Angelique W. Levi, MD
Biography
According to Angelique Levi, MD, Vice Chair and Director of Pathology Reference Services, a pathologist who specializes in cervical diseases and prostate cancer, “the pathologist is the most important doctor you will likely never meet.” That is because pathologists spend their time examining patients with a microscope—not a stethoscope. As a doctor, a pathologist is trained to give diagnoses based upon the appearance of patients' cells or tissue under a high-powered microscope.
“First and foremost, a pathologist’s responsibility to a patient is to arrive at a correct diagnosis,” Dr. Levi says. “The second part is to communicate those results accurately to the treating physician.”
Dr. Levi is skilled in cytopathology, a diagnostic technique that relies on the examination of individual cells in a patient sample, whether from an aspiration/biopsy, smear, or body fluid. For example, cytopathology is used to examine cells from a woman’s Pap smear. This type of examination can also be done on samples collected by fine-needle aspiration and allows for the unique opportunity to perform many additional molecular tests from a single fluid sample. Two examples include high-risk human papilloma virus (HPV) DNA testing from a Pap smear and flow cytometry testing to evaluate for lymphoma. Dr. Levi has extensive experience with cervical disease, HPV, and prostate cancer.
As a fourth-year medical student, Dr. Levi took a pathology course and found herself captivated by the subject. “I’ve always been a visual learner and person by nature,” she says. “Even when I’m not thinking about diseases, I enjoy scanning slides and looking at histology (the study of the structure of cells and tissues).” As an associate professor of pathology at Yale School of Medicine, Dr. Levi conducts clinical based research and is involved with clinical trials related to HPV-related cervical disease and MRI-targeted prostate cancer. She has also been a participant in the Yale School of Management Emerging Physician Leaders program.
Titles
- Associate Professor of Pathology
- Vice Chair of Operations and Director of Pathology Reference Services, Pathology
- CLIA Laboratory Medical Director, Pathology
- Affiliated Faculty, Yale Institute for Global Health
Education & Training
- FellowJohns Hopkins Hospital (2002)
- ResidentJohns Hopkins Hospital (2001)
- MDUniv of Rochester School of Medicine & Dentistry (1997)
Languages Spoken
- English
Additional Information
- AB of Pathology, Cytopathology (2003)
- AB of Pathology, Anatomic & Clinical Pathology (2002)
- Takeda K, Adeniran A, Levi A, Tang H, Cai G. Cytomorphological characteristics of low‐grade papillary urothelial carcinoma in voided urine samples: Distinction from benign and high‐grade papillary urothelial carcinoma. Cytopathology 2024 PMID: 38992916, DOI: 10.1111/cyt.13413.
- Sheth S, Oh J, Bellone S, Siegel E, Greenman M, Mutlu L, McNamara B, Pathy S, Clark M, Azodi M, Altwerger G, Andikyan V, Huang G, Ratner E, Kim D, Iwasaki A, Levi A, Buza N, Hui P, Flaherty S, Schwartz P, Santin A. Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147). Clinical Cancer Research 2024, 30: of1-of10. PMID: 38592381, DOI: 10.1158/1078-0432.ccr-23-3639.
- Khajir G, Sun T, Wang H, Sprenkle P, Adeniran A, Cai G, Levi A. Cytologic evaluation of upper urinary tract specimens: An institutional retrospective study using The Paris System for Reporting Urine Cytology second edition with histopathologic follow‐up. Cytopathology 2023, 35: 235-241. PMID: 37916579, DOI: 10.1111/cyt.13328.
- Paulson N, Zeevi T, Papademetris M, Leapman MS, Onofrey JA, Sprenkle PC, Humphrey PA, Staib LH, Levi AW. Prediction of Adverse Pathology at Radical Prostatectomy in Grade Group 2 and 3 Prostate Biopsies Using Machine Learning. JCO Clinical Cancer Informatics 2022, 6: e2200016. PMID: 36179281, DOI: 10.1200/cci.22.00016.
- Khajir G, Kumar D, Rahman S, Leapman M, Levi A, Humphrey P, Sprenkle P. MP45-09 DISCRIMINATIVE SIGNIFICANCE OF PROSTATE BIOPSY DECIPHER SCORE TO PREDICT ADVERSE PATHOLOGY AND PATHOLOGICAL DISCORDANCE AT RADICAL PROSTATECTOMY. Journal Of Urology 2022, 207: e765. DOI: 10.1097/ju.0000000000002611.09.
- Khajir G, Press B, Levi A, Sprenkle P, Leapman M. Distribution of NCCN risk classifications using MRI-ultrasound fusion versus systematic 12 core biopsies. Journal Of Clinical Oncology 2022, 40: 283-283. DOI: 10.1200/jco.2022.40.6_suppl.283.
- Wibmer AG, Kattan MW, Alessandrino F, Baur ADJ, Boesen L, Franco FB, Bonekamp D, Campa R, Cash H, Catalá V, Crouzet S, Dinnoo S, Eastham J, Fennessy FM, Ghabili K, Hohenfellner M, Levi AW, Ji X, Løgager V, Margolis DJ, Moldovan PC, Panebianco V, Penzkofer T, Puech P, Radtke JP, Rouvière O, Schlemmer HP, Sprenkle PC, Tempany CM, Vilanova JC, Weinreb J, Hricak H, Shukla-Dave A. International Multi-Site Initiative to Develop an MRI-Inclusive Nomogram for Side-Specific Prediction of Extraprostatic Extension of Prostate Cancer. Cancers 2021, 13: 2627. PMID: 34071842, PMCID: PMC8198352, DOI: 10.3390/cancers13112627.
