- FellowChildren's Hospital of Pittsburgh, PA (1981)
- ResidentChildren's Hospital of Pittsburgh, PA (1979)
- MDUniversity of California/San Francisco (1976)
Additional Information
- Master of Arts Privatum (honorary degree): Yale University (1993)
- Fellow, Branford College, Yale University: (1991)
- AB of Pediatrics, Pediatrics (1980)
- American Board of PediatricsInfectious Diseases Subboard, (2005 - 2011): SubBoard of Pediatric Infectious Diseases
- NIH (1998 - Present): NIH Study Section member orchair standing committee plus many ad hoc committees College of CSR Reviewers
- Makhani N, Lebrun-Frenay C, Siva A, Shabanova V, Wassmer E, Santoro J, Narula S, Brenton J, Mar S, Durand-Dubief F, Zephir H, Mathey G, Rojas J, de Seze J, Tenembaum S, Stone R, Casez O, Carra-Dallière C, Neuteboom R, Ahsan N, Arroyo H, Cabre P, Gombolay G, Inglese M, Louapre C, Margoni M, Palavra F, Pohl D, Reich D, Ruet A, Thouvenot E, Timby N, Tintore M, Uygunoglu U, Vargas W, Venkateswaran S, Verhelst H, Wickstrom R, Azevedo C, Kantarci O, Shapiro E, Okuda D, Pelletier D. The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex. Journal Of Neurology 2024, 271: 4019-4027. PMID: 38564056, PMCID: PMC11323224, DOI: 10.1007/s00415-024-12289-1.
- Taylor-Salmon E, Shapiro E. Tick-borne infections in children in North America. Current Opinion In Pediatrics 2024, 36: 156-163. PMID: 38167816, PMCID: PMC10932821, DOI: 10.1097/mop.0000000000001326.
- Makhani N, Lebrun C, Siva A, Narula S, Wassmer E, Brenton J, Dalliere C, De Seze J, Dubief F, Langille M, Neuteboom R, Pelletier J, Pohl D, Rojas J, Shapiro E, Stone R, Tenembaum S, Tintore M, Uygunoglu U, Vargas W, Kantarci O, Okuda D, Pelletier D. Comparison of MRI Dissemination in Space Criteria for Predicting a First Clinical Event in Children with the Radiologically Isolated Syndrome (S2.001). Neurology 2017, 88 DOI: 10.1212/wnl.88.16_supplement.s2.001.
- Ali A, Weiss T, Dutton A, Hua A, Jones K, Kashikar-Zuck S, Silverman W, Shapiro E. (505) Mindfulness-Based Stress Reduction (MBSR) for adolescents with chronic pain: a pilot study. Journal Of Pain 2016, 17: s101. DOI: 10.1016/j.jpain.2016.01.312.
- Shapiro E. Borrelia burgdorferi (Lyme Disease). Pediatrics In Review 2014, 35: 500-509. DOI: 10.1542/pir.35.12.500.
- Solomon C, Shapiro E. Lyme Disease. New England Journal Of Medicine 2014, 370: 1724-1731. PMID: 24785207, PMCID: PMC4487875, DOI: 10.1056/nejmcp1314325.
- Faustino E, Li S, Pinto M, Polikoff L, Tala J, Silva C, Shapiro E. ABSTRACT 114. Pediatric Critical Care Medicine 2014, 15: 31. DOI: 10.1097/01.pcc.0000448840.20300.dd.
- Auwaerter P, Bakken J, Dattwyler R, Halperin J, Nadelman R, O'Connell S, Shapiro E, Weinstein A, Wormser G. Lyme disease antiscience – Authors' reply. The Lancet Infectious Diseases 2012, 12: 362-363. DOI: 10.1016/s1473-3099(12)70056-7.
- Shapiro E, Sood S. Prognosis of Persons with Lyme Borreliosis. 2011, 213-223. DOI: 10.1002/9780470933961.ch11.
- Wormser G, Shapiro E. Authors' Reply. Journal Of Women's Health 2009, 18: 1719-1720. PMCID: PMC2825721, DOI: 10.1089/jwh.2009.1683.
