Chris Pittenger, MD, PhD, earned his MD and PhD degrees from Columbia University, where his graduate work was done with Nobel Prize recipient Eric Kandel. He returned to Yale University, his undergraduate alma mater, for residency and research training in psychiatry in 2003. He joined the faculty as an Assistant Professor in 2007 and is now Elizabeth Mears and House Jameson Professor of Psychiatry, Professor of Psychology and in the Child Study Center, and Deputy Chair for Translational Research in the Department of Psychiatry.

Dr. Pittenger has always been fascinated by the question of how the brain, a complex but ultimately a physical structure, creates thought, feeling, consciousness, and other aspects of the mind. As a psychiatrist he is additionally focused on how these processes go wrong—how brain dysregulation leads to dysregulated cognition, emotion, and behavior and to mental suffering, and how advancing our understanding of these relationships can guide us to new strategies to alleviate that suffering.

Much of his work has focused on obsessive-compulsive disorder and Tourette syndrome and on the cortico-basal ganglia circuitry that is implicated in their pathophysiology. More recently Dr. Pittenger has co-founded the Yale Program for Psychedelic Science, focusing on understanding how molecules like psilocybin and LSD can teach us about brain and behavior and may lead to new treatments for a range of neuropsychiatric pathology. He is also one of the founding Directors of the Yale Center for Brain and Mind Health, which seeks to bridge disciplines and levels of analysis to bring new therapeutics to individuals suffering from disorders of the mind and brain.

Dr. Pittenger's research and clinical work have been acknowledged by a number of prestigious awards, including grant funding from the National Institute of Mental Health, the National Institute of Neurological Disease and Stroke, NARSAD, the Tourette Syndrome of America, the Doris Duke Charitable Trust, and other organizations. He has won a number of awards, including from the National Institute of Mental Health, the Society for Neuroscience, the American College of Neuropsychopharmacology, the American Psychiatric Association, and the American College of Psychiatrists.

He is a member of the Scientific Advisory Board of the International OCD Foundation and Chair of both their Grant Review Committee and their Annual Research Symposium Planning Committee. He is a Fellow of the American College of Neuropsychopharmacology, the American Psychiatric Association, and the American Neurological Association.

Titles

Elizabeth Mears and House Jameson Professor of Psychiatry
Deputy Chair for Translational Research, Psychiatry
Director, Clinical Neuroscience Research Unit, Psychiatry
Director, Yale Program for Psychedelic Science, Psychiatry
Director, Yale Center for Brain and Mind Health, Yale School of Medicine
Director, Yale OCD Research Clinic, Psychiatry
Director, Neuroscience Research Training Program, Yale Department of Psychiatry

Education & Training

McNeil Research Fellow
Yale University (2007)
Resident in Adult Psychiatry
Yale University (2007)
MD
Columbia College of Physicians and Surgeons (2003)
PhD
Columbia University (2002)
MPhil
Columbia University (1998)
MS
Yale University (1994)
BS
Yale University (1994)
Diplomate
American Board of Psychiatry and Neurology