- Paulson N, Vollmer RT, Humphrey PA, Sprenkle PC, Onofrey J, Huber S, Amirkhiz K, Levi AW. Extent of High-Grade Prostatic Adenocarcinoma in Multiparametric Magnetic Resonance Imaging-Targeted Biopsy Enhances Prediction of Pathologic Stage. Archives Of Pathology & Laboratory Medicine 2021, 146: 201-204. PMID: 34015819, DOI: 10.5858/arpa.2020-0568-oa.
- Perincheri S, Levi AW, Celli R, Gershkovich P, Rimm D, Morrow JS, Rothrock B, Raciti P, Klimstra D, Sinard J. An independent assessment of an artificial intelligence system for prostate cancer detection shows strong diagnostic accuracy. Modern Pathology 2021, 34: 1588-1595. PMID: 33782551, PMCID: PMC8295034, DOI: 10.1038/s41379-021-00794-x.
- Zuo T, Levi AW, Lin Q, Abi-Raad R, Adeniran AJ, Cai G. High-Risk Human Papillomavirus Testing, Genotyping, and Histopathologic Follow-up in Women With Abnormal Glandular Cells on Papanicolaou Tests. American Journal Of Clinical Pathology 2021, 156: 569-576. PMID: 33728437, DOI: 10.1093/ajcp/aqaa265.
- Ghabili K, Paulson N, Syed JS, Nawaf CB, Khajir G, Martin DT, Onofrey J, Leapman MS, Levi A, Weinreb JC, Humphrey PA, Sprenkle PC. Doubling of Decipher Biopsy Genomic Score Is Related to Disease Reclassification on Subsequent Surveillance Biopsy but Not Adverse Features on Radical Prostatectomy. Case Reports In Urology 2021, 2021: 2687416. PMID: 33936831, PMCID: PMC8054861, DOI: 10.1155/2021/2687416.
- Morrow JS, Gershkovich P, Gibson J, Gilshannon M, Kowalski D, Levi AW, Nguyen DX, Rimm DL, Xu ML, Sinard J. Measuring Faculty Effort: A Quantitative Approach That Aligns Personal and Institutional Goals in Pathology at Yale. Academic Pathology 2021, 8: 23742895211047985. PMID: 34646939, PMCID: PMC8504692, DOI: 10.1177/23742895211047985.
- Gilani SM, Levi A. Fine needle aspiration cytology of a neck mass. Cytopathology 2020, 31: 622-623. PMID: 32569432, DOI: 10.1111/cyt.12878.
- Levi A, Cai G. Economics, Regulations, and Trends in Practice. 2019, 407-412. DOI: 10.1007/978-3-030-21799-0_15.
- Martin D, Ghabili* K, Levi A, Humphrey P, Schulam P, Sprenkle P. PD11-11 DECIPHER BIOPSY GENOMIC TEST RELATED TO GLEASON GRADE GROUP INDEPENDENT OF PROSTATE IMAGING REPORTING AND DATA SYSTEM VERSION 2. Journal Of Urology 2019, 201 DOI: 10.1097/01.ju.0000555367.28091.c8.
- Martin DT, Ghabili K, Levi A, Humphrey PA, Sprenkle PC. Prostate Cancer Genomic Classifier Relates More Strongly to Gleason Grade Group Than Prostate Imaging Reporting and Data System Score in Multiparametric Prostate Magnetic Resonance Imaging-ultrasound Fusion Targeted Biopsies. Urology 2018, 125: 64-72. PMID: 30552940, DOI: 10.1016/j.urology.2018.12.001.
- Syed JS, Nguyen KA, Nawaf CB, Bhagat AM, Huber S, Levi A, Humphrey P, Weinreb JC, Schulam PG, Sprenkle PC. Prostate zonal anatomy correlates with the detection of prostate cancer on multiparametric magnetic resonance imaging/ultrasound fusion–targeted biopsy in patients with a solitary PI-RADS v2–scored lesion. Urologic Oncology Seminars And Original Investigations 2017, 35: 542.e19-542.e24. PMID: 28501565, DOI: 10.1016/j.urolonc.2017.04.011.
- Lu AJ, Syed JS, Nguyen KA, Nawaf CB, Rosoff J, Spektor M, Levi A, Humphrey PA, Weinreb JC, Schulam PG, Sprenkle PC. Negative Multiparametric Magnetic Resonance Imaging of the Prostate Predicts Absence of Clinically Significant Prostate Cancer on 12-Core Template Prostate Biopsy. Urology 2017, 105: 118-122. PMID: 28322902, DOI: 10.1016/j.urology.2017.01.048.
- Syed J, Javier-desloges J, Nguyen K, Sheridan A, Levi A, Weinreb J, Sprenkle P. The positive predictive value of PI-RADS 4 lesions stratified by lesion number in biopsy naïve men. Journal Of Clinical Oncology 2017, 35: 29-29. DOI: 10.1200/jco.2017.35.6_suppl.29.
- Nawaf C, Rosoff J, Weinreb J, Humphrey P, Levi A, Huber S, Sprenkle P. MP15-17 MP-MRI UPGRADES MEN WHO HAVE HAD A BIOPSY SHOWING PRIOR CANCER. Journal Of Urology 2016, 195: e158. DOI: 10.1016/j.juro.2016.02.2541.
- Lu A, Nawaf C, Rosoff J, Weinreb J, Humphrey P, Levi A, Huber S, Sprenkle P. PD15-11 SHOULD WE STILL BIOPSY NEGATIVE MP-MRIS? Journal Of Urology 2016, 195: e393. DOI: 10.1016/j.juro.2016.02.1137.
- Levi AW, Bernstein JI, Hui P, Duch K, Schofield K, Chhieng DC. A Comparison of the Roche Cobas HPV Test With the Hybrid Capture 2 Test for the Detection of High-Risk Human Papillomavirus Genotypes. Archives Of Pathology & Laboratory Medicine 2016, 140: 153-7. PMID: 26910220, DOI: 10.5858/arpa.2015-0027-oa.
