Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation (I-ACQUIRE) (I-ACQUIRE)

This is a Phase III clinical trial to compare the efficacy of two dosages of a new infant rehabilitation protocol - I-ACQUIRE - to usual and customary forms of infant rehabilitation in infants who experienced Perinatal Arterial Stroke (PAS).

Treatment is also available in Rhode Island:  The Yale Site PI Laura Ment, MD has partnered with Ana Albuja Ponce, MD at Rhode Island Hospital and Dr. Betty Vohr, MD at Women and Infants Hospital. 

Inclusion Criteria: 

• Child will be 8 - 36 months old when study treatment will be delivered
• Child has a diagnosis of Perinatal Arterial Stroke (PAS)
• Parent permission to provide the child's clinical MRI to the study
• Child has hemiparesis parent(s) willing to participate in the home therapy component
• One parent English language proficient and will take the lead in interacting with study staff and completing self-administered forms and interviews in English

Exclusion Criteria:

• Child has medical or sensory condition(s) that prevent(s) full therapy participation (e.g., frequent uncontrolled seizures, fragile health) 
• Child previously received Constraint-Induced Movement Therapy (CIMT) or modified CIMT with a dose of at least 2 hrs/day for ≥10 days
• Child received botulinum toxin in past 3 months
• Child is a ward of the state or other agency