Additional Information

Honors & Recognitions

Professional Service

Publications

Psychedelic medicine in psychiatry residency training: a survey of psychiatric residency program directors
Yaden M, Ching T, Goldway N, Roberts D, Hokanson J, Gukasyan N, Pittenger C, Kelmendi B, Ross S, Glick G, O’Donnell K. Psychedelic medicine in psychiatry residency training: a survey of psychiatric residency program directors. International Review Of Psychiatry 2024, ahead-of-print: 1-6. DOI: 10.1080/09540261.2024.2397039.
Elevated antibody binding to striatal cholinergic interneurons in patients with pediatric acute-onset neuropsychiatric syndrome
Xu J, Frankovich J, Liu R, Thienemann M, Silverman M, Farhadian B, Willett T, Manko C, Columbo L, Leibold C, Vaccarino F, Che A, Pittenger C. Elevated antibody binding to striatal cholinergic interneurons in patients with pediatric acute-onset neuropsychiatric syndrome. Brain Behavior And Immunity 2024, 122: 241-255. PMID: 39084540, DOI: 10.1016/j.bbi.2024.07.044.
Sex differences in the distribution and density of regulatory interneurons in the striatum
Van Zandt M, Flanagan D, Pittenger C. Sex differences in the distribution and density of regulatory interneurons in the striatum. Frontiers In Cellular Neuroscience 2024, 18: 1415015. PMID: 39045533, PMCID: PMC11264243, DOI: 10.3389/fncel.2024.1415015.
Information processing style and institutional trust as factors of COVID vaccine hesitancy
Zhao W, Russell C, Jankovsky A, Cannon T, Pittenger C, Pushkarskaya H. Information processing style and institutional trust as factors of COVID vaccine hesitancy. Scientific Reports 2024, 14: 10416. PMID: 38710827, PMCID: PMC11074285, DOI: 10.1038/s41598-024-60788-y.
497. Prefrontal Cortex Astroglia Modulate Anhedonia-Like Behavior
Codeluppi S, Xu M, Bansal Y, Lepack A, Duric V, Chow M, Muir J, Bagot R, Licznerski P, Wilber S, Sanacora G, Sibille E, Duman R, Pittenger C, Banasr M. 497. Prefrontal Cortex Astroglia Modulate Anhedonia-Like Behavior. Biological Psychiatry 2024, 95: s302. DOI: 10.1016/j.biopsych.2024.02.996.
Activation of M4 muscarinic receptors in the striatum reduces tic‐like behaviours in two distinct murine models of Tourette syndrome
Cadeddu R, Braccagni G, Branca C, van Luik E, Pittenger C, Thomsen M, Bortolato M. Activation of M4 muscarinic receptors in the striatum reduces tic‐like behaviours in two distinct murine models of Tourette syndrome. British Journal Of Pharmacology 2024, 181: 3064-3081. PMID: 38689378, DOI: 10.1111/bph.16392.
Mechanisms of therapeutic change after psychedelic treatment in OCD
Maloney G, Ching T, Kichuk S, Pittenger C, Kelmendi B. Mechanisms of therapeutic change after psychedelic treatment in OCD. Psychiatry Research 2024, 336: 115907. PMID: 38615521, PMCID: PMC11190873, DOI: 10.1016/j.psychres.2024.115907.
Externally orienting cues improve cognitive control in OCD
Bednarek L, Glover S, Ma X, Pittenger C, Pushkarskaya H. Externally orienting cues improve cognitive control in OCD. Journal Of Behavior Therapy And Experimental Psychiatry 2024, 84: 101959. PMID: 38531125, PMCID: PMC11192454, DOI: 10.1016/j.jbtep.2024.101959.
Corrigendum: Safety, feasibility, tolerability, and clinical effects of repeated psilocybin dosing combined with non-directive support in the treatment of obsessive-compulsive disorder: protocol for a randomized, waitlist-controlled trial with blinded ratings
Ching T, Amoroso L, Bohner C, D'Amico E, Eilbott J, Entezar T, Fitzpatrick M, Fram G, Grazioplene R, Hokanson J, Jankovsky A, Kichuk S, Martins B, Patel P, Schaer H, Shnayder S, Witherow C, Pittenger C, Kelmendi B. Corrigendum: Safety, feasibility, tolerability, and clinical effects of repeated psilocybin dosing combined with non-directive support in the treatment of obsessive-compulsive disorder: protocol for a randomized, waitlist-controlled trial with blinded ratings. Frontiers In Psychiatry 2024, 15: 1372373. PMID: 38435972, PMCID: PMC10905264, DOI: 10.3389/fpsyt.2024.1372373.
The endogenous opioid system in the medial prefrontal cortex mediates ketamine’s antidepressant-like actions
Jiang C, DiLeone R, Pittenger C, Duman R. The endogenous opioid system in the medial prefrontal cortex mediates ketamine’s antidepressant-like actions. Translational Psychiatry 2024, 14: 90. PMID: 38346984, PMCID: PMC10861497, DOI: 10.1038/s41398-024-02796-0.
White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group
Kim B, Kim G, Abe Y, Alonso P, Ameis S, Anticevic A, Arnold P, Balachander S, Banaj N, Bargalló N, Batistuzzo M, Benedetti F, Bertolín S, Beucke J, Bollettini I, Brem S, Brennan B, Buitelaar J, Calvo R, Castelo-Branco M, Cheng Y, Chhatkuli R, Ciullo V, Coelho A, Couto B, Dallaspezia S, Ely B, Ferreira S, Fontaine M, Fouche J, Grazioplene R, Gruner P, Hagen K, Hansen B, Hanna G, Hirano Y, Höxter M, Hough M, Hu H, Huyser C, Ikuta T, Jahanshad N, James A, Jaspers-Fayer F, Kasprzak S, Kathmann N, Kaufmann C, Kim M, Koch K, Kvale G, Kwon J, Lazaro L, Lee J, Lochner C, Lu J, Manrique D, Martínez-Zalacaín I, Masuda Y, Matsumoto K, Maziero M, Menchón J, Minuzzi L, Moreira P, Morgado P, Narayanaswamy J, Narumoto J, Ortiz A, Ota J, Pariente J, Perriello C, Picó-Pérez M, Pittenger C, Poletti S, Real E, Reddy Y, van Rooij D, Sakai Y, Sato J, Segalas C, Shavitt R, Shen Z, Shimizu E, Shivakumar V, Soreni N, Soriano-Mas C, Sousa N, Sousa M, Spalletta G, Stern E, Stewart S, Szeszko P, Thomas R, Thomopoulos S, Vecchio D, Venkatasubramanian G, Vriend C, Walitza S, Wang Z, Watanabe A, Wolters L, Xu J, Yamada K, Yun J, Zarei M, Zhao Q, Zhu X, Thompson P, Bruin W, van Wingen G, Piras F, Piras F, Stein D, van den Heuvel O, Simpson H, Marsh R, Cha J. White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group. Molecular Psychiatry 2024, 29: 1063-1074. PMID: 38326559, PMCID: PMC11176060, DOI: 10.1038/s41380-023-02392-6.
A comparison of machine learning methods for quantifying self-grooming behavior in mice
Correia K, Walker R, Pittenger C, Fields C. A comparison of machine learning methods for quantifying self-grooming behavior in mice. Frontiers In Behavioral Neuroscience 2024, 18: 1340357. PMID: 38347909, PMCID: PMC10859524, DOI: 10.3389/fnbeh.2024.1340357.
Safety, feasibility, tolerability, and clinical effects of repeated psilocybin dosing combined with non-directive support in the treatment of obsessive-compulsive disorder: protocol for a randomized, waitlist-controlled trial with blinded ratings
Ching T, Amoroso L, Bohner C, D’Amico E, Eilbott J, Entezar T, Fitzpatrick M, Fram G, Grazioplene R, Hokanson J, Jankovsky A, Kichuk S, Martins B, Patel P, Schaer H, Shnayder S, Witherow C, Pittenger C, Kelmendi B. Safety, feasibility, tolerability, and clinical effects of repeated psilocybin dosing combined with non-directive support in the treatment of obsessive-compulsive disorder: protocol for a randomized, waitlist-controlled trial with blinded ratings. Frontiers In Psychiatry 2024, 14: 1278823. PMID: 38264632, PMCID: PMC10803438, DOI: 10.3389/fpsyt.2023.1278823.
Psilocybin and other Psychedelics
Kaye A, Kelmendi B, Rivera M, Pittenger C. Psilocybin and other Psychedelics. 2024 DOI: 10.1016/b978-0-323-95702-1.00178-0.
What Is in a Name? The Many Meanings of “Psychedelic”
O'Donnell K, Roberts D, Ching T, Glick G, Goldway N, Gukasyan N, Hokansen J, Kelmendi B, Ross S, Yaden M, Pittenger C. What Is in a Name? The Many Meanings of “Psychedelic”. Psychedelic Medicine 2023, 1: 187-189. DOI: 10.1089/psymed.2023.0011.
A novel naïve Bayes approach to identifying grooming behaviors in the force-plate actometric platform
Anderson C, Cadeddu R, Anderson D, Huxford J, VanLuik E, Odeh K, Pittenger C, Pulst S, Bortolato M. A novel naïve Bayes approach to identifying grooming behaviors in the force-plate actometric platform. Journal Of Neuroscience Methods 2023, 403: 110026. PMID: 38029972, DOI: 10.1016/j.jneumeth.2023.110026.
44.3 Antibodies Against Basal Ganglial Cholinergic Interneurons in Youth With PANS/PANDAS
Pittenger C. 44.3 Antibodies Against Basal Ganglial Cholinergic Interneurons in Youth With PANS/PANDAS. Journal Of The American Academy Of Child & Adolescent Psychiatry 2023, 62: s392-s393. DOI: 10.1016/j.jaac.2023.07.871.
Postinfectious Inflammation, Autoimmunity, and Obsessive-Compulsive Disorder: Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection, and Pediatric Acute-Onset Neuropsychiatric Disorder
Vreeland A, Calaprice D, Or-Geva N, Frye R, Agalliu D, Lachman H, Pittenger C, Pallanti S, Williams K, Ma M, Thienemann M, Gagliano A, Mellins E, Frankovich J. Postinfectious Inflammation, Autoimmunity, and Obsessive-Compulsive Disorder: Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection, and Pediatric Acute-Onset Neuropsychiatric Disorder. Developmental Neuroscience 2023, 45: 361-374. PMID: 37742615, DOI: 10.1159/000534261.
Prefrontal cortex astroglia modulate anhedonia-like behavior
Codeluppi S, Xu M, Bansal Y, Lepack A, Duric V, Chow M, Muir J, Bagot R, Licznerski P, Wilber S, Sanacora G, Sibille E, Duman R, Pittenger C, Banasr M. Prefrontal cortex astroglia modulate anhedonia-like behavior. Molecular Psychiatry 2023, 28: 4632-4641. PMID: 37696873, PMCID: PMC10914619, DOI: 10.1038/s41380-023-02246-1.
Frontopolar multifocal transcranial direct current stimulation reduces conditioned fear reactivity during extinction training: A pilot randomized controlled trial
Adams T, Kelmendi B, George J, Forte J, Hubert T, Wild H, Rippey C, Pittenger C. Frontopolar multifocal transcranial direct current stimulation reduces conditioned fear reactivity during extinction training: A pilot randomized controlled trial. Neurobiology Of Learning And Memory 2023, 205: 107825. PMID: 37699439, PMCID: PMC10872945, DOI: 10.1016/j.nlm.2023.107825.
Neurofeedback for obsessive compulsive disorder: A randomized, double-blind trial
Rance M, Zhao Z, Zaboski B, Kichuk S, Romaker E, Koller W, Walsh C, Harris-Starling C, Wasylink S, Adams T, Gruner P, Pittenger C, Hampson M. Neurofeedback for obsessive compulsive disorder: A randomized, double-blind trial. Psychiatry Research 2023, 328: 115458. PMID: 37722238, PMCID: PMC10695074, DOI: 10.1016/j.psychres.2023.115458.
Pharmacotherapy for comorbid antisocial personality and obsessive-compulsive disorder: A case report
Jankovsky A, Zaboski B, Pittenger C. Pharmacotherapy for comorbid antisocial personality and obsessive-compulsive disorder: A case report. Psychiatry Research Case Reports 2023, 2: 100139. PMID: 38240012, PMCID: PMC10795765, DOI: 10.1016/j.psycr.2023.100139.
Pleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders
Wang Z, Lin X, Luo X, Xiao J, Zhang Y, Xu J, Wang S, Zhao F, Wang H, Zheng H, Zhang W, Lin C, Tan Z, Cao L, Wang Z, Tan Y, Chen W, Cao Y, Guo X, Pittenger C, Luo X. Pleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders. Schizophrenia Bulletin 2023, 49: 1174-1184. PMID: 37306960, PMCID: PMC10483336, DOI: 10.1093/schbul/sbad073.
Prefrontal allopregnanolone mediates the adverse effects of acute stress in a mouse model of tic pathophysiology
Cadeddu R, Van Zandt M, Santovito L, Odeh K, Anderson C, Flanagan D, Nordkild P, Pinna G, Pittenger C, Bortolato M. Prefrontal allopregnanolone mediates the adverse effects of acute stress in a mouse model of tic pathophysiology. Neuropsychopharmacology 2023, 48: 1288-1299. PMID: 37198434, PMCID: PMC10354086, DOI: 10.1038/s41386-023-01603-6.
The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium
Bruin W, Abe Y, Alonso P, Anticevic A, Backhausen L, Balachander S, Bargallo N, Batistuzzo M, Benedetti F, Bertolin Triquell S, Brem S, Calesella F, Couto B, Denys D, Echevarria M, Eng G, Ferreira S, Feusner J, Grazioplene R, Gruner P, Guo J, Hagen K, Hansen B, Hirano Y, Hoexter M, Jahanshad N, Jaspers-Fayer F, Kasprzak S, Kim M, Koch K, Bin Kwak Y, Kwon J, Lazaro L, Li C, Lochner C, Marsh R, Martínez-Zalacaín I, Menchon J, Moreira P, Morgado P, Nakagawa A, Nakao T, Narayanaswamy J, Nurmi E, Zorrilla J, Piacentini J, Picó-Pérez M, Piras F, Piras F, Pittenger C, Reddy J, Rodriguez-Manrique D, Sakai Y, Shimizu E, Shivakumar V, Simpson B, Soriano-Mas C, Sousa N, Spalletta G, Stern E, Evelyn Stewart S, Szeszko P, Tang J, Thomopoulos S, Thorsen A, Yoshida T, Tomiyama H, Vai B, Veer I, Venkatasubramanian G, Vetter N, Vriend C, Walitza S, Waller L, Wang Z, Watanabe A, Wolff N, Yun J, Zhao Q, van Leeuwen W, van Marle H, van de Mortel L, van der Straten A, van der Werf Y, Thompson P, Stein D, van den Heuvel O, van Wingen G. The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium. Molecular Psychiatry 2023, 28: 4307-4319. PMID: 37131072, PMCID: PMC10827654, DOI: 10.1038/s41380-023-02077-0.
348. Sexual Dimorphism in the Behavioral Outcomes Following Early Life Stress
Jiang C, Pittenger C. 348. Sexual Dimorphism in the Behavioral Outcomes Following Early Life Stress. Biological Psychiatry 2023, 93: s234. DOI: 10.1016/j.biopsych.2023.02.588.
Circuit- and Behavioral- Level Investigation of Plasticity After Administration of Entactogens in Mice
Kaye A, Kwan A, Pittenger C, Yu A, Yang J. Circuit- and Behavioral- Level Investigation of Plasticity After Administration of Entactogens in Mice. Biological Psychiatry 2023, 93: s57. DOI: 10.1016/j.biopsych.2023.02.156.
511. Common and Distinct Effects of Incentives on Spatial Working Memory in Schizophrenia and Obsessive-Compulsive Disorder
Sarantopoulos C, Shin D, Schleifer C, Moujaes F, Adkinson B, Ji J, Kolabaric A, Flynn M, Santamauro N, Krystal J, Murray J, Repovs G, Martin W, Pittenger C, Anticevic A, Cho Y. 511. Common and Distinct Effects of Incentives on Spatial Working Memory in Schizophrenia and Obsessive-Compulsive Disorder. Biological Psychiatry 2023, 93: s300-s301. DOI: 10.1016/j.biopsych.2023.02.751.
332. 5-MeO-DMT Modifies Innate Behaviors and Promotes Structural Neural Plasticity in Mice
Jefferson S, Gregg I, Dibbs M, Liao C, Wu H, Davoudian P, Kaye A, Pittenger C, Kwan A. 332. 5-MeO-DMT Modifies Innate Behaviors and Promotes Structural Neural Plasticity in Mice. Biological Psychiatry 2023, 93: s228. DOI: 10.1016/j.biopsych.2023.02.572.