- Lu A, Nawaf C, Weinreb J, Rosoff J, Schulam P, Humphrey P, Levi A, Sprenkle P. Prostate cancer detection rates of negative MP-MRIs. Journal Of Clinical Oncology 2016, 34: 91-91. DOI: 10.1200/jco.2016.34.2_suppl.91.
- Nawaf C, Lu A, Rosoff J, Weinreb J, Schulam P, Humphrey P, Levi A, Sprenkle P. MRI-US fusion targeted biopsy results in patients with a history of a prior negative biopsy. Journal Of Clinical Oncology 2016, 34: 90-90. DOI: 10.1200/jco.2016.34.2_suppl.90.
- Nawaf C, Rosoff J, Lu A, Weinreb J, Humphrey P, Levi A, Schulam P, Sprenkle P. MRI-US fusion targeted biopsy results in men with a history of prior cancer. Journal Of Clinical Oncology 2016, 34: 88-88. DOI: 10.1200/jco.2016.34.2_suppl.88.
- Nawaf C, Rosoff J, Weinreb J, Lu A, Levi A, Humphrey P, Schulam P, Sprenkle P. MRI-US fusion targeted biopsy results in patients without history of prostate biopsy. Journal Of Clinical Oncology 2016, 34: 150-150. DOI: 10.1200/jco.2016.34.2_suppl.150.
- Baldassarri R, Aronberg R, Levi AW, Yarbrough WG, Kowalski D, Chhieng D. Detection and Genotype of High-Risk Human Papillomavirus in Fine-Needle Aspirates of Patients With Metastatic Squamous Cell Carcinoma Is Helpful in Determining Tumor Origin. American Journal Of Clinical Pathology 2015, 143: 694-700. PMID: 25873503, DOI: 10.1309/ajcpcza4pszcfhq4.
- Wong R, Aronberg R, Levi A, Yarbrough W, Kowalski D, Chhieng D. Detection and Genotype of High Risk Human Papillomavirus in Fine Needle Aspirates of Patients with Metastatic Squamous Cell Carcinoma is Helpful in Determining Tumor Origin. Journal Of The American Society Of Cytopathology 2014, 3: s49-s50. DOI: 10.1016/j.jasc.2014.09.109.
- Snir O, Baldassarri R, Levi A, Schofield K, Kowalski D, Chhieng D. Human Papillomavirus Testing Using Hybrid Capture II and Cobas 4800 with ThinPrep and SurePath Preparations in Gynecologic Cytology. Journal Of The American Society Of Cytopathology 2014, 3: s43. DOI: 10.1016/j.jasc.2014.09.095.
- Bernstein J, Chhieng D, Levi A. What Would We Miss if HR-HPV Testing Was Used for Primary Cervical Cancer Screening. Journal Of The American Society Of Cytopathology 2014, 3: s37. DOI: 10.1016/j.jasc.2014.09.079.
- Brandsma JL, Harigopal M, Kiviat NB, Sun Y, Deng Y, Zelterman D, Lizardi PM, Shabanova VS, Levi A, Yaping T, Hu X, Feng Q. Methylation of Twelve CpGs in Human Papillomavirus Type 16 (HPV16) as an Informative Biomarker for the Triage of Women Positive for HPV16 Infection. Cancer Prevention Research 2014, 7: 526-533. PMID: 24556390, DOI: 10.1158/1940-6207.capr-13-0354.
- Zhao C, Li Z, Nayar R, Levi AW, Winkler BA, Moriarty AT, Barkan GA, Rao J, Miller F, Fan F, Zhou Z, Si Q, Fischer AH, Sturgis CD, Jing X, Marshall CB, Witt BL, Birdsong GG, Crothers BA. Prior High-Risk Human Papillomavirus Testing and Papanicolaou Test Results of 70 Invasive Cervical Carcinomas Diagnosed in 2012: Results of a Retrospective Multicenter Study. Archives Of Pathology & Laboratory Medicine 2014, 139: 184-8. PMID: 24694342, DOI: 10.5858/arpa.2014-0028-oa.
- Zhao C, Nayar R, Levi A, Winkler B, Moriarty A, Barkan G, Li Z, Rao J, Miller F, Fan F, Si Q, Fischer A, Sturgis C, Jing X, Marshall C, Witt B, Crothers B. Prior High-Risk HPV Testing and Pap Test Results of 58 Invasive Cervical Carcinomas Diagnosed in 2012. Journal Of The American Society Of Cytopathology 2013, 2: s3-s4. DOI: 10.1016/j.jasc.2013.08.004.
- Harigopal M, Sun Y, Chen X, Levi A, Brandsma J. HPV16 DNA Methylation Analysis for Improved Triage of Atypical Squamous Cell of Undetermined Significance (ASCUS). Journal Of The American Society Of Cytopathology 2013, 2: s45. DOI: 10.1016/j.jasc.2013.08.121.
- Levi A, Schofield K, Harigopal M, Chhieng D. High-risk HPV Testing in the Detection of Cervical Carcinoma using Liquid-based Preparations. Journal Of The American Society Of Cytopathology 2013, 2: s33. DOI: 10.1016/j.jasc.2013.08.090.
- Levi AW, Galullo P, Gordy K, Mikolaiski N, Schofield K, Elsheikh TM, Harigopal M, Chhieng DC. Increasing Cytotechnologist Workload Above 100 Slides per Day Using the BD FocalPoint GS Imaging System Negatively Affects Screening Performance. American Journal Of Clinical Pathology 2012, 138: 811-815. PMID: 23161714, DOI: 10.1309/ajcptydd9g2ncumf.
