- The Breast CenterYale New Haven Shoreline Medical Center111 Goose Lane, Fl 2Guilford, CT 06437
- The Breast CenterSmilow Cancer Hospital at Yale New Haven35 Park Street, Ste North Pavilion 1New Haven, CT 06511
Andrea Silber, MD
Biography
Andrea Silber, MD, is the assistant clinical director for health equity and diversity at the Yale Cancer Center. In this role, she provides community education about cancer prevention and screening.
As a breast oncologist, her focus is treating women diagnosed with breast cancer with a special interest in helping women who are socioeconomically disadvantaged.
“Every day, I get to work with wonderful women—some of whom may be not at their healthiest, but they’re at their best, strongest, and most generous, and are trying their hardest,” says Dr. Silber. “I see women who put their bodies through really tough things and do it with a sense of humor or generosity. I’m lucky. People who work with cancer patients see humanity at its best.”
Dr. Silber has received national recognition for her expertise in treating breast cancer in Black women. She dedicates her time to doing outreach work through a grant that supports economically disadvantaged women with breast cancer who are uninsured or underinsured.
She is also an associate professor of clinical medicine (medical oncology) at Yale School of Medicine.
Titles
- Professor of Medicine (Medical Oncology)
Education & Training
- FellowshipYale-New Haven Hospital (1987)
- ResidencyYale-New Haven Hospital (1985)
- Chief ResidentYale New Haven Hospital (1984)
- Attending PhyscianYale New Haven Hospital (1984)
- InternYale University School of Medicine (1982)
- MDNew York University (1981)
- BAOberlin College (1977)
Additional Information
- Connecticut Cancer Partnership 2016 Cancer Champion Award: (2019)
- Yale Cancer Center Award for Excellence in Clinical Care: (2019)
- Women in Strength Award, Get in Touch Foundation: (2010)
- Physician of the Year, Business New Haven: (2009)
- Lane Adams Quality of Life Award: (2007)
- Cover Girls Women at the Their Best Award: (1998)
- Fellowship in Philosophy and Medicine: (1981)
- National Health Service Corps Scholarship: (1978)
- Magna Cum Laude, Oberlin College: (1977)
- AB of Internal Medicine, Medical Oncology (1991, recertified: 2023)
- AB of Internal Medicine, Internal Medicine (1984)
- National Association of Negro Business and Professional Woman (2019 - Present): Lecturer
- New Haven Community Steering Committee (2019 - Present): Yale Cancer Center Initiatives to improve cancer outcomes for minorities, Birchwood's Woodbridge CT
- African American Women's Union Summit (2018 - Present): OwnIt (Oncologists Welcome New Haven Into Trials ) Presentation at Beecher School
- Sisters Journey (2018 - Present): Triple Negative Breast Cancer Discussion at Beecher School
- Breast Cancer Panel Discussion, Health Initiative Day, New Haven, CT (2017 - Present): Lecturer
- Latin Lean Cancer Survivors, Contributions to a healthy diet, New Haven, CT (2017 - Present): Lecturer
- Sisters Journey (2017 - Present): "New Advancements in Treatment for Triple Negative Women", St Luke Church, New Haven, CT
- The Community Foundation (2017 - Present): Local Women Leading Change: "Those Closest to the Challenge are Closest to the Solution", New Haven, CT
- Connecticut Health Foundation (2015 - Present): Leadership Fellow
- Connecticut Cancer Partner (2010 - Present): Health Care Disparities Resource Team
- Foldi J, Blenman K, Marczyk M, Gunasekharan V, Polanska A, Gee R, Davis M, Kahn A, Silber A, Pusztai L. Peripheral blood immune parameters, response, and adverse events after neoadjuvant chemotherapy plus durvalumab in early-stage triple-negative breast cancer. Breast Cancer Research And Treatment 2024, 1-9. PMID: 39002068, DOI: 10.1007/s10549-024-07426-3.
- Chavez-MacGregor M, Miao J, Pusztai L, Goetz M, Rastogi P, Ganz P, Mamounas E, Paik S, Bandos H, Razaq W, O'Dea A, Kaklamani V, Silber A, Flaum L, Andreopoulou E, Wendt A, Carney J, Sharma P, Gralow J, Lew D, Barlow W, Hortobagyi G. Phase III Randomized, Placebo-Controlled Trial of Endocrine Therapy ± 1 Year of Everolimus in Patients With High-Risk, Hormone Receptor–Positive, Early-Stage Breast Cancer. Journal Of Clinical Oncology 2024, 42: 3012-3021. PMID: 38833643, DOI: 10.1200/jco.23.02344.
- Wang J, Sun T, Zhang Q, Shi Y, Wang X, Chen Y, Ouyang Q, Li K, Bupathi M, Edenfield W, Silber A, Zong H, Hamilton E, Juric D, Lathrop K, Zhang Y, Stazzone K, Shi Z, Wang Y, Zhang L, Xu B. Abstract PS15-02: A Phase Ⅰb Study of D-0502 as Monotherapy for Advanced or Metastatic ER-Positive and HER2-Negative Breast Cancer: Results from the Dose-Expansion Stage. Cancer Research 2024, 84: ps15-02-ps15-02. DOI: 10.1158/1538-7445.sabcs23-ps15-02.