390. Altered Confidence Adaptation During Set-Shifting in OCD
Loosen A, Zaboski B, Pushkarskaya H, Pittenger C, Hauser T. 390. Altered Confidence Adaptation During Set-Shifting in OCD. Biological Psychiatry 2023, 93: s252. DOI: 10.1016/j.biopsych.2023.02.630.
Safety, tolerability, and clinical and neural effects of single-dose psilocybin in obsessive–compulsive disorder: protocol for a randomized, double-blind, placebo-controlled, non-crossover trial
Ching T, Grazioplene R, Bohner C, Kichuk S, DePalmer G, D’Amico E, Eilbott J, Jankovsky A, Burke M, Hokanson J, Martins B, Witherow C, Patel P, Amoroso L, Schaer H, Pittenger C, Kelmendi B. Safety, tolerability, and clinical and neural effects of single-dose psilocybin in obsessive–compulsive disorder: protocol for a randomized, double-blind, placebo-controlled, non-crossover trial. Frontiers In Psychiatry 2023, 14: 1178529. PMID: 37181888, PMCID: PMC10166878, DOI: 10.3389/fpsyt.2023.1178529.
5-MeO-DMT modifies innate behaviors and promotes structural neural plasticity in mice
Jefferson S, Gregg I, Dibbs M, Liao C, Wu H, Davoudian P, Woodburn S, Wehrle P, Sprouse J, Sherwood A, Kaye A, Pittenger C, Kwan A. 5-MeO-DMT modifies innate behaviors and promotes structural neural plasticity in mice. Neuropsychopharmacology 2023, 48: 1257-1266. PMID: 37015972, PMCID: PMC10354037, DOI: 10.1038/s41386-023-01572-w.
The histamine H3 receptor modulates dopamine D2 receptor–dependent signaling pathways and mouse behaviors
Xu J, Pittenger C. The histamine H3 receptor modulates dopamine D2 receptor–dependent signaling pathways and mouse behaviors. Journal Of Biological Chemistry 2023, 299: 104583. PMID: 36871761, PMCID: PMC10139999, DOI: 10.1016/j.jbc.2023.104583.
Neuroinflammation in Obsessive-Compulsive Disorder Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections, and Pediatric Acute Onset Neuropsychiatric Syndrome
Vreeland A, Thienemann M, Cunningham M, Muscal E, Pittenger C, Frankovich J. Neuroinflammation in Obsessive-Compulsive Disorder Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections, and Pediatric Acute Onset Neuropsychiatric Syndrome. Psychiatric Clinics Of North America 2023, 46: 69-88. PMID: 36740356, DOI: 10.1016/j.psc.2022.11.004.
Cholinergic neurons in the basal forebrain are involved in behavioral abnormalities associated with Cul3 deficiency: Role of prefrontal cortex projections in cognitive deficits
Rapanelli M, Wang W, Hurley E, Feltri M, Pittenger C, Frick L, Yan Z. Cholinergic neurons in the basal forebrain are involved in behavioral abnormalities associated with Cul3 deficiency: Role of prefrontal cortex projections in cognitive deficits. Translational Psychiatry 2023, 13: 22. PMID: 36693858, PMCID: PMC9873627, DOI: 10.1038/s41398-023-02306-8.
Methylone, a rapid acting entactogen with robust anxiolytic and antidepressant-like activity
Warner-Schmidt J, Pittenger C, Stogniew M, Mandell B, Olmstead S, Kelmendi B. Methylone, a rapid acting entactogen with robust anxiolytic and antidepressant-like activity. Frontiers In Psychiatry 2023, 13: 1041277. PMID: 36704743, PMCID: PMC9873307, DOI: 10.3389/fpsyt.2022.1041277.
The Pharmacological Treatment of Obsessive-Compulsive Disorder
Pittenger C. The Pharmacological Treatment of Obsessive-Compulsive Disorder. Psychiatric Clinics Of North America 2023, 46: 107-119. PMID: 36740347, DOI: 10.1016/j.psc.2022.11.005.
Single-dose psilocybin for treatment-resistant obsessive-compulsive disorder: A case report
Kelmendi B, Kichuk S, DePalmer G, Maloney G, Ching T, Belser A, Pittenger C. Single-dose psilocybin for treatment-resistant obsessive-compulsive disorder: A case report. Heliyon 2022, 8: e12135. PMID: 36536916, PMCID: PMC9758406, DOI: 10.1016/j.heliyon.2022.e12135.
White matter abnormalities in the Hdc knockout mouse, a model of tic and OCD pathophysiology
Jindachomthong K, Yang C, Huang Y, Coman D, Rapanelli M, Hyder F, Dougherty J, Frick L, Pittenger C. White matter abnormalities in the Hdc knockout mouse, a model of tic and OCD pathophysiology. Frontiers In Molecular Neuroscience 2022, 15: 1037481. PMID: 36504678, PMCID: PMC9731796, DOI: 10.3389/fnmol.2022.1037481.
19.1 Renaissance in Psychedelic Research
Pittenger C. 19.1 Renaissance in Psychedelic Research. Journal Of The American Academy Of Child & Adolescent Psychiatry 2022, 61: s305. DOI: 10.1016/j.jaac.2022.07.662.
Imagery Rescripting (ImRs) as an Adjunctive Treatment to Exposure and Response Prevention (ERP)-Resistant Obsessive-Compulsive Disorder: A Case Study
Maloney G, Kelmendi B, Pittenger C. Imagery Rescripting (ImRs) as an Adjunctive Treatment to Exposure and Response Prevention (ERP)-Resistant Obsessive-Compulsive Disorder: A Case Study. Clinical Case Studies 2022, 22: 174-191. DOI: 10.1177/15346501221123797.
P456. The Effects of Early Life Stress on Tourette Syndrome-Relevant Pathology
Jiang C, Pittenger C. P456. The Effects of Early Life Stress on Tourette Syndrome-Relevant Pathology. Biological Psychiatry 2022, 91: s272. DOI: 10.1016/j.biopsych.2022.02.692.
Studying the pathophysiology of tic disorders in animal models
Pittenger C. Studying the pathophysiology of tic disorders in animal models. International Review Of Movement Disorders 2022, 4: 39-61. DOI: 10.1016/bs.irmvd.2022.06.001.
Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity
Xu J, Liu RJ, Fahey S, Frick L, Leckman J, Vaccarino F, Duman RS, Williams K, Swedo S, Pittenger C. Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity. American Journal Of Psychiatry 2020, 178: 48-64. PMID: 32539528, PMCID: PMC8573771, DOI: 10.1176/appi.ajp.2020.19070698.
Histaminergic Regulation of Stereotyped Movements in a Mouse Model of Repetitive Motor Behavior
Emmons E, Xu J, Pittenger C. Histaminergic Regulation of Stereotyped Movements in a Mouse Model of Repetitive Motor Behavior. Biological Psychiatry 2020, 87: s295. DOI: 10.1016/j.biopsych.2020.02.760.
Excessive acquisition of information during simple judgments in individuals with hoarding disorder
Pushkarskaya H, Stern E, Tolin D, Pittenger C. Excessive acquisition of information during simple judgments in individuals with hoarding disorder. Journal Of Obsessive-Compulsive And Related Disorders 2020, 24: 100505. DOI: 10.1016/j.jocrd.2020.100505.
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
Consortium C, Lee P, Anttila V, Won H, Feng Y, Rosenthal J, Zhu Z, Tucker-Drob E, Nivard M, Grotzinger A, Posthuma D, Wang M, Yu D, Stahl E, Walters R, Anney R, Duncan L, Ge T, Adolfsson R, Banaschewski T, Belangero S, Cook E, Coppola G, Derks E, Hoekstra P, Kaprio J, Keski-Rahkonen A, Kirov G, Kranzler H, Luykx J, Rohde L, Zai C, Agerbo E, Arranz M, Asherson P, Bækvad-Hansen M, Baldursson G, Bellgrove M, Belliveau R, Buitelaar J, Burton C, Bybjerg-Grauholm J, Casas M, Cerrato F, Chambert K, Churchhouse C, Cormand B, Crosbie J, Dalsgaard S, Demontis D, Doyle A, Dumont A, Elia J, Grove J, Gudmundsson O, Haavik J, Hakonarson H, Hansen C, Hartman C, Hawi Z, Hervás A, Hougaard D, Howrigan D, Huang H, Kuntsi J, Langley K, Lesch K, Leung P, Loo S, Martin J, Martin A, McGough J, Medland S, Moran J, Mors O, Mortensen P, Oades R, Palmer D, Pedersen C, Pedersen M, Peters T, Poterba T, Poulsen J, Ramos-Quiroga J, Reif A, Ribasés M, Rothenberger A, Rovira P, Sánchez-Mora C, Satterstrom F, Schachar R, Artigas M, Steinberg S, Stefansson H, Turley P, Walters G, Team 2, Werge T, Zayats T, Arking D, Bettella F, Buxbaum J, Christensen J, Collins R, Coon H, De Rubeis S, Delorme R, Grice D, Hansen T, Holmans P, Hope S, Hultman C, Klei L, Ladd-Acosta C, Magnusson P, Nærland T, Nyegaard M, Pinto D, Qvist P, Rehnström K, Reichenberg A, Reichert J, Roeder K, Rouleau G, Saemundsen E, Sanders S, Sandin S, St Pourcain B, Stefansson K, Sutcliffe J, Talkowski M, Weiss L, Willsey A, Agartz I, Akil H, Albani D, Alda M, Als T, Anjorin A, Backlund L, Bass N, Bauer M, Baune B, Bellivier F, Bergen S, Berrettini W, Biernacka J, Blackwood D, Bøen E, Budde M, Bunney W, Burmeister M, Byerley W, Byrne E, Cichon S, Clarke T, Coleman J, Craddock N, Curtis D, Czerski P, Dale A, Dalkner N, Dannlowski U, Degenhardt F, Di Florio A, Elvsåshagen T, Etain B, Fischer S, Forstner A, Forty L, Frank J, Frye M, Fullerton J, Gade K, Gaspar H, Gershon E, Gill M, Goes F, Gordon S, Gordon-Smith K, Green M, Greenwood T, Grigoroiu-Serbanescu M, Guzman-Parra J, Hauser J, Hautzinger M, Heilbronner U, Herms S, Hoffmann P, Holland D, Jamain S, Jones I, Jones L, Kandaswamy R, Kelsoe J, Kennedy J, Joachim O, Kittel-Schneider S, Kogevinas M, Koller A, Lavebratt C, Lewis C, Li Q, Lissowska J, Loohuis L, Lucae S, Maaser A, Malt U, Martin N, Martinsson L, McElroy S, McMahon F, McQuillin A, Melle I, Metspalu A, Millischer V, Mitchell P, Montgomery G, Morken G, Morris D, Müller-Myhsok B, Mullins N, Myers R, Nievergelt C, Nordentoft M, Adolfsson A, Nöthen M, Ophoff R, Owen M, Paciga S, Pato C, Pato M, Perlis R, Perry A, Potash J, Reinbold C, Rietschel M, Rivera M, Roberson M, Schalling M, Schofield P, Schulze T, Scott L, Serretti A, Sigurdsson E, Smeland O, Stordal E, Streit F, Strohmaier J, Thorgeirsson T, Treutlein J, Turecki G, Vaaler A, Vieta E, Vincent J, Wang Y, Witt S, Zandi P, Adan R, Alfredsson L, Ando T, Aschauer H, Baker J, Bencko V, Bergen A, Birgegård A, Perica V, Brandt H, Burghardt R, Carlberg L, Cassina M, Clementi M, Courtet P, Crawford S, Crow S, Crowley J, Danner U, Davis O, Degortes D, DeSocio J, Dick D, Dina C, Docampo E, Egberts K, Ehrlich S, Espeseth T, Fernández-Aranda F, Fichter M, Foretova L, Forzan M, Gambaro G, Giegling I, Gonidakis F, Gorwood P, Mayora M, Guo Y, Halmi K, Hatzikotoulas K, Hebebrand J, Helder S, Herpertz-Dahlmann B, Herzog W, Hinney A, Imgart H, Jiménez-Murcia S, Johnson C, Jordan J, Julià A, Kaminská D, Karhunen L, Karwautz A, Kas M, Kaye W, Kennedy M, Kim Y, Klareskog L, Klump K, Knudsen G, Landén M, Le Hellard S, Levitan R, Li D, Lichtenstein P, Maj M, Marsal S, McDevitt S, Mitchell J, Monteleone P, Monteleone A, Munn-Chernoff M, Nacmias B, Navratilova M, O’Toole J, Padyukov L, Pantel J, Papezova H, Rabionet R, Raevuori A, Ramoz N, Reichborn-Kjennerud T, Ricca V, Roberts M, Rujescu D, Rybakowski F, Scherag A, Schmidt U, Seitz J, Slachtova L, Landt M, Slopien A, Sorbi S, Southam L, Strober M, Tortorella A, Tozzi F, Treasure J, Tziouvas K, van Elburg A, Wade T, Wagner G, Walton E, Watson H, Wichmann H, Woodside D, Zeggini E, Zerwas S, Zipfel S, Adams M, Andlauer T, Berger K, Binder E, Boomsma D, Castelao E, Colodro-Conde L, Direk N, Docherty A, Domenici E, Domschke K, Dunn E, Foo J, de. 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Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell 2019, 179: 1469-1482.e11. PMID: 31835028, PMCID: PMC7077032, DOI: 10.1016/j.cell.2019.11.020.
F16. Aberrant Causal Reasoning in Obsessive-Compulsive Disorder (OCD)
Gruner P, Koller W, Anticevic A, Pittenger C. F16. Aberrant Causal Reasoning in Obsessive-Compulsive Disorder (OCD). Biological Psychiatry 2019, 85: s219. DOI: 10.1016/j.biopsych.2019.03.553.
Exploring Retrospective Biases in Obsessive-Compulsive Disorder: an Experience-Sampling Study
MacLaren Kelly J, Kertz S, Simpson R, Bloch M, Pittenger C. Exploring Retrospective Biases in Obsessive-Compulsive Disorder: an Experience-Sampling Study. Journal Of Technology In Behavioral Science 2018, 4: 297-302. DOI: 10.1007/s41347-018-0078-y.
Analysis of shared heritability in common disorders of the brain
Consortium T, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, Lee PH, Turley P, Grenier-Boley B, Chouraki V, Kamatani Y, Berr C, Letenneur L, Hannequin D, Amouyel P, Boland A, Deleuze JF, Duron E, Vardarajan BN, Reitz C, Goate AM, Huentelman MJ, Kamboh MI, Larson EB, Rogaeva E, St George-Hyslop P, Hakonarson H, Kukull WA, Farrer LA, Barnes LL, Beach TG, Demirci FY, Head E, Hulette CM, Jicha GA, Kauwe JSK, Kaye JA, Leverenz JB, Levey AI, Lieberman AP, Pankratz VS, Poon WW, Quinn JF, Saykin AJ, Schneider LS, Smith AG, Sonnen JA, Stern RA, Van Deerlin VM, Van Eldik LJ, Harold D, Russo G, Rubinsztein DC, Bayer A, Tsolaki M, Proitsi P, Fox NC, Hampel H, Owen MJ, Mead S, Passmore P, Morgan K, Nöthen MM, Schott J, Rossor M, Lupton M, Hoffmann P, Kornhuber J, Lawlor B, McQuillin A, Al-Chalabi A, Bis J, Ruiz A, Boada M, Seshadri S, Beiser A, Rice K, van der Lee S, De Jager P, Geschwind D, Riemenschneider M, Riedel-Heller S, Rotter J, Ransmayr G, Hyman B, Cruchaga C, Alegret M, Winsvold B, Palta P, Farh K, Cuenca-Leon E, Furlotte N, Kurth T, Ligthart L, Terwindt G, Freilinger T, Ran C, Gordon S, Borck G, Adams H, Lehtimäki T, Wedenoja J, Buring J, Schürks M, Hrafnsdottir M, Hottenga J, Penninx B, Artto V, Kaunisto M, Vepsäläinen S, Martin N, Montgomery G, Kurki M, Hämäläinen E, Huang H, Huang J, Sandor C, Webber C, Muller-Myhsok B, Schreiber S, Salomaa V, Loehrer E, Göbel H, Macaya A, Pozo-Rosich P, Hansen T, Werge T, Kaprio J, Metspalu A, Kubisch C, Ferrari M, Belin A, van den Maagdenberg A, Zwart J, Boomsma D, Eriksson N, Olesen J, Chasman D, Nyholt D, Anney R, Avbersek A, Baum L, Berkovic S, Bradfield J, Buono R, Catarino C, Cossette P, De Jonghe P, Depondt C, Dlugos D, Ferraro T, French J, Hjalgrim H, Jamnadas-Khoda J, Kälviäinen R, Kunz W, Lerche H, Leu C, Lindhout D, Lo W, Lowenstein D, McCormack M, Møller R, Molloy A, Ng P, Oliver K, Privitera M, Radtke R, Ruppert A, Sander T, Schachter S, Schankin C, Scheffer I, Schoch S, Sisodiya S, Smith P, Sperling M, Striano P, Surges R, Thomas G, Visscher F, Whelan C, Zara F, Heinzen E, Marson A, Becker F, Stroink H, Zimprich F, Gasser T, Gibbs R, Heutink P, Martinez M, Morris H, Sharma M, Ryten M, Mok K, Pulit S, Bevan S, Holliday E, Attia J, Battey T, Boncoraglio G, Thijs V, Chen W, Mitchell B, Rothwell P, Sharma P, Sudlow C, Vicente A, Markus H, Kourkoulis C, Pera J, Raffeld M, Silliman S, Perica V, Thornton L, Huckins L, Rayner N, Lewis C, Gratacos M, Rybakowski F, Keski-Rahkonen A, Raevuori A, Hudson J, Reichborn-Kjennerud T, Monteleone P, Karwautz A, Mannik K, Baker J, O’Toole J, Trace S, Davis O, Helder S, Ehrlich S, Herpertz-Dahlmann B, Danner U, van Elburg A, Clementi M, Forzan M, Docampo E, Lissowska J, Hauser J, Tortorella A, Maj M, Gonidakis F, Tziouvas K, Papezova H, Yilmaz Z, Wagner G, Cohen-Woods S, Herms S, Julià A, Rabionet R, Dick D, Ripatti S, Andreassen O, Espeseth T, Lundervold 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S, Sim K, So H, Stögmann E, Subramaniam M, Toncheva D, Waddington J, Walters J, Weiser M, Cheng W, Cloninger R, Curtis D, Gejman P, Henskens F, Mattingsdal M, Oh S, Scott R, Webb B, Breen G, Churchhouse C, Bulik C, Daly M, Dichgans M, Faraone S, Guerreiro R, Holmans P, Kendler K, Koeleman B, Mathews C, Price A, Scharf J, Sklar P, Williams J, Wood N, Cotsapas C, Palotie A, Smoller J, Sullivan P, Rosand J, Corvin A, Neale B. Analysis of shared heritability in common disorders of the brain. Science 2018, 360 PMID: 29930110, PMCID: PMC6097237, DOI: 10.1126/science.aap8757.