- Marques A, Shaw P, Schmid C, Steere A, Kaplan R, Hassett A, Shapiro E, Wormser G. A RANDOMIZED, PLACEBO-CONTROLLED TRIAL OF REPEATED IV ANTIBIOTIC THERAPY FOR LYME ENCEPHALOPATHY PROLONGED LYME DISEASE TREATMENT: ENOUGH IS ENOUGH. Neurology 2009, 72: 383-386. PMID: 19171842, DOI: 10.1212/01.wnl.0000343855.45704.7c.
- Baltimore R, Shapiro E. CHAPTER 7 EPIDEMIOLOGY OF INFECTIOUS DISEASES. 2009, 118-135. DOI: 10.1016/b978-1-4160-4044-6.50012-1.
- Wormser G, Dattwyler R, Shapiro E, Dumler J, O'Connell S, Radolf J, Nadelman R. Chemoprophylaxis against Lyme disease. The Lancet Infectious Diseases 2008, 8: 146-147. DOI: 10.1016/s1473-3099(08)70024-0.
- Feder HM, Johnson BJ, O'Connell S, Shapiro ED, Steere AC, Wormser GP, Agger W, Artsob H, Auwaerter P, Dumler J, Bakken J, Bockenstedt L, Green J, Dattwyler R, Munoz J, Nadelman R, Schwartz I, Draper T, McSweegan E, Halperin J, Klempner M, Krause P, Mead P, Morshed M, Porwancher R, Radolf J, Smith R, Sood S, Weinstein A, Wong S, Zemel L. A Critical Appraisal of “Chronic Lyme Disease”. New England Journal Of Medicine 2007, 357: 1422-1430. PMID: 17914043, DOI: 10.1056/nejmra072023.
- Wormser G, Dattwyler R, Shapiro E, Halperin J, Steere A, Klempner M, Krause P, Bakken J, Strle F, Stanek G, Bockenstedt L, Fish D, Dumler J, Nadelman R. Reply to Pollock, Donta, Wilson, and Arne. Clinical Infectious Diseases 2007, 44: 1137-1139. DOI: 10.1086/513029.
- Spiro D, Shapiro E. Wait-and-See Prescription for Acute Otitis Media—Reply. JAMA 2007, 297: 152-153. DOI: 10.1001/jama.297.2.152-c.
- Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC, Klempner MS, Krause PJ, Bakken JS, Strle F, Stanek G, Bockenstedt L, Fish D, Dumler JS, Nadelman RB. The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America. Clinical Infectious Diseases 2006, 43: 1089-1134. PMID: 17029130, DOI: 10.1086/508667.
- Esper F, Shapiro E, Landry M, Kahn J. Reply to van der Hoek and Berkhout, Ebihara et al., and Belay et al. The Journal Of Infectious Diseases 2005, 192: 353-353. PMCID: PMC7110126, DOI: 10.1086/430796.
- Vázquez M, LaRussa PS, Gershon AA, Niccolai LM, Muehlenbein CE, Steinberg SP, Shapiro ED. Effectiveness Over Time of Varicella Vaccine. JAMA 2004, 291: 851-855. PMID: 14970064, DOI: 10.1001/jama.291.7.851.
- Shapiro ED. Case-control studies of the effectiveness of vaccines: validity and assessment of potential bias. The Pediatric Infectious Disease Journal 2004, 23: 127-131. PMID: 14872178, DOI: 10.1097/01.inf.0000109248.32907.1d.
- Wormser G, Shapiro E. Principles and Practice of Clinical Research Edited by John I. Gallin San Diego, CA: Academic Press, 2002. 490 pp., illustrated. $99.95 (cloth). Clinical Infectious Diseases 2003, 36: 677-677. DOI: 10.1086/367672.
- Colson E, Bergman D, Shapiro E, Leventhal J. Position for Newborn Sleep: Associations with Parents' Perceptions of Their Nursery Experience. Birth 2001, 28: 249-253. PMID: 11903213, DOI: 10.1046/j.1523-536x.2001.00249.x.
