- Yale Nuclear CardiologyYale New Haven Hospital20 York StreetNew Haven, CT 06510
- Yale CardiologyYale Physicians Building800 Howard Avenue, Ste 2nd floorNew Haven, CT 06519
Arya Mani, MD, FACC, FAHA
Biography
Arya Mani, MD, director of the Yale Medicine Cardiovascular Genetics Program, is a leading expert on the genetic causes of heart disease. An interest in the genetics of disease and a desire to improve outcomes for cardiac patients led him into his field. “I wanted to make a change not only by diagnosing and healing patients, but also by identifying causes and treatments of disease,” he says.
Through collaborative efforts with physicians and scientists across the world, he has been involved in recruiting large populations of patients and families with early onset coronary artery disease and metabolic syndrome, and in the course of working with them has successfully mapped and identified a number of novel genes for these diseases.
An associate professor of medicine (cardiology) and of genetics at Yale School of Medicine, Dr. Mani studies the role of genetics in disease and the use of genomic knowledge in identifying disease pathways, the sequence of actions within a cell that lead to illness. He has helped identify genes that cause early onset coronary artery disease, metabolic syndrome and several adult congenital disorders.
While he enjoys research, Dr. Mani also loves working with patients and seeing them get better. “It is a joy to see that you’ve had an impact on people’s lives,” he says. “I don’t want to miss a moment of it.”
Titles
- Robert W Berliner Professor of Internal Medicine (Cardiology) and Professor of Genetics
- Director, Cardiovascular Genetics Program
- Director, Cardiovascular Module
Education & Training
- FellowYale University School of Medicine (2001)
- Chief ResidentYale University (1997)
- ResidentYale-New Haven Hospital (1996)
- FellowUniversity of Erlangen-Nuernberg (1992)
- MDJohannes-Gutenberg-University of Mainz (1991)
Languages Spoken
- English
- Fārsī (Farsi)
- Deutsch (German)
Additional Information
- NIH Outstanding Investigator Award 2017: NIH (2022)
- Doris Duke Clinical Scientist Development Awards 2008: Doris Duke (2022)
- The Interurban Clinical Club Sir William Osler Young Investigator Award: (2007)
- Howard Hughes Fellowship Award: Howard Hughes Medical Institute (2001)
- The Certification Board of Nuclear Cardiology, Nuclear Cardiology (2000)
- Lee J, Mani A, Shin M, Krauss R. Leveraging altered lipid metabolism in treating B cell malignancies. Progress In Lipid Research 2024, 95: 101288. PMID: 38964473, PMCID: PMC11347096, DOI: 10.1016/j.plipres.2024.101288.
- Mani A. Update in genetic and epigenetic causes of hypertension. Cellular And Molecular Life Sciences 2024, 81: 201. PMID: 38691164, PMCID: PMC11062952, DOI: 10.1007/s00018-024-05220-4.
- Kim T, DeWan A, Murray M, Wang H, Mani A, Mena-Hurtado C, Guzman R, Ochoa Chaar C. Anticoagulation in Patients with Premature Peripheral Artery Disease Undergoing Lower Extremity Revascularization. Annals Of Vascular Surgery 2024, 105: 150-157. PMID: 38593922, DOI: 10.1016/j.avsg.2024.02.006.
- Mani A. From mouse to human. ELife 2023, 12: e94382. PMID: 38060304, PMCID: PMC10703438, DOI: 10.7554/elife.94382.
- Masoudkabir F, Mohammadifard N, Mani A, Ignaszewski A, Davis M, Vaseghi G, Mansourian M, Franco C, Gotay C, Sarrafzadegan N. Shared Lifestyle-Related Risk Factors of Cardiovascular Disease and Cancer: Evidence for Joint Prevention. The Scientific World JOURNAL 2023, 2023: 2404806. PMID: 37520844, PMCID: PMC10386903, DOI: 10.1155/2023/2404806.
- Wiegand A, Kastury R, Neogi A, Mani A, Bale A, Cox A. FKBP14 kyphoscoliotic Ehlers–Danlos syndrome misdiagnosed as Larsen syndrome: a case report. Molecular Case Studies 2023, 9: a006281. PMID: 37433679, PMCID: PMC10393184, DOI: 10.1101/mcs.a006281.
- Bhat N, Mani A. Dysregulation of Lipid and Glucose Metabolism in Nonalcoholic Fatty Liver Disease. Nutrients 2023, 15: 2323. PMID: 37242206, PMCID: PMC10222271, DOI: 10.3390/nu15102323.
- Gunawardhana K, Hong L, Rugira T, Uebbing S, Kucharczak J, Mehta S, Karunamuni D, Cabera-Mendoza B, Gandotra N, Scharfe C, Polimanti R, Noonan J, Mani A. A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension. Journal Of Clinical Investigation 2023, 133: e160036. PMID: 36602864, PMCID: PMC9927944, DOI: 10.1172/jci160036.
- Anushiravani A, Khamirani H, Mohamadkhani A, Mani A, Dianatpour M, Malekzadeh R. A Form of Metabolic-Associated Fatty Liver Disease Associated with a Novel LIPA Variant. Archives Of Iranian Medicine 2023, 26: 86-91. PMID: 37543928, PMCID: PMC10685898, DOI: 10.34172/aim.2023.14.
- Kim TI, Loh S, DeWan A, Murray M, Mojibian H, Mani A, Mena-Hurtado C, Ochoa Chaar CI. Major Adverse Limb Events Among Patients with Premature Peripheral Artery Disease Compared with Those at the Common Age Undergoing Revascularization in the Vascular Quality Initiative. Annals Of Vascular Surgery 2022, 87: 188-197. PMID: 35926786, DOI: 10.1016/j.avsg.2022.07.007.
- Kim T, DeWan A, Murray M, Wang H, Mani A, Mena-Hurtado C, Guzman R, Chaar C. Escalation of Antithrombotic Therapy in Patients With Premature Peripheral Artery Disease Undergoing Lower Extremity Revascularization. Journal Of Vascular Surgery 2022, 75: e281. DOI: 10.1016/j.jvs.2022.03.640.
- Neogi A, Towne M, Dykas D, Parsa N, Attar A, FATHZADEH M, Bale A, Mani A. Abstract 554: The Association Of Multiple Variants In The TNXB Gene With Vascular Aneurysms And Dissections. Arteriosclerosis Thrombosis And Vascular Biology 2022, 42: a554-a554. DOI: 10.1161/atvb.42.suppl_1.554.
- Ginsberg HN, Mani A. Complex regulation of fatty liver disease. Science 2022, 376: 247-248. PMID: 35420931, PMCID: PMC9619413, DOI: 10.1126/science.abp8276.
- Mani A. PDE4DIP in health and diseases. Cellular Signalling 2022, 94: 110322. PMID: 35346821, PMCID: PMC9618167, DOI: 10.1016/j.cellsig.2022.110322.
- Mani A, Hwa J, Martin KA. Sugar, Fat, and YAP: A Recipe for Vascular Stiffness. Circulation Research 2022, 130: 868-870. PMID: 35298300, PMCID: PMC9112226, DOI: 10.1161/circresaha.122.320880.