- Abiraad R, Schofield K, Harigopal M, Chhieng D, Levi A. Value of 3q26 Gain in the Triage of Low-grade Squamous Abnormalities. Journal Of The American Society Of Cytopathology 2012, 1: s46. DOI: 10.1016/j.jasc.2012.08.101.
- Honarpisheh H, Schofield K, Harigopal M, Chhieng D, Levi A. Accuracy of FocalPoint GS Imaging: Can We Trust the System? Journal Of The American Society Of Cytopathology 2012, 1: s47. DOI: 10.1016/j.jasc.2012.08.103.
- Wong R, Schofield K, Harigopal M, Ratner E, Chhieng D, Levi A. Effectiveness of the FocalPoint GS Imaging System in the Detection of Adenocarcinoma of the Gynecologic System. Journal Of The American Society Of Cytopathology 2012, 1: s34. DOI: 10.1016/j.jasc.2012.08.072.
- Levi AW, Beckman D, Hui P, Schofield K, Harigopal M, Chhieng DC. Comparing Two Methods of Detection for Chlamydia trachomatis in Liquid-Based Papanicolaou Tests. American Journal Of Clinical Pathology 2012, 138: 236-240. PMID: 22904135, DOI: 10.1309/ajcp2b7xqtcnamjp.
- Wong R, Levi AW, Harigopal M, Schofield K, Chhieng DC. The Positive Impact of Simultaneous Implementation of the BD FocalPoint GS Imaging System and Lean Principles on the Operation of Gynecologic Cytology. Archives Of Pathology & Laboratory Medicine 2012, 136: 183-9. PMID: 22288966, DOI: 10.5858/arpa.2011-0139-oa.
- Levi AW, Chhieng DC, Schofield K, Kowalski D, Harigopal M. Implementation of FocalPoint GS location‐guided imaging system. Cancer Cytopathology 2011, 120: 126-133. PMID: 22505211, DOI: 10.1002/cncy.20187.
- Levi AW, Harigopal M, Hui P, Schofield K, Chhieng DC. Use of high‐risk human papillomavirus testing in patients with low‐grade squamous intraepithelial lesions. Cancer Cytopathology 2011, 119: 228-234. PMID: 21732551, DOI: 10.1002/cncy.20172.
- Levi AW, Harigopal M, Hui P, Schofield K, Chhieng DC. Comparison of Affirm VPIII and Papanicolaou Tests in the Detection of Infectious Vaginitis. American Journal Of Clinical Pathology 2011, 135: 442-447. PMID: 21350100, DOI: 10.1309/ajcp7tbn5vzuglzu.
- Panda B, Stiller R, Iruretagoyena I, Levi A. Prenatal diagnosis of an umbilical vein aneurysm: a case report. Connecticut Medicine 2009, 73: 465-7. PMID: 19777980.
- Parwani A, Levi A, Epstein J, Ali S. Urinary Bladder Biopsy With Denuded Mucosa: Denuding Cystitis-Cytopathologic Correlates. Journal Of Urology 2006, 175: 572. DOI: 10.1016/s0022-5347(05)00191-6.
- Parwani AV, Levi AW, Epstein JI, Ali SZ. Urinary bladder biopsy with denuded mucosa: Denuding cystitis—Cytopathologic correlates. Diagnostic Cytopathology 2004, 30: 297-300. PMID: 15108225, DOI: 10.1002/dc.10406.
- Levi AW, Kelly DP, Rosenthal DL, Ronnett BM. Atypical squamous cells of undetermined significance in liquid‐based cytologic specimens. Cancer 2003, 99: 191-197. PMID: 12925979, DOI: 10.1002/cncr.11507.
- Chan TY, Parwani AV, Levi AW, Ali SZ. Mollaret's meningitis: Cytopathologic analysis of fourteen cases. Diagnostic Cytopathology 2003, 28: 227-231. PMID: 12722116, DOI: 10.1002/dc.10261.
- Sehdev A, Levi A, Nadasdy T, Campbell K, Fishman E, Hruban R. The pigmented “black” neuroendocrine tumor of the pancreas. Cancer 2001, 92: 1984-1991. PMID: 11745274, DOI: 10.1002/1097-0142(20011001)92:7<1984::aid-cncr1718>3.0.co;2-0.
- LEVI A, POTTER S, SCHOENBERG M, EPSTEIN J. CLINICAL SIGNIFICANCE OF DENUDED UROTHELIUM IN BLADDER BIOPSY. Journal Of Urology 2001, 166: 457-460. DOI: 10.1097/00005392-200108000-00013.
- LEVI A, POTTER S, SCHOENBERG M, EPSTEIN J. CLINICAL SIGNIFICANCE OF DENUDED UROTHELIUM IN BLADDER BIOPSY. Journal Of Urology 2001, 166: 457-460. PMID: 11458047, DOI: 10.1016/s0022-5347(05)65963-0.
- Nguyen C, Levi A, Montz F, Bristow R. Coexistent Choriocarcinoma and Malignant Mixed Mesodermal Tumor of the Uterus. Gynecologic Oncology 2000, 79: 499-503. PMID: 11104628, DOI: 10.1006/gyno.2000.5976.
- Levi A, Epstein J. Pseudohyperplastic Prostatic Adenocarcinoma on Needle Biopsy and Simple Prostatectomy. The American Journal Of Surgical Pathology 2000, 24: 1039-1046. PMID: 10935644, DOI: 10.1097/00000478-200008000-00001.
- Wolf AN, Ladanyi M, Paull G, Blaugrund JE, Westra WH. The expanding clinical spectrum of desmoplastic small round-cell tumor: a report of two cases with molecular confirmation. Hum Pathol 1999, 30: 430-5. PMID: 10208465, DOI: 10.1016/s0046-8177(99)90119-3.