- Juhn Y, St. Sauver J, Shapiro E, McCarthy P. How do child care center personnel define fever? Child Care Health And Development 2001, 7: 143-148. DOI: 10.1046/j.1467-0658.2001.00137.x.
- Vázquez M, LaRussa P, Gershon A, Steinberg S, Freudigman K, Shapiro E. The Effectiveness of the Varicella Vaccine in Clinical Practice. New England Journal Of Medicine 2001, 344: 955-960. PMID: 11274621, DOI: 10.1056/nejm200103293441302.
- Juhn Y, Shapiro E, McCarthy P, Freudigman K. WILLINGNESS OF DIRECTORS OF CHILD CARE CENTERS TO CARE FOR CHILDREN WITH CHRONIC INFECTIONS. The Pediatric Infectious Disease Journal 2001, 20: 77-79. PMID: 11176573, DOI: 10.1097/00006454-200101000-00016.
- LaRussa P, Steinberg S, Shapiro E, Vazquez M, Gershon A. Varicella vaccine revisited. Nature Medicine 2000, 6: 1299-1299. PMID: 11100089, DOI: 10.1038/82070.
- LARUSSA P, STEINBERG S, SHAPIRO E, VAZQUEZ M, GERSHON A. Viral strain identification in varicella vaccinees with disseminated rashes. The Pediatric Infectious Disease Journal 2000, 19: 1037-1039. PMID: 11099082, DOI: 10.1097/00006454-200011000-00002.
- Shapiro E, Coleman D. The Scholarship of Application. Academic Medicine 2000, 75: 895-898. PMID: 10995610, DOI: 10.1097/00001888-200009000-00010.
- Shapiro E, Gerber M. Lyme Disease. Clinical Infectious Diseases 2000, 31: 533-542. PMID: 10987718, DOI: 10.1086/313982.
- Wormser G, Nadelman R, Dattwyler R, Dennis D, Shapiro E, Steere A, Rush T, Rahn D, Coyle P, Persing D, Fish D, Luft B. Practice Guidelines for the Treatment of Lyme Disease. Clinical Infectious Diseases 2000, 31: s1-s14. PMID: 10982743, DOI: 10.1086/314053.
- SIMPSON J, SHAPIRO E, ANDIMAN W. Prospective cohort study of children born to human immunodeficiency virus-infected mothers, 1985 through 1997: trends in the risk of vertical transmission, mortality and acquired immunodeficiency syndrome indicator diseases in the era before highly active antiretroviral therapy. The Pediatric Infectious Disease Journal 2000, 19: 618-624. PMID: 10917219, DOI: 10.1097/00006454-200007000-00007.
- Wormser G, Nadelman R, Dattwyler R, Dennis D, Shapiro E, Steere A, Rush T, Rahn D, Coyle P, Persing D, Fish D, Luft B. Practice Guidelines for the Treatment of Lyme Disease. Clinical Infectious Diseases 2000, 31: i-i. DOI: 10.1086/512462.
- Seltzer E, Shapiro E, Gerber M. Long-term Outcomes of Lyme Disease—Reply. JAMA 2000, 283: 3069-3069. PMID: 10865292, DOI: 10.1001/jama.283.23.3068b.
- King J, Borkowsky W, Mahidhara N, Madore D, Shapiro E, Rutstein R, Tan T, Farley J, Dankner W, Nachman S, Simoes E, Flynn P, Clemens J, Hamilton R. Group-Specific Antibody Levels Surrounding Invasive Pneumococcal Illness in Children Infected with Human Immunodeficiency Virus. The Journal Of Infectious Diseases 2000, 181: 1817-1821. PMID: 10823792, DOI: 10.1086/315441.
- Butler J, Shapiro E, Carlone G. Pneumococcal vaccines: history, current status, and future directions. The American Journal Of Medicine 1999, 107: 69-76. PMID: 10451012, DOI: 10.1016/s0002-9343(99)00105-9.
- Simpson B, Shapiro E, Andiman W. Trends in the Risk of Vertical Transmission, Survival and AIDS Indicator Diseases among HIV-Infected Children in Southern Connecticut, 1985-1997. Pediatric Research 1999, 45: 106-106. DOI: 10.1203/00006450-199904020-00634.