- Bhat N, Esteghamat F, Chaube BK, Gunawardhana K, Mani M, Thames C, Jain D, Ginsberg HN, Fernandes‐Hernando C, Mani A. TCF7L2 transcriptionally regulates Fgf15 to maintain bile acid and lipid homeostasis through gut‐liver crosstalk. The FASEB Journal 2022, 36: e22185. PMID: 35133032, PMCID: PMC9624374, DOI: 10.1096/fj.202101607r.
- Zogg CK, Avesta A, Bonde PN, Mani A. Echocardiography fails to detect an extensive aortic root abscess in a patient with infective endocarditis: a case report. European Heart Journal - Case Reports 2022, 6: ytac032. PMID: 35295731, PMCID: PMC8922699, DOI: 10.1093/ehjcr/ytac032.
- Hong L, Li N, Gasque V, Mehta S, Ye L, Wu Y, Li J, Gewies A, Ruland J, Hirschi KK, Eichmann A, Hendry C, van Dijk D, Mani A. Prdm6 controls heart development by regulating neural crest cell differentiation and migration. JCI Insight 2022, 7: e156046. PMID: 35108221, PMCID: PMC8876496, DOI: 10.1172/jci.insight.156046.
- Kim T, Loh S, Dewan A, Murray M, Mojibian H, Mani A, Mena-Hurtado C, Chaar C. Lower Extremity Revascularization Among Patients With Premature Peripheral Artery Disease Compared To Patients At The Common Age Of Presentation In The Vascular Quality Initiative. Annals Of Vascular Surgery 2022, 79: 400-401. DOI: 10.1016/j.avsg.2021.12.049.
- Bhat N, Narayanan A, Fathzadeh M, Kahn M, Zhang D, Goedeke L, Neogi A, Cardone RL, Kibbey RG, Fernandez-Hernando C, Ginsberg HN, Jain D, Shulman G, Mani A. Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice. Journal Of Clinical Investigation 2022, 132: e153724. PMID: 34855620, PMCID: PMC8803348, DOI: 10.1172/jci153724.
- Masoudkabir F, Malekzadeh R, Yavari N, Zendehdel K, Mani A, Vasheghani-Farahani A, Ignaszewski A, Toma M, Roayaei P, Turk-Adawi K, Sarrafzadegan N. Does Opium Consumption Have Shared Impact on Atherosclerotic Cardiovascular Disease and Cancer? Archives Of Iranian Medicine 2022, 25: 50-63. PMID: 35128912, DOI: 10.34172/aim.2022.08.
- Ghazizadeh Z, Liu Y, Ugwu N, Adeniran A, Neogi A, Mani A. Abstract 14231: The Role of Altered Notch-Sox9-Hapln1 Signaling in the Pathogenesis of Bicuspid Aortic Valve. Circulation 2021, 144: a14231-a14231. DOI: 10.1161/circ.144.suppl_1.14231.
- Bhat N, Narayanan A, Fathzadeh M, Shah K, Dianatpour M, Abou Ziki MD, Mani A. Dyrk1b promotes autophagy during skeletal muscle differentiation by upregulating 4e-bp1. Cellular Signalling 2021, 90: 110186. PMID: 34752933, PMCID: PMC8712395, DOI: 10.1016/j.cellsig.2021.110186.
- Gharipour M, Mani A, Baghbahadorani M, de Souza Cardoso CK, Jahanfar S, Sarrafzadegan N, de Oliveira C, Silveira EA. How Are Epigenetic Modifications Related to Cardiovascular Disease in Older Adults? International Journal Of Molecular Sciences 2021, 22: 9949. PMID: 34576113, PMCID: PMC8470616, DOI: 10.3390/ijms22189949.
- Ziki M, Bhat N, Neogi A, Abboud J, Chouairi S, Ugwu N, Driscoll T, Liu Y, Smith E, Schwartz M, Akar J, Mani A. B-AB13-03 NOVEL ROLE OF PDE4DIP IN FAMILIAL ATRIAL FIBRILLATION WITH SLOW VENTRICULAR RESPONSE. Heart Rhythm 2021, 18: s26. DOI: 10.1016/j.hrthm.2021.06.078.
- Ziki M, Bhat N, Neogi A, Driscoll TP, Ugwu N, Liu Y, Smith E, Abboud JM, Chouairi S, Schwartz MA, Akar JG, Mani A. Epistatic interaction of PDE4DIP and DES mutations in familial atrial fibrillation with slow conduction. Human Mutation 2021, 42: 1279-1293. PMID: 34289528, PMCID: PMC8434967, DOI: 10.1002/humu.24265.
- Brandt EJ, Brandt DJ, Desai NR, Spatz ES, Nasir K, Mani A. Association of vitamins, minerals, and lead with lipoprotein(a) in a cross-sectional cohort of US adults. International Journal For Vitamin And Nutrition Research 2021, 93: 99-110. PMID: 34024154, PMCID: PMC8964024, DOI: 10.1024/0300-9831/a000709.
- Mani K, Mani A. The significance of plasma collagen degradation products as biomarkers for advanced hypertensive heart disease. Journal Of Clinical Hypertension 2021, 23: 1017-1019. PMID: 33932079, PMCID: PMC8357153, DOI: 10.1111/jch.14205.
- Weerackoon N, Gunawardhana KL, Mani A. Wnt Signaling Cascades and Their Role in Coronary Artery Health and Disease. Journal Of Cellular Signaling 2021, 2: 52-62. PMID: 33969358, PMCID: PMC8098721, DOI: 10.33696/signaling.2.035.
- Dianatpour M, Smith E, Hashemi SB, Farazifard MA, Nezafat N, Razban V, Mani A. Identification of homozygous mutations for hearing loss. Gene 2021, 778: 145464. PMID: 33524517, PMCID: PMC7987747, DOI: 10.1016/j.gene.2021.145464.
- Gholaminejad A, Zare N, Dana N, Shafie D, Mani A, Javanmard SH. A meta-analysis of microRNA expression profiling studies in heart failure. Heart Failure Reviews 2021, 26: 997-1021. PMID: 33443726, DOI: 10.1007/s10741-020-10071-9.
- Ziki M, Akar J, Neogi A, Abboud J, Choueiri S, Driscoll T, Bhat N, Ugwu N, Liu Y, Smith E, Mani A. The pleiotropic effect of a deleterious DES mutation in familial atrial fibrillation and the role of PDE4DIP as a genetic modifier for heart block. European Heart Journal 2020, 41: ehaa946.0330. DOI: 10.1093/ehjci/ehaa946.0330.
- Liu Y, Neogi A, Mani A. The role of Wnt signalling in development of coronary artery disease and its risk factors. Open Biology 2020, 10: 200128. PMID: 33081636, PMCID: PMC7653355, DOI: 10.1098/rsob.200128.
- Brandt EJ, Mani A, Spatz ES, Desai NR, Nasir K. Lipoprotein(a) levels and association with myocardial infarction and stroke in a nationally representative cross-sectional US cohort. Journal Of Clinical Lipidology 2020, 14: 695-706.e4. PMID: 32739333, PMCID: PMC7641964, DOI: 10.1016/j.jacl.2020.06.010.