T18. Characterizing Reward Responsiveness in Obsessive-Compulsive Disorder and Schizophrenia Through a Probabilistic Reward Task
Adkinson B, Kolobaric A, Flynn M, Dowiak C, Schleifer C, Santamauro N, Beech C, Lobe J, Zalevsky O, Cho Y, Pittenger C, Anticevic A. T18. Characterizing Reward Responsiveness in Obsessive-Compulsive Disorder and Schizophrenia Through a Probabilistic Reward Task. Biological Psychiatry 2018, 83: s135. DOI: 10.1016/j.biopsych.2018.02.354.
The Role of Stress in the Pathogenesis and Maintenance of Obsessive-Compulsive Disorder
Adams T, Kelmendi B, Brake C, Gruner P, Badour C, Pittenger C. The Role of Stress in the Pathogenesis and Maintenance of Obsessive-Compulsive Disorder. Chronic Stress 2018, 2: 2470547018758043. PMID: 29527593, PMCID: PMC5841259, DOI: 10.1177/2470547018758043.
Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group
Boedhoe PSW, Schmaal L, Abe Y, Alonso P, Ameis SH, Anticevic A, Arnold PD, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Bose A, Brem S, Calvo A, Calvo R, Cheng Y, Cho KIK, Ciullo V, Dallaspezia S, Denys D, Feusner JD, Fitzgerald KD, Fouche JP, Fridgeirsson EA, Gruner P, Hanna GL, Hibar DP, Hoexter MQ, Hu H, Huyser C, Jahanshad N, James A, Kathmann N, Kaufmann C, Koch K, Kwon JS, Lazaro L, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minuzzi L, Morer A, Nakamae T, Nakao T, Narayanaswamy JC, Nishida S, Nurmi E, O’Neill J, Piacentini J, Piras F, Piras F, Reddy YCJ, Reess TJ, Sakai Y, Sato JR, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stevens MC, Szeszko PR, Tolin DF, van Wingen GA, Venkatasubramanian G, Walitza S, Wang Z, Yun JY, Thompson P, Stein D, van den Heuvel O, Boedhoe P, Schmaal L, Abe Y, Alonso P, Ameis S, Anticevic A, Arnold P, Bargalló N, Batistuzzo M, Benedetti F, Beucke J, Bollettini I, Bose A, Brandeis D, Brem S, Buimer E, Busatto G, Calvo A, Calvo R, Cheng Y, Cho K, Ciullo V, Dallaspezia S, de Vries F, de Wit S, Denys D, Drechsler R, Falini A, Fang Y, Feusner J, Figee M, Fitzgerald K, Fontaine M, Fouche J, Fridgeirsson E, Gruner P, Hanna G, Hauser T, Hibar D, Hoexter M, Hu H, Huyser C, Iorio M, Jahanshad N, James A, Kathmann N, Kaufmann C, Khadka S, Koch K, Kwon J, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, McCracken J, Menchón J, Miguel E, Minuzzi L, Morer A, Nakamae T, Nakao T, Narayanaswamy J, Narumoto J, Nishida S, Nurmi E, O’Neill J, Pariente J, Piacentini J, Pittenger C, Piras F, Piras F, Poletti S, Reddy Y, Reess T, Rus O, Sakai Y, Sato J, Simpson H, Soreni N, Soriano-Mas C, Spalletta G, Stevens M, Szeszko P, Tang J, Tolin D, van der Werf Y, van Wingen G, Vecchio D, Veltman D, Venkatasubramanian G, Walitza S, Wang Z, Watanabe A, Xu J, Xu X, Yamada K, Yun J, Zarei M, Zhao Q, Thompson P, Stein D, van den Heuvel O. Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group. American Journal Of Psychiatry 2017, 175: 453-462. PMID: 29377733, PMCID: PMC7106947, DOI: 10.1176/appi.ajp.2017.17050485.
Association and Causation in Brain Imaging in the Case of OCD: Response to McKay et al.
Boedhoe P, Schmaal L, Mataix-Cols D, Jahanshad N, Thompson P, Stein D, van den Heuvel O, Abe Y, Alonso P, Ameis S, Arnold P, Bargalló N, Batistuzzo M, Benedetti F, Beucke J, Boedhoe P, Bollettini I, Bose A, Brem S, Busatto G, Calvo A, Calvo R, Cath D, Cheng Y, Cho K, Dallaspezia S, de Vries F, de Wit S, Denys D, Fang Y, Fitzgerald K, Fontaine M, Fouche J, Giménez M, Gruner P, Hanna G, Hibar D, Hoexter M, Hu H, Huyser C, Ikari K, Jahanshad N, Kathmann N, Kaufmann C, Khadka S, Koch K, Kwon J, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón J, Miguel E, Minuzzii L, Morer A, Nakamae T, Nakao T, Narayanaswamy J, Piras F, Piras F, Pittenger C, Reddy Y, Sato J, Simpson H, Schmaal L, Soreni N, Soriano-Mas C, Spalletta G, Stein D, Stevens M, Szeszko P, Thompson P, Tolin D, Veltman D, Venkatasubramanian G, van den Heuvel O, van der Werf Y, van Wingen G, Walitza S, Wang Z, Xu J, Xu X, Yun J, Zhao Q. Association and Causation in Brain Imaging in the Case of OCD: Response to McKay et al. American Journal Of Psychiatry 2017, 174: 597-599. PMID: 28565945, PMCID: PMC6546159, DOI: 10.1176/appi.ajp.2017.17010019r.
Obsessive-Compulsive Disorder: Phenomenology, Pathophysiology, and Treatment.
Pittenger, C. (editor). Obsessive-Compulsive Disorder: Phenomenology, Pathophysiology, and Treatment. New York: Oxford University Press
37.5 PATHOPHYSIOLOGICALLY GROUNDED MODELS OF TIC DISORDERS: HISTAMINE DYSREGULATION IN TOURETTE'S DISORDER
Pittenger C. 37.5 PATHOPHYSIOLOGICALLY GROUNDED MODELS OF TIC DISORDERS: HISTAMINE DYSREGULATION IN TOURETTE'S DISORDER. Journal Of The American Academy Of Child & Adolescent Psychiatry 2016, 55: s317. DOI: 10.1016/j.jaac.2016.07.338.
Meta-Analysis of the Symptom Structure of Obsessive-Compulsive Disorder
Bloch M, Landeros-Weisenberger A, Rosario M, Pittenger C, Leckman J. Meta-Analysis of the Symptom Structure of Obsessive-Compulsive Disorder. FOCUS The Journal Of Lifelong Learning In Psychiatry 2015, 13: 232-243. DOI: 10.1176/appi.focus.130209.
Are There Biological Commonalities Among Different Psychiatric Disorders?
Etkin A, Pittenger C. Are There Biological Commonalities Among Different Psychiatric Disorders? 2015, 243-257. DOI: 10.1002/9781118753378.ch15.
Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome
Xu M, Kobets A, Du JC, Lennington J, Li L, Banasr M, Duman RS, Vaccarino FM, DiLeone RJ, Pittenger C. Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 893-898. PMID: 25561540, PMCID: PMC4311862, DOI: 10.1073/pnas.1419533112.
Chapter 47 Animal Models of Tourette Syndrome and Obsessive-Compulsive Disorder
Pittenger C. Chapter 47 Animal Models of Tourette Syndrome and Obsessive-Compulsive Disorder. 2015, 747-764. DOI: 10.1016/b978-0-12-405195-9.00047-0.
Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice
Baldan L, Williams K, Gallezot J, Pogorelov V, Rapanelli M, Crowley M, Anderson G, Loring E, Gorczyca R, Billingslea E, Wasylink S, Panza K, Ercan-Sencicek A, Krusong K, Leventhal B, Ohtsu H, Bloch M, Hughes Z, Krystal J, Mayes L, de Araujo I, Ding Y, State M, Pittenger C. Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice. Neuron 2014, 82: 1186-1187. DOI: 10.1016/j.neuron.2014.05.023.
Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice
Baldan LC, Williams KA, Gallezot JD, Pogorelov V, Rapanelli M, Crowley M, Anderson GM, Loring E, Gorczyca R, Billingslea E, Wasylink S, Panza KE, Ercan-Sencicek AG, Krusong K, Leventhal BL, Ohtsu H, Bloch MH, Hughes ZA, Krystal JH, Mayes L, de Araujo I, Ding YS, State MW, Pittenger C. Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice. Neuron 2014, 81: 77-90. PMID: 24411733, PMCID: PMC3894588, DOI: 10.1016/j.neuron.2013.10.052.
Global Resting-State Functional Magnetic Resonance Imaging Analysis Identifies Frontal Cortex, Striatal, and Cerebellar Dysconnectivity in Obsessive-Compulsive Disorder
Anticevic A, Hu S, Zhang S, Savic A, Billingslea E, Wasylink S, Repovs G, Cole MW, Bednarski S, Krystal JH, Bloch MH, Li CS, Pittenger C. Global Resting-State Functional Magnetic Resonance Imaging Analysis Identifies Frontal Cortex, Striatal, and Cerebellar Dysconnectivity in Obsessive-Compulsive Disorder. Biological Psychiatry 2013, 75: 595-605. PMID: 24314349, PMCID: PMC3969771, DOI: 10.1016/j.biopsych.2013.10.021.
Tourette Syndrome and Tic Disorders
Williams K, Bloch M, State M, Pittenger C. Tourette Syndrome and Tic Disorders. 2013, 1048-1060. DOI: 10.1093/med/9780199934959.003.0079.
Erratum: Genome-wide association study of obsessive-compulsive disorder
Stewart S, Yu D, Scharf J, Neale B, Fagerness J, Mathews C, Arnold P, Evans P, Gamazon E, Osiecki L, McGrath L, Haddad S, Crane J, Hezel D, Illman C, Mayerfeld C, Konkashbaev A, Liu C, Pluzhnikov A, Tikhomirov A, Edlund C, Rauch S, Moessner R, Falkai P, Maier W, Ruhrmann S, Grabe H, Lennertz L, Wagner M, Bellodi L, Cavallini M, Richter M, Cook E, Kennedy J, Rosenberg D, Stein D, Hemmings S, Lochner C, Azzam A, Chavira D, Fournier E, Garrido H, Sheppard B, Umaña P, Murphy D, Wendland J, Veenstra-Vander Weele J, Denys D, Blom R, Deforce D, Van Nieuwerburgh F, Westenberg H, Walitza S, Egberts K, Renner T, Miguel E, Cappi C, Hounie A, Conceição do Rosário M, Sampaio A, Vallada H, Nicolini H, Lanzagorta N, Camarena B, Delorme R, Leboyer M, Pato C, Pato M, Voyiaziakis E, Heutink P, Cath D, Posthuma D, Smit J, Samuels J, Bienvenu O, Cullen B, Fyer A, Grados M, Greenberg B, McCracken J, Riddle M, Wang Y, Coric V, Leckman J, Bloch M, Pittenger C, Eapen V, Black D, Ophoff R, Strengman E, Cusi D, Turiel M, Frau F, Macciardi F, Gibbs J, Cookson M, Singleton A, Hardy J, Crenshaw A, Parkin M, Mirel D, Conti D, Purcell S, Nestadt G, Hanna G, Jenike M, Knowles J, Cox N, Pauls D. Erratum: Genome-wide association study of obsessive-compulsive disorder. Molecular Psychiatry 2013, 18: 843-843. DOI: 10.1038/mp.2013.15.
Genome-wide association study of obsessive-compulsive disorder
Stewart SE, Yu D, Scharf JM, Neale BM, Fagerness JA, Mathews CA, Arnold PD, Evans PD, Gamazon ER, Osiecki L, McGrath L, Haddad S, Crane J, Hezel D, Illman C, Mayerfeld C, Konkashbaev A, Liu C, Pluzhnikov A, Tikhomirov A, Edlund C, Rauch S, Moessner R, Falkai P, Maier W, Ruhrmann S, Grabe H, Lennertz L, Wagner M, Bellodi L, Cavallini M, Richter M, Cook E, Kennedy J, Rosenberg D, Stein D, Hemmings S, Lochner C, Azzam A, Chavira D, Fournier E, Garrido H, Sheppard B, Umaña P, Murphy D, Wendland J, Veenstra-VanderWeele J, Denys D, Blom R, Deforce D, Van Nieuwerburgh F, Westenberg H, Walitza S, Egberts K, Renner T, Miguel E, Cappi C, Hounie A, Conceição do Rosário M, Sampaio A, Vallada H, Nicolini H, Lanzagorta N, Camarena B, Delorme R, Leboyer M, Pato C, Pato M, Voyiaziakis E, Heutink P, Cath D, Posthuma D, Smit J, Samuels J, Bienvenu O, Cullen B, Fyer A, Grados M, Greenberg B, McCracken J, Riddle M, Wang Y, Coric V, Leckman J, Bloch M, Pittenger C, Eapen V, Black D, Ophoff R, Strengman E, Cusi D, Turiel M, Frau F, Macciardi F, Gibbs J, Cookson M, Singleton A, Hardy J, Crenshaw A, Parkin M, Mirel D, Conti D, Purcell S, Nestadt G, Hanna G, Jenike M, Knowles J, Cox N, Pauls D. Genome-wide association study of obsessive-compulsive disorder. Molecular Psychiatry 2012, 18: 788-798. PMID: 22889921, PMCID: PMC4218751, DOI: 10.1038/mp.2012.85.
Effects of Ketamine in Treatment-Refractory Obsessive-Compulsive Disorder
Bloch MH, Wasylink S, Landeros-Weisenberger A, Panza KE, Billingslea E, Leckman JF, Krystal JH, Bhagwagar Z, Sanacora G, Pittenger C. Effects of Ketamine in Treatment-Refractory Obsessive-Compulsive Disorder. Biological Psychiatry 2012, 72: 964-970. PMID: 22784486, PMCID: PMC3667652, DOI: 10.1016/j.biopsych.2012.05.028.
Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety
Hampson M, Stoica T, Saksa J, Scheinost D, Qiu M, Bhawnani J, Pittenger C, Papademetris X, Constable T. Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety. Journal Of Visualized Experiments 2012 DOI: 10.3791/3535-v.
Chapter 22 Cyclic Nucleotides in the Nervous System
Pittenger C, Nestler E, Duman R. Chapter 22 Cyclic Nucleotides in the Nervous System. 2012, 423-441. DOI: 10.1016/b978-0-12-374947-5.00022-5.
O4‐02–06: Blocking Tgf‐β‐smad 2/3 innate immune signaling mitigates Alzheimer‐like pathology in transgenic mice
Town T, Laouar Y, Pittenger C, Mori T, Szekely C, Tan J, Duman R, Flavell R. O4‐02–06: Blocking Tgf‐β‐smad 2/3 innate immune signaling mitigates Alzheimer‐like pathology in transgenic mice. Alzheimer's & Dementia 2008, 4: t187-t188. DOI: 10.1016/j.jalz.2008.05.514.
Response to Chamberlain et al. Re: Systematic Review: Pharmacological and Behavioral Treatments for Trichotillomania
Bloch M, Landeros-Weisenberger A, Dombrowski P, Nudel J, Pittenger C, Leckman J, Kelmendi B, Wegner R, Coric V. Response to Chamberlain et al. Re: Systematic Review: Pharmacological and Behavioral Treatments for Trichotillomania. Biological Psychiatry 2008, 63: e34-e35. DOI: 10.1016/j.biopsych.2008.01.022.
Are there Biological Commonalities among Different Psychiatric Disorders?
Pittenger C, Etkin A. Are there Biological Commonalities among Different Psychiatric Disorders? 2008, 243-256. DOI: 10.1002/9780470515167.ch15.
Some Forms of cAMP-Mediated Long-Lasting Potentiation Are Associated with Release of BDNF and Nuclear Translocation of Phospho-MAP Kinase
Patterson S, Pittenger C, Morozov A, Martin K, Scanlin H, Drake C, Kandel E. Some Forms of cAMP-Mediated Long-Lasting Potentiation Are Associated with Release of BDNF and Nuclear Translocation of Phospho-MAP Kinase. Neuron 2001, 32: 123-140. PMID: 11604144, DOI: 10.1016/s0896-6273(01)00443-3.
The past, the future and the biology of memory storage
Kandel E, Pittenger C. The past, the future and the biology of memory storage. Philosophical Transactions Of The Royal Society B Biological Sciences 1999, 354: 2027-2052. PMID: 10670023, PMCID: PMC1692699, DOI: 10.1098/rstb.1999.0542.