- Vazquez M, Sparrow S, Goudreau D, Catalano A, Klunk J, Davis S, Shapiro E. Long-Term Outcomes of Children with Facial Nerve Palsy Due To Lyme Disease. Pediatric Research 1999, 45: 177-177. DOI: 10.1203/00006450-199904020-01050.
- Gerber M, Zemel L, Shapiro E. Lyme Arthritis in Children: Clinical Epidemiology and Long-term Outcomes. Pediatrics 1998, 102: 905-908. PMID: 9755263, DOI: 10.1542/peds.102.4.905.
- Butler J, Spika J, Nichol K, Shapiro E, Breinan R. Effectiveness of pneumococcal vaccine. The Lancet 1998, 351: 1961. PMID: 9654289, DOI: 10.1016/s0140-6736(05)78647-5.
- Shapiro E. Lyme Disease. Pediatrics In Review 1998, 19: 147-154. PMID: 9584524, DOI: 10.1542/pir.19-5-147.
- Shapiro E. Lyme Disease. Pediatrics In Review 1998, 19: 147-154. DOI: 10.1542/pir.19.5.147.
- McCarthy P, Kahn J, Shapiro E, Klig J. Fever without apparent source on clinical examination, Infectious diseases, and Lower respiratory infections in children. Current Opinion In Pediatrics 1998, 10: 101-116. PMID: 9529649, DOI: 10.1097/00008480-199802000-00021.
- Shapiro E. Epidemiology of acute respiratory infections. Seminars In Pediatric Infectious Diseases 1998, 9: 31-36. DOI: 10.1016/s1045-1870(98)80048-4.
- Baltimore R, Shapiro E. Pneumococcal Infections. 1998, 559-582. DOI: 10.1007/978-1-4615-5327-4_29.
- Shapiro E, LaRussa P. Vaccination for Varicella—Just Do It! JAMA 1997, 278: 1529-1530. DOI: 10.1001/jama.1997.03550180079042.
- Shapiro E, LaRussa P. Vaccination for varicella--just do it! JAMA 1997, 278: 1529-30. PMID: 9363975, DOI: 10.1001/jama.278.18.1529.
- Shapiro E, Seltzer E. Lyme Disease in Children. Seminars In Neurology 1997, 17: 39-44. PMID: 9166958, DOI: 10.1055/s-2008-1040911.
- McCarthy P, Klig J, Kahn J, Shapiro E, Baron M. Fever without apparent source on clinical examination, Lower respiratory infections in children, Other infectious diseases, and Acute gastroenteritis and diarrhea of infancy and early childhood. Current Opinion In Pediatrics 1997, 9: 105-126. PMID: 9088764, DOI: 10.1097/00008480-199702000-00021.
- Simpson B, Shapiro E, Andiman W. Reduction in the Risk of Vertical Transmission of HIV-1 Associated with Treatment of Pregnant Women with Orally Administered Zidovudine Alone. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1997, 14: 145-152. PMID: 9052723, DOI: 10.1097/00042560-199702010-00007.
- Gerber M, Shapiro E, Burke G, Parcells V, Bell G. Lyme Disease in Children in Southeastern Connecticut. New England Journal Of Medicine 1996, 335: 1270-1274. PMID: 8857006, DOI: 10.1056/nejm199610243351703.
- Seltzer EG, Shapiro ED. Misdiagnosis of Lyme disease: when not to order serologic tests. The Pediatric Infectious Disease Journal 1996, 15: 762-3. PMID: 8878216, DOI: 10.1097/00006454-199609000-00003.
- Simpson B, Shapiro E, Andiman W. TRENDS IN THE RISK OF VERTICAL TRANSMISSION, MORTALITY, AND AIDS-DEFINING ILLNESSES AMONG CHILDREN OF HIV+ MOTHERS ENROLLED IN A COHORT STUDY, 1985-1995. • 663. Pediatric Research 1996, 39: 113-113. DOI: 10.1203/00006450-199604001-00685.