- Brandt E, Brandt D, Desai N, Spatz E, Mani A, Nasir K. Association of Serum Vitamins, Minerals, and Heavy Metals with Lipoprotein(a). Journal Of Clinical Lipidology 2020, 14: 560. DOI: 10.1016/j.jacl.2020.05.029.
- Brandt E, Mani A, Spatz E, Desai N, Nasir K. EPIDEMIOLOGY OF LIPOPROTEIN(A) AND ASSOCIATION WITH MYOCARDIAL INFARCTION AND STROKE IN A NATIONALLY REPRESENTATIVE COHORT. Journal Of The American College Of Cardiology 2020, 75: 3669. DOI: 10.1016/s0735-1097(20)34296-0.
- Global longitudinal strain imaging and its utility in assessing risk in early stages of hypertensionMani A. Global longitudinal strain imaging and its utility in assessing risk in early stages of hypertension. Journal Of Clinical Hypertension 2019, 21: 1711-1712. PMID: 31553521, PMCID: PMC8030360, DOI: 10.1111/jch.13703.
- Esteghamat F, Broughton JS, Smith E, Cardone R, Tyagi T, Guerra M, Szabó A, Ugwu N, Mani MV, Azari B, Kayingo G, Chung S, Fathzadeh M, Weiss E, Bender J, Mane S, Lifton RP, Adeniran A, Nathanson MH, Gorelick FS, Hwa J, Sahin-Tóth M, Belfort-DeAguiar R, Kibbey RG, Mani A. CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation. Nature Genetics 2019, 51: 1233-1243. PMID: 31358993, PMCID: PMC6675645, DOI: 10.1038/s41588-019-0470-3.
- Srivastava R, Rolyan H, Xie Y, Li N, Bhat N, Hong L, Esteghamat F, Adeniran A, Geirsson A, Zhang J, Ge G, Nobrega M, Martin KA, Mani A. TCF7L2 (Transcription Factor 7-Like 2) Regulation of GATA6 (GATA-Binding Protein 6)-Dependent and -Independent Vascular Smooth Muscle Cell Plasticity and Intimal Hyperplasia. Arteriosclerosis Thrombosis And Vascular Biology 2018, 39: 250-262. PMID: 30567484, PMCID: PMC6365015, DOI: 10.1161/atvbaha.118.311830.
- Abou Ziki M, Mani A. The interplay of canonical and noncanonical Wnt signaling in metabolic syndrome. Nutrition Research 2018, 70: 18-25. PMID: 30049588, PMCID: PMC6320319, DOI: 10.1016/j.nutres.2018.06.009.
- Mani A, Bhat N, Esteghamat S. Abstract 618: Identification of Novel Disease Genes for Metabolic Syndrome. Arteriosclerosis Thrombosis And Vascular Biology 2018, 38 DOI: 10.1161/atvb.38.suppl_1.618.
- Goetz TG, Mamillapalli R, Sahin C, Majidi-Zolbin M, Ge G, Mani A, Taylor HS. Addition of Estradiol to Cross-Sex Testosterone Therapy Reduces Atherosclerosis Plaque Formation in Female ApoE−/− Mice. Endocrinology 2017, 159: 754-762. PMID: 29253190, PMCID: PMC5774248, DOI: 10.1210/en.2017-00884.
- Hwangbo C, Wu J, Papangeli I, Adachi T, Sharma B, Park S, Zhao L, Ju H, Go GW, Cui G, Inayathullah M, Job JK, Rajadas J, Kwei SL, Li MO, Morrison AR, Quertermous T, Mani A, Red-Horse K, Chun HJ. Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin’s glucose-lowering effects. Science Translational Medicine 2017, 9 PMID: 28904225, PMCID: PMC5703224, DOI: 10.1126/scitranslmed.aad4000.
- Ziki M, Seidelmann SB, Smith E, Atteya G, Jiang Y, Fernandes RG, Marieb MA, Akar JG, Mani A. Deleterious protein‐altering mutations in the SCN10A voltage‐gated sodium channel gene are associated with prolonged QT. Clinical Genetics 2017, 93: 741-751. PMID: 28407228, PMCID: PMC5640462, DOI: 10.1111/cge.13036.
- Ziki M, Mani A. Wnt signaling, a novel pathway regulating blood pressure? State of the art review. Atherosclerosis 2017, 262: 171-178. PMID: 28522145, PMCID: PMC5508596, DOI: 10.1016/j.atherosclerosis.2017.05.001.
- Ziki M, Seidelmann S, Smith E, Narayanan A, Atteya G, Jiang Y, Gil-Fernandez R, Marieb M, Akar J, Mani A. DELETERIOUS MUTATIONS IN SCN10A ARE ASSOCIATED WITH LONG QT SYNDROME. Journal Of The American College Of Cardiology 2017, 69: 509. DOI: 10.1016/s0735-1097(17)33898-6.
- Seidelmann SB, Smith E, Subrahmanyan L, Dykas D, Abou Ziki MD, Azari B, Hannah-Shmouni F, Jiang Y, Akar JG, Marieb M, Jacoby D, Bale AE, Lifton RP, Mani A. Application of Whole Exome Sequencing in the Clinical Diagnosis and Management of Inherited Cardiovascular Diseases in Adults. Circulation Genomic And Precision Medicine 2017, 10: e001573. PMID: 28087566, PMCID: PMC5245580, DOI: 10.1161/circgenetics.116.001573.
- Li N, Subrahmanyan L, Smith E, Yu X, Zaidi S, Choi M, Mane S, Nelson-Williams C, Behjati M, Kazemi M, Hashemi M, Fathzadeh M, Narayanan A, Tian L, Montazeri F, Mani M, Begleiter ML, Coon BG, Lynch HT, Olson EN, Zhao H, Ruland J, Lifton RP, Mani A. Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus. American Journal Of Human Genetics 2016, 99: 1000. PMID: 27716515, PMCID: PMC5065682, DOI: 10.1016/j.ajhg.2016.09.003.
- Li N, Subrahmanyan L, Smith E, Yu X, Zaidi S, Choi M, Mane S, Nelson-Williams C, Behjati M, Kazemi M, Hashemi M, Fathzadeh M, Narayanan A, Tian L, Montazeri F, Mani M, Begleiter ML, Coon BG, Lynch HT, Olson EN, Zhao H, Ruland J, Lifton RP, Mani A. Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus. American Journal Of Human Genetics 2016, 98: 1082-1091. PMID: 27181681, PMCID: PMC4908195, DOI: 10.1016/j.ajhg.2016.03.022.
- Ziki M, Mani A. Metabolic syndrome. Current Opinion In Lipidology 2016, 27: 162-171. PMID: 26825138, PMCID: PMC5141383, DOI: 10.1097/mol.0000000000000276.
- Smith E, Mani A. CORONARY ARTERY DISSECTION IN EHLERS DANLOS SYNDROME. Journal Of The American College Of Cardiology 2016, 67: 1018. DOI: 10.1016/s0735-1097(16)31019-1.
- Ziki M, Smith E, Seidelmann S, Mani A. IMPORTIN 4 ACTS AS A GENETIC MODIFIER OF LAMIN A/C ARG644CYS MUTATION IN PREDISPOITION FOR PREMATURE CORONARY ARTERY DISEASE. Journal Of The American College Of Cardiology 2016, 67: 589. DOI: 10.1016/s0735-1097(16)30590-3.