- Sanft T, Harrigan M, McGowan C, Cartmel B, Zupa M, Li F, Ferrucci L, Puklin L, Cao A, Nguyen T, Neuhouser M, Hershman D, Basen-Engquist K, Jones B, Knobf T, Chagpar A, Silber A, Tanasijevic A, Ligibel J, Irwin M. Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study. Journal Of Clinical Oncology 2023, 41: 5285-5295. PMID: 37656930, PMCID: PMC10691793, DOI: 10.1200/jco.23.00871.
- Westvold S, KC M, Fan J, Hyslop T, Spees L, Wang S, Silber A, Oeffinger K, Dinan M. Demographic and clinical factors associated with cardiovascular events in elderly long-term survivors of breast cancer. Journal Of Clinical Oncology 2023, 41: e24105-e24105. DOI: 10.1200/jco.2023.41.16_suppl.e24105.
- Chavez M, Miao J, Pusztai L, Goetz M, Rastogi P, Ganz P, Mamounas E, Paik S, Bandos H, Razaq W, O’Dea A, Kaklamani V, Silber A, Flaum L, Andreopolu E, Baar J, Wendt A, Carney J, Sharma P, Gralow J, Lew D, Barlow W, Hortobagyi G. Abstract GS1-07: Results from a phase III randomized, placebo-controlled clinical trial evaluating adjuvant endocrine therapy +/- 1 year of everolimus in patients with high-risk hormone receptor-positive, HER2-negative breast cancer: SWOG S1207. Cancer Research 2023, 83: gs1-07-gs1-07. DOI: 10.1158/1538-7445.sabcs22-gs1-07.
- Belzer A, Silber A, Mehra S, Gilani S, Leventhal JS. Mucosal haemangioma in the setting of treatment with trastuzumab emtansine (T‐DM1). British Journal Of Dermatology 2022, 187: e168-e168. PMID: 35633104, DOI: 10.1111/bjd.21654.
- Foldi J, Kahn A, Silber A, Qing T, Reisenbichler E, Fischbach N, Persico J, Adelson K, Katoch A, Chagpar A, Park T, Blanchard A, Blenman K, Rimm DL, Pusztai L. Clinical Outcomes and Immune Markers by Race in a Phase I/II Clinical Trial of Durvalumab Concomitant with Neoadjuvant Chemotherapy in Early-Stage TNBC. Clinical Cancer Research 2022, 28: 3720-3728. PMID: 35903931, PMCID: PMC9444984, DOI: 10.1158/1078-0432.ccr-22-0862.
- Sanft T, Harrigan M, Cartmel B, Li F, Zupa M, McGowan C, Ferrucci L, Puklin L, Nguyen T, Tanasijevic A, Neuhouser M, Hershman D, Basen-Engquist K, Jones B, Knobf M, Chagpar A, Silber A, Ligibel J, Irwin M. Randomized trial of diet and exercise on chemotherapy completion in women with breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) study. Journal Of Clinical Oncology 2022, 40: 12007-12007. DOI: 10.1200/jco.2022.40.16_suppl.12007.
- Foldi J, Kahn A, Silber A, Qing T, Reisenbichler E, Fischbach N, Persico J, Adelson K, Katoch A, Chagpar A, Park T, Blanchard A, Blenman K, Rimm D, Pusztai L. Clinical outcomes and immune markers by race in a phase I/II clinical trial of durvalumab concomitant with neoadjuvant chemotherapy in early-stage TNBC. Journal Of Clinical Oncology 2022, 40: 516-516. DOI: 10.1200/jco.2022.40.16_suppl.516.
- Blenman KRM, Marczyk M, Karn T, Qing T, Li X, Gunasekharan V, Yaghoobi V, Bai Y, Ibrahim EY, Park T, Silber A, Wolf DM, Reisenbichler E, Denkert C, Sinn BV, Rozenblit M, Foldi J, Rimm DL, Loibl S, Pusztai L. Predictive Markers of Response to Neoadjuvant Durvalumab with Nab-Paclitaxel and Dose-Dense Doxorubicin/Cyclophosphamide in Basal-Like Triple-Negative Breast Cancer. Clinical Cancer Research 2022, 28: 2587-2597. PMID: 35377948, PMCID: PMC9464605, DOI: 10.1158/1078-0432.ccr-21-3215.
- Foldi J, Silber A, Reisenbichler E, Singh K, Fischbach N, Persico J, Adelson K, Katoch A, Horowitz N, Lannin D, Chagpar A, Park T, Marczyk M, Frederick C, Burrello T, Ibrahim E, Qing T, Bai Y, Blenman K, Rimm DL, Pusztai L. Author Correction: Neoadjuvant durvalumab plus weekly nab-paclitaxel and dose-dense doxorubicin/cyclophosphamide in triple-negative breast cancer. Npj Breast Cancer 2022, 8: 17. PMID: 35115541, PMCID: PMC8814070, DOI: 10.1038/s41523-022-00392-3.
- Yardley DA, Young RR, Adelson KB, Silber AL, Najera JE, Daniel DB, Peacock N, Finney L, Hoekstra SJ, Shastry M, Hainsworth JD, Burris HA. A Phase II Study Evaluating Orteronel, an Inhibitor of Androgen Biosynthesis, in Patients With Androgen Receptor (AR)-Expressing Metastatic Breast Cancer (MBC). Clinical Breast Cancer 2021, 22: 269-278. PMID: 34824002, DOI: 10.1016/j.clbc.2021.10.011.