- Shapiro E, Seltzer E, Gerber M, Cartter M. LONG-TERM OUTCOMES OF CHILDREN WITH LYME DISEASE. † 1094. Pediatric Research 1996, 39: 185-185. DOI: 10.1203/00006450-199604001-01116.
- McCarthy P, Klig J, Shapiro E, Baron M. Fever without apparent source on clinical examination, Lower respiratory infections in children, Other infectious diseases, and Acute gastroenteritis and diarrhea of infancy and early childhood. Current Opinion In Pediatrics 1996, 8: 75-93. PMID: 8680522, DOI: 10.1097/00008480-199602000-00017.
- Berg A, Shinnar S, Shapiro E, Salomon M, Crain E, Hauser W. Risk Factors for a First Febrile Seizure: A Matched Case‐Control Study. Epilepsia 1995, 36: 334-341. PMID: 7541745, DOI: 10.1111/j.1528-1157.1995.tb01006.x.
- McCarthy P, Bachman D, Shapiro E, Baron M. Office pediatrics. Current Opinion In Pediatrics 1995, 7: 107-125. PMID: 7728195, DOI: 10.1097/00008480-199502000-00020.
- Fedson D, Shapiro E, LaForce F, Mufson M, Musher D, Spika J, Breiman R, Broome C. Pneumococcal Vaccine After 15 Years of Use: Another View. JAMA Internal Medicine 1994, 154: 2531-2535. DOI: 10.1001/archinte.1994.00420220021003.
- Andiman W, Mezger J, Shapiro E. Invasive bacterial infections in children born to women infected with human immunodeficiency virus type 1. The Journal Of Pediatrics 1994, 124: 846-852. PMID: 8201465, DOI: 10.1016/s0022-3476(05)83169-5.
- Baltimore R, Shapiro E. Lyme Disease. Pediatrics In Review 1994, 15: 167-173. PMID: 8036192, DOI: 10.1542/pir.15-5-167.
- Baltimore R, Shapiro E. Lyme Disease. Pediatrics In Review 1994, 15: 167-173. DOI: 10.1542/pir.15.5.167.
- McCarthy P, Bachman D, Shapiro E, Baron M. Fever without apparent source on clinical examination, Lower respiratory infections in children, Bacterial infections, and Acute gastroenteritis and diarrhea of infancy and early childhood. Current Opinion In Pediatrics 1994, 6: 105. PMID: 8205167, DOI: 10.1097/00008480-199402000-00019.
- Ikeda M, Andiman W, Mezger J, Shapiro E, Miller G. Quantitative leukoviremia and immune complex-dissociated antigenemia as predictors of infection status in children born to mothers infected with human immunodeficiency virus type 1. The Journal Of Pediatrics 1993, 122: 524-531. PMID: 8463895, DOI: 10.1016/s0022-3476(05)83530-9.
- Shapiro E, Gerber M, Holabird N, Berg A, Feder H, Bell G, Rys P, Persing D. A Controlled Trial of Antimicrobial Prophylaxis for Lyme Disease after Deer-Tick Bites. New England Journal Of Medicine 1992, 327: 1769-1773. PMID: 1435930, DOI: 10.1056/nejm199212173272501.
- Berg A, Shinnar S, Hauser W, Alemany M, Shapiro E, Salomon M, Crain E. A Prospective Study of Recurrent Febrile Seizures. New England Journal Of Medicine 1992, 327: 1122-1127. PMID: 1528207, DOI: 10.1056/nejm199210153271603.
- KORONES D, MARSHALL G, SHAPIRO E. Outcome of children with occult bacteremia caused by Haemophilus influenzae type b. The Pediatric Infectious Disease Journal 1992, 11: 516-520. PMID: 1528640, DOI: 10.1097/00006454-199207000-00002.
- Gerber M, Shapiro E. Diagnosis of Lyme disease in children. The Journal Of Pediatrics 1992, 121: 157-162. PMID: 1625075, DOI: 10.1016/s0022-3476(05)82569-7.