- Srivastava R, Zhang J, Go GW, Narayanan A, Nottoli TP, Mani A. Impaired LRP6-TCF7L2 Activity Enhances Smooth Muscle Cell Plasticity and Causes Coronary Artery Disease. Cell Reports 2015, 13: 746-759. PMID: 26489464, PMCID: PMC4626307, DOI: 10.1016/j.celrep.2015.09.028.
- Wang S, Song K, Srivastava R, Fathzadeh M, Li N, Mani A. The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis. Journal Of Diabetes Research 2015, 2015: 468627. PMID: 26576435, PMCID: PMC4631899, DOI: 10.1155/2015/468627.
- Hannah-Shmouni F, Seidelmann SB, Sirrs S, Mani A, Jacoby D. The Genetic Challenges and Opportunities in Advanced Heart Failure. Canadian Journal Of Cardiology 2015, 31: 1338-1350. PMID: 26518444, PMCID: PMC5423787, DOI: 10.1016/j.cjca.2015.07.735.
- Martin KA, Mani MV, Mani A. New targets to treat obesity and the metabolic syndrome. European Journal Of Pharmacology 2015, 763: 64-74. PMID: 26001373, PMCID: PMC4573317, DOI: 10.1016/j.ejphar.2015.03.093.
- Fathzadeh M, Keramati A, Go G, Singh R, Sarajzadeh K, Tavakkoly-Bazzaz J, Noorafshan A, Kasaei M, Amini M, Omrani G, Babaee Bigi M, Babaei M, Hosseinian A, Malekzadeh R, Lifton R, Mani A. Abstract 20140: Minibrain Relate Kinase / Dyrk1B Links Skeletal Muscle Glycolytic Metabolism with Insulin Resistance and Causes Metabolic Syndrome. Circulation 2014, 130 DOI: 10.1161/circ.130.suppl_2.20140.
- Song K, Wang S, Mani M, Mani A. Wnt signaling, de novo lipogenesis, adipogenesis and ectopic fat. Oncotarget 2014, 5: 11000-11003. PMID: 25526027, PMCID: PMC4294374, DOI: 10.18632/oncotarget.2769.
- Song K, Wang S, Huang B, Luciano A, Srivastava R, Mani A. Plasma Cardiotrophin‐1 Levels are Associated With Hypertensive Heart Disease: A Meta‐Analysis. Journal Of Clinical Hypertension 2014, 16: 686-692. PMID: 25052897, PMCID: PMC4159421, DOI: 10.1111/jch.12376.
- Mani A, Alizadehasl A. Syndromic Congenital Heart Diseases. 2014, 65-69. DOI: 10.1007/978-1-4471-6383-1_10.
- Go GW, Srivastava R, Hernandez-Ono A, Gang G, Smith SB, Booth CJ, Ginsberg HN, Mani A. The Combined Hyperlipidemia Caused by Impaired Wnt-LRP6 Signaling Is Reversed by Wnt3a Rescue. Cell Metabolism 2014, 19: 209-220. PMID: 24506864, PMCID: PMC3920193, DOI: 10.1016/j.cmet.2013.11.023.
- Mani A, Go G, Ye Z, Singh R. Abstract 321: LRP6 Regulates LDL Receptor Internalization and LDL Uptake. Arteriosclerosis Thrombosis And Vascular Biology 2012, 32 DOI: 10.1161/atvb.32.suppl_1.a321.
- Liu W, Singh R, Choi C, Young L, Keramati A, Samuel V, Lifton R, Shulman G, Mani A. Abstract 140: LRP6 Influences Body Fat and Glucose Homeostasis in Mouse by Activating mTOR Pathway and Inhibiting Mitochondrial Energy Expenditure. Arteriosclerosis Thrombosis And Vascular Biology 2012, 32 DOI: 10.1161/atvb.32.suppl_1.a140.
- Khanna P, Mani A. Prevalence of Obesity and Traditional Cardiovascular Risk Factors in South Asians. Current Cardiovascular Risk Reports 2012, 6: 112-119. DOI: 10.1007/s12170-012-0220-x.
- Keramati AR, Singh R, Lin A, Faramarzi S, Ye ZJ, Mane S, Tellides G, Lifton RP, Mani A. Wild-type LRP6 inhibits, whereas atherosclerosis-linked LRP6R611C increases PDGF-dependent vascular smooth muscle cell proliferation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 1914-1918. PMID: 21245321, PMCID: PMC3033290, DOI: 10.1073/pnas.1019443108.
- Keramati A, Singh R, Liu W, Faramarzi S, Nottoli T, Tellides G, Mani A. W15 THE ANTIPROLIFERATIVE EFFECT OF LRP6 AND ITS IMPAIRMENT BY R611C MUTATION ARE MEDIATED BY INDEPENDENT INTERMEDIATES OF THE PDGF PATHWAY. Atherosclerosis Plus 2010, 11: 4. DOI: 10.1016/s1567-5688(10)70016-7.
- Keramati A, Liu W, Nottoli T, Faramarzi S, Tellides G, Mani A. Abstract 5464: The Cell Proliferative Effect of LRP6 Mutation is Mediated by Increased PDGF Dependent Cyclin D1 Expression. Circulation 2009, 120 DOI: 10.1161/circ.120.suppl_18.s1097.
- Friedman T, Mani A, Elefteriades JA. Bicuspid aortic valve: clinical approach and scientific review of a common clinical entity. Expert Review Of Cardiovascular Therapy 2008, 6: 235-248. PMID: 18248277, DOI: 10.1586/14779072.6.2.235.
- Mani S, Moradi A, Abdolahi N, Martel M, Semnani S, Glazer P, Mani A. The Aberrant Expression of Beta-catenin in Esophageal Squamous Cell Cancer (ESCC) in Northeastern Iran. International Journal Of Radiation Oncology • Biology • Physics 2007, 69: s309-s310. DOI: 10.1016/j.ijrobp.2007.07.1366.
- KARNE S, MANI A, KOLODECIK T, GORELICK F, CT H. In vivo cerulein hyperstimulation of rat pancreas is associated with redistribution of the cation-independent mannose 6-phoshate receptor. Gastroenterology 2001, 120: a719-a719. DOI: 10.1016/s0016-5085(01)83579-4.
- Karne S, Mani A, Kolodecik T, Gorelick F, Haven C. In vivo cerulein hyperstimulation of rat pancreas is associated with redistribution of the cation-independent mannose 6-phoshate receptor. Gastroenterology 2001, 120: a719. DOI: 10.1016/s0016-5085(08)83579-2.
- Nathanson MH, Burgstahler AD, Orloff JJ, Mani A, Moyer MS. Mechanism of desensitization of the cloned vasopressin V1a receptor expressed in Xenopus oocytes. American Journal Of Physiology 1994, 267: c94-c103. PMID: 8048495, DOI: 10.1152/ajpcell.1994.267.1.c94.