- Sanft T, Harrigan M, Cartmel B, Ferrucci LM, Li FY, McGowan C, Zupa M, Nguyen TH, Ligibel J, Neuhouser ML, Hershman DL, Basen-Engquist K, Jones B, Knobf T, Chagpar A, Silber A, Irwin ML. Effect of healthy diet and exercise on chemotherapy completion rate in women with breast cancer: The Lifestyle, Exercise and Nutrition Early after Diagnosis (LEANer) study: Study protocol for a randomized clinical trial. Contemporary Clinical Trials 2021, 109: 106508. PMID: 34274495, PMCID: PMC10424280, DOI: 10.1016/j.cct.2021.106508.
- Yardley D, Young R, Adelson K, Silber A, Kommor M, Najera J, Daniel D, Peacock N, Shastry M, Hainsworth J, Burris H. Abstract PS11-29: A phase 2 study evaluating orteronel, an inhibitor of androgen biosynthesis, in patients with androgen receptor (AR)-expressing metastatic triple-negative breast cancer (TNBC). Cancer Research 2021, 81: ps11-29-ps11-29. DOI: 10.1158/1538-7445.sabcs20-ps11-29.
- Osborne C, Richards D, Wilks S, Diab S, Juric D, Lathrop K, Silber A, Edenfield W, Aulakh A, Cho B, Xu B, Sun T, Ouyang Q, Shi Y, Stazzone K, Shi Z, Zhang L, Wang Y, Hamilton E. Abstract PS11-26: A phase 1 study of D-0502, an orally bioavailable SERD, for advanced or metastatic HR-positive and HER2-negative breast cancer. Cancer Research 2021, 81: ps11-26-ps11-26. DOI: 10.1158/1538-7445.sabcs20-ps11-26.
- Foldi J, Silber A, Reisenbichler E, Singh K, Fischbach N, Persico J, Adelson K, Katoch A, Horowitz N, Lannin D, Chagpar A, Park T, Marczyk M, Frederick C, Burrello T, Ibrahim E, Qing T, Bai Y, Blenman K, Rimm DL, Pusztai L. Neoadjuvant durvalumab plus weekly nab-paclitaxel and dose-dense doxorubicin/cyclophosphamide in triple-negative breast cancer. Npj Breast Cancer 2021, 7: 9. PMID: 33558513, PMCID: PMC7870853, DOI: 10.1038/s41523-021-00219-7.
- Trant AA, Walz L, Allen W, DeJesus J, Hatzis C, Silber A. Increasing accrual of minority patients in breast cancer clinical trials. Breast Cancer Research And Treatment 2020, 184: 499-505. PMID: 32840699, DOI: 10.1007/s10549-020-05873-2.
- Yaghoobi V, Pelekanou V, O'Meara T, Silber A, Pusztai L, Rimm D, Blenman K. Abstract 4973: Comparison of tumor immune microenvironment in triple negative breast cancer (TNBC) of African American versus that of white patients. Cancer Research 2020, 80: 4973-4973. DOI: 10.1158/1538-7445.am2020-4973.
- Trant A, Walz L, Allen W, Verma H, Le M, DeJesus J, Hatzis C, Silber A. Abstract A089: Addressing both community and institutional barriers increases accrual of minority patients in breast cancer clinical trials. Cancer Epidemiology Biomarkers & Prevention 2020, 29: a089-a089. DOI: 10.1158/1538-7755.disp18-a089.
- Pusztai L, Reisenbichler E, Bai Y, Fischbach N, Persico J, Adelson K, Katoch A, Horowitz N, Lannin D, Killelea B, Chagpar A, Frederick C, Burello T, Blenman K, Rimm D, Silber A. Abstract PD1-01: Durvalumab (MEDI4736) concurrent with nab-paclitaxel and dose dense doxorubicin cyclophosphamide (ddAC) as neoadjuvant therapy for triple negative breast cancer (TNBC). Cancer Research 2020, 80: pd1-01-pd1-01. DOI: 10.1158/1538-7445.sabcs19-pd1-01.
- Yaghoobi V, Pelekanou V, O'Meara T, Silber A, Pusztai L, Rimm D. Abstract 2842: Vesal Yaghoobi. 2019, 2842-2842. DOI: 10.1158/1538-7445.sabcs18-2842.
- Yaghoobi V, Pelekanou V, O'Meara T, Silber A, Pusztai L, Rimm D. Abstract 2842: Vesal Yaghoobi. Cancer Research 2019, 79: 2842-2842. DOI: 10.1158/1538-7445.am2019-2842.
- O'Meara T, Yaghoobi V, Blenman K, Pelekanou V, Silber A, Rimm D, Pusztai L. Quantitative assessment of immune cell populations and associations with clinical outcomes in African-American (AA) versus Caucasian triple-negative breast cancer (TNBC). Journal Of Clinical Oncology 2019, 37: e14180-e14180. DOI: 10.1200/jco.2019.37.15_suppl.e14180.
- Szekely B, Bossuyt V, Li X, Baine M, Silber A, Sanft T, Hofstatter E, Mougalian S, Baghwagar S, Neumeister V, Pelekanou V, Hatzis C, Pusztai L. Abstract PD6-02: Immunological differences between primary and metastatic breast cancer. Cancer Research 2018, 78: pd6-02-pd6-02. DOI: 10.1158/1538-7445.sabcs17-pd6-02.