- ANDIMAN W, SILVA T, SHAPIRO E, O'CONNOR T, OLSON B. Predictive value of the human immunodeficiency virus 1 antigen test in children born to infected mothers. The Pediatric Infectious Disease Journal 1992, 11: 436-440. PMID: 1608678, DOI: 10.1097/00006454-199206000-00003.
- Katz B, Berkman A, Shapiro E. Serologic evidence of active Epstein-barr virus infection in epstein-barr virus-associated lymphoproliferative disorders of children with acquired immunodeficiency syndrome. The Journal Of Pediatrics 1992, 120: 228-232. PMID: 1310507, DOI: 10.1016/s0022-3476(05)80432-9.
- Shapiro E, Berg A, Austrian R, Schroeder D, Parcells V, Margolis A, Adair R, Clemens J. The Protective Efficacy of Polyvalent Pneumococcal Polysaccharide Vaccine. New England Journal Of Medicine 1991, 325: 1453-1460. PMID: 1944423, DOI: 10.1056/nejm199111213252101.
- FORSYTH B, SHAPIRO E, HORWITZ R, VISCOLI C, ACAMPORA D. Misdiagnosis of Reye's-like Illness. JAMA Pediatrics 1991, 145: 964-966. PMID: 1877570, DOI: 10.1001/archpedi.1991.02160090014005.
- Baltimore R, Shapiro E. Pneumococcal Infections. 1991, 525-546. DOI: 10.1007/978-1-4757-1211-7_25.
- Shapiro E. New Vaccines Against Haemophilus Influenzae Type b. Pediatric Clinics Of North America 1990, 37: 567-583. PMID: 2190140, DOI: 10.1016/s0031-3955(16)36905-x.
- Shapiro E, Berg A. Protective efficacy of Haemophilus influenzae type b polysaccharide vaccine. Pediatrics 1990, 85: 643-7. PMID: 2179854, DOI: 10.1542/peds.85.4.643.
- Shapiro E. Lyme disease. Current Opinion In Pediatrics 1990, 2: 81-86. DOI: 10.1097/00008480-199002000-00015.
- D'Cruz O, Shapiro E, Spiegelman K, Leicher C, Breningstall G, Khatri B, Dobyns W. Acute inflammatory demyelinating polyradiculoneuropathy (Guillain-Barré syndrome) after immunization with Haemophilus influenzae type b conjugate vaccine. The Journal Of Pediatrics 1989, 115: 743-746. PMID: 2809907, DOI: 10.1016/s0022-3476(89)80653-5.
- Leventhal J, Shapiro E, Bauchner H. Science versus Opinion: A Response to Cunningham's Critique. Journal Of Human Lactation 1989, 5: 126-128. PMID: 2775462, DOI: 10.1177/089033448900500308.
- Alario A, Nelson E, Shapiro E. Blood cultures in the management of febrile outpatients later found to have bacteremia. The Journal Of Pediatrics 1989, 115: 195-199. PMID: 2787855, DOI: 10.1016/s0022-3476(89)80064-2.
- Forsyth B, Horwitz R, Acampora D, Shapiro E, Viscoli C, Feinstein A, Henner R, Holabird N, Jones B, Karabelas A, Kramer M, Miclette M, Wells J. New Epidemiologic Evidence Confirming That Bias Does Not Explain the Aspirin/Reye's Syndrome Association. JAMA 1989, 261: 2517-2524. PMID: 2704111, DOI: 10.1001/jama.1989.03420170061031.
- Shapiro E. Analytic Strategies in Hospital Epidemiology: Case-Control Studies. Infection Control And Hospital Epidemiology 1989, 10: 167-169. DOI: 10.2307/30144323.
- WOOD C, MCNAMARA J, SCHWARZ D, MERRILL W, SHAPIRO E. Prevention of pneumococcal bacteremia in a child with acquired immunodeficiency syndrome-related complex. The Pediatric Infectious Disease Journal 1987, 6: 564-566. PMID: 3112723, DOI: 10.1097/00006454-198706000-00015.
- Shapiro E, Lichtman J, Petersen L, Hadler J, Leventhal J. USE OF HAEMOPHILUS VACCINE IN CONNECTICUT. Pediatric Research 1987, 21: 287-287. DOI: 10.1203/00006450-198704010-00719.