Biography
According to Angelique Levi, MD, Vice Chair and Director of Pathology Reference Services, a pathologist who specializes in cervical diseases and prostate cancer, “the pathologist is the most important doctor you will likely never meet.” That is because pathologists spend their time examining patients with a microscope—not a stethoscope. As a doctor, a pathologist is trained to give diagnoses based upon the appearance of patients' cells or tissue under a high-powered microscope.
“First and foremost, a pathologist’s responsibility to a patient is to arrive at a correct diagnosis,” Dr. Levi says. “The second part is to communicate those results accurately to the treating physician.”
Dr. Levi is skilled in cytopathology, a diagnostic technique that relies on the examination of individual cells in a patient sample, whether from an aspiration/biopsy, smear, or body fluid. For example, cytopathology is used to examine cells from a woman’s Pap smear. This type of examination can also be done on samples collected by fine-needle aspiration and allows for the unique opportunity to perform many additional molecular tests from a single fluid sample. Two examples include high-risk human papilloma virus (HPV) DNA testing from a Pap smear and flow cytometry testing to evaluate for lymphoma. Dr. Levi has extensive experience with cervical disease, HPV, and prostate cancer.
As a fourth-year medical student, Dr. Levi took a pathology course and found herself captivated by the subject. “I’ve always been a visual learner and person by nature,” she says. “Even when I’m not thinking about diseases, I enjoy scanning slides and looking at histology (the study of the structure of cells and tissues).” As an associate professor of pathology at Yale School of Medicine, Dr. Levi conducts clinical based research and is involved with clinical trials related to HPV-related cervical disease and MRI-targeted prostate cancer. She has also been a participant in the Yale School of Management Emerging Physician Leaders program.
Titles
- Associate Professor of Pathology
- Vice Chair of Operations and Director of Pathology Reference Services, Pathology
- CLIA Laboratory Medical Director, Pathology
- Affiliated Faculty, Yale Institute for Global Health
Education & Training
- FellowJohns Hopkins Hospital (2002)
- ResidentJohns Hopkins Hospital (2001)
- MDUniv of Rochester School of Medicine & Dentistry (1997)
Languages Spoken
- English
Additional Information
- AB of Pathology, Cytopathology (2003)
- AB of Pathology, Anatomic & Clinical Pathology (2002)
- Takeda K, Adeniran A, Levi A, Tang H, Cai G. Cytomorphological characteristics of low‐grade papillary urothelial carcinoma in voided urine samples: Distinction from benign and high‐grade papillary urothelial carcinoma. Cytopathology 2024 PMID: 38992916, DOI: 10.1111/cyt.13413.
- Sheth S, Oh J, Bellone S, Siegel E, Greenman M, Mutlu L, McNamara B, Pathy S, Clark M, Azodi M, Altwerger G, Andikyan V, Huang G, Ratner E, Kim D, Iwasaki A, Levi A, Buza N, Hui P, Flaherty S, Schwartz P, Santin A. Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147). Clinical Cancer Research 2024, 30: of1-of10. PMID: 38592381, DOI: 10.1158/1078-0432.ccr-23-3639.
- Khajir G, Sun T, Wang H, Sprenkle P, Adeniran A, Cai G, Levi A. Cytologic evaluation of upper urinary tract specimens: An institutional retrospective study using The Paris System for Reporting Urine Cytology second edition with histopathologic follow‐up. Cytopathology 2023, 35: 235-241. PMID: 37916579, DOI: 10.1111/cyt.13328.
- Paulson N, Zeevi T, Papademetris M, Leapman MS, Onofrey JA, Sprenkle PC, Humphrey PA, Staib LH, Levi AW. Prediction of Adverse Pathology at Radical Prostatectomy in Grade Group 2 and 3 Prostate Biopsies Using Machine Learning. JCO Clinical Cancer Informatics 2022, 6: e2200016. PMID: 36179281, DOI: 10.1200/cci.22.00016.
- Khajir G, Kumar D, Rahman S, Leapman M, Levi A, Humphrey P, Sprenkle P. MP45-09 DISCRIMINATIVE SIGNIFICANCE OF PROSTATE BIOPSY DECIPHER SCORE TO PREDICT ADVERSE PATHOLOGY AND PATHOLOGICAL DISCORDANCE AT RADICAL PROSTATECTOMY. Journal Of Urology 2022, 207: e765. DOI: 10.1097/ju.0000000000002611.09.
- Khajir G, Press B, Levi A, Sprenkle P, Leapman M. Distribution of NCCN risk classifications using MRI-ultrasound fusion versus systematic 12 core biopsies. Journal Of Clinical Oncology 2022, 40: 283-283. DOI: 10.1200/jco.2022.40.6_suppl.283.
- Wibmer AG, Kattan MW, Alessandrino F, Baur ADJ, Boesen L, Franco FB, Bonekamp D, Campa R, Cash H, Catalá V, Crouzet S, Dinnoo S, Eastham J, Fennessy FM, Ghabili K, Hohenfellner M, Levi AW, Ji X, Løgager V, Margolis DJ, Moldovan PC, Panebianco V, Penzkofer T, Puech P, Radtke JP, Rouvière O, Schlemmer HP, Sprenkle PC, Tempany CM, Vilanova JC, Weinreb J, Hricak H, Shukla-Dave A. International Multi-Site Initiative to Develop an MRI-Inclusive Nomogram for Side-Specific Prediction of Extraprostatic Extension of Prostate Cancer. Cancers 2021, 13: 2627. PMID: 34071842, PMCID: PMC8198352, DOI: 10.3390/cancers13112627.