- Pusztai L, Silber A, Hofstatter E, Chung G, Horowitz N, Lannin D, Killelea B, Chagpar A, Szekely B, Frederick C, Rispoli L, DiGiovanna M. Safety of MEDI4736 (anti-PD-L1 antibody) administered concomitant with weekly nab-paclitaxel and dose dense doxorubicin/cyclophosphamide (ddAC) as neoadjuvant chemotherapy for stage I-III triple negative breast cancer (TNBC): A Phase I/II trial. Journal Of Clinical Oncology 2017, 35: 572-572. DOI: 10.1200/jco.2017.35.15_suppl.572.
- Foldi J, Mougalian S, Silber A, Lannin D, Killelea B, Chagpar A, Horowitz N, Frederick C, Rispoli L, Abu-Khalaf M, Sabbath K, Sanft T, Fischbach N, Brandt D, Hofstatter E, DiGiovanna M, Pusztai L. Pathologic complete response (pCR) rates after neoadjuvant pertuzumab (P) and trastuzumab (H) administered concomitantly with weekly paclitaxel (T) and 5-fluorouracil/epirubicin/cyclophosphamide (FEC) chemotherapy for clinical stage I-III HER2-positive breast cancer. Journal Of Clinical Oncology 2017, 35: 577-577. DOI: 10.1200/jco.2017.35.15_suppl.577.
- Szekely B, Safonov A, Karn T, Bhagwagar S, Killelea B, Silber A, Hatzis C, Pusztai L. Differences in the immune microenvironment and genomic characteristics of TNBC in African American women compared to other races. Journal Of Clinical Oncology 2017, 35: e13028-e13028. DOI: 10.1200/jco.2017.35.15_suppl.e13028.
- Epstein L, Jhaveri A, Han G, Abu-Khalaf M, Hofstatter E, Sanft T, DiGiovanna M, Silber A, Adelson K, Chung G, Gross C, Pusztai L, Mougalian S. Onset of side effects and adherence to endocrine therapy in the Breast Cancer Endocrine Therapy Adherence (BETA) pilot study. Journal Of Clinical Oncology 2016, 34: e18136-e18136. DOI: 10.1200/jco.2016.34.15_suppl.e18136.
- Epstein L, Jhaveri A, Han G, Abu-Khalaf M, Hofstatter E, Sanft T, DiGiovanna M, Silber A, Adelson K, Chung G, Pusztai L, Gross C, Mougalian S. Abstract P5-11-03: Development of an interactive text messaging tool to improve adherence with adjuvant endocrine therapy: Breast cancer endocrine therapy adherence (BETA) pilot study. Cancer Research 2016, 76: p5-11-03-p5-11-03. DOI: 10.1158/1538-7445.sabcs15-p5-11-03.
- Yardley D, Peacock N, Young R, Silber A, Chung G, Webb C, Jones S, Shastry M, Midha R, DeBusk L, Hainsworth J, Burris H. Abstract P5-14-04: A phase 2 study evaluating orteronel, an inhibitor of androgen biosynthesis, in patients with androgen receptor (AR)-expressing metastatic breast cancer: Interim analysis. Cancer Research 2016, 76: p5-14-04-p5-14-04. DOI: 10.1158/1538-7445.sabcs15-p5-14-04.
- Sanft T, Aktas B, Schroeder B, Bossuyt V, DiGiovanna M, Abu-Khalaf M, Chung G, Silber A, Hofstatter E, Mougalian S, Epstein L, Hatzis C, Schnabel C, Pusztai L. Prospective study of the decision-making impact of the Breast Cancer Index in the selection of patients with ER+ breast cancer for extended endocrine therapy. Journal Of Clinical Oncology 2015, 33: 538-538. DOI: 10.1200/jco.2015.33.15_suppl.538.
- Patel J, Reiner E, Bossuyt V, Epstein L, Platt J, DiGiovanna M, Chung G, Silber A, Sanft T, Hofstatter E, Mougalian S, Abu-Khalaf M, Gershkovich P, Hatzis C, Pusztai L. Mutation-based treatment recommendations from next generation sequencing data: A comparison of web tools. Journal Of Clinical Oncology 2015, 33: e12564-e12564. DOI: 10.1200/jco.2015.33.15_suppl.e12564.
- Jhaveri A, Abu-Khalaf M, DiGiovanna M, Pusztai L, Hofstatter E, Sanft T, Sowers N, Lurie B, Silber A, Brandt D, Hochster H, Lacy J, Stein S, Chung G. Pilot study of sorafenib and biweekly capecitabine in patients with advanced breast and gastrointestinal tumors. Journal Of Clinical Oncology 2014, 32: 2561-2561. DOI: 10.1200/jco.2014.32.15_suppl.2561.
- Park E, Abu-Khalaf M, Hatzis C, LaSala J, Silber A, Hofstatter E, Sanft T, Russell R. Cardiac outcomes in women receiving aromatase inhibitors as adjuvant endocrine therapy for breast cancer. Journal Of Clinical Oncology 2014, 32: e11501-e11501. DOI: 10.1200/jco.2014.32.15_suppl.e11501.
- The Breast CenterYale New Haven Shoreline Medical Center111 Goose Lane, Fl 2Guilford, CT 06437
- The Breast CenterSmilow Cancer Hospital at Yale New Haven35 Park Street, Ste North Pavilion 1New Haven, CT 06511
Biography
Andrea Silber, MD, is the assistant clinical director for health equity and diversity at the Yale Cancer Center. In this role, she provides community education about cancer prevention and screening.