- Shapiro E. A COMMUNITY-BASED CASE-CONTROL STUDY OF THE ASSOCIATION BETWEEN THE ATTENDANDCE OF GROUP DAY CARE AND DISEASE DUE TO HAEMOPHILUS INFLUNZAE TYPE B (Hib). Pediatric Research 1987, 21: 262-262. DOI: 10.1203/00006450-198704010-00569.
- Shapiro E. Lack of transmission of hepatitis B in a day care center. The Journal Of Pediatrics 1987, 110: 90-92. PMID: 3794892, DOI: 10.1016/s0022-3476(87)80296-2.
- Leventhal J, Shapiro E, Aten C, Berg A, Egerter S. Does breast-feeding protect against infections in infants less than 3 months of age? Pediatrics 1986, 78: 896-903. PMID: 3093969, DOI: 10.1542/peds.78.5.896.
- Katz B, Shapiro E. PREDICTORS OF PERSISTENTLY POSITIVE BLOOD CULTURES IN CHILDREN WITH “OCCULT” SALMONELLA BACTEREMIA. The Pediatric Infectious Disease Journal 1986, 5: 713. PMID: 3797307, DOI: 10.1097/00006454-198611000-00029.
- Bauchner H, Leventhal J, Shapiro E. Studies of Breast-feeding and Infections: How Good Is the Evidence? JAMA 1986, 256: 887-892. DOI: 10.1001/jama.1986.03380070093026.
- Shapiro E, Aaron N, Wald E, Chiponis D. Risk factors for development of bacterial meningitis among children with occult bacteremia. The Journal Of Pediatrics 1986, 109: 15-19. PMID: 3088242, DOI: 10.1016/s0022-3476(86)80564-9.
- Katz J, Horwitz R, Dolan T, Shapiro E. Clinical features as predictors of functional status in children with cystic fibrosis. The Journal Of Pediatrics 1986, 108: 352-358. PMID: 3950815, DOI: 10.1016/s0022-3476(86)80872-1.
- Kovatch A, Wald E, Albo V, Prin W, Orlando S, Wollman M, Phebus C, Shapiro E. Oral trimethoprim/sulfamethoxazole for prevention of bacterial infection during the induction phase of cancer chemotherapy in children. Pediatrics 1985, 76: 754-60. PMID: 3903647, DOI: 10.1542/peds.76.5.754.
- Shapiro E. Prophylaxis for Bacterial Meningitis. Medical Clinics Of North America 1985, 69: 269-280. PMID: 3990434, DOI: 10.1016/s0025-7125(16)31042-2.
- Baron J, Shapiro E. UNSUSPECTED BACTEREMIA CAUSED BY BRANHAMELLA CATARRHALIS. The Pediatric Infectious Disease Journal 1985, 4: 100. PMID: 3969356, DOI: 10.1097/00006454-198501000-00025.
- Shapiro E. Exclusion of III Children from Day-care Centers. Clinical Pediatrics 1984, 23: 689-691. PMID: 6499349, DOI: 10.1177/000992288402301207.
- Clemens J, Shapiro E. Resolving the Pneumococcal Vaccine Controversy: Are There Alternatives to Randomized Clinical Trials? Clinical Infectious Diseases 1984, 6: 589-600. PMID: 6390636, DOI: 10.1093/clinids/6.5.589.
- Shapiro E, Clemens J. A controlled evaluation of the protective efficacy of pneumococcal vaccine for patients at high risk of serious pneumococcal infections. Annals Of Internal Medicine 1984, 101: 325-30. PMID: 6380367, DOI: 10.7326/0003-4819-101-3-325.
- Shapiro E, Wald E. LONG-TERM FOLLOW-UP OF THE RATE OF PHARYNGEAL COLONIZATION WITH HAEMOPHILUS INFLUENZAE TYPE B (Hib) AT A CHRONIC-CARE FACILITY FOLLOWING PROPHYLAXIS WITH RIFAMPIN. Pediatric Research 1984, 18: 187-187. DOI: 10.1203/00006450-198404001-00565.