- Paulson N, Vollmer RT, Humphrey PA, Sprenkle PC, Onofrey J, Huber S, Amirkhiz K, Levi AW. Extent of High-Grade Prostatic Adenocarcinoma in Multiparametric Magnetic Resonance Imaging-Targeted Biopsy Enhances Prediction of Pathologic Stage. Archives Of Pathology & Laboratory Medicine 2021, 146: 201-204. PMID: 34015819, DOI: 10.5858/arpa.2020-0568-oa.
- Perincheri S, Levi AW, Celli R, Gershkovich P, Rimm D, Morrow JS, Rothrock B, Raciti P, Klimstra D, Sinard J. An independent assessment of an artificial intelligence system for prostate cancer detection shows strong diagnostic accuracy. Modern Pathology 2021, 34: 1588-1595. PMID: 33782551, PMCID: PMC8295034, DOI: 10.1038/s41379-021-00794-x.
- Zuo T, Levi AW, Lin Q, Abi-Raad R, Adeniran AJ, Cai G. High-Risk Human Papillomavirus Testing, Genotyping, and Histopathologic Follow-up in Women With Abnormal Glandular Cells on Papanicolaou Tests. American Journal Of Clinical Pathology 2021, 156: 569-576. PMID: 33728437, DOI: 10.1093/ajcp/aqaa265.
- Ghabili K, Paulson N, Syed JS, Nawaf CB, Khajir G, Martin DT, Onofrey J, Leapman MS, Levi A, Weinreb JC, Humphrey PA, Sprenkle PC. Doubling of Decipher Biopsy Genomic Score Is Related to Disease Reclassification on Subsequent Surveillance Biopsy but Not Adverse Features on Radical Prostatectomy. Case Reports In Urology 2021, 2021: 2687416. PMID: 33936831, PMCID: PMC8054861, DOI: 10.1155/2021/2687416.
- Morrow JS, Gershkovich P, Gibson J, Gilshannon M, Kowalski D, Levi AW, Nguyen DX, Rimm DL, Xu ML, Sinard J. Measuring Faculty Effort: A Quantitative Approach That Aligns Personal and Institutional Goals in Pathology at Yale. Academic Pathology 2021, 8: 23742895211047985. PMID: 34646939, PMCID: PMC8504692, DOI: 10.1177/23742895211047985.
- Gilani SM, Levi A. Fine needle aspiration cytology of a neck mass. Cytopathology 2020, 31: 622-623. PMID: 32569432, DOI: 10.1111/cyt.12878.
- Levi A, Cai G. Economics, Regulations, and Trends in Practice. 2019, 407-412. DOI: 10.1007/978-3-030-21799-0_15.
- Martin D, Ghabili* K, Levi A, Humphrey P, Schulam P, Sprenkle P. PD11-11 DECIPHER BIOPSY GENOMIC TEST RELATED TO GLEASON GRADE GROUP INDEPENDENT OF PROSTATE IMAGING REPORTING AND DATA SYSTEM VERSION 2. Journal Of Urology 2019, 201 DOI: 10.1097/01.ju.0000555367.28091.c8.
- Martin DT, Ghabili K, Levi A, Humphrey PA, Sprenkle PC. Prostate Cancer Genomic Classifier Relates More Strongly to Gleason Grade Group Than Prostate Imaging Reporting and Data System Score in Multiparametric Prostate Magnetic Resonance Imaging-ultrasound Fusion Targeted Biopsies. Urology 2018, 125: 64-72. PMID: 30552940, DOI: 10.1016/j.urology.2018.12.001.
- Syed JS, Nguyen KA, Nawaf CB, Bhagat AM, Huber S, Levi A, Humphrey P, Weinreb JC, Schulam PG, Sprenkle PC. Prostate zonal anatomy correlates with the detection of prostate cancer on multiparametric magnetic resonance imaging/ultrasound fusion–targeted biopsy in patients with a solitary PI-RADS v2–scored lesion. Urologic Oncology Seminars And Original Investigations 2017, 35: 542.e19-542.e24. PMID: 28501565, DOI: 10.1016/j.urolonc.2017.04.011.
- Lu AJ, Syed JS, Nguyen KA, Nawaf CB, Rosoff J, Spektor M, Levi A, Humphrey PA, Weinreb JC, Schulam PG, Sprenkle PC. Negative Multiparametric Magnetic Resonance Imaging of the Prostate Predicts Absence of Clinically Significant Prostate Cancer on 12-Core Template Prostate Biopsy. Urology 2017, 105: 118-122. PMID: 28322902, DOI: 10.1016/j.urology.2017.01.048.
- Syed J, Javier-desloges J, Nguyen K, Sheridan A, Levi A, Weinreb J, Sprenkle P. The positive predictive value of PI-RADS 4 lesions stratified by lesion number in biopsy naïve men. Journal Of Clinical Oncology 2017, 35: 29-29. DOI: 10.1200/jco.2017.35.6_suppl.29.
- Nawaf C, Rosoff J, Weinreb J, Humphrey P, Levi A, Huber S, Sprenkle P. MP15-17 MP-MRI UPGRADES MEN WHO HAVE HAD A BIOPSY SHOWING PRIOR CANCER. Journal Of Urology 2016, 195: e158. DOI: 10.1016/j.juro.2016.02.2541.
- Lu A, Nawaf C, Rosoff J, Weinreb J, Humphrey P, Levi A, Huber S, Sprenkle P. PD15-11 SHOULD WE STILL BIOPSY NEGATIVE MP-MRIS? Journal Of Urology 2016, 195: e393. DOI: 10.1016/j.juro.2016.02.1137.
- Levi AW, Bernstein JI, Hui P, Duch K, Schofield K, Chhieng DC. A Comparison of the Roche Cobas HPV Test With the Hybrid Capture 2 Test for the Detection of High-Risk Human Papillomavirus Genotypes. Archives Of Pathology & Laboratory Medicine 2016, 140: 153-7. PMID: 26910220, DOI: 10.5858/arpa.2015-0027-oa.