As a breast oncologist, her focus is treating women diagnosed with breast cancer with a special interest in helping women who are socioeconomically disadvantaged.
“Every day, I get to work with wonderful women—some of whom may be not at their healthiest, but they’re at their best, strongest, and most generous, and are trying their hardest,” says Dr. Silber. “I see women who put their bodies through really tough things and do it with a sense of humor or generosity. I’m lucky. People who work with cancer patients see humanity at its best.”
Dr. Silber has received national recognition for her expertise in treating breast cancer in Black women. She dedicates her time to doing outreach work through a grant that supports economically disadvantaged women with breast cancer who are uninsured or underinsured.
She is also an associate professor of clinical medicine (medical oncology) at Yale School of Medicine.
Titles
- Professor of Medicine (Medical Oncology)
Education & Training
- FellowshipYale-New Haven Hospital (1987)
- ResidencyYale-New Haven Hospital (1985)
- Chief ResidentYale New Haven Hospital (1984)
- Attending PhyscianYale New Haven Hospital (1984)
- InternYale University School of Medicine (1982)
- MDNew York University (1981)
- BAOberlin College (1977)
Additional Information
- Connecticut Cancer Partnership 2016 Cancer Champion Award: (2019)
- Yale Cancer Center Award for Excellence in Clinical Care: (2019)
- Women in Strength Award, Get in Touch Foundation: (2010)
- Physician of the Year, Business New Haven: (2009)
- Lane Adams Quality of Life Award: (2007)
- Cover Girls Women at the Their Best Award: (1998)
- Fellowship in Philosophy and Medicine: (1981)
- National Health Service Corps Scholarship: (1978)
- Magna Cum Laude, Oberlin College: (1977)
- AB of Internal Medicine, Medical Oncology (1991, recertified: 2023)
- AB of Internal Medicine, Internal Medicine (1984)
- National Association of Negro Business and Professional Woman (2019 - Present): Lecturer
- New Haven Community Steering Committee (2019 - Present): Yale Cancer Center Initiatives to improve cancer outcomes for minorities, Birchwood's Woodbridge CT
- African American Women's Union Summit (2018 - Present): OwnIt (Oncologists Welcome New Haven Into Trials ) Presentation at Beecher School
- Sisters Journey (2018 - Present): Triple Negative Breast Cancer Discussion at Beecher School
- Breast Cancer Panel Discussion, Health Initiative Day, New Haven, CT (2017 - Present): Lecturer
- Latin Lean Cancer Survivors, Contributions to a healthy diet, New Haven, CT (2017 - Present): Lecturer
- Sisters Journey (2017 - Present): "New Advancements in Treatment for Triple Negative Women", St Luke Church, New Haven, CT
- The Community Foundation (2017 - Present): Local Women Leading Change: "Those Closest to the Challenge are Closest to the Solution", New Haven, CT
- Connecticut Health Foundation (2015 - Present): Leadership Fellow
- Connecticut Cancer Partner (2010 - Present): Health Care Disparities Resource Team
- Foldi J, Blenman K, Marczyk M, Gunasekharan V, Polanska A, Gee R, Davis M, Kahn A, Silber A, Pusztai L. Peripheral blood immune parameters, response, and adverse events after neoadjuvant chemotherapy plus durvalumab in early-stage triple-negative breast cancer. Breast Cancer Research And Treatment 2024, 1-9. PMID: 39002068, DOI: 10.1007/s10549-024-07426-3.
- Chavez-MacGregor M, Miao J, Pusztai L, Goetz M, Rastogi P, Ganz P, Mamounas E, Paik S, Bandos H, Razaq W, O'Dea A, Kaklamani V, Silber A, Flaum L, Andreopoulou E, Wendt A, Carney J, Sharma P, Gralow J, Lew D, Barlow W, Hortobagyi G. Phase III Randomized, Placebo-Controlled Trial of Endocrine Therapy ± 1 Year of Everolimus in Patients With High-Risk, Hormone Receptor–Positive, Early-Stage Breast Cancer. Journal Of Clinical Oncology 2024, 42: 3012-3021. PMID: 38833643, DOI: 10.1200/jco.23.02344.
- Wang J, Sun T, Zhang Q, Shi Y, Wang X, Chen Y, Ouyang Q, Li K, Bupathi M, Edenfield W, Silber A, Zong H, Hamilton E, Juric D, Lathrop K, Zhang Y, Stazzone K, Shi Z, Wang Y, Zhang L, Xu B. Abstract PS15-02: A Phase Ⅰb Study of D-0502 as Monotherapy for Advanced or Metastatic ER-Positive and HER2-Negative Breast Cancer: Results from the Dose-Expansion Stage. Cancer Research 2024, 84: ps15-02-ps15-02. DOI: 10.1158/1538-7445.sabcs23-ps15-02.
- Sanft T, Harrigan M, McGowan C, Cartmel B, Zupa M, Li F, Ferrucci L, Puklin L, Cao A, Nguyen T, Neuhouser M, Hershman D, Basen-Engquist K, Jones B, Knobf T, Chagpar A, Silber A, Tanasijevic A, Ligibel J, Irwin M. Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study. Journal Of Clinical Oncology 2023, 41: 5285-5295. PMID: 37656930, PMCID: PMC10691793, DOI: 10.1200/jco.23.00871.