Departments and Programs

Locations

Clinical Neuroscience Research Unit

Connecticut Mental Health Center

34 Park Street, Ste 3rd floor

New Haven, CT 06519

1-203-974-7523

Directions

Clinical Neuroscience Research Unit
Connecticut Mental Health Center
34 Park Street, Ste 3rd floor
New Haven, CT 06519
- 1-203-974-7523
- Directions

View Academic Profile

Click here to view more about this specialist's research and educational efforts on https://medicine.yale.edu

Click here to view more about this specialist's research and educational efforts onhttps://medicine.yale.edu

Biography

Titles

Elizabeth Mears and House Jameson Professor of Psychiatry
Deputy Chair for Translational Research, Psychiatry
Director, Clinical Neuroscience Research Unit, Psychiatry
Director, Yale Program for Psychedelic Science, Psychiatry
Director, Yale Center for Brain and Mind Health, Yale School of Medicine
Director, Yale OCD Research Clinic, Psychiatry
Director, Neuroscience Research Training Program, Yale Department of Psychiatry

Education & Training

McNeil Research Fellow
Yale University (2007)
Resident in Adult Psychiatry
Yale University (2007)
MD
Columbia College of Physicians and Surgeons (2003)
PhD
Columbia University (2002)
MPhil
Columbia University (1998)
MS
Yale University (1994)
BS
Yale University (1994)
Diplomate
American Board of Psychiatry and Neurology