- Yale Nuclear CardiologyYale New Haven Hospital20 York StreetNew Haven, CT 06510
- Yale CardiologyYale Physicians Building800 Howard Avenue, Ste 2nd floorNew Haven, CT 06519
Biography
Arya Mani, MD, director of the Yale Medicine Cardiovascular Genetics Program, is a leading expert on the genetic causes of heart disease. An interest in the genetics of disease and a desire to improve outcomes for cardiac patients led him into his field. “I wanted to make a change not only by diagnosing and healing patients, but also by identifying causes and treatments of disease,” he says.
Through collaborative efforts with physicians and scientists across the world, he has been involved in recruiting large populations of patients and families with early onset coronary artery disease and metabolic syndrome, and in the course of working with them has successfully mapped and identified a number of novel genes for these diseases.
An associate professor of medicine (cardiology) and of genetics at Yale School of Medicine, Dr. Mani studies the role of genetics in disease and the use of genomic knowledge in identifying disease pathways, the sequence of actions within a cell that lead to illness. He has helped identify genes that cause early onset coronary artery disease, metabolic syndrome and several adult congenital disorders.
While he enjoys research, Dr. Mani also loves working with patients and seeing them get better. “It is a joy to see that you’ve had an impact on people’s lives,” he says. “I don’t want to miss a moment of it.”
Titles
- Robert W Berliner Professor of Internal Medicine (Cardiology) and Professor of Genetics
- Director, Cardiovascular Genetics Program
- Director, Cardiovascular Module
Education & Training
- FellowYale University School of Medicine (2001)
- Chief ResidentYale University (1997)
- ResidentYale-New Haven Hospital (1996)
- FellowUniversity of Erlangen-Nuernberg (1992)
- MDJohannes-Gutenberg-University of Mainz (1991)
Languages Spoken
- English
- Fārsī (Farsi)
- Deutsch (German)
Additional Information
- NIH Outstanding Investigator Award 2017: NIH (2022)
- Doris Duke Clinical Scientist Development Awards 2008: Doris Duke (2022)
- The Interurban Clinical Club Sir William Osler Young Investigator Award: (2007)
- Howard Hughes Fellowship Award: Howard Hughes Medical Institute (2001)
- The Certification Board of Nuclear Cardiology, Nuclear Cardiology (2000)
- Lee J, Mani A, Shin M, Krauss R. Leveraging altered lipid metabolism in treating B cell malignancies. Progress In Lipid Research 2024, 95: 101288. PMID: 38964473, PMCID: PMC11347096, DOI: 10.1016/j.plipres.2024.101288.
- Mani A. Update in genetic and epigenetic causes of hypertension. Cellular And Molecular Life Sciences 2024, 81: 201. PMID: 38691164, PMCID: PMC11062952, DOI: 10.1007/s00018-024-05220-4.
- Kim T, DeWan A, Murray M, Wang H, Mani A, Mena-Hurtado C, Guzman R, Ochoa Chaar C. Anticoagulation in Patients with Premature Peripheral Artery Disease Undergoing Lower Extremity Revascularization. Annals Of Vascular Surgery 2024, 105: 150-157. PMID: 38593922, DOI: 10.1016/j.avsg.2024.02.006.
- Mani A. From mouse to human. ELife 2023, 12: e94382. PMID: 38060304, PMCID: PMC10703438, DOI: 10.7554/elife.94382.
- Masoudkabir F, Mohammadifard N, Mani A, Ignaszewski A, Davis M, Vaseghi G, Mansourian M, Franco C, Gotay C, Sarrafzadegan N. Shared Lifestyle-Related Risk Factors of Cardiovascular Disease and Cancer: Evidence for Joint Prevention. The Scientific World JOURNAL 2023, 2023: 2404806. PMID: 37520844, PMCID: PMC10386903, DOI: 10.1155/2023/2404806.
- Wiegand A, Kastury R, Neogi A, Mani A, Bale A, Cox A. FKBP14 kyphoscoliotic Ehlers–Danlos syndrome misdiagnosed as Larsen syndrome: a case report. Molecular Case Studies 2023, 9: a006281. PMID: 37433679, PMCID: PMC10393184, DOI: 10.1101/mcs.a006281.
- Bhat N, Mani A. Dysregulation of Lipid and Glucose Metabolism in Nonalcoholic Fatty Liver Disease. Nutrients 2023, 15: 2323. PMID: 37242206, PMCID: PMC10222271, DOI: 10.3390/nu15102323.
- Gunawardhana K, Hong L, Rugira T, Uebbing S, Kucharczak J, Mehta S, Karunamuni D, Cabera-Mendoza B, Gandotra N, Scharfe C, Polimanti R, Noonan J, Mani A. A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension. Journal Of Clinical Investigation 2023, 133: e160036. PMID: 36602864, PMCID: PMC9927944, DOI: 10.1172/jci160036.
- Anushiravani A, Khamirani H, Mohamadkhani A, Mani A, Dianatpour M, Malekzadeh R. A Form of Metabolic-Associated Fatty Liver Disease Associated with a Novel LIPA Variant. Archives Of Iranian Medicine 2023, 26: 86-91. PMID: 37543928, PMCID: PMC10685898, DOI: 10.34172/aim.2023.14.
- Kim TI, Loh S, DeWan A, Murray M, Mojibian H, Mani A, Mena-Hurtado C, Ochoa Chaar CI. Major Adverse Limb Events Among Patients with Premature Peripheral Artery Disease Compared with Those at the Common Age Undergoing Revascularization in the Vascular Quality Initiative. Annals Of Vascular Surgery 2022, 87: 188-197. PMID: 35926786, DOI: 10.1016/j.avsg.2022.07.007.
- Kim T, DeWan A, Murray M, Wang H, Mani A, Mena-Hurtado C, Guzman R, Chaar C. Escalation of Antithrombotic Therapy in Patients With Premature Peripheral Artery Disease Undergoing Lower Extremity Revascularization. Journal Of Vascular Surgery 2022, 75: e281. DOI: 10.1016/j.jvs.2022.03.640.
- Neogi A, Towne M, Dykas D, Parsa N, Attar A, FATHZADEH M, Bale A, Mani A. Abstract 554: The Association Of Multiple Variants In The TNXB Gene With Vascular Aneurysms And Dissections. Arteriosclerosis Thrombosis And Vascular Biology 2022, 42: a554-a554. DOI: 10.1161/atvb.42.suppl_1.554.
- Ginsberg HN, Mani A. Complex regulation of fatty liver disease. Science 2022, 376: 247-248. PMID: 35420931, PMCID: PMC9619413, DOI: 10.1126/science.abp8276.
- Mani A. PDE4DIP in health and diseases. Cellular Signalling 2022, 94: 110322. PMID: 35346821, PMCID: PMC9618167, DOI: 10.1016/j.cellsig.2022.110322.
- Mani A, Hwa J, Martin KA. Sugar, Fat, and YAP: A Recipe for Vascular Stiffness. Circulation Research 2022, 130: 868-870. PMID: 35298300, PMCID: PMC9112226, DOI: 10.1161/circresaha.122.320880.
- Bhat N, Esteghamat F, Chaube BK, Gunawardhana K, Mani M, Thames C, Jain D, Ginsberg HN, Fernandes‐Hernando C, Mani A. TCF7L2 transcriptionally regulates Fgf15 to maintain bile acid and lipid homeostasis through gut‐liver crosstalk. The FASEB Journal 2022, 36: e22185. PMID: 35133032, PMCID: PMC9624374, DOI: 10.1096/fj.202101607r.