- Westvold S, KC M, Fan J, Hyslop T, Spees L, Wang S, Silber A, Oeffinger K, Dinan M. Demographic and clinical factors associated with cardiovascular events in elderly long-term survivors of breast cancer. Journal Of Clinical Oncology 2023, 41: e24105-e24105. DOI: 10.1200/jco.2023.41.16_suppl.e24105.
- Chavez M, Miao J, Pusztai L, Goetz M, Rastogi P, Ganz P, Mamounas E, Paik S, Bandos H, Razaq W, O’Dea A, Kaklamani V, Silber A, Flaum L, Andreopolu E, Baar J, Wendt A, Carney J, Sharma P, Gralow J, Lew D, Barlow W, Hortobagyi G. Abstract GS1-07: Results from a phase III randomized, placebo-controlled clinical trial evaluating adjuvant endocrine therapy +/- 1 year of everolimus in patients with high-risk hormone receptor-positive, HER2-negative breast cancer: SWOG S1207. Cancer Research 2023, 83: gs1-07-gs1-07. DOI: 10.1158/1538-7445.sabcs22-gs1-07.
- Belzer A, Silber A, Mehra S, Gilani S, Leventhal JS. Mucosal haemangioma in the setting of treatment with trastuzumab emtansine (T‐DM1). British Journal Of Dermatology 2022, 187: e168-e168. PMID: 35633104, DOI: 10.1111/bjd.21654.
- Foldi J, Kahn A, Silber A, Qing T, Reisenbichler E, Fischbach N, Persico J, Adelson K, Katoch A, Chagpar A, Park T, Blanchard A, Blenman K, Rimm DL, Pusztai L. Clinical Outcomes and Immune Markers by Race in a Phase I/II Clinical Trial of Durvalumab Concomitant with Neoadjuvant Chemotherapy in Early-Stage TNBC. Clinical Cancer Research 2022, 28: 3720-3728. PMID: 35903931, PMCID: PMC9444984, DOI: 10.1158/1078-0432.ccr-22-0862.
- Sanft T, Harrigan M, Cartmel B, Li F, Zupa M, McGowan C, Ferrucci L, Puklin L, Nguyen T, Tanasijevic A, Neuhouser M, Hershman D, Basen-Engquist K, Jones B, Knobf M, Chagpar A, Silber A, Ligibel J, Irwin M. Randomized trial of diet and exercise on chemotherapy completion in women with breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) study. Journal Of Clinical Oncology 2022, 40: 12007-12007. DOI: 10.1200/jco.2022.40.16_suppl.12007.
- Foldi J, Kahn A, Silber A, Qing T, Reisenbichler E, Fischbach N, Persico J, Adelson K, Katoch A, Chagpar A, Park T, Blanchard A, Blenman K, Rimm D, Pusztai L. Clinical outcomes and immune markers by race in a phase I/II clinical trial of durvalumab concomitant with neoadjuvant chemotherapy in early-stage TNBC. Journal Of Clinical Oncology 2022, 40: 516-516. DOI: 10.1200/jco.2022.40.16_suppl.516.
- Blenman KRM, Marczyk M, Karn T, Qing T, Li X, Gunasekharan V, Yaghoobi V, Bai Y, Ibrahim EY, Park T, Silber A, Wolf DM, Reisenbichler E, Denkert C, Sinn BV, Rozenblit M, Foldi J, Rimm DL, Loibl S, Pusztai L. Predictive Markers of Response to Neoadjuvant Durvalumab with Nab-Paclitaxel and Dose-Dense Doxorubicin/Cyclophosphamide in Basal-Like Triple-Negative Breast Cancer. Clinical Cancer Research 2022, 28: 2587-2597. PMID: 35377948, PMCID: PMC9464605, DOI: 10.1158/1078-0432.ccr-21-3215.
- Foldi J, Silber A, Reisenbichler E, Singh K, Fischbach N, Persico J, Adelson K, Katoch A, Horowitz N, Lannin D, Chagpar A, Park T, Marczyk M, Frederick C, Burrello T, Ibrahim E, Qing T, Bai Y, Blenman K, Rimm DL, Pusztai L. Author Correction: Neoadjuvant durvalumab plus weekly nab-paclitaxel and dose-dense doxorubicin/cyclophosphamide in triple-negative breast cancer. Npj Breast Cancer 2022, 8: 17. PMID: 35115541, PMCID: PMC8814070, DOI: 10.1038/s41523-022-00392-3.
- Yardley DA, Young RR, Adelson KB, Silber AL, Najera JE, Daniel DB, Peacock N, Finney L, Hoekstra SJ, Shastry M, Hainsworth JD, Burris HA. A Phase II Study Evaluating Orteronel, an Inhibitor of Androgen Biosynthesis, in Patients With Androgen Receptor (AR)-Expressing Metastatic Breast Cancer (MBC). Clinical Breast Cancer 2021, 22: 269-278. PMID: 34824002, DOI: 10.1016/j.clbc.2021.10.011.