Additional Information

Honors & Recognitions

Professional Service

Publications

Psychedelic medicine in psychiatry residency training: a survey of psychiatric residency program directors
Yaden M, Ching T, Goldway N, Roberts D, Hokanson J, Gukasyan N, Pittenger C, Kelmendi B, Ross S, Glick G, O’Donnell K. Psychedelic medicine in psychiatry residency training: a survey of psychiatric residency program directors. International Review Of Psychiatry 2024, ahead-of-print: 1-6. DOI: 10.1080/09540261.2024.2397039.
Elevated antibody binding to striatal cholinergic interneurons in patients with pediatric acute-onset neuropsychiatric syndrome
Xu J, Frankovich J, Liu R, Thienemann M, Silverman M, Farhadian B, Willett T, Manko C, Columbo L, Leibold C, Vaccarino F, Che A, Pittenger C. Elevated antibody binding to striatal cholinergic interneurons in patients with pediatric acute-onset neuropsychiatric syndrome. Brain Behavior And Immunity 2024, 122: 241-255. PMID: 39084540, DOI: 10.1016/j.bbi.2024.07.044.
Sex differences in the distribution and density of regulatory interneurons in the striatum
Van Zandt M, Flanagan D, Pittenger C. Sex differences in the distribution and density of regulatory interneurons in the striatum. Frontiers In Cellular Neuroscience 2024, 18: 1415015. PMID: 39045533, PMCID: PMC11264243, DOI: 10.3389/fncel.2024.1415015.
Information processing style and institutional trust as factors of COVID vaccine hesitancy
Zhao W, Russell C, Jankovsky A, Cannon T, Pittenger C, Pushkarskaya H. Information processing style and institutional trust as factors of COVID vaccine hesitancy. Scientific Reports 2024, 14: 10416. PMID: 38710827, PMCID: PMC11074285, DOI: 10.1038/s41598-024-60788-y.
497. Prefrontal Cortex Astroglia Modulate Anhedonia-Like Behavior
Codeluppi S, Xu M, Bansal Y, Lepack A, Duric V, Chow M, Muir J, Bagot R, Licznerski P, Wilber S, Sanacora G, Sibille E, Duman R, Pittenger C, Banasr M. 497. Prefrontal Cortex Astroglia Modulate Anhedonia-Like Behavior. Biological Psychiatry 2024, 95: s302. DOI: 10.1016/j.biopsych.2024.02.996.
Activation of M4 muscarinic receptors in the striatum reduces tic‐like behaviours in two distinct murine models of Tourette syndrome
Cadeddu R, Braccagni G, Branca C, van Luik E, Pittenger C, Thomsen M, Bortolato M. Activation of M4 muscarinic receptors in the striatum reduces tic‐like behaviours in two distinct murine models of Tourette syndrome. British Journal Of Pharmacology 2024, 181: 3064-3081. PMID: 38689378, DOI: 10.1111/bph.16392.
Mechanisms of therapeutic change after psychedelic treatment in OCD
Maloney G, Ching T, Kichuk S, Pittenger C, Kelmendi B. Mechanisms of therapeutic change after psychedelic treatment in OCD. Psychiatry Research 2024, 336: 115907. PMID: 38615521, PMCID: PMC11190873, DOI: 10.1016/j.psychres.2024.115907.
Externally orienting cues improve cognitive control in OCD
Bednarek L, Glover S, Ma X, Pittenger C, Pushkarskaya H. Externally orienting cues improve cognitive control in OCD. Journal Of Behavior Therapy And Experimental Psychiatry 2024, 84: 101959. PMID: 38531125, PMCID: PMC11192454, DOI: 10.1016/j.jbtep.2024.101959.
Corrigendum: Safety, feasibility, tolerability, and clinical effects of repeated psilocybin dosing combined with non-directive support in the treatment of obsessive-compulsive disorder: protocol for a randomized, waitlist-controlled trial with blinded ratings
Ching T, Amoroso L, Bohner C, D'Amico E, Eilbott J, Entezar T, Fitzpatrick M, Fram G, Grazioplene R, Hokanson J, Jankovsky A, Kichuk S, Martins B, Patel P, Schaer H, Shnayder S, Witherow C, Pittenger C, Kelmendi B. Corrigendum: Safety, feasibility, tolerability, and clinical effects of repeated psilocybin dosing combined with non-directive support in the treatment of obsessive-compulsive disorder: protocol for a randomized, waitlist-controlled trial with blinded ratings. Frontiers In Psychiatry 2024, 15: 1372373. PMID: 38435972, PMCID: PMC10905264, DOI: 10.3389/fpsyt.2024.1372373.
The endogenous opioid system in the medial prefrontal cortex mediates ketamine’s antidepressant-like actions
Jiang C, DiLeone R, Pittenger C, Duman R. The endogenous opioid system in the medial prefrontal cortex mediates ketamine’s antidepressant-like actions. Translational Psychiatry 2024, 14: 90. PMID: 38346984, PMCID: PMC10861497, DOI: 10.1038/s41398-024-02796-0.
White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group
Kim B, Kim G, Abe Y, Alonso P, Ameis S, Anticevic A, Arnold P, Balachander S, Banaj N, Bargalló N, Batistuzzo M, Benedetti F, Bertolín S, Beucke J, Bollettini I, Brem S, Brennan B, Buitelaar J, Calvo R, Castelo-Branco M, Cheng Y, Chhatkuli R, Ciullo V, Coelho A, Couto B, Dallaspezia S, Ely B, Ferreira S, Fontaine M, Fouche J, Grazioplene R, Gruner P, Hagen K, Hansen B, Hanna G, Hirano Y, Höxter M, Hough M, Hu H, Huyser C, Ikuta T, Jahanshad N, James A, Jaspers-Fayer F, Kasprzak S, Kathmann N, Kaufmann C, Kim M, Koch K, Kvale G, Kwon J, Lazaro L, Lee J, Lochner C, Lu J, Manrique D, Martínez-Zalacaín I, Masuda Y, Matsumoto K, Maziero M, Menchón J, Minuzzi L, Moreira P, Morgado P, Narayanaswamy J, Narumoto J, Ortiz A, Ota J, Pariente J, Perriello C, Picó-Pérez M, Pittenger C, Poletti S, Real E, Reddy Y, van Rooij D, Sakai Y, Sato J, Segalas C, Shavitt R, Shen Z, Shimizu E, Shivakumar V, Soreni N, Soriano-Mas C, Sousa N, Sousa M, Spalletta G, Stern E, Stewart S, Szeszko P, Thomas R, Thomopoulos S, Vecchio D, Venkatasubramanian G, Vriend C, Walitza S, Wang Z, Watanabe A, Wolters L, Xu J, Yamada K, Yun J, Zarei M, Zhao Q, Zhu X, Thompson P, Bruin W, van Wingen G, Piras F, Piras F, Stein D, van den Heuvel O, Simpson H, Marsh R, Cha J. White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group. Molecular Psychiatry 2024, 29: 1063-1074. PMID: 38326559, PMCID: PMC11176060, DOI: 10.1038/s41380-023-02392-6.
A comparison of machine learning methods for quantifying self-grooming behavior in mice
Correia K, Walker R, Pittenger C, Fields C. A comparison of machine learning methods for quantifying self-grooming behavior in mice. Frontiers In Behavioral Neuroscience 2024, 18: 1340357. PMID: 38347909, PMCID: PMC10859524, DOI: 10.3389/fnbeh.2024.1340357.
Safety, feasibility, tolerability, and clinical effects of repeated psilocybin dosing combined with non-directive support in the treatment of obsessive-compulsive disorder: protocol for a randomized, waitlist-controlled trial with blinded ratings
Ching T, Amoroso L, Bohner C, D’Amico E, Eilbott J, Entezar T, Fitzpatrick M, Fram G, Grazioplene R, Hokanson J, Jankovsky A, Kichuk S, Martins B, Patel P, Schaer H, Shnayder S, Witherow C, Pittenger C, Kelmendi B. Safety, feasibility, tolerability, and clinical effects of repeated psilocybin dosing combined with non-directive support in the treatment of obsessive-compulsive disorder: protocol for a randomized, waitlist-controlled trial with blinded ratings. Frontiers In Psychiatry 2024, 14: 1278823. PMID: 38264632, PMCID: PMC10803438, DOI: 10.3389/fpsyt.2023.1278823.
Psilocybin and other Psychedelics
Kaye A, Kelmendi B, Rivera M, Pittenger C. Psilocybin and other Psychedelics. 2024 DOI: 10.1016/b978-0-323-95702-1.00178-0.
What Is in a Name? The Many Meanings of “Psychedelic”
O'Donnell K, Roberts D, Ching T, Glick G, Goldway N, Gukasyan N, Hokansen J, Kelmendi B, Ross S, Yaden M, Pittenger C. What Is in a Name? The Many Meanings of “Psychedelic”. Psychedelic Medicine 2023, 1: 187-189. DOI: 10.1089/psymed.2023.0011.
A novel naïve Bayes approach to identifying grooming behaviors in the force-plate actometric platform
Anderson C, Cadeddu R, Anderson D, Huxford J, VanLuik E, Odeh K, Pittenger C, Pulst S, Bortolato M. A novel naïve Bayes approach to identifying grooming behaviors in the force-plate actometric platform. Journal Of Neuroscience Methods 2023, 403: 110026. PMID: 38029972, DOI: 10.1016/j.jneumeth.2023.110026.
44.3 Antibodies Against Basal Ganglial Cholinergic Interneurons in Youth With PANS/PANDAS
Pittenger C. 44.3 Antibodies Against Basal Ganglial Cholinergic Interneurons in Youth With PANS/PANDAS. Journal Of The American Academy Of Child & Adolescent Psychiatry 2023, 62: s392-s393. DOI: 10.1016/j.jaac.2023.07.871.
Postinfectious Inflammation, Autoimmunity, and Obsessive-Compulsive Disorder: Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection, and Pediatric Acute-Onset Neuropsychiatric Disorder
Vreeland A, Calaprice D, Or-Geva N, Frye R, Agalliu D, Lachman H, Pittenger C, Pallanti S, Williams K, Ma M, Thienemann M, Gagliano A, Mellins E, Frankovich J. Postinfectious Inflammation, Autoimmunity, and Obsessive-Compulsive Disorder: Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection, and Pediatric Acute-Onset Neuropsychiatric Disorder. Developmental Neuroscience 2023, 45: 361-374. PMID: 37742615, DOI: 10.1159/000534261.
Prefrontal cortex astroglia modulate anhedonia-like behavior
Codeluppi S, Xu M, Bansal Y, Lepack A, Duric V, Chow M, Muir J, Bagot R, Licznerski P, Wilber S, Sanacora G, Sibille E, Duman R, Pittenger C, Banasr M. Prefrontal cortex astroglia modulate anhedonia-like behavior. Molecular Psychiatry 2023, 28: 4632-4641. PMID: 37696873, PMCID: PMC10914619, DOI: 10.1038/s41380-023-02246-1.
Frontopolar multifocal transcranial direct current stimulation reduces conditioned fear reactivity during extinction training: A pilot randomized controlled trial
Adams T, Kelmendi B, George J, Forte J, Hubert T, Wild H, Rippey C, Pittenger C. Frontopolar multifocal transcranial direct current stimulation reduces conditioned fear reactivity during extinction training: A pilot randomized controlled trial. Neurobiology Of Learning And Memory 2023, 205: 107825. PMID: 37699439, PMCID: PMC10872945, DOI: 10.1016/j.nlm.2023.107825.
Neurofeedback for obsessive compulsive disorder: A randomized, double-blind trial
Rance M, Zhao Z, Zaboski B, Kichuk S, Romaker E, Koller W, Walsh C, Harris-Starling C, Wasylink S, Adams T, Gruner P, Pittenger C, Hampson M. Neurofeedback for obsessive compulsive disorder: A randomized, double-blind trial. Psychiatry Research 2023, 328: 115458. PMID: 37722238, PMCID: PMC10695074, DOI: 10.1016/j.psychres.2023.115458.
Pharmacotherapy for comorbid antisocial personality and obsessive-compulsive disorder: A case report
Jankovsky A, Zaboski B, Pittenger C. Pharmacotherapy for comorbid antisocial personality and obsessive-compulsive disorder: A case report. Psychiatry Research Case Reports 2023, 2: 100139. PMID: 38240012, PMCID: PMC10795765, DOI: 10.1016/j.psycr.2023.100139.
Pleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders
Wang Z, Lin X, Luo X, Xiao J, Zhang Y, Xu J, Wang S, Zhao F, Wang H, Zheng H, Zhang W, Lin C, Tan Z, Cao L, Wang Z, Tan Y, Chen W, Cao Y, Guo X, Pittenger C, Luo X. Pleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders. Schizophrenia Bulletin 2023, 49: 1174-1184. PMID: 37306960, PMCID: PMC10483336, DOI: 10.1093/schbul/sbad073.
Prefrontal allopregnanolone mediates the adverse effects of acute stress in a mouse model of tic pathophysiology
Cadeddu R, Van Zandt M, Santovito L, Odeh K, Anderson C, Flanagan D, Nordkild P, Pinna G, Pittenger C, Bortolato M. Prefrontal allopregnanolone mediates the adverse effects of acute stress in a mouse model of tic pathophysiology. Neuropsychopharmacology 2023, 48: 1288-1299. PMID: 37198434, PMCID: PMC10354086, DOI: 10.1038/s41386-023-01603-6.
The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium
Bruin W, Abe Y, Alonso P, Anticevic A, Backhausen L, Balachander S, Bargallo N, Batistuzzo M, Benedetti F, Bertolin Triquell S, Brem S, Calesella F, Couto B, Denys D, Echevarria M, Eng G, Ferreira S, Feusner J, Grazioplene R, Gruner P, Guo J, Hagen K, Hansen B, Hirano Y, Hoexter M, Jahanshad N, Jaspers-Fayer F, Kasprzak S, Kim M, Koch K, Bin Kwak Y, Kwon J, Lazaro L, Li C, Lochner C, Marsh R, Martínez-Zalacaín I, Menchon J, Moreira P, Morgado P, Nakagawa A, Nakao T, Narayanaswamy J, Nurmi E, Zorrilla J, Piacentini J, Picó-Pérez M, Piras F, Piras F, Pittenger C, Reddy J, Rodriguez-Manrique D, Sakai Y, Shimizu E, Shivakumar V, Simpson B, Soriano-Mas C, Sousa N, Spalletta G, Stern E, Evelyn Stewart S, Szeszko P, Tang J, Thomopoulos S, Thorsen A, Yoshida T, Tomiyama H, Vai B, Veer I, Venkatasubramanian G, Vetter N, Vriend C, Walitza S, Waller L, Wang Z, Watanabe A, Wolff N, Yun J, Zhao Q, van Leeuwen W, van Marle H, van de Mortel L, van der Straten A, van der Werf Y, Thompson P, Stein D, van den Heuvel O, van Wingen G. The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium. Molecular Psychiatry 2023, 28: 4307-4319. PMID: 37131072, PMCID: PMC10827654, DOI: 10.1038/s41380-023-02077-0.
348. Sexual Dimorphism in the Behavioral Outcomes Following Early Life Stress
Jiang C, Pittenger C. 348. Sexual Dimorphism in the Behavioral Outcomes Following Early Life Stress. Biological Psychiatry 2023, 93: s234. DOI: 10.1016/j.biopsych.2023.02.588.
Circuit- and Behavioral- Level Investigation of Plasticity After Administration of Entactogens in Mice
Kaye A, Kwan A, Pittenger C, Yu A, Yang J. Circuit- and Behavioral- Level Investigation of Plasticity After Administration of Entactogens in Mice. Biological Psychiatry 2023, 93: s57. DOI: 10.1016/j.biopsych.2023.02.156.
511. Common and Distinct Effects of Incentives on Spatial Working Memory in Schizophrenia and Obsessive-Compulsive Disorder
Sarantopoulos C, Shin D, Schleifer C, Moujaes F, Adkinson B, Ji J, Kolabaric A, Flynn M, Santamauro N, Krystal J, Murray J, Repovs G, Martin W, Pittenger C, Anticevic A, Cho Y. 511. Common and Distinct Effects of Incentives on Spatial Working Memory in Schizophrenia and Obsessive-Compulsive Disorder. Biological Psychiatry 2023, 93: s300-s301. DOI: 10.1016/j.biopsych.2023.02.751.
332. 5-MeO-DMT Modifies Innate Behaviors and Promotes Structural Neural Plasticity in Mice
Jefferson S, Gregg I, Dibbs M, Liao C, Wu H, Davoudian P, Kaye A, Pittenger C, Kwan A. 332. 5-MeO-DMT Modifies Innate Behaviors and Promotes Structural Neural Plasticity in Mice. Biological Psychiatry 2023, 93: s228. DOI: 10.1016/j.biopsych.2023.02.572.
390. Altered Confidence Adaptation During Set-Shifting in OCD
Loosen A, Zaboski B, Pushkarskaya H, Pittenger C, Hauser T. 390. Altered Confidence Adaptation During Set-Shifting in OCD. Biological Psychiatry 2023, 93: s252. DOI: 10.1016/j.biopsych.2023.02.630.
Safety, tolerability, and clinical and neural effects of single-dose psilocybin in obsessive–compulsive disorder: protocol for a randomized, double-blind, placebo-controlled, non-crossover trial
Ching T, Grazioplene R, Bohner C, Kichuk S, DePalmer G, D’Amico E, Eilbott J, Jankovsky A, Burke M, Hokanson J, Martins B, Witherow C, Patel P, Amoroso L, Schaer H, Pittenger C, Kelmendi B. Safety, tolerability, and clinical and neural effects of single-dose psilocybin in obsessive–compulsive disorder: protocol for a randomized, double-blind, placebo-controlled, non-crossover trial. Frontiers In Psychiatry 2023, 14: 1178529. PMID: 37181888, PMCID: PMC10166878, DOI: 10.3389/fpsyt.2023.1178529.
5-MeO-DMT modifies innate behaviors and promotes structural neural plasticity in mice
Jefferson S, Gregg I, Dibbs M, Liao C, Wu H, Davoudian P, Woodburn S, Wehrle P, Sprouse J, Sherwood A, Kaye A, Pittenger C, Kwan A. 5-MeO-DMT modifies innate behaviors and promotes structural neural plasticity in mice. Neuropsychopharmacology 2023, 48: 1257-1266. PMID: 37015972, PMCID: PMC10354037, DOI: 10.1038/s41386-023-01572-w.
The histamine H3 receptor modulates dopamine D2 receptor–dependent signaling pathways and mouse behaviors
Xu J, Pittenger C. The histamine H3 receptor modulates dopamine D2 receptor–dependent signaling pathways and mouse behaviors. Journal Of Biological Chemistry 2023, 299: 104583. PMID: 36871761, PMCID: PMC10139999, DOI: 10.1016/j.jbc.2023.104583.
Neuroinflammation in Obsessive-Compulsive Disorder Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections, and Pediatric Acute Onset Neuropsychiatric Syndrome