- Bowers S, Shapiro E. Reply to Dr. Plauché. American Journal Of Obstetrics And Gynecology 1982, 144: 863. DOI: 10.1016/0002-9378(82)90374-x.
- SHAPIRO E. Short course antimicrobial treatment of urinary tract infections in children. The Pediatric Infectious Disease Journal 1982, 1: 294-297. PMID: 6760145, DOI: 10.1097/00006454-198209000-00002.
- Shapiro E, Wald E, Nelson K, Spiegelman K. Broviac Catheter-Related Bacteremia in Oncology Patients. JAMA Pediatrics 1982, 136: 679-681. PMID: 7102618, DOI: 10.1001/archpedi.1982.03970440023006.
- Shapiro E, Wald E. Replies. The Journal Of Pediatrics 1982, 101: 316. DOI: 10.1016/s0022-3476(82)80159-5.
- Bowers S, MacDonald H, Shapiro E. Prevention of iatrogenic neonatal respiratory distress syndrome: Elective repeat cesarean section and spontaneous labor. American Journal Of Obstetrics And Gynecology 1982, 143: 186-189. PMID: 7081331, DOI: 10.1016/0002-9378(82)90653-6.
- SHAPIRO E. Prophylaxis for contacts of patients with meningococcal or Haemophilus influenzae type b disease. The Pediatric Infectious Disease Journal 1982, 1: 132-138. PMID: 6757888, DOI: 10.1097/00006454-198203000-00015.
- SHAPIRO E, WALD E, BROZANSKI B. Periorbital cellulitis and paranasal sinusitis. The Pediatric Infectious Disease Journal 1982, 1: 91-94. PMID: 7177909, DOI: 10.1097/00006454-198203000-00005.
- Shapiro E, Doyle W, Wald E, Rohn D. Bacteriology of the Maxillary Sinus of Rhesus Monkeys. Annals Of Otology Rhinology & Laryngology 1982, 91: 150-151. PMID: 7081875, DOI: 10.1177/000348948209100205.
- Shapiro E, Wald E. Single-dose amoxicillin treatment of urinary tract infections. The Journal Of Pediatrics 1981, 99: 989-992. PMID: 7031216, DOI: 10.1016/s0022-3476(81)80039-x.
- Shapiro E, Wald E, Bronzanski B, Michaels R. 688 PERIORBITAL AND ORBITAL CELLULITIS-A REAPPRAISAL. Pediatric Research 1981, 15: 557-557. DOI: 10.1203/00006450-198104001-00711.
- Shapiro E, Spiegelman K, Wald E, Nelson K, Michaels R. 870 CATHETER RELATED BACTEREMIA IN ONCOLOGY PATIENTS WITH INDWELLING BROVIAC CATHETERS. Pediatric Research 1981, 15: 587-587. DOI: 10.1203/00006450-198104001-00895.
- Shapiro E, Wald E, Doyle W, Rohn D. 1068 THE NORMAL BACTERIAL FLORA OF THE MAXILLARY SINUS OF RHESUS MONKEYS. Pediatric Research 1981, 15: 620-620. DOI: 10.1203/00006450-198104001-01094.
- Bowers S, Macdonald H, Shapiro E. 1255 PRECEDING SPONTANEOUS LABOR (PSL), ELECTIVE REPEAT CESAREAN SECTION(RCS), AND IATROGENIC RESPIRATORY DISTRESS SYNDROME(IaRDS). Pediatric Research 1981, 15: 652-652. DOI: 10.1203/00006450-198104001-01283.
- Yale Pediatric Infectious DiseaseYale New Haven Hospital - West Pavilion1 Park Street, Fl 2New Haven, CT 06510
- Yale Pediatric Infectious DiseaseYale New Haven Hospital20 York StreetNew Haven, CT 06510
- Yale Pediatric Infectious DiseaseYale New Haven Hospital - West Pavilion1 Park Street, Fl 2New Haven, CT 06510
- Yale Pediatric Infectious DiseaseYale New Haven Hospital20 York StreetNew Haven, CT 06510