- Sanft T, Harrigan M, Cartmel B, Ferrucci LM, Li FY, McGowan C, Zupa M, Nguyen TH, Ligibel J, Neuhouser ML, Hershman DL, Basen-Engquist K, Jones B, Knobf T, Chagpar A, Silber A, Irwin ML. Effect of healthy diet and exercise on chemotherapy completion rate in women with breast cancer: The Lifestyle, Exercise and Nutrition Early after Diagnosis (LEANer) study: Study protocol for a randomized clinical trial. Contemporary Clinical Trials 2021, 109: 106508. PMID: 34274495, PMCID: PMC10424280, DOI: 10.1016/j.cct.2021.106508.
- Yardley D, Young R, Adelson K, Silber A, Kommor M, Najera J, Daniel D, Peacock N, Shastry M, Hainsworth J, Burris H. Abstract PS11-29: A phase 2 study evaluating orteronel, an inhibitor of androgen biosynthesis, in patients with androgen receptor (AR)-expressing metastatic triple-negative breast cancer (TNBC). Cancer Research 2021, 81: ps11-29-ps11-29. DOI: 10.1158/1538-7445.sabcs20-ps11-29.
- Osborne C, Richards D, Wilks S, Diab S, Juric D, Lathrop K, Silber A, Edenfield W, Aulakh A, Cho B, Xu B, Sun T, Ouyang Q, Shi Y, Stazzone K, Shi Z, Zhang L, Wang Y, Hamilton E. Abstract PS11-26: A phase 1 study of D-0502, an orally bioavailable SERD, for advanced or metastatic HR-positive and HER2-negative breast cancer. Cancer Research 2021, 81: ps11-26-ps11-26. DOI: 10.1158/1538-7445.sabcs20-ps11-26.
- Foldi J, Silber A, Reisenbichler E, Singh K, Fischbach N, Persico J, Adelson K, Katoch A, Horowitz N, Lannin D, Chagpar A, Park T, Marczyk M, Frederick C, Burrello T, Ibrahim E, Qing T, Bai Y, Blenman K, Rimm DL, Pusztai L. Neoadjuvant durvalumab plus weekly nab-paclitaxel and dose-dense doxorubicin/cyclophosphamide in triple-negative breast cancer. Npj Breast Cancer 2021, 7: 9. PMID: 33558513, PMCID: PMC7870853, DOI: 10.1038/s41523-021-00219-7.
- Trant AA, Walz L, Allen W, DeJesus J, Hatzis C, Silber A. Increasing accrual of minority patients in breast cancer clinical trials. Breast Cancer Research And Treatment 2020, 184: 499-505. PMID: 32840699, DOI: 10.1007/s10549-020-05873-2.
- Yaghoobi V, Pelekanou V, O'Meara T, Silber A, Pusztai L, Rimm D, Blenman K. Abstract 4973: Comparison of tumor immune microenvironment in triple negative breast cancer (TNBC) of African American versus that of white patients. Cancer Research 2020, 80: 4973-4973. DOI: 10.1158/1538-7445.am2020-4973.
- Trant A, Walz L, Allen W, Verma H, Le M, DeJesus J, Hatzis C, Silber A. Abstract A089: Addressing both community and institutional barriers increases accrual of minority patients in breast cancer clinical trials. Cancer Epidemiology Biomarkers & Prevention 2020, 29: a089-a089. DOI: 10.1158/1538-7755.disp18-a089.
- Pusztai L, Reisenbichler E, Bai Y, Fischbach N, Persico J, Adelson K, Katoch A, Horowitz N, Lannin D, Killelea B, Chagpar A, Frederick C, Burello T, Blenman K, Rimm D, Silber A. Abstract PD1-01: Durvalumab (MEDI4736) concurrent with nab-paclitaxel and dose dense doxorubicin cyclophosphamide (ddAC) as neoadjuvant therapy for triple negative breast cancer (TNBC). Cancer Research 2020, 80: pd1-01-pd1-01. DOI: 10.1158/1538-7445.sabcs19-pd1-01.
- Yaghoobi V, Pelekanou V, O'Meara T, Silber A, Pusztai L, Rimm D. Abstract 2842: Vesal Yaghoobi. 2019, 2842-2842. DOI: 10.1158/1538-7445.sabcs18-2842.
- Yaghoobi V, Pelekanou V, O'Meara T, Silber A, Pusztai L, Rimm D. Abstract 2842: Vesal Yaghoobi. Cancer Research 2019, 79: 2842-2842. DOI: 10.1158/1538-7445.am2019-2842.
- O'Meara T, Yaghoobi V, Blenman K, Pelekanou V, Silber A, Rimm D, Pusztai L. Quantitative assessment of immune cell populations and associations with clinical outcomes in African-American (AA) versus Caucasian triple-negative breast cancer (TNBC). Journal Of Clinical Oncology 2019, 37: e14180-e14180. DOI: 10.1200/jco.2019.37.15_suppl.e14180.
- Szekely B, Bossuyt V, Li X, Baine M, Silber A, Sanft T, Hofstatter E, Mougalian S, Baghwagar S, Neumeister V, Pelekanou V, Hatzis C, Pusztai L. Abstract PD6-02: Immunological differences between primary and metastatic breast cancer. Cancer Research 2018, 78: pd6-02-pd6-02. DOI: 10.1158/1538-7445.sabcs17-pd6-02.