Vreeland A, Thienemann M, Cunningham M, Muscal E, Pittenger C, Frankovich J. Neuroinflammation in Obsessive-Compulsive Disorder Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections, and Pediatric Acute Onset Neuropsychiatric Syndrome. Psychiatric Clinics Of North America 2023, 46: 69-88. PMID: 36740356, DOI: 10.1016/j.psc.2022.11.004.
Cholinergic neurons in the basal forebrain are involved in behavioral abnormalities associated with Cul3 deficiency: Role of prefrontal cortex projections in cognitive deficits
Rapanelli M, Wang W, Hurley E, Feltri M, Pittenger C, Frick L, Yan Z. Cholinergic neurons in the basal forebrain are involved in behavioral abnormalities associated with Cul3 deficiency: Role of prefrontal cortex projections in cognitive deficits. Translational Psychiatry 2023, 13: 22. PMID: 36693858, PMCID: PMC9873627, DOI: 10.1038/s41398-023-02306-8.
Methylone, a rapid acting entactogen with robust anxiolytic and antidepressant-like activity
Warner-Schmidt J, Pittenger C, Stogniew M, Mandell B, Olmstead S, Kelmendi B. Methylone, a rapid acting entactogen with robust anxiolytic and antidepressant-like activity. Frontiers In Psychiatry 2023, 13: 1041277. PMID: 36704743, PMCID: PMC9873307, DOI: 10.3389/fpsyt.2022.1041277.
The Pharmacological Treatment of Obsessive-Compulsive Disorder
Pittenger C. The Pharmacological Treatment of Obsessive-Compulsive Disorder. Psychiatric Clinics Of North America 2023, 46: 107-119. PMID: 36740347, DOI: 10.1016/j.psc.2022.11.005.
Single-dose psilocybin for treatment-resistant obsessive-compulsive disorder: A case report
Kelmendi B, Kichuk S, DePalmer G, Maloney G, Ching T, Belser A, Pittenger C. Single-dose psilocybin for treatment-resistant obsessive-compulsive disorder: A case report. Heliyon 2022, 8: e12135. PMID: 36536916, PMCID: PMC9758406, DOI: 10.1016/j.heliyon.2022.e12135.
White matter abnormalities in the Hdc knockout mouse, a model of tic and OCD pathophysiology
Jindachomthong K, Yang C, Huang Y, Coman D, Rapanelli M, Hyder F, Dougherty J, Frick L, Pittenger C. White matter abnormalities in the Hdc knockout mouse, a model of tic and OCD pathophysiology. Frontiers In Molecular Neuroscience 2022, 15: 1037481. PMID: 36504678, PMCID: PMC9731796, DOI: 10.3389/fnmol.2022.1037481.
19.1 Renaissance in Psychedelic Research
Pittenger C. 19.1 Renaissance in Psychedelic Research. Journal Of The American Academy Of Child & Adolescent Psychiatry 2022, 61: s305. DOI: 10.1016/j.jaac.2022.07.662.
Imagery Rescripting (ImRs) as an Adjunctive Treatment to Exposure and Response Prevention (ERP)-Resistant Obsessive-Compulsive Disorder: A Case Study
Maloney G, Kelmendi B, Pittenger C. Imagery Rescripting (ImRs) as an Adjunctive Treatment to Exposure and Response Prevention (ERP)-Resistant Obsessive-Compulsive Disorder: A Case Study. Clinical Case Studies 2022, 22: 174-191. DOI: 10.1177/15346501221123797.
P456. The Effects of Early Life Stress on Tourette Syndrome-Relevant Pathology
Jiang C, Pittenger C. P456. The Effects of Early Life Stress on Tourette Syndrome-Relevant Pathology. Biological Psychiatry 2022, 91: s272. DOI: 10.1016/j.biopsych.2022.02.692.
Studying the pathophysiology of tic disorders in animal models
Pittenger C. Studying the pathophysiology of tic disorders in animal models. International Review Of Movement Disorders 2022, 4: 39-61. DOI: 10.1016/bs.irmvd.2022.06.001.
Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity
Xu J, Liu RJ, Fahey S, Frick L, Leckman J, Vaccarino F, Duman RS, Williams K, Swedo S, Pittenger C. Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity. American Journal Of Psychiatry 2020, 178: 48-64. PMID: 32539528, PMCID: PMC8573771, DOI: 10.1176/appi.ajp.2020.19070698.
Histaminergic Regulation of Stereotyped Movements in a Mouse Model of Repetitive Motor Behavior
Emmons E, Xu J, Pittenger C. Histaminergic Regulation of Stereotyped Movements in a Mouse Model of Repetitive Motor Behavior. Biological Psychiatry 2020, 87: s295. DOI: 10.1016/j.biopsych.2020.02.760.
Excessive acquisition of information during simple judgments in individuals with hoarding disorder
Pushkarskaya H, Stern E, Tolin D, Pittenger C. Excessive acquisition of information during simple judgments in individuals with hoarding disorder. Journal Of Obsessive-Compulsive And Related Disorders 2020, 24: 100505. DOI: 10.1016/j.jocrd.2020.100505.
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
Consortium C, Lee P, Anttila V, Won H, Feng Y, Rosenthal J, Zhu Z, Tucker-Drob E, Nivard M, Grotzinger A, Posthuma D, Wang M, Yu D, Stahl E, Walters R, Anney R, Duncan L, Ge T, Adolfsson R, Banaschewski T, Belangero S, Cook E, Coppola G, Derks E, Hoekstra P, Kaprio J, Keski-Rahkonen A, Kirov G, Kranzler H, Luykx J, Rohde L, Zai C, Agerbo E, Arranz M, Asherson P, Bækvad-Hansen M, Baldursson G, Bellgrove M, Belliveau R, Buitelaar J, Burton C, Bybjerg-Grauholm J, Casas M, Cerrato F, Chambert K, Churchhouse C, Cormand B, Crosbie J, Dalsgaard S, Demontis D, Doyle A, Dumont A, Elia J, Grove J, Gudmundsson O, Haavik J, Hakonarson H, Hansen C, Hartman C, Hawi Z, Hervás A, Hougaard D, Howrigan D, Huang H, Kuntsi J, Langley K, Lesch K, Leung P, Loo S, Martin J, Martin A, McGough J, Medland S, Moran J, Mors O, Mortensen P, Oades R, Palmer D, Pedersen C, Pedersen M, Peters T, Poterba T, Poulsen J, Ramos-Quiroga J, Reif A, Ribasés M, Rothenberger A, Rovira P, Sánchez-Mora C, Satterstrom F, Schachar R, Artigas M, Steinberg S, Stefansson H, Turley P, Walters G, Team 2, Werge T, Zayats T, Arking D, Bettella F, Buxbaum J, Christensen J, Collins R, Coon H, De Rubeis S, Delorme R, Grice D, Hansen T, Holmans P, Hope S, Hultman C, Klei L, Ladd-Acosta C, Magnusson P, Nærland T, Nyegaard M, Pinto D, Qvist P, Rehnström K, Reichenberg A, Reichert J, Roeder K, Rouleau G, Saemundsen E, Sanders S, Sandin S, St Pourcain B, Stefansson K, Sutcliffe J, Talkowski M, Weiss L, Willsey A, Agartz I, Akil H, Albani D, Alda M, Als T, Anjorin A, Backlund L, Bass N, Bauer M, Baune B, Bellivier F, Bergen S, Berrettini W, Biernacka J, Blackwood D, Bøen E, Budde M, Bunney W, Burmeister M, Byerley W, Byrne E, Cichon S, Clarke T, Coleman J, Craddock N, Curtis D, Czerski P, Dale A, Dalkner N, Dannlowski U, Degenhardt F, Di Florio A, Elvsåshagen T, Etain B, Fischer S, Forstner A, Forty L, Frank J, Frye M, Fullerton J, Gade K, Gaspar H, Gershon E, Gill M, Goes F, Gordon S, Gordon-Smith K, Green M, Greenwood T, Grigoroiu-Serbanescu M, Guzman-Parra J, Hauser J, Hautzinger M, Heilbronner U, Herms S, Hoffmann P, Holland D, Jamain S, Jones I, Jones L, Kandaswamy R, Kelsoe J, Kennedy J, Joachim O, Kittel-Schneider S, Kogevinas M, Koller A, Lavebratt C, Lewis C, Li Q, Lissowska J, Loohuis L, Lucae S, Maaser A, Malt U, Martin N, Martinsson L, McElroy S, McMahon F, McQuillin A, Melle I, Metspalu A, Millischer V, Mitchell P, Montgomery G, Morken G, Morris D, Müller-Myhsok B, Mullins N, Myers R, Nievergelt C, Nordentoft M, Adolfsson A, Nöthen M, Ophoff R, Owen M, Paciga S, Pato C, Pato M, Perlis R, Perry A, Potash J, Reinbold C, Rietschel M, Rivera M, Roberson M, Schalling M, Schofield P, Schulze T, Scott L, Serretti A, Sigurdsson E, Smeland O, Stordal E, Streit F, Strohmaier J, Thorgeirsson T, Treutlein J, Turecki G, Vaaler A, Vieta E, Vincent J, Wang Y, Witt S, Zandi P, Adan R, Alfredsson L, Ando T, Aschauer H, Baker J, Bencko V, Bergen A, Birgegård A, Perica V, Brandt H, Burghardt R, Carlberg L, Cassina M, Clementi M, Courtet P, Crawford S, Crow S, Crowley J, Danner U, Davis O, Degortes D, DeSocio J, Dick D, Dina C, Docampo E, Egberts K, Ehrlich S, Espeseth T, Fernández-Aranda F, Fichter M, Foretova L, Forzan M, Gambaro G, Giegling I, Gonidakis F, Gorwood P, Mayora M, Guo Y, Halmi K, Hatzikotoulas K, Hebebrand J, Helder S, Herpertz-Dahlmann B, Herzog W, Hinney A, Imgart H, Jiménez-Murcia S, Johnson C, Jordan J, Julià A, Kaminská D, Karhunen L, Karwautz A, Kas M, Kaye W, Kennedy M, Kim Y, Klareskog L, Klump K, Knudsen G, Landén M, Le Hellard S, Levitan R, Li D, Lichtenstein P, Maj M, Marsal S, McDevitt S, Mitchell J, Monteleone P, Monteleone A, Munn-Chernoff M, Nacmias B, Navratilova M, O’Toole J, Padyukov L, Pantel J, Papezova H, Rabionet R, Raevuori A, Ramoz N, Reichborn-Kjennerud T, Ricca V, Roberts M, Rujescu D, Rybakowski F, Scherag A, Schmidt U, Seitz J, Slachtova L, Landt M, Slopien A, Sorbi S, Southam L, Strober M, Tortorella A, Tozzi F, Treasure J, Tziouvas K, van Elburg A, Wade T, Wagner G, Walton E, Watson H, Wichmann H, Woodside D, Zeggini E, Zerwas S, Zipfel S, Adams M, Andlauer T, Berger K, Binder E, Boomsma D, Castelao E, Colodro-Conde L, Direk N, Docherty A, Domenici E, Domschke K, Dunn E, Foo J, de. Geus E, Grabe H, Hamilton S, Horn C, Hottenga J, Howard D, Ising M, Kloiber S, Levinson D, Lewis G, Magnusson P, Mbarek H, Middeldorp C, Mostafavi S, Nyholt D, Penninx B, Peterson R, Pistis G, Porteous D, Preisig M, Quiroz J, Schaefer C, Schulte E, Shi J, Smith D, Thomson P, Tiemeier H, Uher R, van der Auwera S, Weissman M, Alexander M, Begemann M, Bramon E, Buccola N, Cairns M, Campion D, Carr V, Cloninger C, Cohen D, Collier D, Corvin A, DeLisi L, Donohoe G, Dudbridge F, Duan J, Freedman R, Gejman P, Golimbet V, Godard S, Ehrenreich H, Hartmann A, Henskens F, Ikeda M, Iwata N, Jablensky A, Joa I, Jönsson E, Kelly B, Knight J, Konte B, Laurent-Levinson C, Lee J, Lencz T, Lerer B, Loughland C, Malhotra A, Mallet J, McDonald C, Mitjans M, Mowry B, Murphy K, Murray R, O’Neill F, Oh S, Palotie A, Pantelis C, Pulver A, Consortium P, Petryshen T, Quested D, Riley B, Sanders A, Schall U, Schwab S, Scott R, Sham P, Silverman J, Sim K, Steixner A, Tooney P, van Os J, Vawter P, Walsh D, Weiser M, Wildenauer D, Williams N, Wormley B, Consortium W, Zhang F, Androutsos C, Arnold P, Barr C, Barta C, Bey K, Bienvenu O, Black D, Brown L, Budman C, Cath D, Cheon K, Ciullo V, Coffey B, Cusi D, Davis L, Denys D, Depienne C, Dietrich A, Eapen V, Falkai P, Fernandez T, Garcia-Delgar B, Geller D, Gilbert D, Grados M, Greenberg E, Grünblatt E, Hagstrøm J, Hanna G, Hartmann A, Hedderly T, Heiman G, Heyman I, Hong H, Huang A, Huyser C, Ibanez-Gomez L, Khramtsova E, Kim Y, Kim Y, King R, Koh Y, Konstantinidis A, Kook S, Kuperman S, Leventhal B, Lochner C, Ludolph A, Madruga-Garrido M, Malaty I, Maras A, McCracken J, Meijer I, Mir P, Morer A, Müller-Vahl K, Münchau A, Murphy T, Naarden A, Nagy P, Nestadt G, Nestadt P, Nicolini H, Nurmi E, Okun M, Paschou P, Piras F, Piras F, Pittenger C, Plessen K, Richter M, Rizzo R, Robertson M, Roessner V, Ruhrmann S, Samuels J, Sandor P, Schlögelhofer M, Shin E, Singer H, Song D, Song J, Spalletta G, Stein D, Stewart S, Storch E, Stranger B, Stuhrmann M, Tarnok Z, Tischfield J, Tübing J, Visscher F, Vulink N, Wagner M, Walitza S, Wanderer S, Woods M, Worbe Y, Zai G, Zinner S, Sullivan P, Franke B, Daly M, Bulik C, McIntosh A, O’Donovan M, Zheutlin A, Andreassen O, Børglum A, Breen G, Edenberg H, Fanous A, Faraone S, Gelernter J, Mathews C, Mattheisen M, Mitchell K, Neale M, Nurnberger J, Ripke S, Santangelo S, Scharf J, Stein M, Thornton L, Walters J, Wray N, Geschwind D, Neale B, Kendler K, Smoller J. Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell 2019, 179: 1469-1482.e11. PMID: 31835028, PMCID: PMC7077032, DOI: 10.1016/j.cell.2019.11.020.
F16. Aberrant Causal Reasoning in Obsessive-Compulsive Disorder (OCD)
Gruner P, Koller W, Anticevic A, Pittenger C. F16. Aberrant Causal Reasoning in Obsessive-Compulsive Disorder (OCD). Biological Psychiatry 2019, 85: s219. DOI: 10.1016/j.biopsych.2019.03.553.
Exploring Retrospective Biases in Obsessive-Compulsive Disorder: an Experience-Sampling Study
MacLaren Kelly J, Kertz S, Simpson R, Bloch M, Pittenger C. Exploring Retrospective Biases in Obsessive-Compulsive Disorder: an Experience-Sampling Study. Journal Of Technology In Behavioral Science 2018, 4: 297-302. DOI: 10.1007/s41347-018-0078-y.
Analysis of shared heritability in common disorders of the brain
Consortium T, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, Lee PH, Turley P, Grenier-Boley B, Chouraki V, Kamatani Y, Berr C, Letenneur L, Hannequin D, Amouyel P, Boland A, Deleuze JF, Duron E, Vardarajan BN, Reitz C, Goate AM, Huentelman MJ, Kamboh MI, Larson EB, Rogaeva E, St George-Hyslop P, Hakonarson H, Kukull WA, Farrer LA, Barnes LL, Beach TG, Demirci FY, Head E, Hulette CM, Jicha GA, Kauwe JSK, Kaye JA, Leverenz JB, Levey AI, Lieberman AP, Pankratz VS, Poon WW, Quinn JF, Saykin AJ, Schneider LS, Smith AG, Sonnen JA, Stern RA, Van Deerlin VM, Van Eldik LJ, Harold D, Russo G, Rubinsztein DC, Bayer A, Tsolaki M, Proitsi P, Fox NC, Hampel H, Owen MJ, Mead S, Passmore P, Morgan K, Nöthen MM, Schott J, Rossor M, Lupton M, Hoffmann P, Kornhuber J, Lawlor B, McQuillin A, Al-Chalabi A, Bis J, Ruiz A, Boada M, Seshadri S, Beiser A, Rice K, van der Lee S, De Jager P, Geschwind D, Riemenschneider M, Riedel-Heller S, Rotter J, Ransmayr G, Hyman B, Cruchaga C, Alegret M, Winsvold B, Palta P, Farh K, Cuenca-Leon E, Furlotte N, Kurth T, Ligthart L, Terwindt G, Freilinger T, Ran C, Gordon S, Borck G, Adams H, Lehtimäki T, Wedenoja J, Buring J, Schürks M, Hrafnsdottir M, Hottenga J, Penninx B, Artto V, Kaunisto M, Vepsäläinen S, Martin N, Montgomery G, Kurki M, Hämäläinen E, Huang H, Huang J, Sandor C, Webber C, Muller-Myhsok B, Schreiber S, Salomaa V, Loehrer E, Göbel H, Macaya A, Pozo-Rosich P, Hansen T, Werge T, Kaprio J, Metspalu A, Kubisch C, Ferrari M, Belin A, van den Maagdenberg A, Zwart J, Boomsma D, Eriksson N, Olesen J, Chasman D, Nyholt D, Anney R, Avbersek A, Baum L, Berkovic S, Bradfield J, Buono R, Catarino C, Cossette P, De Jonghe P, Depondt C, Dlugos D, Ferraro T, French J, Hjalgrim H, Jamnadas-Khoda J, Kälviäinen R, Kunz W, Lerche H, Leu C, Lindhout D, Lo W, Lowenstein D, McCormack M, Møller R, Molloy A, Ng P, Oliver K, Privitera M, Radtke R, Ruppert A, Sander T, Schachter S, Schankin C, Scheffer I, Schoch S, Sisodiya S, Smith P, Sperling M, Striano P, Surges R, Thomas G, Visscher F, Whelan C, Zara F, Heinzen E, Marson A, Becker F, Stroink H, Zimprich F, Gasser T, Gibbs R, Heutink P, Martinez M, Morris H, Sharma M, Ryten M, Mok K, Pulit S, Bevan S, Holliday E, Attia J, Battey T, Boncoraglio G, Thijs V, Chen W, Mitchell B, Rothwell P, Sharma P, Sudlow C, Vicente A, Markus H, Kourkoulis C, Pera J, Raffeld M, Silliman S, Perica V, Thornton L, Huckins L, Rayner N, Lewis C, Gratacos M, Rybakowski F, Keski-Rahkonen A, Raevuori A, Hudson J, Reichborn-Kjennerud T, Monteleone P, Karwautz A, Mannik K, Baker J, O’Toole J, Trace S, Davis O, Helder S, Ehrlich S, Herpertz-Dahlmann B, Danner U, van Elburg A, Clementi M, Forzan M, Docampo E, Lissowska J, Hauser J, Tortorella A, Maj M, Gonidakis F, Tziouvas K, Papezova H, Yilmaz Z, Wagner G, Cohen-Woods S, Herms S, Julià A, Rabionet R, Dick D, Ripatti S, Andreassen O, Espeseth T, Lundervold A, Steen V, Pinto D, Scherer S, Aschauer H, Schosser A, Alfredsson L, Padyukov L, Halmi K, Mitchell J, Strober M, Bergen A, Kaye W, Szatkiewicz J, Cormand B, Ramos-Quiroga J, Sánchez-Mora C, Ribasés M, Casas M, Hervas A, Arranz M, Haavik J, Zayats T, Johansson S, Williams N, Elia J, Dempfle A, Rothenberger A, Kuntsi J, Oades R, Banaschewski T, Franke B, Buitelaar J, Vasquez A, Doyle A, Reif A, Lesch K, Freitag C, Rivero O, Palmason H, Romanos M, Langley K, Rietschel M, Witt S, Dalsgaard S, Børglum A, Waldman I, Wilmot B, Molly N, Bau C, Crosbie J, Schachar R, Loo S, McGough J, Grevet E, Medland S, Robinson E, Weiss L, Bacchelli E, Bailey A, Bal V, Battaglia A, Betancur C, Bolton P, Cantor R, Celestino-Soper P, Dawson G, De Rubeis S, Duque F, Green A, Klauck S, Leboyer M, Levitt P, Maestrini E, Mane S, De-Luca D, Parr J, Regan R, Reichenberg A, Sandin S, Vorstman J, Wassink T, Wijsman E, Cook E, Santangelo S, Delorme R, Rogé B, Magalhaes T, Arking D, Schulze T, Thompson R, Strohmaier J, Matthews K, Melle I, Morris D, Blackwood D, McIntosh A, Bergen S, Schalling M, Jamain S, Maaser A, Fischer S, Reinbold C, Fullerton J, Grigoroiu-Serbanescu M, Guzman-Parra J, Mayoral F, Schofield P, Cichon S, Mühleisen T, Degenhardt F, Schumacher J, Bauer M, Mitchell P, Gershon E, Rice J, Potash J, Zandi P, Craddock N, Ferrier I, Alda M, Rouleau G, Turecki G, Ophoff R, Pato C, Anjorin A, Stahl E, Leber M, Czerski P, Edenberg H, Cruceanu C, Jones I, Posthuma D, Andlauer T, Forstner A, Streit F, Baune B, Air T, Sinnamon G, Wray N, MacIntyre D, Porteous D, Homuth G, Rivera M, Grove J, Middeldorp C, Hickie I, Pergadia M, Mehta D, Smit J, Jansen R, de Geus E, Dunn E, Li Q, Nauck M, Schoevers R, Beekman A, Knowles J, Viktorin A, Arnold P, Barr C, Bedoya-Berrio G, Bienvenu O, Brentani H, Burton C, Camarena B, Cappi C, Cath D, Cavallini M, Cusi D, Darrow S, Denys D, Derks E, Dietrich A, Fernandez T, Figee M, Freimer N, Gerber G, Grados M, Greenberg E, Hanna G, Hartmann A, Hirschtritt M, Hoekstra P, Huang A, Huyser C, Illmann C, Jenike M, Kuperman S, Leventhal B, Lochner C, Lyon G, Macciardi F, Madruga-Garrido M, Malaty I, Maras A, McGrath L, Miguel E, Mir P, Nestadt G, Nicolini H, Okun M, Pakstis A, Paschou P, Piacentini J, Pittenger C, Plessen K, Ramensky V, Ramos E, Reus V, Richter M, Riddle M, Robertson M, Roessner V, Rosário M, Samuels J, Sandor P, Stein D, Tsetsos F, Van Nieuwerburgh F, Weatherall S, Wendland J, Wolanczyk T, Worbe Y, Zai G, Goes F, McLaughlin N, Nestadt P, Grabe H, Depienne C, Konkashbaev A, Lanzagorta N, Valencia-Duarte A, Bramon E, Buccola N, Cahn W, Cairns M, Chong S, Cohen D, Crespo-Facorro B, Crowley J, Davidson M, DeLisi L, Dinan T, Donohoe G, Drapeau E, Duan J, Haan L, Hougaard D, Karachanak-Yankova S, Khrunin A, Klovins J, Kučinskas V, Keong J, Limborska S, Loughland C, Lönnqvist J, Maher B, Mattheisen M, McDonald C, Murphy K, Murray R, Nenadic I, van Os J, Pantelis C, Pato M, Petryshen T, Quested D, Roussos P, Sanders A, Schall U, Schwab S, Sim K, So H, Stögmann E, Subramaniam M, Toncheva D, Waddington J, Walters J, Weiser M, Cheng W, Cloninger R, Curtis D, Gejman P, Henskens F, Mattingsdal M, Oh S, Scott R, Webb B, Breen G, Churchhouse C, Bulik C, Daly M, Dichgans M, Faraone S, Guerreiro R, Holmans P, Kendler K, Koeleman B, Mathews C, Price A, Scharf J, Sklar P, Williams J, Wood N, Cotsapas C, Palotie A, Smoller J, Sullivan P, Rosand J, Corvin A, Neale B. Analysis of shared heritability in common disorders of the brain. Science 2018, 360 PMID: 29930110, PMCID: PMC6097237, DOI: 10.1126/science.aap8757.