- Zogg CK, Avesta A, Bonde PN, Mani A. Echocardiography fails to detect an extensive aortic root abscess in a patient with infective endocarditis: a case report. European Heart Journal - Case Reports 2022, 6: ytac032. PMID: 35295731, PMCID: PMC8922699, DOI: 10.1093/ehjcr/ytac032.
- Hong L, Li N, Gasque V, Mehta S, Ye L, Wu Y, Li J, Gewies A, Ruland J, Hirschi KK, Eichmann A, Hendry C, van Dijk D, Mani A. Prdm6 controls heart development by regulating neural crest cell differentiation and migration. JCI Insight 2022, 7: e156046. PMID: 35108221, PMCID: PMC8876496, DOI: 10.1172/jci.insight.156046.
- Kim T, Loh S, Dewan A, Murray M, Mojibian H, Mani A, Mena-Hurtado C, Chaar C. Lower Extremity Revascularization Among Patients With Premature Peripheral Artery Disease Compared To Patients At The Common Age Of Presentation In The Vascular Quality Initiative. Annals Of Vascular Surgery 2022, 79: 400-401. DOI: 10.1016/j.avsg.2021.12.049.
- Bhat N, Narayanan A, Fathzadeh M, Kahn M, Zhang D, Goedeke L, Neogi A, Cardone RL, Kibbey RG, Fernandez-Hernando C, Ginsberg HN, Jain D, Shulman G, Mani A. Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice. Journal Of Clinical Investigation 2022, 132: e153724. PMID: 34855620, PMCID: PMC8803348, DOI: 10.1172/jci153724.
- Masoudkabir F, Malekzadeh R, Yavari N, Zendehdel K, Mani A, Vasheghani-Farahani A, Ignaszewski A, Toma M, Roayaei P, Turk-Adawi K, Sarrafzadegan N. Does Opium Consumption Have Shared Impact on Atherosclerotic Cardiovascular Disease and Cancer? Archives Of Iranian Medicine 2022, 25: 50-63. PMID: 35128912, DOI: 10.34172/aim.2022.08.
- Ghazizadeh Z, Liu Y, Ugwu N, Adeniran A, Neogi A, Mani A. Abstract 14231: The Role of Altered Notch-Sox9-Hapln1 Signaling in the Pathogenesis of Bicuspid Aortic Valve. Circulation 2021, 144: a14231-a14231. DOI: 10.1161/circ.144.suppl_1.14231.
- Bhat N, Narayanan A, Fathzadeh M, Shah K, Dianatpour M, Abou Ziki MD, Mani A. Dyrk1b promotes autophagy during skeletal muscle differentiation by upregulating 4e-bp1. Cellular Signalling 2021, 90: 110186. PMID: 34752933, PMCID: PMC8712395, DOI: 10.1016/j.cellsig.2021.110186.
- Gharipour M, Mani A, Baghbahadorani M, de Souza Cardoso CK, Jahanfar S, Sarrafzadegan N, de Oliveira C, Silveira EA. How Are Epigenetic Modifications Related to Cardiovascular Disease in Older Adults? International Journal Of Molecular Sciences 2021, 22: 9949. PMID: 34576113, PMCID: PMC8470616, DOI: 10.3390/ijms22189949.
- Ziki M, Bhat N, Neogi A, Abboud J, Chouairi S, Ugwu N, Driscoll T, Liu Y, Smith E, Schwartz M, Akar J, Mani A. B-AB13-03 NOVEL ROLE OF PDE4DIP IN FAMILIAL ATRIAL FIBRILLATION WITH SLOW VENTRICULAR RESPONSE. Heart Rhythm 2021, 18: s26. DOI: 10.1016/j.hrthm.2021.06.078.
- Ziki M, Bhat N, Neogi A, Driscoll TP, Ugwu N, Liu Y, Smith E, Abboud JM, Chouairi S, Schwartz MA, Akar JG, Mani A. Epistatic interaction of PDE4DIP and DES mutations in familial atrial fibrillation with slow conduction. Human Mutation 2021, 42: 1279-1293. PMID: 34289528, PMCID: PMC8434967, DOI: 10.1002/humu.24265.
- Brandt EJ, Brandt DJ, Desai NR, Spatz ES, Nasir K, Mani A. Association of vitamins, minerals, and lead with lipoprotein(a) in a cross-sectional cohort of US adults. International Journal For Vitamin And Nutrition Research 2021, 93: 99-110. PMID: 34024154, PMCID: PMC8964024, DOI: 10.1024/0300-9831/a000709.
- Mani K, Mani A. The significance of plasma collagen degradation products as biomarkers for advanced hypertensive heart disease. Journal Of Clinical Hypertension 2021, 23: 1017-1019. PMID: 33932079, PMCID: PMC8357153, DOI: 10.1111/jch.14205.
- Weerackoon N, Gunawardhana KL, Mani A. Wnt Signaling Cascades and Their Role in Coronary Artery Health and Disease. Journal Of Cellular Signaling 2021, 2: 52-62. PMID: 33969358, PMCID: PMC8098721, DOI: 10.33696/signaling.2.035.
- Dianatpour M, Smith E, Hashemi SB, Farazifard MA, Nezafat N, Razban V, Mani A. Identification of homozygous mutations for hearing loss. Gene 2021, 778: 145464. PMID: 33524517, PMCID: PMC7987747, DOI: 10.1016/j.gene.2021.145464.
- Gholaminejad A, Zare N, Dana N, Shafie D, Mani A, Javanmard SH. A meta-analysis of microRNA expression profiling studies in heart failure. Heart Failure Reviews 2021, 26: 997-1021. PMID: 33443726, DOI: 10.1007/s10741-020-10071-9.
- Ziki M, Akar J, Neogi A, Abboud J, Choueiri S, Driscoll T, Bhat N, Ugwu N, Liu Y, Smith E, Mani A. The pleiotropic effect of a deleterious DES mutation in familial atrial fibrillation and the role of PDE4DIP as a genetic modifier for heart block. European Heart Journal 2020, 41: ehaa946.0330. DOI: 10.1093/ehjci/ehaa946.0330.
- Liu Y, Neogi A, Mani A. The role of Wnt signalling in development of coronary artery disease and its risk factors. Open Biology 2020, 10: 200128. PMID: 33081636, PMCID: PMC7653355, DOI: 10.1098/rsob.200128.
- Brandt EJ, Mani A, Spatz ES, Desai NR, Nasir K. Lipoprotein(a) levels and association with myocardial infarction and stroke in a nationally representative cross-sectional US cohort. Journal Of Clinical Lipidology 2020, 14: 695-706.e4. PMID: 32739333, PMCID: PMC7641964, DOI: 10.1016/j.jacl.2020.06.010.
- Brandt E, Brandt D, Desai N, Spatz E, Mani A, Nasir K. Association of Serum Vitamins, Minerals, and Heavy Metals with Lipoprotein(a). Journal Of Clinical Lipidology 2020, 14: 560. DOI: 10.1016/j.jacl.2020.05.029.