- Lu A, Nawaf C, Weinreb J, Rosoff J, Schulam P, Humphrey P, Levi A, Sprenkle P. Prostate cancer detection rates of negative MP-MRIs. Journal Of Clinical Oncology 2016, 34: 91-91. DOI: 10.1200/jco.2016.34.2_suppl.91.
- Nawaf C, Lu A, Rosoff J, Weinreb J, Schulam P, Humphrey P, Levi A, Sprenkle P. MRI-US fusion targeted biopsy results in patients with a history of a prior negative biopsy. Journal Of Clinical Oncology 2016, 34: 90-90. DOI: 10.1200/jco.2016.34.2_suppl.90.
- Nawaf C, Rosoff J, Lu A, Weinreb J, Humphrey P, Levi A, Schulam P, Sprenkle P. MRI-US fusion targeted biopsy results in men with a history of prior cancer. Journal Of Clinical Oncology 2016, 34: 88-88. DOI: 10.1200/jco.2016.34.2_suppl.88.
- Nawaf C, Rosoff J, Weinreb J, Lu A, Levi A, Humphrey P, Schulam P, Sprenkle P. MRI-US fusion targeted biopsy results in patients without history of prostate biopsy. Journal Of Clinical Oncology 2016, 34: 150-150. DOI: 10.1200/jco.2016.34.2_suppl.150.
- Baldassarri R, Aronberg R, Levi AW, Yarbrough WG, Kowalski D, Chhieng D. Detection and Genotype of High-Risk Human Papillomavirus in Fine-Needle Aspirates of Patients With Metastatic Squamous Cell Carcinoma Is Helpful in Determining Tumor Origin. American Journal Of Clinical Pathology 2015, 143: 694-700. PMID: 25873503, DOI: 10.1309/ajcpcza4pszcfhq4.
- Wong R, Aronberg R, Levi A, Yarbrough W, Kowalski D, Chhieng D. Detection and Genotype of High Risk Human Papillomavirus in Fine Needle Aspirates of Patients with Metastatic Squamous Cell Carcinoma is Helpful in Determining Tumor Origin. Journal Of The American Society Of Cytopathology 2014, 3: s49-s50. DOI: 10.1016/j.jasc.2014.09.109.
- Snir O, Baldassarri R, Levi A, Schofield K, Kowalski D, Chhieng D. Human Papillomavirus Testing Using Hybrid Capture II and Cobas 4800 with ThinPrep and SurePath Preparations in Gynecologic Cytology. Journal Of The American Society Of Cytopathology 2014, 3: s43. DOI: 10.1016/j.jasc.2014.09.095.
- Bernstein J, Chhieng D, Levi A. What Would We Miss if HR-HPV Testing Was Used for Primary Cervical Cancer Screening. Journal Of The American Society Of Cytopathology 2014, 3: s37. DOI: 10.1016/j.jasc.2014.09.079.
- Brandsma JL, Harigopal M, Kiviat NB, Sun Y, Deng Y, Zelterman D, Lizardi PM, Shabanova VS, Levi A, Yaping T, Hu X, Feng Q. Methylation of Twelve CpGs in Human Papillomavirus Type 16 (HPV16) as an Informative Biomarker for the Triage of Women Positive for HPV16 Infection. Cancer Prevention Research 2014, 7: 526-533. PMID: 24556390, DOI: 10.1158/1940-6207.capr-13-0354.
- Zhao C, Li Z, Nayar R, Levi AW, Winkler BA, Moriarty AT, Barkan GA, Rao J, Miller F, Fan F, Zhou Z, Si Q, Fischer AH, Sturgis CD, Jing X, Marshall CB, Witt BL, Birdsong GG, Crothers BA. Prior High-Risk Human Papillomavirus Testing and Papanicolaou Test Results of 70 Invasive Cervical Carcinomas Diagnosed in 2012: Results of a Retrospective Multicenter Study. Archives Of Pathology & Laboratory Medicine 2014, 139: 184-8. PMID: 24694342, DOI: 10.5858/arpa.2014-0028-oa.
- Zhao C, Nayar R, Levi A, Winkler B, Moriarty A, Barkan G, Li Z, Rao J, Miller F, Fan F, Si Q, Fischer A, Sturgis C, Jing X, Marshall C, Witt B, Crothers B. Prior High-Risk HPV Testing and Pap Test Results of 58 Invasive Cervical Carcinomas Diagnosed in 2012. Journal Of The American Society Of Cytopathology 2013, 2: s3-s4. DOI: 10.1016/j.jasc.2013.08.004.
- Harigopal M, Sun Y, Chen X, Levi A, Brandsma J. HPV16 DNA Methylation Analysis for Improved Triage of Atypical Squamous Cell of Undetermined Significance (ASCUS). Journal Of The American Society Of Cytopathology 2013, 2: s45. DOI: 10.1016/j.jasc.2013.08.121.
- Levi A, Schofield K, Harigopal M, Chhieng D. High-risk HPV Testing in the Detection of Cervical Carcinoma using Liquid-based Preparations. Journal Of The American Society Of Cytopathology 2013, 2: s33. DOI: 10.1016/j.jasc.2013.08.090.
- Levi AW, Galullo P, Gordy K, Mikolaiski N, Schofield K, Elsheikh TM, Harigopal M, Chhieng DC. Increasing Cytotechnologist Workload Above 100 Slides per Day Using the BD FocalPoint GS Imaging System Negatively Affects Screening Performance. American Journal Of Clinical Pathology 2012, 138: 811-815. PMID: 23161714, DOI: 10.1309/ajcptydd9g2ncumf.