T18. Characterizing Reward Responsiveness in Obsessive-Compulsive Disorder and Schizophrenia Through a Probabilistic Reward Task
Adkinson B, Kolobaric A, Flynn M, Dowiak C, Schleifer C, Santamauro N, Beech C, Lobe J, Zalevsky O, Cho Y, Pittenger C, Anticevic A. T18. Characterizing Reward Responsiveness in Obsessive-Compulsive Disorder and Schizophrenia Through a Probabilistic Reward Task. Biological Psychiatry 2018, 83: s135. DOI: 10.1016/j.biopsych.2018.02.354.
The Role of Stress in the Pathogenesis and Maintenance of Obsessive-Compulsive Disorder
Adams T, Kelmendi B, Brake C, Gruner P, Badour C, Pittenger C. The Role of Stress in the Pathogenesis and Maintenance of Obsessive-Compulsive Disorder. Chronic Stress 2018, 2: 2470547018758043. PMID: 29527593, PMCID: PMC5841259, DOI: 10.1177/2470547018758043.
Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group
Boedhoe PSW, Schmaal L, Abe Y, Alonso P, Ameis SH, Anticevic A, Arnold PD, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Bose A, Brem S, Calvo A, Calvo R, Cheng Y, Cho KIK, Ciullo V, Dallaspezia S, Denys D, Feusner JD, Fitzgerald KD, Fouche JP, Fridgeirsson EA, Gruner P, Hanna GL, Hibar DP, Hoexter MQ, Hu H, Huyser C, Jahanshad N, James A, Kathmann N, Kaufmann C, Koch K, Kwon JS, Lazaro L, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minuzzi L, Morer A, Nakamae T, Nakao T, Narayanaswamy JC, Nishida S, Nurmi E, O’Neill J, Piacentini J, Piras F, Piras F, Reddy YCJ, Reess TJ, Sakai Y, Sato JR, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stevens MC, Szeszko PR, Tolin DF, van Wingen GA, Venkatasubramanian G, Walitza S, Wang Z, Yun JY, Thompson P, Stein D, van den Heuvel O, Boedhoe P, Schmaal L, Abe Y, Alonso P, Ameis S, Anticevic A, Arnold P, Bargalló N, Batistuzzo M, Benedetti F, Beucke J, Bollettini I, Bose A, Brandeis D, Brem S, Buimer E, Busatto G, Calvo A, Calvo R, Cheng Y, Cho K, Ciullo V, Dallaspezia S, de Vries F, de Wit S, Denys D, Drechsler R, Falini A, Fang Y, Feusner J, Figee M, Fitzgerald K, Fontaine M, Fouche J, Fridgeirsson E, Gruner P, Hanna G, Hauser T, Hibar D, Hoexter M, Hu H, Huyser C, Iorio M, Jahanshad N, James A, Kathmann N, Kaufmann C, Khadka S, Koch K, Kwon J, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, McCracken J, Menchón J, Miguel E, Minuzzi L, Morer A, Nakamae T, Nakao T, Narayanaswamy J, Narumoto J, Nishida S, Nurmi E, O’Neill J, Pariente J, Piacentini J, Pittenger C, Piras F, Piras F, Poletti S, Reddy Y, Reess T, Rus O, Sakai Y, Sato J, Simpson H, Soreni N, Soriano-Mas C, Spalletta G, Stevens M, Szeszko P, Tang J, Tolin D, van der Werf Y, van Wingen G, Vecchio D, Veltman D, Venkatasubramanian G, Walitza S, Wang Z, Watanabe A, Xu J, Xu X, Yamada K, Yun J, Zarei M, Zhao Q, Thompson P, Stein D, van den Heuvel O. Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group. American Journal Of Psychiatry 2017, 175: 453-462. PMID: 29377733, PMCID: PMC7106947, DOI: 10.1176/appi.ajp.2017.17050485.
Association and Causation in Brain Imaging in the Case of OCD: Response to McKay et al.
Boedhoe P, Schmaal L, Mataix-Cols D, Jahanshad N, Thompson P, Stein D, van den Heuvel O, Abe Y, Alonso P, Ameis S, Arnold P, Bargalló N, Batistuzzo M, Benedetti F, Beucke J, Boedhoe P, Bollettini I, Bose A, Brem S, Busatto G, Calvo A, Calvo R, Cath D, Cheng Y, Cho K, Dallaspezia S, de Vries F, de Wit S, Denys D, Fang Y, Fitzgerald K, Fontaine M, Fouche J, Giménez M, Gruner P, Hanna G, Hibar D, Hoexter M, Hu H, Huyser C, Ikari K, Jahanshad N, Kathmann N, Kaufmann C, Khadka S, Koch K, Kwon J, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón J, Miguel E, Minuzzii L, Morer A, Nakamae T, Nakao T, Narayanaswamy J, Piras F, Piras F, Pittenger C, Reddy Y, Sato J, Simpson H, Schmaal L, Soreni N, Soriano-Mas C, Spalletta G, Stein D, Stevens M, Szeszko P, Thompson P, Tolin D, Veltman D, Venkatasubramanian G, van den Heuvel O, van der Werf Y, van Wingen G, Walitza S, Wang Z, Xu J, Xu X, Yun J, Zhao Q. Association and Causation in Brain Imaging in the Case of OCD: Response to McKay et al. American Journal Of Psychiatry 2017, 174: 597-599. PMID: 28565945, PMCID: PMC6546159, DOI: 10.1176/appi.ajp.2017.17010019r.
Obsessive-Compulsive Disorder: Phenomenology, Pathophysiology, and Treatment.
Pittenger, C. (editor). Obsessive-Compulsive Disorder: Phenomenology, Pathophysiology, and Treatment. New York: Oxford University Press
37.5 PATHOPHYSIOLOGICALLY GROUNDED MODELS OF TIC DISORDERS: HISTAMINE DYSREGULATION IN TOURETTE'S DISORDER
Pittenger C. 37.5 PATHOPHYSIOLOGICALLY GROUNDED MODELS OF TIC DISORDERS: HISTAMINE DYSREGULATION IN TOURETTE'S DISORDER. Journal Of The American Academy Of Child & Adolescent Psychiatry 2016, 55: s317. DOI: 10.1016/j.jaac.2016.07.338.
Meta-Analysis of the Symptom Structure of Obsessive-Compulsive Disorder
Bloch M, Landeros-Weisenberger A, Rosario M, Pittenger C, Leckman J. Meta-Analysis of the Symptom Structure of Obsessive-Compulsive Disorder. FOCUS The Journal Of Lifelong Learning In Psychiatry 2015, 13: 232-243. DOI: 10.1176/appi.focus.130209.
Are There Biological Commonalities Among Different Psychiatric Disorders?
Etkin A, Pittenger C. Are There Biological Commonalities Among Different Psychiatric Disorders? 2015, 243-257. DOI: 10.1002/9781118753378.ch15.
Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome
Xu M, Kobets A, Du JC, Lennington J, Li L, Banasr M, Duman RS, Vaccarino FM, DiLeone RJ, Pittenger C. Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 893-898. PMID: 25561540, PMCID: PMC4311862, DOI: 10.1073/pnas.1419533112.
Chapter 47 Animal Models of Tourette Syndrome and Obsessive-Compulsive Disorder
Pittenger C. Chapter 47 Animal Models of Tourette Syndrome and Obsessive-Compulsive Disorder. 2015, 747-764. DOI: 10.1016/b978-0-12-405195-9.00047-0.
Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice
Baldan L, Williams K, Gallezot J, Pogorelov V, Rapanelli M, Crowley M, Anderson G, Loring E, Gorczyca R, Billingslea E, Wasylink S, Panza K, Ercan-Sencicek A, Krusong K, Leventhal B, Ohtsu H, Bloch M, Hughes Z, Krystal J, Mayes L, de Araujo I, Ding Y, State M, Pittenger C. Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice. Neuron 2014, 82: 1186-1187. DOI: 10.1016/j.neuron.2014.05.023.
Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice
Baldan LC, Williams KA, Gallezot JD, Pogorelov V, Rapanelli M, Crowley M, Anderson GM, Loring E, Gorczyca R, Billingslea E, Wasylink S, Panza KE, Ercan-Sencicek AG, Krusong K, Leventhal BL, Ohtsu H, Bloch MH, Hughes ZA, Krystal JH, Mayes L, de Araujo I, Ding YS, State MW, Pittenger C. Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice. Neuron 2014, 81: 77-90. PMID: 24411733, PMCID: PMC3894588, DOI: 10.1016/j.neuron.2013.10.052.
Global Resting-State Functional Magnetic Resonance Imaging Analysis Identifies Frontal Cortex, Striatal, and Cerebellar Dysconnectivity in Obsessive-Compulsive Disorder
Anticevic A, Hu S, Zhang S, Savic A, Billingslea E, Wasylink S, Repovs G, Cole MW, Bednarski S, Krystal JH, Bloch MH, Li CS, Pittenger C. Global Resting-State Functional Magnetic Resonance Imaging Analysis Identifies Frontal Cortex, Striatal, and Cerebellar Dysconnectivity in Obsessive-Compulsive Disorder. Biological Psychiatry 2013, 75: 595-605. PMID: 24314349, PMCID: PMC3969771, DOI: 10.1016/j.biopsych.2013.10.021.
Tourette Syndrome and Tic Disorders
Williams K, Bloch M, State M, Pittenger C. Tourette Syndrome and Tic Disorders. 2013, 1048-1060. DOI: 10.1093/med/9780199934959.003.0079.
Erratum: Genome-wide association study of obsessive-compulsive disorder
Stewart S, Yu D, Scharf J, Neale B, Fagerness J, Mathews C, Arnold P, Evans P, Gamazon E, Osiecki L, McGrath L, Haddad S, Crane J, Hezel D, Illman C, Mayerfeld C, Konkashbaev A, Liu C, Pluzhnikov A, Tikhomirov A, Edlund C, Rauch S, Moessner R, Falkai P, Maier W, Ruhrmann S, Grabe H, Lennertz L, Wagner M, Bellodi L, Cavallini M, Richter M, Cook E, Kennedy J, Rosenberg D, Stein D, Hemmings S, Lochner C, Azzam A, Chavira D, Fournier E, Garrido H, Sheppard B, Umaña P, Murphy D, Wendland J, Veenstra-Vander Weele J, Denys D, Blom R, Deforce D, Van Nieuwerburgh F, Westenberg H, Walitza S, Egberts K, Renner T, Miguel E, Cappi C, Hounie A, Conceição do Rosário M, Sampaio A, Vallada H, Nicolini H, Lanzagorta N, Camarena B, Delorme R, Leboyer M, Pato C, Pato M, Voyiaziakis E, Heutink P, Cath D, Posthuma D, Smit J, Samuels J, Bienvenu O, Cullen B, Fyer A, Grados M, Greenberg B, McCracken J, Riddle M, Wang Y, Coric V, Leckman J, Bloch M, Pittenger C, Eapen V, Black D, Ophoff R, Strengman E, Cusi D, Turiel M, Frau F, Macciardi F, Gibbs J, Cookson M, Singleton A, Hardy J, Crenshaw A, Parkin M, Mirel D, Conti D, Purcell S, Nestadt G, Hanna G, Jenike M, Knowles J, Cox N, Pauls D. Erratum: Genome-wide association study of obsessive-compulsive disorder. Molecular Psychiatry 2013, 18: 843-843. DOI: 10.1038/mp.2013.15.
Genome-wide association study of obsessive-compulsive disorder
Stewart SE, Yu D, Scharf JM, Neale BM, Fagerness JA, Mathews CA, Arnold PD, Evans PD, Gamazon ER, Osiecki L, McGrath L, Haddad S, Crane J, Hezel D, Illman C, Mayerfeld C, Konkashbaev A, Liu C, Pluzhnikov A, Tikhomirov A, Edlund C, Rauch S, Moessner R, Falkai P, Maier W, Ruhrmann S, Grabe H, Lennertz L, Wagner M, Bellodi L, Cavallini M, Richter M, Cook E, Kennedy J, Rosenberg D, Stein D, Hemmings S, Lochner C, Azzam A, Chavira D, Fournier E, Garrido H, Sheppard B, Umaña P, Murphy D, Wendland J, Veenstra-VanderWeele J, Denys D, Blom R, Deforce D, Van Nieuwerburgh F, Westenberg H, Walitza S, Egberts K, Renner T, Miguel E, Cappi C, Hounie A, Conceição do Rosário M, Sampaio A, Vallada H, Nicolini H, Lanzagorta N, Camarena B, Delorme R, Leboyer M, Pato C, Pato M, Voyiaziakis E, Heutink P, Cath D, Posthuma D, Smit J, Samuels J, Bienvenu O, Cullen B, Fyer A, Grados M, Greenberg B, McCracken J, Riddle M, Wang Y, Coric V, Leckman J, Bloch M, Pittenger C, Eapen V, Black D, Ophoff R, Strengman E, Cusi D, Turiel M, Frau F, Macciardi F, Gibbs J, Cookson M, Singleton A, Hardy J, Crenshaw A, Parkin M, Mirel D, Conti D, Purcell S, Nestadt G, Hanna G, Jenike M, Knowles J, Cox N, Pauls D. Genome-wide association study of obsessive-compulsive disorder. Molecular Psychiatry 2012, 18: 788-798. PMID: 22889921, PMCID: PMC4218751, DOI: 10.1038/mp.2012.85.
Effects of Ketamine in Treatment-Refractory Obsessive-Compulsive Disorder
Bloch MH, Wasylink S, Landeros-Weisenberger A, Panza KE, Billingslea E, Leckman JF, Krystal JH, Bhagwagar Z, Sanacora G, Pittenger C. Effects of Ketamine in Treatment-Refractory Obsessive-Compulsive Disorder. Biological Psychiatry 2012, 72: 964-970. PMID: 22784486, PMCID: PMC3667652, DOI: 10.1016/j.biopsych.2012.05.028.
Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety
Hampson M, Stoica T, Saksa J, Scheinost D, Qiu M, Bhawnani J, Pittenger C, Papademetris X, Constable T. Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety. Journal Of Visualized Experiments 2012 DOI: 10.3791/3535-v.
Chapter 22 Cyclic Nucleotides in the Nervous System
Pittenger C, Nestler E, Duman R. Chapter 22 Cyclic Nucleotides in the Nervous System. 2012, 423-441. DOI: 10.1016/b978-0-12-374947-5.00022-5.
O4‐02–06: Blocking Tgf‐β‐smad 2/3 innate immune signaling mitigates Alzheimer‐like pathology in transgenic mice
Town T, Laouar Y, Pittenger C, Mori T, Szekely C, Tan J, Duman R, Flavell R. O4‐02–06: Blocking Tgf‐β‐smad 2/3 innate immune signaling mitigates Alzheimer‐like pathology in transgenic mice. Alzheimer's & Dementia 2008, 4: t187-t188. DOI: 10.1016/j.jalz.2008.05.514.
Response to Chamberlain et al. Re: Systematic Review: Pharmacological and Behavioral Treatments for Trichotillomania
Bloch M, Landeros-Weisenberger A, Dombrowski P, Nudel J, Pittenger C, Leckman J, Kelmendi B, Wegner R, Coric V. Response to Chamberlain et al. Re: Systematic Review: Pharmacological and Behavioral Treatments for Trichotillomania. Biological Psychiatry 2008, 63: e34-e35. DOI: 10.1016/j.biopsych.2008.01.022.
Are there Biological Commonalities among Different Psychiatric Disorders?
Pittenger C, Etkin A. Are there Biological Commonalities among Different Psychiatric Disorders? 2008, 243-256. DOI: 10.1002/9780470515167.ch15.
Some Forms of cAMP-Mediated Long-Lasting Potentiation Are Associated with Release of BDNF and Nuclear Translocation of Phospho-MAP Kinase
Patterson S, Pittenger C, Morozov A, Martin K, Scanlin H, Drake C, Kandel E. Some Forms of cAMP-Mediated Long-Lasting Potentiation Are Associated with Release of BDNF and Nuclear Translocation of Phospho-MAP Kinase. Neuron 2001, 32: 123-140. PMID: 11604144, DOI: 10.1016/s0896-6273(01)00443-3.
The past, the future and the biology of memory storage
Kandel E, Pittenger C. The past, the future and the biology of memory storage. Philosophical Transactions Of The Royal Society B Biological Sciences 1999, 354: 2027-2052. PMID: 10670023, PMCID: PMC1692699, DOI: 10.1098/rstb.1999.0542.

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Clinical Neuroscience Research Unit

Connecticut Mental Health Center

34 Park Street, Ste 3rd floor

New Haven, CT 06519

1-203-974-7523

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Clinical Neuroscience Research Unit
Connecticut Mental Health Center
34 Park Street, Ste 3rd floor
New Haven, CT 06519
- 1-203-974-7523
- Directions

Clinical Neuroscience Research Unit

Connecticut Mental Health Center

34 Park Street, Ste 3rd floor

New Haven, CT 06519

1-203-974-7523

Directions

Clinical Neuroscience Research Unit
Connecticut Mental Health Center
34 Park Street, Ste 3rd floor
New Haven, CT 06519
- 1-203-974-7523
- Directions

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