- Brandt E, Mani A, Spatz E, Desai N, Nasir K. EPIDEMIOLOGY OF LIPOPROTEIN(A) AND ASSOCIATION WITH MYOCARDIAL INFARCTION AND STROKE IN A NATIONALLY REPRESENTATIVE COHORT. Journal Of The American College Of Cardiology 2020, 75: 3669. DOI: 10.1016/s0735-1097(20)34296-0.
- Global longitudinal strain imaging and its utility in assessing risk in early stages of hypertensionMani A. Global longitudinal strain imaging and its utility in assessing risk in early stages of hypertension. Journal Of Clinical Hypertension 2019, 21: 1711-1712. PMID: 31553521, PMCID: PMC8030360, DOI: 10.1111/jch.13703.
- Esteghamat F, Broughton JS, Smith E, Cardone R, Tyagi T, Guerra M, Szabó A, Ugwu N, Mani MV, Azari B, Kayingo G, Chung S, Fathzadeh M, Weiss E, Bender J, Mane S, Lifton RP, Adeniran A, Nathanson MH, Gorelick FS, Hwa J, Sahin-Tóth M, Belfort-DeAguiar R, Kibbey RG, Mani A. CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation. Nature Genetics 2019, 51: 1233-1243. PMID: 31358993, PMCID: PMC6675645, DOI: 10.1038/s41588-019-0470-3.
- Srivastava R, Rolyan H, Xie Y, Li N, Bhat N, Hong L, Esteghamat F, Adeniran A, Geirsson A, Zhang J, Ge G, Nobrega M, Martin KA, Mani A. TCF7L2 (Transcription Factor 7-Like 2) Regulation of GATA6 (GATA-Binding Protein 6)-Dependent and -Independent Vascular Smooth Muscle Cell Plasticity and Intimal Hyperplasia. Arteriosclerosis Thrombosis And Vascular Biology 2018, 39: 250-262. PMID: 30567484, PMCID: PMC6365015, DOI: 10.1161/atvbaha.118.311830.
- Abou Ziki M, Mani A. The interplay of canonical and noncanonical Wnt signaling in metabolic syndrome. Nutrition Research 2018, 70: 18-25. PMID: 30049588, PMCID: PMC6320319, DOI: 10.1016/j.nutres.2018.06.009.
- Mani A, Bhat N, Esteghamat S. Abstract 618: Identification of Novel Disease Genes for Metabolic Syndrome. Arteriosclerosis Thrombosis And Vascular Biology 2018, 38 DOI: 10.1161/atvb.38.suppl_1.618.
- Goetz TG, Mamillapalli R, Sahin C, Majidi-Zolbin M, Ge G, Mani A, Taylor HS. Addition of Estradiol to Cross-Sex Testosterone Therapy Reduces Atherosclerosis Plaque Formation in Female ApoE−/− Mice. Endocrinology 2017, 159: 754-762. PMID: 29253190, PMCID: PMC5774248, DOI: 10.1210/en.2017-00884.
- Hwangbo C, Wu J, Papangeli I, Adachi T, Sharma B, Park S, Zhao L, Ju H, Go GW, Cui G, Inayathullah M, Job JK, Rajadas J, Kwei SL, Li MO, Morrison AR, Quertermous T, Mani A, Red-Horse K, Chun HJ. Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin’s glucose-lowering effects. Science Translational Medicine 2017, 9 PMID: 28904225, PMCID: PMC5703224, DOI: 10.1126/scitranslmed.aad4000.
- Ziki M, Seidelmann SB, Smith E, Atteya G, Jiang Y, Fernandes RG, Marieb MA, Akar JG, Mani A. Deleterious protein‐altering mutations in the SCN10A voltage‐gated sodium channel gene are associated with prolonged QT. Clinical Genetics 2017, 93: 741-751. PMID: 28407228, PMCID: PMC5640462, DOI: 10.1111/cge.13036.
- Ziki M, Mani A. Wnt signaling, a novel pathway regulating blood pressure? State of the art review. Atherosclerosis 2017, 262: 171-178. PMID: 28522145, PMCID: PMC5508596, DOI: 10.1016/j.atherosclerosis.2017.05.001.
- Ziki M, Seidelmann S, Smith E, Narayanan A, Atteya G, Jiang Y, Gil-Fernandez R, Marieb M, Akar J, Mani A. DELETERIOUS MUTATIONS IN SCN10A ARE ASSOCIATED WITH LONG QT SYNDROME. Journal Of The American College Of Cardiology 2017, 69: 509. DOI: 10.1016/s0735-1097(17)33898-6.
- Seidelmann SB, Smith E, Subrahmanyan L, Dykas D, Abou Ziki MD, Azari B, Hannah-Shmouni F, Jiang Y, Akar JG, Marieb M, Jacoby D, Bale AE, Lifton RP, Mani A. Application of Whole Exome Sequencing in the Clinical Diagnosis and Management of Inherited Cardiovascular Diseases in Adults. Circulation Genomic And Precision Medicine 2017, 10: e001573. PMID: 28087566, PMCID: PMC5245580, DOI: 10.1161/circgenetics.116.001573.
- Li N, Subrahmanyan L, Smith E, Yu X, Zaidi S, Choi M, Mane S, Nelson-Williams C, Behjati M, Kazemi M, Hashemi M, Fathzadeh M, Narayanan A, Tian L, Montazeri F, Mani M, Begleiter ML, Coon BG, Lynch HT, Olson EN, Zhao H, Ruland J, Lifton RP, Mani A. Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus. American Journal Of Human Genetics 2016, 99: 1000. PMID: 27716515, PMCID: PMC5065682, DOI: 10.1016/j.ajhg.2016.09.003.
- Li N, Subrahmanyan L, Smith E, Yu X, Zaidi S, Choi M, Mane S, Nelson-Williams C, Behjati M, Kazemi M, Hashemi M, Fathzadeh M, Narayanan A, Tian L, Montazeri F, Mani M, Begleiter ML, Coon BG, Lynch HT, Olson EN, Zhao H, Ruland J, Lifton RP, Mani A. Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus. American Journal Of Human Genetics 2016, 98: 1082-1091. PMID: 27181681, PMCID: PMC4908195, DOI: 10.1016/j.ajhg.2016.03.022.
- Ziki M, Mani A. Metabolic syndrome. Current Opinion In Lipidology 2016, 27: 162-171. PMID: 26825138, PMCID: PMC5141383, DOI: 10.1097/mol.0000000000000276.
- Smith E, Mani A. CORONARY ARTERY DISSECTION IN EHLERS DANLOS SYNDROME. Journal Of The American College Of Cardiology 2016, 67: 1018. DOI: 10.1016/s0735-1097(16)31019-1.
- Ziki M, Smith E, Seidelmann S, Mani A. IMPORTIN 4 ACTS AS A GENETIC MODIFIER OF LAMIN A/C ARG644CYS MUTATION IN PREDISPOITION FOR PREMATURE CORONARY ARTERY DISEASE. Journal Of The American College Of Cardiology 2016, 67: 589. DOI: 10.1016/s0735-1097(16)30590-3.