- Pusztai L, Silber A, Hofstatter E, Chung G, Horowitz N, Lannin D, Killelea B, Chagpar A, Szekely B, Frederick C, Rispoli L, DiGiovanna M. Safety of MEDI4736 (anti-PD-L1 antibody) administered concomitant with weekly nab-paclitaxel and dose dense doxorubicin/cyclophosphamide (ddAC) as neoadjuvant chemotherapy for stage I-III triple negative breast cancer (TNBC): A Phase I/II trial. Journal Of Clinical Oncology 2017, 35: 572-572. DOI: 10.1200/jco.2017.35.15_suppl.572.
- Foldi J, Mougalian S, Silber A, Lannin D, Killelea B, Chagpar A, Horowitz N, Frederick C, Rispoli L, Abu-Khalaf M, Sabbath K, Sanft T, Fischbach N, Brandt D, Hofstatter E, DiGiovanna M, Pusztai L. Pathologic complete response (pCR) rates after neoadjuvant pertuzumab (P) and trastuzumab (H) administered concomitantly with weekly paclitaxel (T) and 5-fluorouracil/epirubicin/cyclophosphamide (FEC) chemotherapy for clinical stage I-III HER2-positive breast cancer. Journal Of Clinical Oncology 2017, 35: 577-577. DOI: 10.1200/jco.2017.35.15_suppl.577.
- Szekely B, Safonov A, Karn T, Bhagwagar S, Killelea B, Silber A, Hatzis C, Pusztai L. Differences in the immune microenvironment and genomic characteristics of TNBC in African American women compared to other races. Journal Of Clinical Oncology 2017, 35: e13028-e13028. DOI: 10.1200/jco.2017.35.15_suppl.e13028.
- Epstein L, Jhaveri A, Han G, Abu-Khalaf M, Hofstatter E, Sanft T, DiGiovanna M, Silber A, Adelson K, Chung G, Gross C, Pusztai L, Mougalian S. Onset of side effects and adherence to endocrine therapy in the Breast Cancer Endocrine Therapy Adherence (BETA) pilot study. Journal Of Clinical Oncology 2016, 34: e18136-e18136. DOI: 10.1200/jco.2016.34.15_suppl.e18136.
- Epstein L, Jhaveri A, Han G, Abu-Khalaf M, Hofstatter E, Sanft T, DiGiovanna M, Silber A, Adelson K, Chung G, Pusztai L, Gross C, Mougalian S. Abstract P5-11-03: Development of an interactive text messaging tool to improve adherence with adjuvant endocrine therapy: Breast cancer endocrine therapy adherence (BETA) pilot study. Cancer Research 2016, 76: p5-11-03-p5-11-03. DOI: 10.1158/1538-7445.sabcs15-p5-11-03.
- Yardley D, Peacock N, Young R, Silber A, Chung G, Webb C, Jones S, Shastry M, Midha R, DeBusk L, Hainsworth J, Burris H. Abstract P5-14-04: A phase 2 study evaluating orteronel, an inhibitor of androgen biosynthesis, in patients with androgen receptor (AR)-expressing metastatic breast cancer: Interim analysis. Cancer Research 2016, 76: p5-14-04-p5-14-04. DOI: 10.1158/1538-7445.sabcs15-p5-14-04.
- Sanft T, Aktas B, Schroeder B, Bossuyt V, DiGiovanna M, Abu-Khalaf M, Chung G, Silber A, Hofstatter E, Mougalian S, Epstein L, Hatzis C, Schnabel C, Pusztai L. Prospective study of the decision-making impact of the Breast Cancer Index in the selection of patients with ER+ breast cancer for extended endocrine therapy. Journal Of Clinical Oncology 2015, 33: 538-538. DOI: 10.1200/jco.2015.33.15_suppl.538.
- Patel J, Reiner E, Bossuyt V, Epstein L, Platt J, DiGiovanna M, Chung G, Silber A, Sanft T, Hofstatter E, Mougalian S, Abu-Khalaf M, Gershkovich P, Hatzis C, Pusztai L. Mutation-based treatment recommendations from next generation sequencing data: A comparison of web tools. Journal Of Clinical Oncology 2015, 33: e12564-e12564. DOI: 10.1200/jco.2015.33.15_suppl.e12564.
- Jhaveri A, Abu-Khalaf M, DiGiovanna M, Pusztai L, Hofstatter E, Sanft T, Sowers N, Lurie B, Silber A, Brandt D, Hochster H, Lacy J, Stein S, Chung G. Pilot study of sorafenib and biweekly capecitabine in patients with advanced breast and gastrointestinal tumors. Journal Of Clinical Oncology 2014, 32: 2561-2561. DOI: 10.1200/jco.2014.32.15_suppl.2561.
- Park E, Abu-Khalaf M, Hatzis C, LaSala J, Silber A, Hofstatter E, Sanft T, Russell R. Cardiac outcomes in women receiving aromatase inhibitors as adjuvant endocrine therapy for breast cancer. Journal Of Clinical Oncology 2014, 32: e11501-e11501. DOI: 10.1200/jco.2014.32.15_suppl.e11501.
- The Breast CenterYale New Haven Shoreline Medical Center111 Goose Lane, Fl 2Guilford, CT 06437
- The Breast CenterSmilow Cancer Hospital at Yale New Haven35 Park Street, Ste North Pavilion 1New Haven, CT 06511
- The Breast CenterYale New Haven Shoreline Medical Center111 Goose Lane, Fl 2Guilford, CT 06437
- The Breast CenterSmilow Cancer Hospital at Yale New Haven35 Park Street, Ste North Pavilion 1New Haven, CT 06511