- Abiraad R, Schofield K, Harigopal M, Chhieng D, Levi A. Value of 3q26 Gain in the Triage of Low-grade Squamous Abnormalities. Journal Of The American Society Of Cytopathology 2012, 1: s46. DOI: 10.1016/j.jasc.2012.08.101.
- Honarpisheh H, Schofield K, Harigopal M, Chhieng D, Levi A. Accuracy of FocalPoint GS Imaging: Can We Trust the System? Journal Of The American Society Of Cytopathology 2012, 1: s47. DOI: 10.1016/j.jasc.2012.08.103.
- Wong R, Schofield K, Harigopal M, Ratner E, Chhieng D, Levi A. Effectiveness of the FocalPoint GS Imaging System in the Detection of Adenocarcinoma of the Gynecologic System. Journal Of The American Society Of Cytopathology 2012, 1: s34. DOI: 10.1016/j.jasc.2012.08.072.
- Levi AW, Beckman D, Hui P, Schofield K, Harigopal M, Chhieng DC. Comparing Two Methods of Detection for Chlamydia trachomatis in Liquid-Based Papanicolaou Tests. American Journal Of Clinical Pathology 2012, 138: 236-240. PMID: 22904135, DOI: 10.1309/ajcp2b7xqtcnamjp.
- Wong R, Levi AW, Harigopal M, Schofield K, Chhieng DC. The Positive Impact of Simultaneous Implementation of the BD FocalPoint GS Imaging System and Lean Principles on the Operation of Gynecologic Cytology. Archives Of Pathology & Laboratory Medicine 2012, 136: 183-9. PMID: 22288966, DOI: 10.5858/arpa.2011-0139-oa.
- Levi AW, Chhieng DC, Schofield K, Kowalski D, Harigopal M. Implementation of FocalPoint GS location‐guided imaging system. Cancer Cytopathology 2011, 120: 126-133. PMID: 22505211, DOI: 10.1002/cncy.20187.
- Levi AW, Harigopal M, Hui P, Schofield K, Chhieng DC. Use of high‐risk human papillomavirus testing in patients with low‐grade squamous intraepithelial lesions. Cancer Cytopathology 2011, 119: 228-234. PMID: 21732551, DOI: 10.1002/cncy.20172.
- Levi AW, Harigopal M, Hui P, Schofield K, Chhieng DC. Comparison of Affirm VPIII and Papanicolaou Tests in the Detection of Infectious Vaginitis. American Journal Of Clinical Pathology 2011, 135: 442-447. PMID: 21350100, DOI: 10.1309/ajcp7tbn5vzuglzu.
- Panda B, Stiller R, Iruretagoyena I, Levi A. Prenatal diagnosis of an umbilical vein aneurysm: a case report. Connecticut Medicine 2009, 73: 465-7. PMID: 19777980.
- Parwani A, Levi A, Epstein J, Ali S. Urinary Bladder Biopsy With Denuded Mucosa: Denuding Cystitis-Cytopathologic Correlates. Journal Of Urology 2006, 175: 572. DOI: 10.1016/s0022-5347(05)00191-6.
- Parwani AV, Levi AW, Epstein JI, Ali SZ. Urinary bladder biopsy with denuded mucosa: Denuding cystitis—Cytopathologic correlates. Diagnostic Cytopathology 2004, 30: 297-300. PMID: 15108225, DOI: 10.1002/dc.10406.
- Levi AW, Kelly DP, Rosenthal DL, Ronnett BM. Atypical squamous cells of undetermined significance in liquid‐based cytologic specimens. Cancer 2003, 99: 191-197. PMID: 12925979, DOI: 10.1002/cncr.11507.
- Chan TY, Parwani AV, Levi AW, Ali SZ. Mollaret's meningitis: Cytopathologic analysis of fourteen cases. Diagnostic Cytopathology 2003, 28: 227-231. PMID: 12722116, DOI: 10.1002/dc.10261.
- Sehdev A, Levi A, Nadasdy T, Campbell K, Fishman E, Hruban R. The pigmented “black” neuroendocrine tumor of the pancreas. Cancer 2001, 92: 1984-1991. PMID: 11745274, DOI: 10.1002/1097-0142(20011001)92:7<1984::aid-cncr1718>3.0.co;2-0.
- LEVI A, POTTER S, SCHOENBERG M, EPSTEIN J. CLINICAL SIGNIFICANCE OF DENUDED UROTHELIUM IN BLADDER BIOPSY. Journal Of Urology 2001, 166: 457-460. DOI: 10.1097/00005392-200108000-00013.
- LEVI A, POTTER S, SCHOENBERG M, EPSTEIN J. CLINICAL SIGNIFICANCE OF DENUDED UROTHELIUM IN BLADDER BIOPSY. Journal Of Urology 2001, 166: 457-460. PMID: 11458047, DOI: 10.1016/s0022-5347(05)65963-0.
- Nguyen C, Levi A, Montz F, Bristow R. Coexistent Choriocarcinoma and Malignant Mixed Mesodermal Tumor of the Uterus. Gynecologic Oncology 2000, 79: 499-503. PMID: 11104628, DOI: 10.1006/gyno.2000.5976.
- Levi A, Epstein J. Pseudohyperplastic Prostatic Adenocarcinoma on Needle Biopsy and Simple Prostatectomy. The American Journal Of Surgical Pathology 2000, 24: 1039-1046. PMID: 10935644, DOI: 10.1097/00000478-200008000-00001.
- Wolf AN, Ladanyi M, Paull G, Blaugrund JE, Westra WH. The expanding clinical spectrum of desmoplastic small round-cell tumor: a report of two cases with molecular confirmation. Hum Pathol 1999, 30: 430-5. PMID: 10208465, DOI: 10.1016/s0046-8177(99)90119-3.