- Srivastava R, Zhang J, Go GW, Narayanan A, Nottoli TP, Mani A. Impaired LRP6-TCF7L2 Activity Enhances Smooth Muscle Cell Plasticity and Causes Coronary Artery Disease. Cell Reports 2015, 13: 746-759. PMID: 26489464, PMCID: PMC4626307, DOI: 10.1016/j.celrep.2015.09.028.
- Wang S, Song K, Srivastava R, Fathzadeh M, Li N, Mani A. The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis. Journal Of Diabetes Research 2015, 2015: 468627. PMID: 26576435, PMCID: PMC4631899, DOI: 10.1155/2015/468627.
- Hannah-Shmouni F, Seidelmann SB, Sirrs S, Mani A, Jacoby D. The Genetic Challenges and Opportunities in Advanced Heart Failure. Canadian Journal Of Cardiology 2015, 31: 1338-1350. PMID: 26518444, PMCID: PMC5423787, DOI: 10.1016/j.cjca.2015.07.735.
- Martin KA, Mani MV, Mani A. New targets to treat obesity and the metabolic syndrome. European Journal Of Pharmacology 2015, 763: 64-74. PMID: 26001373, PMCID: PMC4573317, DOI: 10.1016/j.ejphar.2015.03.093.
- Fathzadeh M, Keramati A, Go G, Singh R, Sarajzadeh K, Tavakkoly-Bazzaz J, Noorafshan A, Kasaei M, Amini M, Omrani G, Babaee Bigi M, Babaei M, Hosseinian A, Malekzadeh R, Lifton R, Mani A. Abstract 20140: Minibrain Relate Kinase / Dyrk1B Links Skeletal Muscle Glycolytic Metabolism with Insulin Resistance and Causes Metabolic Syndrome. Circulation 2014, 130 DOI: 10.1161/circ.130.suppl_2.20140.
- Song K, Wang S, Mani M, Mani A. Wnt signaling, de novo lipogenesis, adipogenesis and ectopic fat. Oncotarget 2014, 5: 11000-11003. PMID: 25526027, PMCID: PMC4294374, DOI: 10.18632/oncotarget.2769.
- Song K, Wang S, Huang B, Luciano A, Srivastava R, Mani A. Plasma Cardiotrophin‐1 Levels are Associated With Hypertensive Heart Disease: A Meta‐Analysis. Journal Of Clinical Hypertension 2014, 16: 686-692. PMID: 25052897, PMCID: PMC4159421, DOI: 10.1111/jch.12376.
- Mani A, Alizadehasl A. Syndromic Congenital Heart Diseases. 2014, 65-69. DOI: 10.1007/978-1-4471-6383-1_10.
- Go GW, Srivastava R, Hernandez-Ono A, Gang G, Smith SB, Booth CJ, Ginsberg HN, Mani A. The Combined Hyperlipidemia Caused by Impaired Wnt-LRP6 Signaling Is Reversed by Wnt3a Rescue. Cell Metabolism 2014, 19: 209-220. PMID: 24506864, PMCID: PMC3920193, DOI: 10.1016/j.cmet.2013.11.023.
- Mani A, Go G, Ye Z, Singh R. Abstract 321: LRP6 Regulates LDL Receptor Internalization and LDL Uptake. Arteriosclerosis Thrombosis And Vascular Biology 2012, 32 DOI: 10.1161/atvb.32.suppl_1.a321.
- Liu W, Singh R, Choi C, Young L, Keramati A, Samuel V, Lifton R, Shulman G, Mani A. Abstract 140: LRP6 Influences Body Fat and Glucose Homeostasis in Mouse by Activating mTOR Pathway and Inhibiting Mitochondrial Energy Expenditure. Arteriosclerosis Thrombosis And Vascular Biology 2012, 32 DOI: 10.1161/atvb.32.suppl_1.a140.
- Khanna P, Mani A. Prevalence of Obesity and Traditional Cardiovascular Risk Factors in South Asians. Current Cardiovascular Risk Reports 2012, 6: 112-119. DOI: 10.1007/s12170-012-0220-x.
- Keramati AR, Singh R, Lin A, Faramarzi S, Ye ZJ, Mane S, Tellides G, Lifton RP, Mani A. Wild-type LRP6 inhibits, whereas atherosclerosis-linked LRP6R611C increases PDGF-dependent vascular smooth muscle cell proliferation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 1914-1918. PMID: 21245321, PMCID: PMC3033290, DOI: 10.1073/pnas.1019443108.
- Keramati A, Singh R, Liu W, Faramarzi S, Nottoli T, Tellides G, Mani A. W15 THE ANTIPROLIFERATIVE EFFECT OF LRP6 AND ITS IMPAIRMENT BY R611C MUTATION ARE MEDIATED BY INDEPENDENT INTERMEDIATES OF THE PDGF PATHWAY. Atherosclerosis Plus 2010, 11: 4. DOI: 10.1016/s1567-5688(10)70016-7.
- Keramati A, Liu W, Nottoli T, Faramarzi S, Tellides G, Mani A. Abstract 5464: The Cell Proliferative Effect of LRP6 Mutation is Mediated by Increased PDGF Dependent Cyclin D1 Expression. Circulation 2009, 120 DOI: 10.1161/circ.120.suppl_18.s1097.
- Friedman T, Mani A, Elefteriades JA. Bicuspid aortic valve: clinical approach and scientific review of a common clinical entity. Expert Review Of Cardiovascular Therapy 2008, 6: 235-248. PMID: 18248277, DOI: 10.1586/14779072.6.2.235.
- Mani S, Moradi A, Abdolahi N, Martel M, Semnani S, Glazer P, Mani A. The Aberrant Expression of Beta-catenin in Esophageal Squamous Cell Cancer (ESCC) in Northeastern Iran. International Journal Of Radiation Oncology • Biology • Physics 2007, 69: s309-s310. DOI: 10.1016/j.ijrobp.2007.07.1366.
- KARNE S, MANI A, KOLODECIK T, GORELICK F, CT H. In vivo cerulein hyperstimulation of rat pancreas is associated with redistribution of the cation-independent mannose 6-phoshate receptor. Gastroenterology 2001, 120: a719-a719. DOI: 10.1016/s0016-5085(01)83579-4.
- Karne S, Mani A, Kolodecik T, Gorelick F, Haven C. In vivo cerulein hyperstimulation of rat pancreas is associated with redistribution of the cation-independent mannose 6-phoshate receptor. Gastroenterology 2001, 120: a719. DOI: 10.1016/s0016-5085(08)83579-2.
- Nathanson MH, Burgstahler AD, Orloff JJ, Mani A, Moyer MS. Mechanism of desensitization of the cloned vasopressin V1a receptor expressed in Xenopus oocytes. American Journal Of Physiology 1994, 267: c94-c103. PMID: 8048495, DOI: 10.1152/ajpcell.1994.267.1.c94.
- Yale Nuclear CardiologyYale New Haven Hospital20 York StreetNew Haven, CT 06510
- Yale CardiologyYale Physicians Building800 Howard Avenue, Ste 2nd floorNew Haven, CT 06519
- Yale Nuclear CardiologyYale New Haven Hospital20 York StreetNew Haven, CT 06510
- Yale CardiologyYale Physicians Building800 Howard Avenue, Ste 2nd floorNew Haven, CT 06519